Identification of Pathogenicity-Associated Loci in Klebsiella pneumoniae from Hospitalized Patients.

abstract：:The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host's genome, the microbiome is amenable to change over the course of an organism's lifetime, providing an opportunity to therapeutically modulate the microbiome's im...

journal_title：mSystems

authors： Uhr GT,Dohnalová L,Thaiss CA

更新日期：2019-02-19 00:00:00

abstract：:Despite increasing acknowledgment that microorganisms underpin the healthy functioning of basically all multicellular life, few cross-disciplinary teams address the diversity and function of microbiota across organisms and ecosystems. Our newly formed consortium of junior faculty spanning fields such as ecology and ge...

journal_title：mSystems

authors： Hynson NA,Frank KL,Alegado RA,Amend AS,Arif M,Bennett GM,Jani AJ,Medeiros MCI,Mileyko Y,Nelson CE,Nguyen NH,Nigro OD,Prisic S,Shin S,Takagi D,Wilson ST,Yew JY

更新日期：2018-03-13 00:00:00

abstract：:In the female genital ecosystem, the complex interplay between the host immune system and the resident microflora protects against urogenital pathogens, like Chlamydia trachomatisC. trachomatis is responsible for urethritis and cervicitis; however, most chlamydial infections are asymptomatic and, thus, not treated, po...

journal_title：mSystems

authors： Filardo S,Di Pietro M,Tranquilli G,Latino MA,Recine N,Porpora MG,Sessa R

更新日期：2019-06-04 00:00:00

abstract：:Apoptosis is generally considered the first line of defense against viral infection. However, the role of apoptosis in the interactions between plant viruses and their insect vectors has rarely been investigated. By studying plant DNA viruses of the genus Begomovirus within the family Geminiviridae, which are transmit...

journal_title：mSystems

authors： Wang XR,Wang C,Ban FX,Ghanim M,Pan LL,Qian LX,Liu YQ,Wang XW,Liu SS

更新日期：2020-09-22 00:00:00

abstract：:Acinetobacter baumannii has been reported as a multidrug-resistant bacterium due to biofilms and antimicrobial resistance mechanisms. Hence, novel therapeutic strategies are necessary to overcome A. baumannii infections. This study revealed that citral at 200 μg/ml attenuated A. baumannii biofilms by up to 90% without...

journal_title：mSystems

authors： Selvaraj A,Valliammai A,Muthuramalingam P,Sethupathy S,Subramenium GA,Ramesh M,Pandian SK

更新日期：2020-11-17 00:00:00

abstract：:Marine microbes are known to degrade hydrocarbons; however, microbes inhabiting deep-sea sediments remain largely unexplored. Previous studies into the classical pathways of marine microbial metabolism reveal diverse chemistries; however, metabolic profiling of marine microbes cultured with hydrocarbons is limited. In...

journal_title：mSystems

authors： Moreno-Ulloa A,Sicairos Diaz V,Tejeda-Mora JA,Macias Contreras MI,Castillo FD,Guerrero A,Gonzalez Sanchez R,Mendoza-Porras O,Vazquez Duhalt R,Licea-Navarro A

更新日期：2020-11-10 00:00:00

abstract：:Microbiology, like many areas of life science research, is increasingly data-intensive. As such, bioinformatics and data science skills have become essential to leverage microbiome sequencing data for discovery. Short intensive courses have sprung up as formal computational training opportunities at individual institu...

journal_title：mSystems

authors： Taroni JN

更新日期：2019-08-20 00:00:00

abstract：:Salmonella infection is one of the main causes of food-borne diarrheal diseases worldwide. Although most Salmonella infections can be cleared without treatment, some cause serious illnesses that require antibiotic treatment. In view of the growing emergence of antibiotic-resistant Salmonella strains, novel treatments ...

journal_title：mSystems

authors： Hu YOO,Hugerth LW,Bengtsson C,Alisjahbana A,Seifert M,Kamal A,Sjöling Å,Midtvedt T,Norin E,Du J,Engstrand L

更新日期：2018-10-02 00:00:00

abstract：:Health-associated oral Streptococcus species are promising probiotic candidates to protect against dental caries. Ammonia production through the arginine deiminase system (ADS), which can increase the pH of oral biofilms, and direct antagonism of caries-associated bacterial species are desirable properties for oral pr...

journal_title：mSystems

authors： Velsko IM,Chakraborty B,Nascimento MM,Burne RA,Richards VP

更新日期：2018-12-18 00:00:00

abstract：:Recent studies of mammalian microbiomes have identified strong phylogenetic effects on bacterial community composition. Bats (Mammalia: Chiroptera) are among the most speciose mammals on the planet and the only mammal capable of true flight. We examined 1,236 16S rRNA amplicon libraries of the gut, oral, and skin micr...

