A Complex Interplay between Nitric Oxide, Quorum Sensing, and the Unique Secondary Metabolite Tundrenone Constitutes the Hypoxia Response in Methylobacter.

abstract：:Marine microbes are known to degrade hydrocarbons; however, microbes inhabiting deep-sea sediments remain largely unexplored. Previous studies into the classical pathways of marine microbial metabolism reveal diverse chemistries; however, metabolic profiling of marine microbes cultured with hydrocarbons is limited. In...

journal_title：mSystems

authors： Moreno-Ulloa A,Sicairos Diaz V,Tejeda-Mora JA,Macias Contreras MI,Castillo FD,Guerrero A,Gonzalez Sanchez R,Mendoza-Porras O,Vazquez Duhalt R,Licea-Navarro A

更新日期：2020-11-10 00:00:00

abstract：:Given the complexity of host-microbiota symbioses, scientists and philosophers are asking questions at new biological levels of hierarchical organization-what is a holobiont and hologenome? When should this vocabulary be applied? Are these concepts a null hypothesis for host-microbe systems or limited to a certain spe...

journal_title：mSystems

authors： Theis KR,Dheilly NM,Klassen JL,Brucker RM,Baines JF,Bosch TC,Cryan JF,Gilbert SF,Goodnight CJ,Lloyd EA,Sapp J,Vandenkoornhuyse P,Zilber-Rosenberg I,Rosenberg E,Bordenstein SR

更新日期：2016-03-29 00:00:00

abstract：:Thaumarchaeota are frequently reported to associate with marine sponges (phylum Porifera); however, little is known about the features that distinguish them from their free-living thaumarchaeal counterparts. In this study, thaumarchaeal metagenome-assembled genomes (MAGs) were reconstructed from metagenomic data sets ...

journal_title：mSystems

authors： Zhang S,Song W,Wemheuer B,Reveillaud J,Webster N,Thomas T

更新日期：2019-08-13 00:00:00

abstract：:The 2,3-seco pathway, the pathway for anaerobic cholesterol degradation, has been established in the denitrifying betaproteobacterium Sterolibacterium denitrificans. However, knowledge of how microorganisms respond to cholesterol at the community level is elusive. Here, we applied mesocosm incubation and 16S rRNA sequ...

journal_title：mSystems

authors： Wei ST,Wu YW,Lee TH,Huang YS,Yang CY,Chen YL,Chiang YR

更新日期：2018-10-30 00:00:00

abstract：:Apoptosis is generally considered the first line of defense against viral infection. However, the role of apoptosis in the interactions between plant viruses and their insect vectors has rarely been investigated. By studying plant DNA viruses of the genus Begomovirus within the family Geminiviridae, which are transmit...

journal_title：mSystems

authors： Wang XR,Wang C,Ban FX,Ghanim M,Pan LL,Qian LX,Liu YQ,Wang XW,Liu SS

更新日期：2020-09-22 00:00:00

abstract：:Multispecies microbial communities determine the fate of materials in the environment and can be harnessed to produce beneficial products from renewable resources. In a recent example, fermentations by microbial communities have produced medium-chain fatty acids (MCFAs). Tools to predict, assess, and improve the perfo...

journal_title：mSystems

authors： Scarborough MJ,Hamilton JJ,Erb EA,Donohue TJ,Noguera DR

更新日期：2020-09-29 00:00:00

abstract：:In pregnant and lactating sows, metabolism and immunity undergo drastic changes, which can lead to constipation, abortion, and intrauterine growth restriction (IUGR) and reduce production performance. Dietary fiber can regulate animal gut microbiota, alleviate inflammatory responses, and improve performance. Here, 48 ...

journal_title：mSystems

authors： Liu B,Zhu X,Cui Y,Wang W,Liu H,Li Z,Guo Z,Ma S,Li D,Wang C,Shi Y

更新日期：2021-01-26 00:00:00

abstract：:Quantitative understanding and prediction of microbial community dynamics are an outstanding challenge. We test the hypothesis that metabolic mechanisms provide a foundation for accurate prediction of dynamics in microbial systems. In our research, metabolic models have been able to accurately predict species interact...

journal_title：mSystems

authors： Chacón JM,Harcombe WR

更新日期：2019-06-11 00:00:00

abstract：:The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host's genome, the microbiome is amenable to change over the course of an organism's lifetime, providing an opportunity to therapeutically modulate the microbiome's im...

journal_title：mSystems

authors： Uhr GT,Dohnalová L,Thaiss CA

更新日期：2019-02-19 00:00:00

abstract：:In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of expression from ribosomal promoters; this can deplete the pool of RNA polyme...

