Reconciling Ecological and Engineering Design Principles for Building Microbiomes.

abstract：:Interactions between plant pathogens and root-associated microbes play an important role in determining disease outcomes. While several studies have suggested that steering these interactions may improve plant health, such approaches have remained challenging in practice. Because of low iron availability in most soils...

journal_title：mSystems

authors： Gu S,Yang T,Shao Z,Wang T,Cao K,Jousset A,Friman VP,Mallon C,Mei X,Wei Z,Xu Y,Shen Q,Pommier T

更新日期：2020-06-30 00:00:00

abstract：:The identification of ancestral traits is essential to understanding the evolution of any group. In the case of parasitic groups, this helps us understand the adaptation to this lifestyle and a particular host. Most diplomonads are parasites, but there are free-living members of the group nested among the host-associa...

journal_title：mSystems

authors： Jiménez-González A,Andersson JO

更新日期：2020-12-22 00:00:00

abstract：:Many pathogenic bacteria of the family Enterobacteriaceae use type III secretion systems to inject virulence proteins, termed "effectors," into the host cell cytosol. Although host-cellular activities of several effectors have been demonstrated, the function and host-targeted pathways of most of the effectors identifi...

journal_title：mSystems

authors： Sontag RL,Nakayasu ES,Brown RN,Niemann GS,Sydor MA,Sanchez O,Ansong C,Lu SY,Choi H,Valleau D,Weitz KK,Savchenko A,Cambronne ED,Adkins JN

更新日期：2016-07-12 00:00:00

abstract：:Networks encode the interactions between the components in complex systems and play an essential role in understanding complex systems. Microbial ecological networks provide a system-level insight for comprehensively understanding complex microbial interactions, which play important roles in microbial community assemb...

journal_title：mSystems

authors： Lv X,Zhao K,Xue R,Liu Y,Xu J,Ma B

更新日期：2019-05-21 00:00:00

abstract：:Globally, dental caries is the most prevalent chronic oral disease and affects roughly half of all children. The aim of this report was to use metagenomic analyses to investigate the relationship between the oral microbiome and caries in preschool children. A total of 25 preschoolers, aged 3 to 5 years old with severe...

journal_title：mSystems

authors： Wang Y,Wang S,Wu C,Chen X,Duan Z,Xu Q,Jiang W,Xu L,Wang T,Su L,Wang Y,Chen Y,Zhang J,Huang Y,Tong S,Zhou C,Deng S,Qin N

更新日期：2019-11-05 00:00:00

abstract：:Soil metagenomics has been touted as the "grand challenge" for metagenomics, as the high microbial diversity and spatial heterogeneity of soils make them unamenable to current assembly platforms. Here, we aimed to improve soil metagenomic sequence assembly by applying the Moleculo synthetic long-read sequencing techno...

journal_title：mSystems

authors： White RA 3rd,Bottos EM,Roy Chowdhury T,Zucker JD,Brislawn CJ,Nicora CD,Fansler SJ,Glaesemann KR,Glass K,Jansson JK

更新日期：2016-06-28 00:00:00

abstract：:Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for the Human Microbiome Project stool sample database and revealed 279 unique GUS enzymes org...

journal_title：mSystems

authors： Creekmore BC,Gray JH,Walton WG,Biernat KA,Little MS,Xu Y,Liu J,Gharaibeh RZ,Redinbo MR

更新日期：2019-08-27 00:00:00

abstract：:Biological sulfur cycling in polar, low-temperature ecosystems is an understudied phenomenon in part due to difficulty of access and the dynamic nature of glacial environments. One such environment where sulfur cycling is known to play an important role in microbial metabolisms is located at Borup Fiord Pass (BFP) in ...

journal_title：mSystems

authors： Trivedi CB,Stamps BW,Lau GE,Grasby SE,Templeton AS,Spear JR

更新日期：2020-08-04 00:00:00

abstract：:Fecal microbiota transplantation (FMT) is a proposedly useful strategy for the treatment of gastrointestinal (GI) disorders through remediation of the patient gut microbiota. However, its therapeutic success has been variable, necessitating research to uncover mechanisms that improve patient response. Antibiotic pretr...

journal_title：mSystems

authors： Oliphant K,Cochrane K,Schroeter K,Daigneault MC,Yen S,Verdu EF,Allen-Vercoe E

更新日期：2020-01-28 00:00:00

abstract：:The gut microbiota has been implicated in immunoglobin A nephropathy (IgAN) because the intestinal immune response is assumed to be one of the disease triggers. Since the microbial composition is heritable, we hypothesize that genetic variants controlling gut microbiota composition may be associated with susceptibilit...

journal_title：mSystems

authors： He JW,Zhou XJ,Li YF,Wang YN,Liu LJ,Shi SF,Xin XH,Li RS,Falchi M,Lv JC,Zhang H