journal_title：mSystems

authors： Lutz HL,Jackson EW,Webala PW,Babyesiza WS,Kerbis Peterhans JC,Demos TC,Patterson BD,Gilbert JA

更新日期：2019-11-12 00:00:00

abstract：:High-nucleic-acid (HNA) and low-nucleic-acid (LNA) bacteria are two operational groups identified by flow cytometry (FCM) in aquatic systems. A number of reports have shown that HNA cell density correlates strongly with heterotrophic production, while LNA cell density does not. However, which taxa are specifically ass...

journal_title：mSystems

authors： Rubbens P,Schmidt ML,Props R,Biddanda BA,Boon N,Waegeman W,Denef VJ

更新日期：2019-09-10 00:00:00

abstract：:Increasing rates of antibiotic-resistant bacterial infection are one of the most pressing contemporary global health concerns. The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) have been identified as the...

journal_title：mSystems

authors： Brooks LE,Ul-Hasan S,Chan BK,Sistrom MJ

更新日期：2018-04-17 00:00:00

abstract：:Streptococcus mutans is a Gram-positive bacterium that thrives under acidic conditions and is a primary cause of tooth decay (dental caries). To better understand the metabolism of S. mutans on a systematic level, we manually constructed a genome-scale metabolic model of the S. mutans type strain UA159. The model, cal...

journal_title：mSystems

authors： Jijakli K,Jensen PA

更新日期：2019-10-29 00:00:00

abstract：:Vitamin B12 is synthesized by prokaryotes in the rumens of dairy cows-and this has implications in human nutrition since humans rely on consumption of dairy products for vitamin B12 acquisition. However, the concentration of vitamin B12 in milk is highly variable, and there is interest in determining what causes vitam...

journal_title：mSystems

authors： Franco-Lopez J,Duplessis M,Bui A,Reymond C,Poisson W,Blais L,Chong J,Gervais R,Rico DE,Cue RI,Girard CL,Ronholm J

更新日期：2020-03-03 00:00:00

abstract：:Social behavior can alter the microbiome composition via transmission among social partners, but there have been few controlled experimental studies of gut microbiome transmission among social partners in primates. We collected longitudinal fecal samples from eight unrelated male-female pairs of marmoset monkeys prior...

journal_title：mSystems

authors： Zhu L,Clayton JB,Suhr Van Haute MJ,Yang Q,Hassenstab HR,Mustoe AC,Knights D,Benson AK,French JA

更新日期：2020-03-24 00:00:00

abstract：:Biological sulfur cycling in polar, low-temperature ecosystems is an understudied phenomenon in part due to difficulty of access and the dynamic nature of glacial environments. One such environment where sulfur cycling is known to play an important role in microbial metabolisms is located at Borup Fiord Pass (BFP) in ...

journal_title：mSystems

authors： Trivedi CB,Stamps BW,Lau GE,Grasby SE,Templeton AS,Spear JR

更新日期：2020-08-04 00:00:00

abstract：:Vibrio anguillarum is a marine bacterium that can cause vibriosis in many fish and shellfish species, leading to high mortalities and economic losses in aquaculture. Although putative virulence factors have been identified, the mechanism of pathogenesis of V. anguillarum is not fully understood. Here, we analyzed whol...

journal_title：mSystems

authors： Castillo D,Alvise PD,Xu R,Zhang F,Middelboe M,Gram L

更新日期：2017-02-28 00:00:00

abstract：:Persister cells are genetically identical variants in a bacterial population that have phenotypically modified their physiology to survive environmental stress. In bacterial pathogens, persisters are able to survive antibiotic treatment and reinfect patients in a frustrating cycle of chronic infection. To better defin...

journal_title：mSystems

authors： Micheva-Viteva SN,Shakya M,Adikari SH,Gleasner CD,Velappan N,Mourant JR,Chain PSG,Hong-Geller E

更新日期：2020-02-11 00:00:00

abstract：:In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of expression from ribosomal promoters; this can deplete the pool of RNA polyme...

journal_title：mSystems

authors： Zhang Q,Brambilla E,Li R,Shi H,Cosentino Lagomarsino M,Sclavi B

更新日期：2020-09-08 00:00:00

abstract：:Fecal microbiota transplantation (FMT) is a proposedly useful strategy for the treatment of gastrointestinal (GI) disorders through remediation of the patient gut microbiota. However, its therapeutic success has been variable, necessitating research to uncover mechanisms that improve patient response. Antibiotic pretr...

