Strengthening Insights in Microbial Ecological Networks from Theory to Applications.

abstract：:Health-associated oral Streptococcus species are promising probiotic candidates to protect against dental caries. Ammonia production through the arginine deiminase system (ADS), which can increase the pH of oral biofilms, and direct antagonism of caries-associated bacterial species are desirable properties for oral pr...

journal_title：mSystems

authors： Velsko IM,Chakraborty B,Nascimento MM,Burne RA,Richards VP

更新日期：2018-12-18 00:00:00

abstract：:Tripartite symbioses between bacteriophages, the epithelial cell layers of the human gut, and bacterial symbionts may play an important and unrecognized role in the function of the gut microbiome. Traditionally, phages residing within the gut were considered to interact only with their bacterial hosts and thereby to f...

journal_title：mSystems

authors： Barr JJ

更新日期：2019-05-07 00:00:00

abstract：:The gut microbiota has been implicated in immunoglobin A nephropathy (IgAN) because the intestinal immune response is assumed to be one of the disease triggers. Since the microbial composition is heritable, we hypothesize that genetic variants controlling gut microbiota composition may be associated with susceptibilit...

journal_title：mSystems

authors： He JW,Zhou XJ,Li YF,Wang YN,Liu LJ,Shi SF,Xin XH,Li RS,Falchi M,Lv JC,Zhang H

更新日期：2021-01-12 00:00:00

abstract：:Single mutations frequently alter several aspects of cell behavior but rarely reveal whether a particular statistically significant change is biologically significant. To determine which behavioral changes are most important for multicellular self-organization, we devised a new methodology using Myxococcus xanthus as ...

journal_title：mSystems

authors： Zhang Z,Cotter CR,Lyu Z,Shimkets LJ,Igoshin OA

更新日期：2020-07-14 00:00:00

abstract：:Quantitative understanding and prediction of microbial community dynamics are an outstanding challenge. We test the hypothesis that metabolic mechanisms provide a foundation for accurate prediction of dynamics in microbial systems. In our research, metabolic models have been able to accurately predict species interact...

journal_title：mSystems

authors： Chacón JM,Harcombe WR

更新日期：2019-06-11 00:00:00

abstract：:Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such minin...

journal_title：mSystems

authors： Medema MH

更新日期：2018-03-06 00:00:00

abstract：:Despite insights gained through experimental models, the set of bacterial genes important for human infection is unclear for many of our most threatening pathogens. Klebsiella pneumoniae is a leading cause of health care-associated infections (HAIs) and commonly colonizes hospitalized patients, but the factors that de...

journal_title：mSystems

authors： Martin RM,Cao J,Wu W,Zhao L,Manthei DM,Pirani A,Snitkin E,Malani PN,Rao K,Bachman MA

更新日期：2018-06-26 00:00:00

abstract：:Thaumarchaeota are frequently reported to associate with marine sponges (phylum Porifera); however, little is known about the features that distinguish them from their free-living thaumarchaeal counterparts. In this study, thaumarchaeal metagenome-assembled genomes (MAGs) were reconstructed from metagenomic data sets ...

journal_title：mSystems

authors： Zhang S,Song W,Wemheuer B,Reveillaud J,Webster N,Thomas T

更新日期：2019-08-13 00:00:00

abstract：:Despite increasing acknowledgment that microorganisms underpin the healthy functioning of basically all multicellular life, few cross-disciplinary teams address the diversity and function of microbiota across organisms and ecosystems. Our newly formed consortium of junior faculty spanning fields such as ecology and ge...

journal_title：mSystems

authors： Hynson NA,Frank KL,Alegado RA,Amend AS,Arif M,Bennett GM,Jani AJ,Medeiros MCI,Mileyko Y,Nelson CE,Nguyen NH,Nigro OD,Prisic S,Shin S,Takagi D,Wilson ST,Yew JY

更新日期：2018-03-13 00:00:00

abstract：:Social behavior can alter the microbiome composition via transmission among social partners, but there have been few controlled experimental studies of gut microbiome transmission among social partners in primates. We collected longitudinal fecal samples from eight unrelated male-female pairs of marmoset monkeys prior...

journal_title：mSystems

authors： Zhu L,Clayton JB,Suhr Van Haute MJ,Yang Q,Hassenstab HR,Mustoe AC,Knights D,Benson AK,French JA

更新日期：2020-03-24 00:00:00

abstract：:Studying perturbations in the gut ecosystem using animal models of disease continues to provide valuable insights into the role of the microbiome in various pathological conditions. However, understanding whether these changes are consistent across animal models of different genetic backgrounds, and hence potentially ...