更新日期：2021-01-12 00:00:00

abstract：:In the female genital ecosystem, the complex interplay between the host immune system and the resident microflora protects against urogenital pathogens, like Chlamydia trachomatisC. trachomatis is responsible for urethritis and cervicitis; however, most chlamydial infections are asymptomatic and, thus, not treated, po...

journal_title：mSystems

authors： Filardo S,Di Pietro M,Tranquilli G,Latino MA,Recine N,Porpora MG,Sessa R

更新日期：2019-06-04 00:00:00

abstract：:Insights into the interaction between phages and their bacterial hosts are crucial for the development of phage therapy. However, only one study has investigated global gene expression of Clostridioides (formerly Clostridium) difficile carrying prophage, and transcriptional reprogramming during lytic infection has not...

journal_title：mSystems

authors： Li T,Zhang Y,Dong K,Kuo CJ,Li C,Zhu YQ,Qin J,Li QT,Chang YF,Guo X,Zhu Y

更新日期：2020-05-05 00:00:00

abstract：:Bumble bees are important pollinators in natural and agricultural ecosystems. Their social colonies are founded by individual queens, which, as the predominant reproductive females of colonies, contribute to colony function through worker production and fitness through male and new queen production. Therefore, queen h...

journal_title：mSystems

authors： Wang L,Wu J,Li K,Sadd BM,Guo Y,Zhuang D,Zhang Z,Chen Y,Evans JD,Guo J,Zhang Z,Li J

更新日期：2019-12-10 00:00:00

abstract：:Studying perturbations in the gut ecosystem using animal models of disease continues to provide valuable insights into the role of the microbiome in various pathological conditions. However, understanding whether these changes are consistent across animal models of different genetic backgrounds, and hence potentially ...

journal_title：mSystems

authors： Tripathi A,Xu ZZ,Xue J,Poulsen O,Gonzalez A,Humphrey G,Meehan MJ,Melnik AV,Ackermann G,Zhou D,Malhotra A,Haddad GG,Dorrestein PC,Knight R

更新日期：2019-04-30 00:00:00

abstract：:Thaumarchaeota are frequently reported to associate with marine sponges (phylum Porifera); however, little is known about the features that distinguish them from their free-living thaumarchaeal counterparts. In this study, thaumarchaeal metagenome-assembled genomes (MAGs) were reconstructed from metagenomic data sets ...

journal_title：mSystems

authors： Zhang S,Song W,Wemheuer B,Reveillaud J,Webster N,Thomas T

更新日期：2019-08-13 00:00:00

abstract：:Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such minin...

journal_title：mSystems

authors： Medema MH

更新日期：2018-03-06 00:00:00

abstract：:The 2,3-seco pathway, the pathway for anaerobic cholesterol degradation, has been established in the denitrifying betaproteobacterium Sterolibacterium denitrificans. However, knowledge of how microorganisms respond to cholesterol at the community level is elusive. Here, we applied mesocosm incubation and 16S rRNA sequ...

journal_title：mSystems

authors： Wei ST,Wu YW,Lee TH,Huang YS,Yang CY,Chen YL,Chiang YR

更新日期：2018-10-30 00:00:00

abstract：:Dimorphic plant and human mycopathogens require a switch from the usual yeast growth to filamentous growth for host tissue penetration, and the switch is controlled by multiple signaling systems other than the central developmental pathway. Unlike these fungi, dimorphic insect mycopathogens usually grow by hyphal exte...

journal_title：mSystems

authors： Zhang AX,Mouhoumed AZ,Tong SM,Ying SH,Feng MG

更新日期：2019-07-09 00:00:00

abstract：:The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be fully elucidated. This knowle...

journal_title：mSystems

authors： Brinkac LM,Rahman N,Chua LL,Thomas S

更新日期：2020-10-27 00:00:00

abstract：:Arctic regions, which are changing rapidly as they warm 2 to 3 times faster than the global average, still retain microbial habitats that serve as natural laboratories for understanding mechanisms of microbial adaptation to extreme conditions. Seawater-derived brines within both sea ice (sea-ice brine) and ancient lay...

journal_title：mSystems

authors： Zhong ZP,Rapp JZ,Wainaina JM,Solonenko NE,Maughan H,Carpenter SD,Cooper ZS,Jang HB,Bolduc B,Deming JW,Sullivan MB

更新日期：2020-06-16 00:00:00

abstract：:ABSRTACTKlebsiella pneumoniae is a common cause of human-pneumonia-derived sepsis with high morbidity and mortality. The microbiota promotes and maintains host immune homeostasis. The mechanisms by which the gut microbiota affects the host defenses in the respiratory system systematically, however, remain poorly under...

