Abstract:
:Resistance to polymyxins in most Gram-negative bacteria arises from chemical modifications to the lipid A portion of their lipopolysaccharide (LPS) mediated by chromosomally encoded mutations or the recently discovered plasmid-encoded mcr genes that have further complicated the landscape of colistin resistance. Currently, minimal inhibitory concentration (MIC) determination by broth microdilution, the gold standard for the detection of polymyxin resistance, is time consuming (24 h) and challenging to perform in clinical and veterinary laboratories. Here we present the use of the MALDIxin to detect colistin resistant Salmonella enterica using the MALDxin test on the routine matrix-assisted laser desorption ionization (MALDI) Biotyper Sirius system.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Dortet L,Bonnin RA,Le Hello S,Fabre L,Bonnet R,Kostrzewa M,Filloux A,Larrouy-Maumus Gdoi
10.3389/fmicb.2020.01141subject
Has Abstractpub_date
2020-06-03 00:00:00pages
1141issn
1664-302Xjournal_volume
11pub_type
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