当前位置： SCI文献检索 > JOURNAL OF AFFECTIVE DISORDERS期刊下所有文献 > hTERT genetic variation in depression.

hTERT genetic variation in depression.

Abstract：

BACKGROUND:Telomeres are protective DNA-protein complexes forming the chromosome ends. TL differs between tissues. Shorter telomere length (TL) in blood leukocytes (LTL) has been associated with major depression, and with previous exposure to childhood adversity. TL studies on non-invasively sampled salivary DNA are less common. Telomerase, with its catalytic subunit hTERT, counteracts telomere shortening. Reduced telomerase activity associates with depression-like behavior in mice. Recently, the minor allele of the hTERT polymorphism rs2736100 was associated with shorter LTL among primarily healthy individuals. We hypothesized that (i) TL in saliva DNA is shortened in adults with a history of depression, and that (ii) rs2736100 is implicated in depression and depressive episodes in bipolar disorder type 1 (BD1). METHODS:Individuals with a history of depression and those without (controls) were identified using self-reported questionnaires from a well-characterized population-based cohort. Clinical BD1 patients were diagnosed by specialized psychiatrists. Saliva TL was measured in age-matched depressed individuals and controls (n=662) using qRT-PCR. rs2736100 was genotyped in 436 depressed individuals, 1590 controls, and 368 BD1 patients. RESULTS:Saliva TL was shorter in depressed individuals compared to controls. The rs2736100 minor allele was associated with depression among those without experience of childhood adversity, and with number of depressive episodes in BD1 patients responding well to lithium. LIMITATION:Psychopathological symptoms were recorded at two time points only, 3 and 6 years prior to DNA sampling. CONCLUSIONS:This is the first report on hTERT genetic variation in mood disorder. It proposes that genetic variation in hTERT may influence the susceptibility to depression.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Wei YB,Martinsson L,Liu JJ,Forsell Y,Schalling M,Backlund L,Lavebratt C

doi

10.1016/j.jad.2015.09.025

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

62-9

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(15)00466-8

journal_volume

189

pub_type

杂志文章

相关文献

JOURNAL OF AFFECTIVE DISORDERS文献大全
  • Schizoaffective disorder diagnosed according to different diagnostic criteria--systematic literature search and meta-analysis of key clinical characteristics and heterogeneity.

    abstract：BACKGROUND:Schizoaffective disorder is viewed as a heterogeneous diagnosis among psychotic illnesses. Different diagnostic systems differ in their definition with DSM (-IIIR, -IV, and -V) providing a narrower definition than RDC and ICD-10. It is unclear whether this difference is reflected in patient samples diagnosed...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jad.2013.12.001

    authors： Pagel T,Franklin J,Baethge C

    更新日期：2014-03-01 00:00:00

  • Comments on "Malondialdehyde: A novel predictive biomarker for post-stroke depression".

    abstract：:In a recent work by Liu et al. (2017) appeared in this journal, malondialdehyde levels proposed as a novel biomarker. Despite of wide usage of malondialdehyde as a biomarker, there are some points from analytical viewpoint which should be considered in future works. This work aimed to discuss the points briefly. ...

    journal_title：Journal of affective disorders

    pub_type： 评论,信件

    doi：10.1016/j.jad.2017.07.050

    authors： Jouyban A,Khoubnasabjafari M

    更新日期：2018-01-01 00:00:00

  • Racial/ethnic differences in the treatment of adolescent major depressive disorders (MDD) across healthcare providers participating in the medicaid program.

    abstract：BACKGROUND:To examine whether racial/ethnic differences in receipt of MDD treatment could be explained by the specialty of provider diagnosing the adolescent. METHOD:Adolescents (10-20 years-old) with ≥2 MDD diagnoses were identified using 2005-2007 Medicaid data from Texas. Patients were categorized based on the type...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2018.04.045

    authors： Yucel A,Essien EJ,Sanyal S,Mgbere O,Aparasu RR,Bhatara VS,Alonzo JP,Chen H

    更新日期：2018-08-01 00:00:00

  • Suicidal behaviour during different phases of bipolar disorder.

    abstract：BACKGROUND:There are no previous studies comparing the prevalence and risk factors for suicidal behaviour during different phases of bipolar disorder. METHODS:In the Jorvi Bipolar Study (JoBS), 1630 psychiatric in- and outpatients were screened for bipolar disorders with the Mood Disorder Questionnaire. Using SCID I a...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2006.05.033

    authors： Valtonen HM,Suominen K,Mantere O,Leppämäki S,Arvilommi P,Isometsä E

    更新日期：2007-01-01 00:00:00

  • Obesity and anxiety during pregnancy and postpartum: A systematic review.