journal_title：mSystems

authors： Zhang Q,Brambilla E,Li R,Shi H,Cosentino Lagomarsino M,Sclavi B

更新日期：2020-09-08 00:00:00

abstract：:Tripartite symbioses between bacteriophages, the epithelial cell layers of the human gut, and bacterial symbionts may play an important and unrecognized role in the function of the gut microbiome. Traditionally, phages residing within the gut were considered to interact only with their bacterial hosts and thereby to f...

journal_title：mSystems

authors： Barr JJ

更新日期：2019-05-07 00:00:00

abstract：:The identification of ancestral traits is essential to understanding the evolution of any group. In the case of parasitic groups, this helps us understand the adaptation to this lifestyle and a particular host. Most diplomonads are parasites, but there are free-living members of the group nested among the host-associa...

journal_title：mSystems

authors： Jiménez-González A,Andersson JO

更新日期：2020-12-22 00:00:00

abstract：:Sulfur is an essential nutrient that contributes to cellular redox homeostasis, transcriptional regulation, and translation initiation when incorporated into different biomolecules. Transport and reduction of extracellular sulfate followed by cysteine biosynthesis is a major pathway of bacterial sulfur assimilation. F...

journal_title：mSystems

authors： Anderson MT,Mitchell LA,Sintsova A,Rice KA,Mobley HLT

更新日期：2019-08-06 00:00:00

abstract：:Environmental strains of the soil bacterium Bacillus subtilis have valuable applications in agriculture, industry, and biotechnology; however, environmental strains are genetically less accessible. This reduced accessibility is in sharp contrast to laboratory strains, which are well known for their natural competence,...

journal_title：mSystems

authors： She Q,Hunter E,Qin Y,Nicolau S,Zalis EA,Wang H,Chen Y,Chai Y

更新日期：2020-09-01 00:00:00

abstract：:The intestinal microbiota and the expanded endocannabinoid (eCB) system, or endocannabinoidome (eCBome), have both been implicated in diet-induced obesity and dysmetabolism. These systems were recently suggested to interact during the development of obesity. We aimed at identifying the potential interactions between g...

journal_title：mSystems

authors： Lacroix S,Pechereau F,Leblanc N,Boubertakh B,Houde A,Martin C,Flamand N,Silvestri C,Raymond F,Di Marzo V,Veilleux A

更新日期：2019-12-17 00:00:00

abstract：:Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S Pullorum infection ...

journal_title：mSystems

authors： Ding J,Zhou H,Luo L,Xiao L,Yang K,Yang L,Zheng Y,Xu K,He C,Han C,Luo H,Qin C,Akinyemi FT,Gu C,Zhou Z,Huang Q,Meng H

更新日期：2021-01-05 00:00:00

abstract：:Many pathogenic bacteria of the family Enterobacteriaceae use type III secretion systems to inject virulence proteins, termed "effectors," into the host cell cytosol. Although host-cellular activities of several effectors have been demonstrated, the function and host-targeted pathways of most of the effectors identifi...

journal_title：mSystems

authors： Sontag RL,Nakayasu ES,Brown RN,Niemann GS,Sydor MA,Sanchez O,Ansong C,Lu SY,Choi H,Valleau D,Weitz KK,Savchenko A,Cambronne ED,Adkins JN

更新日期：2016-07-12 00:00:00

abstract：:Salmonella infection is one of the main causes of food-borne diarrheal diseases worldwide. Although most Salmonella infections can be cleared without treatment, some cause serious illnesses that require antibiotic treatment. In view of the growing emergence of antibiotic-resistant Salmonella strains, novel treatments ...

journal_title：mSystems

authors： Hu YOO,Hugerth LW,Bengtsson C,Alisjahbana A,Seifert M,Kamal A,Sjöling Å,Midtvedt T,Norin E,Du J,Engstrand L

更新日期：2018-10-02 00:00:00

abstract：:Simplified microbial communities, or "benchtop microbiomes," enable us to manage the profound complexity of microbial ecosystems. Widespread activities aiming to design and control communities result in novel resources for testing ecological theories and also for realizing new biotechnologies. There is much to be gain...

journal_title：mSystems

authors： Bernstein HC

更新日期：2019-05-28 00:00:00

abstract：:Studying perturbations in the gut ecosystem using animal models of disease continues to provide valuable insights into the role of the microbiome in various pathological conditions. However, understanding whether these changes are consistent across animal models of different genetic backgrounds, and hence potentially ...

journal_title：mSystems

authors： Tripathi A,Xu ZZ,Xue J,Poulsen O,Gonzalez A,Humphrey G,Meehan MJ,Melnik AV,Ackermann G,Zhou D,Malhotra A,Haddad GG,Dorrestein PC,Knight R

