Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways.

abstract：:Studying perturbations in the gut ecosystem using animal models of disease continues to provide valuable insights into the role of the microbiome in various pathological conditions. However, understanding whether these changes are consistent across animal models of different genetic backgrounds, and hence potentially ...

journal_title：mSystems

authors： Tripathi A,Xu ZZ,Xue J,Poulsen O,Gonzalez A,Humphrey G,Meehan MJ,Melnik AV,Ackermann G,Zhou D,Malhotra A,Haddad GG,Dorrestein PC,Knight R

更新日期：2019-04-30 00:00:00

abstract：:Biocathodes provide a stable electron source to drive reduction reactions in electrotrophic microbial electrochemical systems. Electroautotrophic biocathode communities may be more robust than monocultures in environmentally relevant settings, but some members are not easily cultivated outside the electrode environmen...

journal_title：mSystems

authors： Eddie BJ,Wang Z,Hervey WJ 4th,Leary DH,Malanoski AP,Tender LM,Lin B,Strycharz-Glaven SM

更新日期：2017-03-28 00:00:00

abstract：:Fecal microbiota transplantation (FMT) is a proposedly useful strategy for the treatment of gastrointestinal (GI) disorders through remediation of the patient gut microbiota. However, its therapeutic success has been variable, necessitating research to uncover mechanisms that improve patient response. Antibiotic pretr...

journal_title：mSystems

authors： Oliphant K,Cochrane K,Schroeter K,Daigneault MC,Yen S,Verdu EF,Allen-Vercoe E

更新日期：2020-01-28 00:00:00

abstract：:Microbial heterotopic metabolism in the ocean is fueled by a supply of essential nutrients acquired via exoenzymes catalyzing depolymerization of high-molecular-weight compounds. Although the rates of activity for a variety of exoenzymes across various marine environments are well established, the factors regulating t...

journal_title：mSystems

authors： Kamalanathan M,Doyle SM,Xu C,Achberger AM,Wade TL,Schwehr K,Santschi PH,Sylvan JB,Quigg A

更新日期：2020-04-14 00:00:00

abstract：:DNA methylation in prokaryotes is widespread. The most common modification of the genome is the methylation of adenine at the N-6 position. In Escherichia coli K-12 and many gammaproteobacteria, this modification is catalyzed by DNA adenine methyltransferase (Dam) at the GATC consensus sequence and is known to modulat...

journal_title：mSystems

authors： Westphal LL,Sauvey P,Champion MM,Ehrenreich IM,Finkel SE

更新日期：2016-12-13 00:00:00

abstract：:When organisms encounter an unfavorable environment, they transition to a physiologically distinct, quiescent state wherein abundant transcripts from the previous active growth state continue to persist, albeit their active transcription is downregulated. In order to generate proteins for the new quiescent physiologic...

journal_title：mSystems

authors： López García de Lomana A,Kusebauch U,Raman AV,Pan M,Turkarslan S,Lorenzetti APR,Moritz RL,Baliga NS

更新日期：2020-07-28 00:00:00

abstract：:Methylobacter species, members of the Methylococcales, have recently emerged as some of the globally widespread, cosmopolitan species that play a key role in the environmental consumption of methane across gradients of dioxygen tensions. In this work, we approached the question of how Methylobacter copes with hypoxia,...

journal_title：mSystems

authors： Yu Z,Pesesky M,Zhang L,Huang J,Winkler M,Chistoserdova L

更新日期：2020-01-21 00:00:00

abstract：:Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study employed comparative meta...

journal_title：mSystems

authors： Han ML,Zhu Y,Creek DJ,Lin YW,Gutu AD,Hertzog P,Purcell T,Shen HH,Moskowitz SM,Velkov T,Li J

更新日期：2019-01-08 00:00:00

abstract：:The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be fully elucidated. This knowle...

journal_title：mSystems

authors： Brinkac LM,Rahman N,Chua LL,Thomas S

更新日期：2020-10-27 00:00:00

abstract：:Classified as a biosafety level 4 (BSL4) select agent, Nipah virus (NiV) is a deadly henipavirus in the Paramyxoviridae family, with a nearly 75% mortality rate in humans, underscoring its global and animal health importance. Elucidating the process of viral particle production in host cells is imperative both for tar...

journal_title：mSystems

authors： Johnston GP,Bradel-Tretheway B,Piehowski PD,Brewer HM,Lee BNR,Usher NT,Zamora JLR,Ortega V,Contreras EM,Teuton JR,Wendler JP,Matz KM,Adkins JN,Aguilar HC

更新日期：2019-09-24 00:00:00

abstract：:Dietary intake is difficult to measure reliably in humans because approaches typically rely on self-reporting, which can be incomplete and biased. In field studies of animals, DNA sequencing-based approaches such as metabarcoding have been developed to characterize diets, but such approaches have not previously been w...

