Abstract：
:New insecticides are urgently needed for the control of arthropod vectors of public health diseases. As resistance to many insecticides used for the control of public health pests is ubiquitous, all available chemistries should be evaluated for their potential to effectively control both insecticide-susceptible and insecticide-resistant strains of mosquitoes. This study aimed to evaluate p-p'-difluoro-diphenyl-trichloroethane (DFDT) as a mosquito control technology and relate its activity to that of DDT. We found that topical DFDT was significantly less toxic than DDT to both pyrethroid-susceptible and pyrethroid-resistant strains of Anopheles gambiae and Aedes aegypti. Direct nervous system recording from Drosophila melanogaster CNS demonstrated that DFDT is approximately 10-times less potent than DDT at blocking nerve firing, which may explain its relatively lower toxicity. DFDT was shown to be at least 4500 times more vapor-active than DDT, with an LC50 in a vapor toxicity screening assay of 2.2 μg/cm2. Resistance to DFDT was assessed in two mosquito strains that possess target-site mutations in the voltage-gated sodium channel and upregulated metabolic activity. Resistance ratios for Akdr (An. gambiae) and Puerto Rico (Ae. aegypti) strains were 9.2 and 12.2, respectively. Overall, this study demonstrates that DFDT is unlikely to be a viable public health vector control insecticide.
journal_name
Pestic Biochem Physioljournal_title
Pesticide biochemistry and physiologyauthors
Norris EJ,Demares F,Zhu X,Bloomquist JRdoi
10.1016/j.pestbp.2020.104686subject
Has Abstractpub_date
2020-11-01 00:00:00pages
104686eissn
0048-3575issn
1095-9939pii
S0048-3575(20)30181-4journal_volume
170pub_type
杂志文章abstract：:The European red mite Panonychus ulmi (Koch) is a major pest of apple trees worldwide and causes significant damage to apple orchards in Iran. Pyrethroid insecticides/acaricides, such as fenpropathrin and fenvalerate, are widely used to control P. ulmi, but their long-term use may lead to low efficacy. Earlier studies...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.03.008
更新日期：2019-06-01 00:00:00
abstract：:Inheritance of resistance to phosphine fumigant was investigated in three field-collected strains of rusty grain beetle, Cryptolestes ferrugineus, Susceptible (S-strain), Weakly Resistant (Weak-R) and Strongly Resistant (Strong-R). The strains were purified for susceptibility, weak resistance and strong resistance to ...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2015.09.008
更新日期：2016-02-01 00:00:00
abstract：:American sloughgrass (Beckmannia syzigachne Steud.) has become a dominant weed in fields with rice-wheat rotation. Moreover, herbicide resistance has rendered weed control difficult. We identified a biotype showing resistance to ALS inhibitor mesosulfuron-methyl with a resistant index 3.3, but without any ALS mutation...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104738
更新日期：2021-01-01 00:00:00
abstract：:The organophosphorus pesticide, triazophos (TAP) was banned to use in agriculture in several countries due to its high toxicity. However, TAP was still widely used and frequently detected in foods. Recently, many studies reported the endocrine-disrupting effect of pesticides, especially the hypothalamic-pituitary-thyr...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.05.021
更新日期：2019-09-01 00:00:00
abstract：:Honeybees ensure a key ecosystemic service by pollinating many agricultural crops and wild plants. However, since few decades, managed bee colonies have declined worldwide. This phenomenon is considered to be multifactorial, with a strong emphasis on both parasites and pesticides. Infection by the parasite Nosema cera...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.11.006
更新日期：2020-02-01 00:00:00
abstract：:The tomato leafminer, Tuta absoluta, now a major pest of tomato crops worldwide, is primarily controlled using chemical insecticides. Recently, high levels of resistance to the insecticide spinosad have been described in T. absoluta populations in Brazil. Selection of a resistant field-collected strain led to very hig...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2016.02.006
更新日期：2016-07-01 00:00:00
abstract：:The incidence of mosquito-borne disease poses a significant threat to human and animal health throughout the world, with effective chemical control interventions limited by widespread insecticide resistance. Recent evidence suggests that gut bacteria of mosquitoes, known to be essential in nutritional homeostasis and ...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.07.016
更新日期：2019-11-01 00:00:00