journal_title：mSystems

authors： Tripathi A,Xu ZZ,Xue J,Poulsen O,Gonzalez A,Humphrey G,Meehan MJ,Melnik AV,Ackermann G,Zhou D,Malhotra A,Haddad GG,Dorrestein PC,Knight R

更新日期：2019-04-30 00:00:00

abstract：:Primary production by Prochlorococcus, the smallest known free-living photosynthetic organism in terms of both physical and genomic size, is thought to have a significant role in global carbon cycles. Despite its small size and low growth rate, Prochlorococcus numerically dominates the phytoplankton community in the n...

journal_title：mSystems

authors： Szul MJ,Dearth SP,Campagna SR,Zinser ER

更新日期：2019-02-26 00:00:00

abstract：:Biological sulfur cycling in polar, low-temperature ecosystems is an understudied phenomenon in part due to difficulty of access and the dynamic nature of glacial environments. One such environment where sulfur cycling is known to play an important role in microbial metabolisms is located at Borup Fiord Pass (BFP) in ...

journal_title：mSystems

authors： Trivedi CB,Stamps BW,Lau GE,Grasby SE,Templeton AS,Spear JR

更新日期：2020-08-04 00:00:00

abstract：:Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study employed comparative meta...

journal_title：mSystems

authors： Han ML,Zhu Y,Creek DJ,Lin YW,Gutu AD,Hertzog P,Purcell T,Shen HH,Moskowitz SM,Velkov T,Li J

更新日期：2019-01-08 00:00:00

abstract：:Here, the role of the dairy-processing chain as a reservoir of antimicrobial resistance (AR) determinants and a source of novel biocontrol quorum-sensing inhibitors is assessed through a functional metagenomics approach. A metagenomic library comprising ∼22,000 recombinant clones was built from DNA isolated from raw m...

journal_title：mSystems

authors： Alexa Oniciuc EA,Walsh CJ,Coughlan LM,Awad A,Simon CA,Ruiz L,Crispie F,Cotter PD,Alvarez-Ordóñez A

更新日期：2020-02-18 00:00:00

abstract：:Soil metagenomics has been touted as the "grand challenge" for metagenomics, as the high microbial diversity and spatial heterogeneity of soils make them unamenable to current assembly platforms. Here, we aimed to improve soil metagenomic sequence assembly by applying the Moleculo synthetic long-read sequencing techno...

journal_title：mSystems

authors： White RA 3rd,Bottos EM,Roy Chowdhury T,Zucker JD,Brislawn CJ,Nicora CD,Fansler SJ,Glaesemann KR,Glass K,Jansson JK

更新日期：2016-06-28 00:00:00

abstract：:Persister cells are genetically identical variants in a bacterial population that have phenotypically modified their physiology to survive environmental stress. In bacterial pathogens, persisters are able to survive antibiotic treatment and reinfect patients in a frustrating cycle of chronic infection. To better defin...

journal_title：mSystems

authors： Micheva-Viteva SN,Shakya M,Adikari SH,Gleasner CD,Velappan N,Mourant JR,Chain PSG,Hong-Geller E

更新日期：2020-02-11 00:00:00

abstract：:The reactive intermediate deaminase RidA (EC 3.5.99.10) is conserved across all domains of life and deaminates reactive enamine species. When Salmonella entericaridA mutants are grown in minimal medium, 2-aminoacrylate (2AA) accumulates, damages several pyridoxal 5'-phosphate (PLP)-dependent enzymes, and elicits an ob...

journal_title：mSystems

authors： Borchert AJ,Gouveia GJ,Edison AS,Downs DM

更新日期：2020-03-10 00:00:00

abstract：:Microbiology, like many areas of life science research, is increasingly data-intensive. As such, bioinformatics and data science skills have become essential to leverage microbiome sequencing data for discovery. Short intensive courses have sprung up as formal computational training opportunities at individual institu...

journal_title：mSystems

authors： Taroni JN

更新日期：2019-08-20 00:00:00

abstract：:In the female genital ecosystem, the complex interplay between the host immune system and the resident microflora protects against urogenital pathogens, like Chlamydia trachomatisC. trachomatis is responsible for urethritis and cervicitis; however, most chlamydial infections are asymptomatic and, thus, not treated, po...

journal_title：mSystems

authors： Filardo S,Di Pietro M,Tranquilli G,Latino MA,Recine N,Porpora MG,Sessa R

更新日期：2019-06-04 00:00:00

abstract：:Increasing rates of antibiotic-resistant bacterial infection are one of the most pressing contemporary global health concerns. The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) have been identified as the...

