Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia.

Abstract:

:Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up.Methods The subjects were categorized in two groups: short-term decline in global cognitive score and those with short-term stability or improvement. IL-6 174 G > C information were compared among these groups.Results We observed that individuals with cognitive impairment no dementia with GGlowergenotype were more frequent among global cognitive score non-decliners while carriers of at least one Chigherallele were more frequent in the group with global cognitive score decliners (p = 0.012; RR = 3.095 IC95%= 1.087-8.812).Conclusion These results suggest that the higher expression of IL-6 gene may be an independent risk factor for cognitive decline among individuals with cognitive impairment no dementia.

journal_name

Arq Neuropsiquiatr

authors

Fraga VG,Guimarães HC,Teixeira AL,Barbosa MT,Mateo EC,Carvalho MG,Caramelli P,Gomes KB

doi

10.1590/0004-282X20150137

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

899-902

issue

11

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2015001100899

journal_volume

73

pub_type

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