journal_title：mSystems

authors： Oliphant K,Cochrane K,Schroeter K,Daigneault MC,Yen S,Verdu EF,Allen-Vercoe E

更新日期：2020-01-28 00:00:00

abstract：:Bacterial motility is thought to play an important role in virulence. We have previously shown that proficient bacterial swimming and swarming in vitro is correlated with the persistent intramammary infection phenotype observed in cattle. However, little is known about the gene regulation differences important for dif...

journal_title：mSystems

authors： Lippolis JD,Brunelle BW,Reinhardt TA,Sacco RE,Thacker TC,Looft TP,Casey TA

更新日期：2016-08-09 00:00:00

abstract：:Microbial heterotopic metabolism in the ocean is fueled by a supply of essential nutrients acquired via exoenzymes catalyzing depolymerization of high-molecular-weight compounds. Although the rates of activity for a variety of exoenzymes across various marine environments are well established, the factors regulating t...

journal_title：mSystems

authors： Kamalanathan M,Doyle SM,Xu C,Achberger AM,Wade TL,Schwehr K,Santschi PH,Sylvan JB,Quigg A

更新日期：2020-04-14 00:00:00

abstract：:Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such minin...

journal_title：mSystems

authors： Medema MH

更新日期：2018-03-06 00:00:00

abstract：:Quantitative understanding and prediction of microbial community dynamics are an outstanding challenge. We test the hypothesis that metabolic mechanisms provide a foundation for accurate prediction of dynamics in microbial systems. In our research, metabolic models have been able to accurately predict species interact...

journal_title：mSystems

authors： Chacón JM,Harcombe WR

更新日期：2019-06-11 00:00:00

abstract：:Arctic regions, which are changing rapidly as they warm 2 to 3 times faster than the global average, still retain microbial habitats that serve as natural laboratories for understanding mechanisms of microbial adaptation to extreme conditions. Seawater-derived brines within both sea ice (sea-ice brine) and ancient lay...

journal_title：mSystems

authors： Zhong ZP,Rapp JZ,Wainaina JM,Solonenko NE,Maughan H,Carpenter SD,Cooper ZS,Jang HB,Bolduc B,Deming JW,Sullivan MB

更新日期：2020-06-16 00:00:00

abstract：:Sulfur is an essential nutrient that contributes to cellular redox homeostasis, transcriptional regulation, and translation initiation when incorporated into different biomolecules. Transport and reduction of extracellular sulfate followed by cysteine biosynthesis is a major pathway of bacterial sulfur assimilation. F...

journal_title：mSystems

authors： Anderson MT,Mitchell LA,Sintsova A,Rice KA,Mobley HLT

更新日期：2019-08-06 00:00:00

abstract：:Biocathodes provide a stable electron source to drive reduction reactions in electrotrophic microbial electrochemical systems. Electroautotrophic biocathode communities may be more robust than monocultures in environmentally relevant settings, but some members are not easily cultivated outside the electrode environmen...

journal_title：mSystems

authors： Eddie BJ,Wang Z,Hervey WJ 4th,Leary DH,Malanoski AP,Tender LM,Lin B,Strycharz-Glaven SM

更新日期：2017-03-28 00:00:00

abstract：:Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S Pullorum infection ...

journal_title：mSystems

authors： Ding J,Zhou H,Luo L,Xiao L,Yang K,Yang L,Zheng Y,Xu K,He C,Han C,Luo H,Qin C,Akinyemi FT,Gu C,Zhou Z,Huang Q,Meng H

更新日期：2021-01-05 00:00:00

abstract：:ABSRTACTKlebsiella pneumoniae is a common cause of human-pneumonia-derived sepsis with high morbidity and mortality. The microbiota promotes and maintains host immune homeostasis. The mechanisms by which the gut microbiota affects the host defenses in the respiratory system systematically, however, remain poorly under...

journal_title：mSystems

authors： Wu T,Li H,Su C,Xu F,Yang G,Sun K,Xu M,Lv N,Meng B,Liu Y,Hu L,Liu Y,Gao Y,Wang H,Lan Y,Xu D,Li J

更新日期：2020-11-03 00:00:00

abstract：:Soil metagenomics has been touted as the "grand challenge" for metagenomics, as the high microbial diversity and spatial heterogeneity of soils make them unamenable to current assembly platforms. Here, we aimed to improve soil metagenomic sequence assembly by applying the Moleculo synthetic long-read sequencing techno...

journal_title：mSystems

authors： White RA 3rd,Bottos EM,Roy Chowdhury T,Zucker JD,Brislawn CJ,Nicora CD,Fansler SJ,Glaesemann KR,Glass K,Jansson JK

更新日期：2016-06-28 00:00:00