    abstract：BACKGROUND:Obesity and anxiety during the perinatal period are common and associated with poor health outcomes for the mother and the child. Despite the well-documented health risks of both pregnancy obesity and anxiety, associations between the two have rarely been explored. With this review we aim to provide a system...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.jad.2015.06.054

    authors： Nagl M,Linde K,Stepan H,Kersting A

    更新日期：2015-11-01 00:00:00

  • Psychosocial work factors, major depressive and generalised anxiety disorders: results from the French national SIP study.

    abstract：BACKGROUND:Anxiety and depression are prevalent mental disorders in working populations. The risk factors of these disorders are not completely well known. Developing knowledge on occupational risk factors for mental disorders appears crucial. This study investigates the association between various classical and emerge...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2012.09.014

    authors： Murcia M,Chastang JF,Niedhammer I

    更新日期：2013-04-25 00:00:00

  • Emotional arousal modulation of right temporoparietal cortex in depression depends on parental depression status in women: first evidence.

    abstract：BACKGROUND:Structural and Electroencephalography (EEG) abnormalities in right temporoparietal cortex have been associated with family history of depression (FH). Here we investigate if functional abnormalities in this area, indexed by attenuated responses to emotionally arousing stimuli, are also family-history-depende...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2015.02.031

    authors： Moratti S,Strange B,Rubio G

    更新日期：2015-06-01 00:00:00

  • The prevalence of depression in Alzheimer's disease and vascular dementia in a population sample.

    abstract：BACKGROUND:Previous studies have shown that depression is more prevalent in vascular dementia than Alzheimer's disease (AD). Subjects for these studies were either psychiatry or neurology patients, raising the issue of whether factors leading to treatment might have introduced sampling bias. METHODS:Data for the prese...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/s0165-0327(98)00070-6

    authors： Newman SC

    更新日期：1999-01-01 00:00:00

  • Relationship between maternal pregnancy-related anxiety and infant brain responses to emotional speech - a pilot study.

    abstract：BACKGROUND:Maternal pregnancy-related anxiety (PRA) is reportedly related to neurodevelopmental outcomes of infants. However, the relationship between maternal PRA and the processing of emotions in the infant brain has not been extensively studied with neuroimaging. The objective of the present pilot study is to invest...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2019.10.047

    authors： Maria A,Nissilä I,Shekhar S,Kotilahti K,Tuulari JJ,Hirvi P,Huotilainen M,Heiskala J,Karlsson L,Karlsson H

    更新日期：2020-02-01 00:00:00

  • Magnetization transfer imaging reveals the brain deficit in patients with treatment-refractory depression.

    abstract：BACKGROUND:Studies on treatment resistant depression (TRD) using advanced magnetic resonance imaging techniques are very limited. METHODS:A group of 15 patients with clinically defined TRD and 15 matched healthy controls underwent magnetization transfer imaging (MTI) and T1-weighted (T1W) imaging. MTI data were proces...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2009.01.003

    authors： Zhang TJ,Wu QZ,Huang XQ,Sun XL,Zou K,Lui S,Liu F,Hu JM,Kuang WH,Li DM,Li F,Chen HF,Chan RC,Mechelli A,Gong QY

    更新日期：2009-10-01 00:00:00

  • Development of the Macquarie Anxiety Behavioural Scale (MABS): A parent measure to assess anxiety in children and adolescents including young people with autism spectrum disorder.

    abstract：OBJECTIVE:This study examined measurement variance for Autism Spectrum Disorder (ASD) in the Spence Children's Anxiety Scale - Parent Form (SCAS-P; Spence, 1999). In addition, we developed and evaluated a new parent report measure for anxiety (Macquarie Anxiety Behavioural Scale; MABS). METHOD:The sample consisted of ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.06.076

    authors： Toscano R,Hudson JL,Baillie AJ,Lyneham HJ,McLellan LF

    更新日期：2020-11-01 00:00:00

  • Age-dependent decreases of high energy phosphates in cerebral gray matter of patients with bipolar I disorder: a preliminary phosphorus-31 magnetic resonance spectroscopic imaging study.

    abstract：OBJECTIVES:To identify abnormalities in high energy phosphate cerebral metabolism in euthymic bipolar disorder. METHODS:Phosphorus-31 magnetic resonance spectroscopic imaging ((31)P MRSI) data were acquired from the entire brain of 9 euthymic adults with bipolar disorder and 13 healthy adults. Estimates of phosphocrea...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2015.01.026

    authors： Dudley JA,Lee JH,Durling M,Strakowski SM,Eliassen JC

    更新日期：2015-04-01 00:00:00

  • Neuroticism and depression in alcoholics.

