Proximal conduction block in the pharyngeal-cervical-brachial variant of Guillain-Barré syndrome.

Abstract:

INTRODUCTION:Conduction block (CB) has been included in the Rajabally criteria for axonal Guillain-Barré syndrome (GBS). Because the nerve roots may be affected early in GBS, detection of proximal CB by the triple stimulation technique (TST) can be useful. METHODS:We describe TST findings in 2 patients who presented with the pharyngeal-cervical-brachial (PCB) variant of axonal GBS. RESULTS:In the first patient, although conventional nerve conduction studies (NCS) did not fit electrodiagnostic criteria for axonal GBS, the TST detected proximal CB in the median and ulnar nerves. In the second patient, NCS fulfilled criteria for axonal GBS, and the TST detected proximal CB in the median nerve. After plasmapheresis, NCS and TST findings were normalized, suggesting reversible conduction failure rather than demyelinating CB. CONCLUSION:The TST may be useful for diagnosis of PCB when NCS remain inconclusive. The technique provides additional clues for classifying PCB into the acute nodo-paranodopathies.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Taieb G,Grapperon AM,Duclos Y,Franques J,Labauge P,Renard D,Yuki N,Attarian S

doi

10.1002/mus.24729

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1102-6

issue

6

eissn

0148-639X

issn

1097-4598

journal_volume

52

pub_type

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