journal_title：mSystems

authors： Reese AT,Kartzinel TR,Petrone BL,Turnbaugh PJ,Pringle RM,David LA

更新日期：2019-10-08 00:00:00

abstract：:In pregnant and lactating sows, metabolism and immunity undergo drastic changes, which can lead to constipation, abortion, and intrauterine growth restriction (IUGR) and reduce production performance. Dietary fiber can regulate animal gut microbiota, alleviate inflammatory responses, and improve performance. Here, 48 ...

journal_title：mSystems

authors： Liu B,Zhu X,Cui Y,Wang W,Liu H,Li Z,Guo Z,Ma S,Li D,Wang C,Shi Y

更新日期：2021-01-26 00:00:00

abstract：:Vitamin B12 is synthesized by prokaryotes in the rumens of dairy cows-and this has implications in human nutrition since humans rely on consumption of dairy products for vitamin B12 acquisition. However, the concentration of vitamin B12 in milk is highly variable, and there is interest in determining what causes vitam...

journal_title：mSystems

authors： Franco-Lopez J,Duplessis M,Bui A,Reymond C,Poisson W,Blais L,Chong J,Gervais R,Rico DE,Cue RI,Girard CL,Ronholm J

更新日期：2020-03-03 00:00:00

abstract：:Despite increasing acknowledgment that microorganisms underpin the healthy functioning of basically all multicellular life, few cross-disciplinary teams address the diversity and function of microbiota across organisms and ecosystems. Our newly formed consortium of junior faculty spanning fields such as ecology and ge...

journal_title：mSystems

authors： Hynson NA,Frank KL,Alegado RA,Amend AS,Arif M,Bennett GM,Jani AJ,Medeiros MCI,Mileyko Y,Nelson CE,Nguyen NH,Nigro OD,Prisic S,Shin S,Takagi D,Wilson ST,Yew JY

更新日期：2018-03-13 00:00:00

abstract：:The identification of ancestral traits is essential to understanding the evolution of any group. In the case of parasitic groups, this helps us understand the adaptation to this lifestyle and a particular host. Most diplomonads are parasites, but there are free-living members of the group nested among the host-associa...

journal_title：mSystems

authors： Jiménez-González A,Andersson JO

更新日期：2020-12-22 00:00:00

abstract：:Streptococcus mutans is a Gram-positive bacterium that thrives under acidic conditions and is a primary cause of tooth decay (dental caries). To better understand the metabolism of S. mutans on a systematic level, we manually constructed a genome-scale metabolic model of the S. mutans type strain UA159. The model, cal...

journal_title：mSystems

authors： Jijakli K,Jensen PA

更新日期：2019-10-29 00:00:00

abstract：:Biological sulfur cycling in polar, low-temperature ecosystems is an understudied phenomenon in part due to difficulty of access and the dynamic nature of glacial environments. One such environment where sulfur cycling is known to play an important role in microbial metabolisms is located at Borup Fiord Pass (BFP) in ...

journal_title：mSystems

authors： Trivedi CB,Stamps BW,Lau GE,Grasby SE,Templeton AS,Spear JR

更新日期：2020-08-04 00:00:00

abstract：:Acinetobacter baumannii has been reported as a multidrug-resistant bacterium due to biofilms and antimicrobial resistance mechanisms. Hence, novel therapeutic strategies are necessary to overcome A. baumannii infections. This study revealed that citral at 200 μg/ml attenuated A. baumannii biofilms by up to 90% without...

journal_title：mSystems

authors： Selvaraj A,Valliammai A,Muthuramalingam P,Sethupathy S,Subramenium GA,Ramesh M,Pandian SK

更新日期：2020-11-17 00:00:00

abstract：:Arctic regions, which are changing rapidly as they warm 2 to 3 times faster than the global average, still retain microbial habitats that serve as natural laboratories for understanding mechanisms of microbial adaptation to extreme conditions. Seawater-derived brines within both sea ice (sea-ice brine) and ancient lay...

journal_title：mSystems

authors： Zhong ZP,Rapp JZ,Wainaina JM,Solonenko NE,Maughan H,Carpenter SD,Cooper ZS,Jang HB,Bolduc B,Deming JW,Sullivan MB

更新日期：2020-06-16 00:00:00

abstract：:The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host's genome, the microbiome is amenable to change over the course of an organism's lifetime, providing an opportunity to therapeutically modulate the microbiome's im...

journal_title：mSystems

authors： Uhr GT,Dohnalová L,Thaiss CA

更新日期：2019-02-19 00:00:00

abstract：:High-nucleic-acid (HNA) and low-nucleic-acid (LNA) bacteria are two operational groups identified by flow cytometry (FCM) in aquatic systems. A number of reports have shown that HNA cell density correlates strongly with heterotrophic production, while LNA cell density does not. However, which taxa are specifically ass...