    abstract：BACKGROUND:To examine neuroticism as a possible determinant of depression in alcoholics. METHOD:24 euthymic depressed alcoholics and 18 never-depressed alcoholic controls completed the Eysenck Personality Questionnaire. RESULT:Euthymic depressed alcoholics had significantly higher neuroticism scores than alcoholic co...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0165-0327(98)00071-8

    authors： Roy A

    更新日期：1999-01-01 00:00:00

  • Features of dissociation differentially predict antidepressant response to ketamine in treatment-resistant depression.

    abstract：BACKGROUND:Ketamine induces rapid and robust antidepressant effects, and many patients also describe dissociation, which is associated with antidepressant response. This follow-up study investigated whether antidepressant efficacy is uniquely related to dissociative symptom clusters. METHODS:Treatment-resistant patien...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jad.2018.02.049

    authors： Niciu MJ,Shovestul BJ,Jaso BA,Farmer C,Luckenbaugh DA,Brutsche NE,Park LT,Ballard ED,Zarate CA Jr

    更新日期：2018-05-01 00:00:00

  • Identification of circadian gene variants in bipolar disorder in Latino populations.

    abstract：BACKGROUND:Variations in circadian genes can impact biological rhythms. Given the rhythm disturbances that characterize bipolar disorder (BD), genes encoding components of molecular clocks are good candidate genes for the illness. METHODS:A family based association analysis of circadian gene single nucleotide polymorp...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2015.07.014

    authors： Gonzalez R,Gonzalez S,Villa E,Ramirez M,Zavala J,Armas R,Contreras J,Dassori A,Leach RJ,Flores D,Jerez A,Raventós H,Ontiveros A,Nicolini H,Escamilla M

    更新日期：2015-11-01 00:00:00

  • Onset of Depression Inventory (ODI)--assessment of the speed of onset of depressive episodes.

    abstract：BACKGROUND:The development of a full blown depressive episode may be very rapid, taking less than one hour, or be very slow, taking up to months. In a previous study with outpatients it was found that the majority (58%) of depressive episodes within bipolar affective disorders (BD) develop within one week whereas this ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2012.05.002

    authors： Strauss M,Sander C,Mergl R,Merz C,Schönknecht P,Hegerl U

    更新日期：2012-12-15 00:00:00

  • Effects of vitamin D supplementation on depression and some involved neurotransmitters.

    abstract：BACKGROUND:Low vitamin D levels are associated with a dysregulated hypothalamic-pituitary-adrenal (HPA) axis and depression but a causal relationship has not been established. This study aimed to evaluate the effects of vitamin D supplementation on depression severity, serum 25(OH)D, and some neurotransmitters in patie...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.03.029

    authors： Kaviani M,Nikooyeh B,Zand H,Yaghmaei P,Neyestani TR

    更新日期：2020-05-15 00:00:00

  • Teaching front-line health and voluntary workers to assess and manage suicidal patients.

    abstract：BACKGROUND:To devise and evaluate the retention of a new brief training package for non-psychiatrically trained multidisciplinary staff to assess suicide risk and manage suicidal patients, including referral of patients at significant risk to psychiatric staff. METHOD:8 h of interview skills training, using role play ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/s0165-0327(98)00080-9

    authors： Morriss R,Gask L,Battersby L,Francheschini A,Robson M

    更新日期：1999-01-01 00:00:00

  • Do the dissociative side effects of ketamine mediate its antidepressant effects?

    abstract：BACKGROUND:The N-methyl-d-aspartate receptor antagonist ketamine has rapid antidepressant effects in major depression. Psychotomimetic symptoms, dissociation and hemodynamic changes are known side effects of ketamine, but it is unclear if these side effects relate to its antidepressant efficacy. METHODS:Data from 108 ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2014.02.017

    authors： Luckenbaugh DA,Niciu MJ,Ionescu DF,Nolan NM,Richards EM,Brutsche NE,Guevara S,Zarate CA

    更新日期：2014-04-01 00:00:00

  • Effect of valproic acid on dementia onset in patients with bipolar disorder.

    abstract：BACKGROUND:Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse effects on cognitive function. This study investigated the effect of VPA on the risk of dementia in patients with bipolar disorder. METHODS:We analyzed data from Taiwan's Longitudinal Health Insurance Dat...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2016.05.010

    authors： Tsai PS,Liu IC,Chiu CH,Huang CJ,Wang MY

    更新日期：2016-09-01 00:00:00

  • The neurochemistry of mania. The effect of lithium on catecholamines, indoleamines and calcium mobilization.

    abstract：:In an attempt to elucidate the chemical pathology of mania one has to consider the pharmacology of the two most effective treatments for this illness: lithium and the neuroleptics. Some of the possible mechanisms of action of these drugs on catecholamine and indoleamine mechanisms are discussed. The majority of this a...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(85)90019-9

    authors： Wood K

    更新日期：1985-05-01 00:00:00

  • Dependency, matching adversities, length of survival and relapse in major depression.