abstract：:A novel fumigant, chlorine dioxide (ClO2) is a commercial bleaching and disinfection agent. Recent study indicates its insecticidal activity. However, its mode of action to kill insects is yet to be understood. This study set up a hypothesis that an oxidative stress induced by ClO2 is a main factor to kill insects. Th...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2015.04.003
更新日期：2015-10-01 00:00:00
abstract：:The purpose of this research was to explore the effect of phenazine-1-carboxamide (PCN) on Rhizoctonia solani and to elucidate its mechanisms of action. The toxicity of PCN to R. solani was measured using a growth rate method. The results indicated that PCN inhibited R. solani with a 50% effective concentration (EC50)...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2017.10.006
更新日期：2018-05-01 00:00:00
abstract：:House fly (Musca domestica) CYP6D1 is a cytochrome P450 involved in metabolism of xenobiotics. CYP6D1 is located on chromosome 1 and its expression is inducible in response to the prototypical P450 inducer phenobarbital (PB) in insecticide susceptible strains. Increased transcription of CYP6D1 confers resistance to pe...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2011.02.012
更新日期：2011-06-01 00:00:00
abstract：:Imidacloprid is very effective in controlling Nilaparvata lugens Stål, which severely damages rice plants. Following heavy imidacloprid use, imidacloprid-resistant N. lugens, which showed cross-resistance to other neonicotinoids, appeared. We used the baculovirus/Sf9 expression system to express CYP6ER1 variants carry...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.02.004
更新日期：2020-05-01 00:00:00
abstract：:Antidesmone, isolated from Waltheria brachypetala Turcz., owns special structural features as two α,β-unsaturated carbonyl groups and a side alkyl chain that can compete with the quinones involved in the pool of plastoquinones at photosystem II (PSII). In this work, we showed that the alkaloid is an inhibitor of Hill ...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2016.04.006
更新日期：2016-11-01 00:00:00
abstract：:Tetrahydrophthalimidobenzoates are a class of protoporphyrinogen oxidase herbicides acting on the protoporphyrinogen oxidase enzyme. After the discovery of compound 1, a series of novel tetrahydrophthalimidobenzoate derivatives were designed and synthesized, and some synthesized compounds exhibited good herbicidal act...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2017.04.007
更新日期：2017-06-01 00:00:00
abstract：:The objective of this study was to determine the structural requirements of organophosphorus insecticides (OPI) for reducing chicken embryo nicotinamide adenine dinucleotide (NAD(+)) content in OPI-induced teratogenesis and compare them with those needed for OPI inhibition of yolk sac membrane kynurenine formamidase (...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2015.10.015
更新日期：2016-05-01 00:00:00
abstract：:Polyunsaturated fatty acids usually undergo lipid peroxidation induced by reactive oxygen species (ROS). Calcium-independent cellular phospholipase A2 (iPLA2) can maintain fatty acid compositions in phospholipids depending on physiological conditions. An insect iPLA2 (Pi-iPLA2) was predicted from the transciptome of t...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2017.09.010
更新日期：2017-11-01 00:00:00
abstract：:The peach-potato aphid Myzus persicae is a pest of many commercial crops due to its polyphagous nature of feeding and has a well-documented history of acquiring resistance to insecticides. In 2009 a strain (M. persicae FRC) emerged in southern France with a point mutation (R81T) at the nicotinic acetylcholine receptor...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2013.08.005
更新日期：2013-11-01 00:00:00
abstract：:Since sequencing the human body louse genome, substantial advances have occurred in the utilization of the information gathered from louse genomes and transcriptomes. Comparatively, the body louse genome contains far fewer genes involved in environmental response, such as xenobiotic detoxification and innate immune re...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章,评审
doi：10.1016/j.pestbp.2014.11.008
更新日期：2015-05-01 00:00:00
abstract：:1-Deoxynojirimycin (DNJ) is a natural d-glucose analogue from mulberry with promising physiological activity in vivo. Up to the present, the antidiabetic effects of DNJ on lowering blood sugar and accelerating lipid metabolism in mammals were broadly reported, but the specific character of DNJ against insects was vast...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2018.08.009
更新日期：2018-11-01 00:00:00
abstract：:Methyl salicylate (MeSA) is a volatile biological compound synthesized from salicylic acid (SA) and is a plant hormone that helps defend against pests and pathogens. A major bacterial pathogen of rice, Xanthomonas oryzae pv. oryzae (Xoo) causes severe disease. Seed and plant treatments with MeSA can stimulate the defe...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104718