journal_title：mSystems

authors： Brooks LE,Ul-Hasan S,Chan BK,Sistrom MJ

更新日期：2018-04-17 00:00:00

abstract：:Polymyxins are used as treatments of last resort for Gram-negative bacterial infections. Their increased use has led to concerns about emerging polymyxin resistance (PR). Phenotypic polymyxin susceptibility testing is resource intensive and difficult to perform accurately. The complex polygenic nature of PR and our in...

journal_title：mSystems

authors： Macesic N,Bear Don't Walk OJ IV,,Pe'er I,Tatonetti NP,Peleg AY,Uhlemann AC

更新日期：2020-05-26 00:00:00

abstract：:Wastewater surveillance represents a complementary approach to clinical surveillance to measure the presence and prevalence of emerging infectious diseases like the novel coronavirus SARS-CoV-2. This innovative data source can improve the precision of epidemiological modeling to understand the penetrance of SARS-CoV-2...

journal_title：mSystems

authors： Wu F,Zhang J,Xiao A,Gu X,Lee WL,Armas F,Kauffman K,Hanage W,Matus M,Ghaeli N,Endo N,Duvallet C,Poyet M,Moniz K,Washburne AD,Erickson TB,Chai PR,Thompson J,Alm EJ

更新日期：2020-07-21 00:00:00

abstract：:Intestinal bacterial dysbiosis has been increasingly linked to ankylosing spondylitis (AS), which is a prototypic and best studied subtype of spondyloarthritis (SpA). Fungi and bacteria coexist in the human gut and interact with each other. Although they have been shown to contribute actively to health or disease, no ...

journal_title：mSystems

authors： Li M,Dai B,Tang Y,Lei L,Li N,Liu C,Ge T,Zhang L,Xu Y,Hu Y,Li P,Zhang Y,Yuan J,Li X

更新日期：2019-03-26 00:00:00

abstract：:Many pathogenic bacteria of the family Enterobacteriaceae use type III secretion systems to inject virulence proteins, termed "effectors," into the host cell cytosol. Although host-cellular activities of several effectors have been demonstrated, the function and host-targeted pathways of most of the effectors identifi...

journal_title：mSystems

authors： Sontag RL,Nakayasu ES,Brown RN,Niemann GS,Sydor MA,Sanchez O,Ansong C,Lu SY,Choi H,Valleau D,Weitz KK,Savchenko A,Cambronne ED,Adkins JN

更新日期：2016-07-12 00:00:00

abstract：:Classified as a biosafety level 4 (BSL4) select agent, Nipah virus (NiV) is a deadly henipavirus in the Paramyxoviridae family, with a nearly 75% mortality rate in humans, underscoring its global and animal health importance. Elucidating the process of viral particle production in host cells is imperative both for tar...

journal_title：mSystems

authors： Johnston GP,Bradel-Tretheway B,Piehowski PD,Brewer HM,Lee BNR,Usher NT,Zamora JLR,Ortega V,Contreras EM,Teuton JR,Wendler JP,Matz KM,Adkins JN,Aguilar HC

更新日期：2019-09-24 00:00:00

abstract：:Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for the Human Microbiome Project stool sample database and revealed 279 unique GUS enzymes org...

journal_title：mSystems

authors： Creekmore BC,Gray JH,Walton WG,Biernat KA,Little MS,Xu Y,Liu J,Gharaibeh RZ,Redinbo MR

更新日期：2019-08-27 00:00:00

abstract：:Methylobacter species, members of the Methylococcales, have recently emerged as some of the globally widespread, cosmopolitan species that play a key role in the environmental consumption of methane across gradients of dioxygen tensions. In this work, we approached the question of how Methylobacter copes with hypoxia,...

journal_title：mSystems

authors： Yu Z,Pesesky M,Zhang L,Huang J,Winkler M,Chistoserdova L

更新日期：2020-01-21 00:00:00

abstract：:Marine oil spills can impact both coastal and offshore marine environments, but little information is available on how the microbial response to oil and dispersants might differ between these biomes. Here, we describe the compositional and functional response of microbial communities to different concentrations of oil...

journal_title：mSystems

authors： Doyle SM,Lin G,Morales-McDevitt M,Wade TL,Quigg A,Sylvan JB

更新日期：2020-08-25 00:00:00

abstract：:The intestinal microbiota and the expanded endocannabinoid (eCB) system, or endocannabinoidome (eCBome), have both been implicated in diet-induced obesity and dysmetabolism. These systems were recently suggested to interact during the development of obesity. We aimed at identifying the potential interactions between g...

journal_title：mSystems

authors： Lacroix S,Pechereau F,Leblanc N,Boubertakh B,Houde A,Martin C,Flamand N,Silvestri C,Raymond F,Di Marzo V,Veilleux A

更新日期：2019-12-17 00:00:00