journal_title：mSystems

authors： Rubbens P,Schmidt ML,Props R,Biddanda BA,Boon N,Waegeman W,Denef VJ

更新日期：2019-09-10 00:00:00

abstract：:Given the complexity of host-microbiota symbioses, scientists and philosophers are asking questions at new biological levels of hierarchical organization-what is a holobiont and hologenome? When should this vocabulary be applied? Are these concepts a null hypothesis for host-microbe systems or limited to a certain spe...

journal_title：mSystems

authors： Theis KR,Dheilly NM,Klassen JL,Brucker RM,Baines JF,Bosch TC,Cryan JF,Gilbert SF,Goodnight CJ,Lloyd EA,Sapp J,Vandenkoornhuyse P,Zilber-Rosenberg I,Rosenberg E,Bordenstein SR

更新日期：2016-03-29 00:00:00

abstract：:Bumble bees are important pollinators in natural and agricultural ecosystems. Their social colonies are founded by individual queens, which, as the predominant reproductive females of colonies, contribute to colony function through worker production and fitness through male and new queen production. Therefore, queen h...

journal_title：mSystems

authors： Wang L,Wu J,Li K,Sadd BM,Guo Y,Zhuang D,Zhang Z,Chen Y,Evans JD,Guo J,Zhang Z,Li J

更新日期：2019-12-10 00:00:00

abstract：:Recent studies of mammalian microbiomes have identified strong phylogenetic effects on bacterial community composition. Bats (Mammalia: Chiroptera) are among the most speciose mammals on the planet and the only mammal capable of true flight. We examined 1,236 16S rRNA amplicon libraries of the gut, oral, and skin micr...

journal_title：mSystems

authors： Lutz HL,Jackson EW,Webala PW,Babyesiza WS,Kerbis Peterhans JC,Demos TC,Patterson BD,Gilbert JA

更新日期：2019-11-12 00:00:00

abstract：:A diverse set of prophage-mediated mechanisms protecting bacterial hosts from infection has been recently uncovered within cluster N mycobacteriophages isolated on the host, Mycobacterium smegmatis mc2155. In that context, we unveil a novel defense mechanism in cluster N prophage Butters. By using bioinformatics analy...

journal_title：mSystems

authors： Mageeney CM,Mohammed HT,Dies M,Anbari S,Cudkevich N,Chen Y,Buceta J,Ware VC

更新日期：2020-10-06 00:00:00

abstract：:Advances in sequencing technologies have enabled novel insights into microbial niche differentiation, from analyzing environmental samples to understanding human diseases and informing dietary studies. However, identifying the microbial taxa that differentiate these samples can be challenging. These issues stem from t...

journal_title：mSystems

authors： Morton JT,Sanders J,Quinn RA,McDonald D,Gonzalez A,Vázquez-Baeza Y,Navas-Molina JA,Song SJ,Metcalf JL,Hyde ER,Lladser M,Dorrestein PC,Knight R

更新日期：2017-01-17 00:00:00

abstract：:Salmonella infection is one of the main causes of food-borne diarrheal diseases worldwide. Although most Salmonella infections can be cleared without treatment, some cause serious illnesses that require antibiotic treatment. In view of the growing emergence of antibiotic-resistant Salmonella strains, novel treatments ...

journal_title：mSystems

authors： Hu YOO,Hugerth LW,Bengtsson C,Alisjahbana A,Seifert M,Kamal A,Sjöling Å,Midtvedt T,Norin E,Du J,Engstrand L

更新日期：2018-10-02 00:00:00

abstract：:Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenges to existing appro...

journal_title：mSystems

authors： Langille MGI

更新日期：2018-03-27 00:00:00

abstract：:Insights into the interaction between phages and their bacterial hosts are crucial for the development of phage therapy. However, only one study has investigated global gene expression of Clostridioides (formerly Clostridium) difficile carrying prophage, and transcriptional reprogramming during lytic infection has not...

journal_title：mSystems

authors： Li T,Zhang Y,Dong K,Kuo CJ,Li C,Zhu YQ,Qin J,Li QT,Chang YF,Guo X,Zhu Y

更新日期：2020-05-05 00:00:00

abstract：:The reactive intermediate deaminase RidA (EC 3.5.99.10) is conserved across all domains of life and deaminates reactive enamine species. When Salmonella entericaridA mutants are grown in minimal medium, 2-aminoacrylate (2AA) accumulates, damages several pyridoxal 5'-phosphate (PLP)-dependent enzymes, and elicits an ob...

journal_title：mSystems

authors： Borchert AJ,Gouveia GJ,Edison AS,Downs DM

更新日期：2020-03-10 00:00:00