当前位置： SCI文献检索 > ANNALS OF THE RHEUMATIC DISEASES期刊下所有文献 > First step in the development of an ultrasound joint inflammation score for rheumatoid arthritis using a data-driven approach.

First step in the development of an ultrasound joint inflammation score for rheumatoid arthritis using a data-driven approach.

Abstract：

OBJECTIVES:To develop and validate candidate sets of joints and tendons for assessment of ultrasound (US) joint inflammation in rheumatoid arthritis (RA). METHODS:Patients were included in one of two cohorts from 2010 to June 2013: disease-modifying antirheumatic drug naïve early RA or established RA starting/switching biologics. An extensive US examination was performed by experienced sonographers using a validated grey-scale (GSUS) and power Doppler (PDUS) semiquantitative scoring system with scores 0-3 for both GSUS and PDUS in 36 joints and four tendons. We performed factor analysis in the early RA US data and selected candidate joint/tendon sets based on these results. The proportion of information in the total US scores retained in these candidate sets was assessed by R(2) from linear regression analysis. Finally, the candidate sets and previously proposed joint scores were tested in the established RA cohort, and we also evaluated the sensitivity to change with standardised response means. RESULTS:227 patients with early RA and 212 patients with established RA were included. We identified two candidate sets of joints/tendons: candidate set A consisted of seven joints/two tendons (meatacarpophalangeal 1 (MCP1), MCP2, proximal interphalangeal 3, radiocarpal, elbow, metatarsophalangeal 1 (MTP1), MTP2, tibialis posterior tendon, extensor carpi ulnaris tendon) and set B of nine joints/two tendons (MCP5 and MTP5 added to set A). Unilateral reduced scores retained 78%-85% of the information in total score, while bilateral reduced scores retained 89%-93%, and both sets performed better than previously proposed reduced joint scores, and similar or slightly better regarding sensitivity to change. CONCLUSIONS:The reduced GSUS and PDUS scores retained most of the information from the total score and performed well in a validation cohort of established RA. TRIAL REGISTATION NUMBER:NCT01205854, ACTRN12610000284066.

journal_name

Ann Rheum Dis

journal_title

Annals of the rheumatic diseases

authors

Aga AB,Hammer HB,Olsen IC,Uhlig T,Kvien TK,van der Heijde D,Fremstad H,Madland TM,Lexberg ÅS,Haukeland H,Rødevand E,Høili C,Stray H,Bendvold AN,Soldal DM,Bakland G,Lie E,Haavardsholm EA

doi

10.1136/annrheumdis-2015-207572

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1444-51

issue

eissn

0003-4967

issn

1468-2060

pii

annrheumdis-2015-207572

journal_volume

pub_type

临床试验,杂志文章,多中心研究

在线工具

First step in the development of an ultrasound joint inflammation score for rheumatoid arthritis using a data-driven approach.