Bone fractures and lumbar mineral density after renal transplantation. A long-term cross-sectional study.

Abstract:

BACKGROUND:The purpose of this work was to investigate the association of vertebral and peripheral fractures 10 yr after grafting with bone metabolic markers and body mass density (BMD). PATIENTS AND METHODS:One hundred thirty-eight recipients with stable graft function were included in a cross-sectional study. Graft function, biochemical mineral metabolism markers and body mass density (DEXA) were measured. Vertebral fractures were assessed by a semiquantitative analysis of lateral spine X-ray exam. RESULTS:At the time of the study, intact parathyroid hormone levels were 127.5 ± 78.4 pg/mL and serum calcidiol 20.4 ± 9.3 ng/mL. DEXA showed osteopenia in 47% and osteoporosis in 23% at lumbar spine, 51% and 14% at femoral neck, and 53% and 8% at trochanter. Eighty-five recipients presented vertebral fractures, 69 mild and 16 moderate/severe fractures. In the multivariate analysis, vertebral fractures were associated with older age (p = 0.010), length of follow-up (p = 0.022) and trochanter T-score (p = 0.038). Twenty-three patients presented peripheral fractures and 19 of them also had vertebral fractures. Patients with peripheral fractures were younger, mostly women and had lower BMD. CONCLUSIONS:Vertebral fractures were associated with lower BMD at trochanter. Most fractures were mild and were several times more frequent than in general population. Their clinical significance needs to be determined.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Jiménez S,Marcén R,Vaamonde C,Caballero C,Fernández-Rodríguez A,Villafruela JJ,Galeano C,Teruel JL,Quereda C

doi

10.1111/ctr.12666

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

131-7

issue

2

eissn

0902-0063

issn

1399-0012

journal_volume

30

pub_type

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