    abstract：:This paper reports the 1-year follow-up of a sample of depressed patients. Social cognitive variables obtained during the index episode, including ideal emotional support, roles and goals investment in various domains and dysfunctional attitudes were used to predict subjects' likelihood for subsequent relapse. More su...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0165-0327(95)00075-5

    authors： Lam DH,Green B,Power MJ,Checkley S

    更新日期：1996-04-12 00:00:00

  • The prognosis of undetected depression in older general practice patients. A one year follow-up study.

    abstract：BACKGROUND:Late-life depression often remains undetected in primary care. However, as there is evidence that GPs do identify those with the most severe and persistent disorders, it is important to know more about the prognosis of depressive disorders that are not detected by GPs. METHODS:A one-year follow-up study of ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2008.06.006

    authors： Licht-Strunk E,Beekman AT,de Haan M,van Marwijk HW

    更新日期：2009-04-01 00:00:00

  • Tyrosine negatively affects flexible-like behaviour under cognitively demanding conditions.

    abstract：BACKGROUND:The catecholaminergic precursor to dopamine, tyrosine, is an important modulator of cognitive performance. A number of studies have demonstrated that the beneficial effects of tyrosine on cognitive performance are most pronounced when individuals are exposed to stressful situations, such as hypothermia. Howe...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jad.2019.09.031

    authors： Robson A,Lim LW,Aquili L

    更新日期：2020-01-01 00:00:00

  • Predictors of response to repeated ketamine infusions in depression with suicidal ideation: An ROC curve analysis.

    abstract：BACKGROUND:Ketamine has rapid-acting antidepressant and antisuicidal properties, while a proportion of patients do not adequately achieve a complete response to ketamine. Our aim was to explore the applicability of using clinical factors and serum tryptophan (TRP) metabolites to predict the response to six doses of ket...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.01.001

    authors： Zhou Y,Liu W,Zheng W,Wang C,Zhan Y,Lan X,Zhang B,Zhang C,Ning Y

    更新日期：2020-03-01 00:00:00

  • Impaired mitogen-induced lymphocyte responses and the hypothalamic-pituitary-adrenal axis in depressive disorders.

    abstract：:The lymphocyte stimulation responses to the mitogens phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed (PWM) were investigated in 30 hospitalized depressed women undergoing a dexamethasone suppression test (DST). Patients were classified according to DSM-III as having major depression with melancholia, wit...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(89)90054-2

    authors： Cosyns P,Maes M,Vandewoude M,Stevens WJ,De Clerck LS,Schotte C

    更新日期：1989-01-01 00:00:00

  • Imbalanced spontaneous brain activity in orbitofrontal-insular circuits in individuals with cognitive vulnerability to depression.

    abstract：BACKGROUND:The hopelessness theory of depression posits that individuals with negative cognitive styles are at risk of developing depression following negative life events. The purpose of this work was to examine whether individuals with cognitive vulnerability to depression (CVD) exhibit similar spontaneous brain acti...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2016.03.001

    authors： Zhang X,Di X,Lei H,Yang J,Xiao J,Wang X,Yao S,Rao H

    更新日期：2016-07-01 00:00:00

  • Suicidality among patients with asthma: A systematic review and meta-analysis.

    abstract：BACKGROUND:Asthma is associated with multiple psychiatric comorbidities. However, the relationship between asthma and suicidality has not be well established. METHODS:According to the PRISMA guidelines, protocol of the study was registered in the PROSPERO database (CRD42019123150). A systematic search of the PubMed, E...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jad.2019.06.031

    authors： Zhang Y,Cheng J,Li Y,He R,Choudhry AA,Jiang J,Pan P,Su X,Hu C

    更新日期：2019-09-01 00:00:00

  • Fluoxetine versus sertraline and paroxetine in major depression: tolerability and efficacy in anxious depression.

    abstract：BACKGROUND:Major depression with high levels of anxiety (anxious depression) is a common subtype of depression associated with greater psychosocial impairment and poorer response to antidepressant treatment. It is unclear whether in this population there are differences in efficacy or tolerability across selective sero...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0165-0327(99)00131-7

    authors： Fava M,Rosenbaum JF,Hoog SL,Tepner RG,Kopp JB,Nilsson ME

    更新日期：2000-08-01 00:00:00

  • Mindfulness-based interventions in the early phase of affective and non-affective psychoses: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD.

    abstract：BACKGROUND:In the last 10 years, psychological approaches based on mindfulness techniques have been proposed for the management of psychotic experiences. METHOD:In this brief review we summarized, to our knowledge for the first time, published studies on mindfulness-based interventions (MBIs) applied to the early phas...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2019.10.011

    authors： Perlini C,Bellani M,Rossetti MG,Rossin G,Zovetti N,Rossi A,Bressi C,Piccolo LD,Brambilla P

    更新日期：2020-02-15 00:00:00