Abstract:
:The aim of this study was to assess the effects and reversibility of the synthetic estrogen compound, quinestrol, on the reproductive organs, steroid hormones, and drug-metabolizing enzymes CYP3A4 and CYP1A2 in liver and kidney over time after two quinestrol treatments in female Mongolian gerbils (Meriones unguiculatus). Female gerbils were treated with 4mg/kg quinestrol (9 gerbils/group, 3 treated group) (1 control group, 0mg/kg) for 3days and treated again after 25days. Animals were killed for collection of samples at 5, 10 and 15days after the second treatment ending. Two interval quinestrol treatments significantly increased uterine weight, with trend of increase over time, but no change could be detected in ovarian weights. Quinestrol treatment increased progesterone and estradiol levels, both with trend of decline over time. Quinestrol increased liver and kidney weights and total enzyme content of CYP3A4 and CYP1A2, with trend of decline over time. On the basis of reversible changes of detoxification enzymes or organs, interval quinestrol treatment effectively and reversibly influenced the reproductive hormone and organ to some extent.
journal_name
Pestic Biochem Physioljournal_title
Pesticide biochemistry and physiologyauthors
Su QQ,Chen Y,Qin J,Wang TL,Wang DH,Liu QSdoi
10.1016/j.pestbp.2017.08.008subject
Has Abstractpub_date
2017-11-01 00:00:00pages
122-126eissn
0048-3575issn
1095-9939pii
S0048-3575(16)30225-5journal_volume
143pub_type
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