当前位置： SCI文献检索 > JOURNAL OF CLINICAL EPIDEMIOLOGY期刊下所有文献 > Early studies reported extreme findings with large variability: a meta-epidemiologic study in the field of endocrinology.

Early studies reported extreme findings with large variability: a meta-epidemiologic study in the field of endocrinology.

Abstract：

OBJECTIVES:To evaluate the presence of extreme findings and fluctuation in effect size in endocrinology. STUDY DESIGN AND SETTINGS:We systematically identified all meta-analyses published in 2014 in the field of endocrinology. Within each meta-analysis, the effect size of the primary binary outcome was compared across studies according to their order of publication. We pooled studies using the DerSimonian and Laird random-effects method. Heterogeneity was evaluated using the I(2) and tau(2). RESULTS:Twelve percent of the included 100 meta-analyses reported the largest effect size in the very first published study. The largest effect size occurred in the first 2 earliest studies in 31% of meta-analyses. When the effect size was the largest in the first published study, it was three times larger than the final pooled effect (ratio of rates, 3.26; 95% confidence interval: 1.80, 5.90). The largest heterogeneity measured by I(2) was observed in 18% of the included meta-analyses when combining the first 2 studies or 17% when combing the first 3 studies. CONCLUSIONS:In endocrinology, early studies reported extreme findings with large variability. This behavior of the evidence needs to be taken into account when used to formulate clinical policies.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Wang Z,Alahdab F,Almasri J,Haydour Q,Mohammed K,Abu Dabrh AM,Prokop LJ,Alfarkh W,Lakis S,Montori VM,Murad MH

doi

10.1016/j.jclinepi.2015.10.015

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

27-32

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(15)00502-8

journal_volume

72

pub_type

杂志文章,meta分析,评审

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