当前位置： SCI文献检索 > International Journal of Clinical Oncology期刊下所有文献 > Short-term low-volume hydration in cisplatin-based chemotherapy for patients with lung cancer: the second prospective feasibility study in the Okayama Lung Cancer Study Group Trial 1201.

Short-term low-volume hydration in cisplatin-based chemotherapy for patients with lung cancer: the second prospective feasibility study in the Okayama Lung Cancer Study Group Trial 1201.

Abstract：

OBJECTIVE:We previously reported the feasibility of short-term low-volume hydration in patients with advanced lung cancer who received cisplatin-based chemotherapy (Jpn J Clin Oncol 2013). We sought to determine the clinical usefulness of a more convenient hydration method, evaluating the safety and efficacy of shorter-term and lower-volume hydration. METHOD:Chemonaïve patients with advanced lung cancer who were ≤ 75 years and reserved an adequate renal function for cisplatin use (≥ 60 mg/m(2)) were eligible. An intravenously administered hydration of 1700 ml in ~3.5 h with 1500 ml of orally administered hydration was investigated. The primary endpoint was the proportion of patients without grade 2 or worse renal toxicity in the first cycle. RESULTS:A total of 45 patients were registered, all of whom were evaluable for renal toxicity. The median baseline creatinine score was 0.70 mg/dl, and the median cisplatin dose on day 1 was 75 mg/m(2). In the first cycle, one patient (2 %) developed grade 2 creatinine toxicity, and thus, the proportion of patients with less than grade 2 was 98 % (the lower limit of 95 % confidence interval; 93 %), which met the primary endpoint. Five patients (11 %) had grade 1 or greater nephrotoxicity, three of whom successfully recovered. The objective response rate was 24 % and median progression-free survival 5.8 months. CONCLUSION:This prospective study demonstrated the safety and efficacy of shorter-term lower-volume hydration.

journal_name

Int J Clin Oncol

journal_title

International journal of clinical oncology

authors

Ninomiya K,Hotta K,Hisamoto-Sato A,Ichihara E,Gotoda H,Morichika D,Tamura T,Kayatani H,Minami D,Kubo T,Tabata M,Tanimoto M,Kiura K

doi

10.1007/s10147-015-0860-1

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

81-7

issue

1

eissn

1341-9625

issn

1437-7772

pii

10.1007/s10147-015-0860-1

journal_volume

21

pub_type

杂志文章

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