Abstract：
:Apigenin, is a natural compound that found in high amounts in vegetables and fruits. This natural flavone has shown strong cardioprotective effects in animal and clinical studies. Due to cardioprotective effects of apigenin in previous studies, we hypothesized that apigenin protects isolated cardiomyocytes from aluminum phosphide(AlP)-induced toxicity as the most common disturbances after exposure with this agent. By using of biochemical and flowcytometry techniques; cell viability, reactive oxygen species (ROS) generation, mitochondria membrane potential (MMP), lysosomal membrane integrity, malondialdehyde (MDA) and oxidized/reduced glutathione (GSH/GSSG) content were measured in rat heart isolated cardiomyocytes. Our results showed that the administration of apigenin (5-100 μM) efficiently decreased (P < .05) cytotoxicity, oxidative, lysosomal and mitochondrial damages induced by AlP (20 μg/ml) in isolated cardiomyocytes. Taken together, apigenin protected the cardiomyocytes against AlP toxicity via the protection of mitochondria and lysosome mediated by its antioxidant properties.
journal_name
Pestic Biochem Physioljournal_title
Pesticide biochemistry and physiologyauthors
Jahedsani A,Khezri S,Ahangari M,Bakhshii S,Salimi Adoi
10.1016/j.pestbp.2020.104585subject
Has Abstractpub_date
2020-07-01 00:00:00pages
104585eissn
0048-3575issn
1095-9939pii
S0048-3575(20)30080-8journal_volume
167pub_type
杂志文章abstract：:The purpose of this research was to explore the effect of phenazine-1-carboxamide (PCN) on Rhizoctonia solani and to elucidate its mechanisms of action. The toxicity of PCN to R. solani was measured using a growth rate method. The results indicated that PCN inhibited R. solani with a 50% effective concentration (EC50)...
journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104757
更新日期：2021-02-01 00:00:00