更新日期：2019-04-30 00:00:00

abstract：:Social behavior can alter the microbiome composition via transmission among social partners, but there have been few controlled experimental studies of gut microbiome transmission among social partners in primates. We collected longitudinal fecal samples from eight unrelated male-female pairs of marmoset monkeys prior...

journal_title：mSystems

authors： Zhu L,Clayton JB,Suhr Van Haute MJ,Yang Q,Hassenstab HR,Mustoe AC,Knights D,Benson AK,French JA

更新日期：2020-03-24 00:00:00

abstract：:The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be fully elucidated. This knowle...

journal_title：mSystems

authors： Brinkac LM,Rahman N,Chua LL,Thomas S

更新日期：2020-10-27 00:00:00

abstract：:The gut microbiota has been implicated in immunoglobin A nephropathy (IgAN) because the intestinal immune response is assumed to be one of the disease triggers. Since the microbial composition is heritable, we hypothesize that genetic variants controlling gut microbiota composition may be associated with susceptibilit...

journal_title：mSystems

authors： He JW,Zhou XJ,Li YF,Wang YN,Liu LJ,Shi SF,Xin XH,Li RS,Falchi M,Lv JC,Zhang H

更新日期：2021-01-12 00:00:00

abstract：:ABSRTACTKlebsiella pneumoniae is a common cause of human-pneumonia-derived sepsis with high morbidity and mortality. The microbiota promotes and maintains host immune homeostasis. The mechanisms by which the gut microbiota affects the host defenses in the respiratory system systematically, however, remain poorly under...

journal_title：mSystems

authors： Wu T,Li H,Su C,Xu F,Yang G,Sun K,Xu M,Lv N,Meng B,Liu Y,Hu L,Liu Y,Gao Y,Wang H,Lan Y,Xu D,Li J

更新日期：2020-11-03 00:00:00

abstract：:The mechanisms by which microbes interact in communities remain poorly understood. Here, we interrogated specific interactions between photoautotrophic and heterotrophic members of a model consortium to infer mechanisms that mediate metabolic coupling and acclimation to partnership. This binary consortium was composed...

journal_title：mSystems

authors： Bernstein HC,McClure RS,Thiel V,Sadler NC,Kim YM,Chrisler WB,Hill EA,Bryant DA,Romine MF,Jansson JK,Fredrickson JK,Beliaev AS

更新日期：2017-03-07 00:00:00

abstract：:Trauma patients (TPs) are highly susceptible to infections, which often lead to sepsis. Among the numerous causative agents, Pseudomonas aeruginosa is especially important, as P. aeruginosa sepsis is often fatal. Understanding the mechanism of its pathogenesis in bloodstream infections is imperative; however, this mec...

journal_title：mSystems

authors： Elmassry MM,Mudaliar NS,Kottapalli KR,Dissanaike S,Griswold JA,San Francisco MJ,Colmer-Hamood JA,Hamood AN

更新日期：2019-05-07 00:00:00

abstract：:Although a few studies have investigated the intestinal microbiota of women with polycystic ovary syndrome (PCOS), the functional and metabolic mechanisms of the microbes associated with PCOS, as well as potential microbial biomarkers, have not yet been identified. To address this gap, we designed a two-phase experime...

journal_title：mSystems

authors： Zhang J,Sun Z,Jiang S,Bai X,Ma C,Peng Q,Chen K,Chang H,Fang T,Zhang H

更新日期：2019-04-16 00:00:00

abstract：:Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for the Human Microbiome Project stool sample database and revealed 279 unique GUS enzymes org...

journal_title：mSystems

authors： Creekmore BC,Gray JH,Walton WG,Biernat KA,Little MS,Xu Y,Liu J,Gharaibeh RZ,Redinbo MR

更新日期：2019-08-27 00:00:00

abstract：:Insights into the interaction between phages and their bacterial hosts are crucial for the development of phage therapy. However, only one study has investigated global gene expression of Clostridioides (formerly Clostridium) difficile carrying prophage, and transcriptional reprogramming during lytic infection has not...

journal_title：mSystems

authors： Li T,Zhang Y,Dong K,Kuo CJ,Li C,Zhu YQ,Qin J,Li QT,Chang YF,Guo X,Zhu Y

更新日期：2020-05-05 00:00:00

abstract：:Soil metagenomics has been touted as the "grand challenge" for metagenomics, as the high microbial diversity and spatial heterogeneity of soils make them unamenable to current assembly platforms. Here, we aimed to improve soil metagenomic sequence assembly by applying the Moleculo synthetic long-read sequencing techno...

journal_title：mSystems

authors： White RA 3rd,Bottos EM,Roy Chowdhury T,Zucker JD,Brislawn CJ,Nicora CD,Fansler SJ,Glaesemann KR,Glass K,Jansson JK

更新日期：2016-06-28 00:00:00