journal_title：mSystems

authors： Wu T,Li H,Su C,Xu F,Yang G,Sun K,Xu M,Lv N,Meng B,Liu Y,Hu L,Liu Y,Gao Y,Wang H,Lan Y,Xu D,Li J

更新日期：2020-11-03 00:00:00

abstract：:Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S Pullorum infection ...

journal_title：mSystems

authors： Ding J,Zhou H,Luo L,Xiao L,Yang K,Yang L,Zheng Y,Xu K,He C,Han C,Luo H,Qin C,Akinyemi FT,Gu C,Zhou Z,Huang Q,Meng H

更新日期：2021-01-05 00:00:00

abstract：:Salmonella infection is one of the main causes of food-borne diarrheal diseases worldwide. Although most Salmonella infections can be cleared without treatment, some cause serious illnesses that require antibiotic treatment. In view of the growing emergence of antibiotic-resistant Salmonella strains, novel treatments ...

journal_title：mSystems

authors： Hu YOO,Hugerth LW,Bengtsson C,Alisjahbana A,Seifert M,Kamal A,Sjöling Å,Midtvedt T,Norin E,Du J,Engstrand L

更新日期：2018-10-02 00:00:00

abstract：:Nutrient acquisition from the host environment is crucial for the survival of intracellular pathogens, but conceptual and technical challenges limit our knowledge of pathogen diets. To overcome some of these technical roadblocks, we exploited an experimentally accessible model for early infection of human macrophages ...

journal_title：mSystems

authors： Zimmermann M,Kogadeeva M,Gengenbacher M,McEwen G,Mollenkopf HJ,Zamboni N,Kaufmann SHE,Sauer U

更新日期：2017-08-22 00:00:00

abstract：:Intestinal bacterial dysbiosis has been increasingly linked to ankylosing spondylitis (AS), which is a prototypic and best studied subtype of spondyloarthritis (SpA). Fungi and bacteria coexist in the human gut and interact with each other. Although they have been shown to contribute actively to health or disease, no ...

journal_title：mSystems

authors： Li M,Dai B,Tang Y,Lei L,Li N,Liu C,Ge T,Zhang L,Xu Y,Hu Y,Li P,Zhang Y,Yuan J,Li X

更新日期：2019-03-26 00:00:00

abstract：:Given the complexity of host-microbiota symbioses, scientists and philosophers are asking questions at new biological levels of hierarchical organization-what is a holobiont and hologenome? When should this vocabulary be applied? Are these concepts a null hypothesis for host-microbe systems or limited to a certain spe...

journal_title：mSystems

authors： Theis KR,Dheilly NM,Klassen JL,Brucker RM,Baines JF,Bosch TC,Cryan JF,Gilbert SF,Goodnight CJ,Lloyd EA,Sapp J,Vandenkoornhuyse P,Zilber-Rosenberg I,Rosenberg E,Bordenstein SR

更新日期：2016-03-29 00:00:00

abstract：:The intestinal microbiota and the expanded endocannabinoid (eCB) system, or endocannabinoidome (eCBome), have both been implicated in diet-induced obesity and dysmetabolism. These systems were recently suggested to interact during the development of obesity. We aimed at identifying the potential interactions between g...

journal_title：mSystems

authors： Lacroix S,Pechereau F,Leblanc N,Boubertakh B,Houde A,Martin C,Flamand N,Silvestri C,Raymond F,Di Marzo V,Veilleux A

更新日期：2019-12-17 00:00:00

abstract：:Marine oil spills can impact both coastal and offshore marine environments, but little information is available on how the microbial response to oil and dispersants might differ between these biomes. Here, we describe the compositional and functional response of microbial communities to different concentrations of oil...

journal_title：mSystems

authors： Doyle SM,Lin G,Morales-McDevitt M,Wade TL,Quigg A,Sylvan JB

更新日期：2020-08-25 00:00:00

abstract：:Although a few studies have investigated the intestinal microbiota of women with polycystic ovary syndrome (PCOS), the functional and metabolic mechanisms of the microbes associated with PCOS, as well as potential microbial biomarkers, have not yet been identified. To address this gap, we designed a two-phase experime...

journal_title：mSystems

authors： Zhang J,Sun Z,Jiang S,Bai X,Ma C,Peng Q,Chen K,Chang H,Fang T,Zhang H

更新日期：2019-04-16 00:00:00

abstract：:For mammals, oxalate enters the body through the diet or is endogenously produced by the liver; it is removed by microbial oxalate metabolism in the gut and/or excretion in feces or urine. Deficiencies in any one of the these pathways can lead to complications, such as calcium oxalate urinary stones. While considerabl...

journal_title：mSystems

authors： Miller AW,Dale C,Dearing MD

更新日期：2017-09-26 00:00:00