更新日期：2021-01-01 00:00:00
abstract：:Control of Bemisia tabaci has depended primarily and heavily on insecticides, especially neonicotinoids. The novel sulfoximine insecticide sulfoxaflor exhibits high potency against a broad range of sap-feeding insect species, including those resistant to neonicotinoids. The resistance levels of Q-biotype B. tabaci fie...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2016.08.005
更新日期：2017-03-01 00:00:00
abstract：:To understand the nematicidal mode of action of phytochemicals derived from plant essential oils against the pinewood nematode (Bursaphelenchus xylophilus), we evaluated 97 compounds (49 monoterpenes, 17 phenylpropenes, 16 sesquiterpenes, and 15 sulfides) for their inhibitory effects on B. xylophilus acetylcholinester...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2012.11.007
更新日期：2013-01-01 00:00:00
abstract：:Botrytis cinerea has a high risk of developing resistance to fungicides. Fludioxonil, belonging to phenylpyrroles, has been used for more than three decades, however, only few cases of field resistance against phenylpyrroles have been reported. In this study, the highly fludioxonil-resistant (HR) isolates of Botrytis ...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2018.01.012
更新日期：2018-05-01 00:00:00
abstract：:Spirotetramat were now widely used for control insecticides resistant aphids since 2011 in China. In order to elucidate the possible resistance mechanism, a laboratory selected resistant strain (SR) of cotton aphid was established with a 578.93-fold and 14.91-fold resistance ratio to spirotetramat for adult aphids and...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2015.02.002
更新日期：2015-03-01 00:00:00
abstract：:The comparative efficacy and mechanism of action of the herbicide dymuron and its two optically active monomethyl analogues, (R)-1-(alpha-methylbenzyl)-3-(p-tolylurea) (R-MBTU) and S-MBTU, as safeners of rice against injury from bensulfuron-methyl were investigated. Bioassays using etiolated seedlings of rice (Oryza s...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1006/pest.1996.0035
更新日期：1996-05-01 00:00:00
abstract：:A series of novel aryloxyphenoxypropionate (APP) herbicides containing benzofuran moiety were designed, synthesized and tested for herbicidal activity. The bioassay results indicated that most of target compounds possessed moderate to good herbicidal activity against monocotyledonous weeds. Compounds 5a-5d and 6a-6d s...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2018.12.011
更新日期：2019-02-01 00:00:00
abstract：:Three sweet corn genotypes, two inbred lines (IBER001 and IBER002) and their hybrid (ER00X), differ in their phenotypic responses to several P450-metabolized herbicides, used in sweet corn, namely, foramsulfuron, iodosulfuron, rimsulfuron and tembotrione. Foramsulfuron is a sulfonylurea herbicide commonly formulated w...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2017.02.002
更新日期：2017-05-01 00:00:00
abstract：:Although it is well known that Bacillus thuringiensis Cry toxins kill insect pest by disrupting midgut cells of susceptible larvae through their pore formation activity, it is not clear what intracellular events are triggered after pore formation on the cell membrane of the target cells. Here we analyzed the role of C...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104728
更新日期：2021-01-01 00:00:00
abstract：:Xanthomonas oryzae pv. oryzae (Xoo) is the casual agent of bacterial blight, which is one of the most serious diseases of rice. The antibiotic phenazine-1-carboxylic acid (PCA), which is primarily produced by Pseudomonas spp., was found and previously reported very effective against Xoo. However, the biological effect...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2014.10.006
更新日期：2015-01-01 00:00:00
abstract：:Selectivity to insects over mammals is one of the important characteristics for a chemical to become a useful insecticide. Fipronil was found to block cockroach GABA receptors more potently than rat GABA(A) receptors. Furthermore, glutamate-activated chloride channels (GluCls), which are present in cockroaches but not...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2009.07.008
更新日期：2010-06-01 00:00:00
abstract：:In vitro experiments were performed to ascertain the impact of kitazin, hexaconazole, metalaxyl and carbendazim on growth behaviour, enzymatic profile, ultrastructure, cell permeability and bioactive molecules of phosphate-solubilizing bacterium. Strain BC8 isolated from Brassica oleracea rhizosphere was characterized...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2018.05.001
更新日期：2018-07-01 00:00:00
