Correlations between the Composition of the Bovine Microbiota and Vitamin B12 Abundance.

abstract：:Simplified microbial communities, or "benchtop microbiomes," enable us to manage the profound complexity of microbial ecosystems. Widespread activities aiming to design and control communities result in novel resources for testing ecological theories and also for realizing new biotechnologies. There is much to be gain...

journal_title：mSystems

authors： Bernstein HC

更新日期：2019-05-28 00:00:00

abstract：:Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for the Human Microbiome Project stool sample database and revealed 279 unique GUS enzymes org...

journal_title：mSystems

authors： Creekmore BC,Gray JH,Walton WG,Biernat KA,Little MS,Xu Y,Liu J,Gharaibeh RZ,Redinbo MR

更新日期：2019-08-27 00:00:00

abstract：:The gut microbiota has been implicated in immunoglobin A nephropathy (IgAN) because the intestinal immune response is assumed to be one of the disease triggers. Since the microbial composition is heritable, we hypothesize that genetic variants controlling gut microbiota composition may be associated with susceptibilit...

journal_title：mSystems

authors： He JW,Zhou XJ,Li YF,Wang YN,Liu LJ,Shi SF,Xin XH,Li RS,Falchi M,Lv JC,Zhang H

更新日期：2021-01-12 00:00:00

abstract：:Bumble bees are important pollinators in natural and agricultural ecosystems. Their social colonies are founded by individual queens, which, as the predominant reproductive females of colonies, contribute to colony function through worker production and fitness through male and new queen production. Therefore, queen h...

journal_title：mSystems

authors： Wang L,Wu J,Li K,Sadd BM,Guo Y,Zhuang D,Zhang Z,Chen Y,Evans JD,Guo J,Zhang Z,Li J

更新日期：2019-12-10 00:00:00

abstract：:Marine microbes are known to degrade hydrocarbons; however, microbes inhabiting deep-sea sediments remain largely unexplored. Previous studies into the classical pathways of marine microbial metabolism reveal diverse chemistries; however, metabolic profiling of marine microbes cultured with hydrocarbons is limited. In...

journal_title：mSystems

authors： Moreno-Ulloa A,Sicairos Diaz V,Tejeda-Mora JA,Macias Contreras MI,Castillo FD,Guerrero A,Gonzalez Sanchez R,Mendoza-Porras O,Vazquez Duhalt R,Licea-Navarro A

更新日期：2020-11-10 00:00:00

abstract：:Polymyxins are used as treatments of last resort for Gram-negative bacterial infections. Their increased use has led to concerns about emerging polymyxin resistance (PR). Phenotypic polymyxin susceptibility testing is resource intensive and difficult to perform accurately. The complex polygenic nature of PR and our in...

journal_title：mSystems

authors： Macesic N,Bear Don't Walk OJ IV,,Pe'er I,Tatonetti NP,Peleg AY,Uhlemann AC

更新日期：2020-05-26 00:00:00

abstract：:The identification of ancestral traits is essential to understanding the evolution of any group. In the case of parasitic groups, this helps us understand the adaptation to this lifestyle and a particular host. Most diplomonads are parasites, but there are free-living members of the group nested among the host-associa...

journal_title：mSystems

authors： Jiménez-González A,Andersson JO

更新日期：2020-12-22 00:00:00

abstract：:Here, the role of the dairy-processing chain as a reservoir of antimicrobial resistance (AR) determinants and a source of novel biocontrol quorum-sensing inhibitors is assessed through a functional metagenomics approach. A metagenomic library comprising ∼22,000 recombinant clones was built from DNA isolated from raw m...

journal_title：mSystems

authors： Alexa Oniciuc EA,Walsh CJ,Coughlan LM,Awad A,Simon CA,Ruiz L,Crispie F,Cotter PD,Alvarez-Ordóñez A

更新日期：2020-02-18 00:00:00

abstract：:Classified as a biosafety level 4 (BSL4) select agent, Nipah virus (NiV) is a deadly henipavirus in the Paramyxoviridae family, with a nearly 75% mortality rate in humans, underscoring its global and animal health importance. Elucidating the process of viral particle production in host cells is imperative both for tar...

journal_title：mSystems

authors： Johnston GP,Bradel-Tretheway B,Piehowski PD,Brewer HM,Lee BNR,Usher NT,Zamora JLR,Ortega V,Contreras EM,Teuton JR,Wendler JP,Matz KM,Adkins JN,Aguilar HC

更新日期：2019-09-24 00:00:00

abstract：:Persister cells are genetically identical variants in a bacterial population that have phenotypically modified their physiology to survive environmental stress. In bacterial pathogens, persisters are able to survive antibiotic treatment and reinfect patients in a frustrating cycle of chronic infection. To better defin...

journal_title：mSystems

authors： Micheva-Viteva SN,Shakya M,Adikari SH,Gleasner CD,Velappan N,Mourant JR,Chain PSG,Hong-Geller E

更新日期：2020-02-11 00:00:00

abstract：:When organisms encounter an unfavorable environment, they transition to a physiologically distinct, quiescent state wherein abundant transcripts from the previous active growth state continue to persist, albeit their active transcription is downregulated. In order to generate proteins for the new quiescent physiologic...

journal_title：mSystems

authors： López García de Lomana A,Kusebauch U,Raman AV,Pan M,Turkarslan S,Lorenzetti APR,Moritz RL,Baliga NS

更新日期：2020-07-28 00:00:00

abstract：:Globally, dental caries is the most prevalent chronic oral disease and affects roughly half of all children. The aim of this report was to use metagenomic analyses to investigate the relationship between the oral microbiome and caries in preschool children. A total of 25 preschoolers, aged 3 to 5 years old with severe...

journal_title：mSystems

authors： Wang Y,Wang S,Wu C,Chen X,Duan Z,Xu Q,Jiang W,Xu L,Wang T,Su L,Wang Y,Chen Y,Zhang J,Huang Y,Tong S,Zhou C,Deng S,Qin N

更新日期：2019-11-05 00:00:00

abstract：:Antimicrobial therapies against cystic fibrosis (CF) lung infections are largely aimed at the traditional, well-studied CF pathogens such as Pseudomonas aeruginosa and Burkholderia cepacia complex, despite the fact that the CF lung harbors a complex and dynamic polymicrobial community. A clinical focus on the dominant...

journal_title：mSystems

authors： Khanolkar RA,Clark ST,Wang PW,Hwang DM,Yau YCW,Waters VJ,Guttman DS

更新日期：2020-12-01 00:00:00

abstract：:GapMind is a Web-based tool for annotating amino acid biosynthesis in bacteria and archaea (http://papers.genomics.lbl.gov/gaps). GapMind incorporates many variant pathways and 130 different reactions, and it analyzes a genome in just 15 s. To avoid error-prone transitive annotations, GapMind relies primarily on a dat...

journal_title：mSystems

authors： Price MN,Deutschbauer AM,Arkin AP

更新日期：2020-06-23 00:00:00

abstract：:Although a few studies have investigated the intestinal microbiota of women with polycystic ovary syndrome (PCOS), the functional and metabolic mechanisms of the microbes associated with PCOS, as well as potential microbial biomarkers, have not yet been identified. To address this gap, we designed a two-phase experime...

journal_title：mSystems

authors： Zhang J,Sun Z,Jiang S,Bai X,Ma C,Peng Q,Chen K,Chang H,Fang T,Zhang H

更新日期：2019-04-16 00:00:00

abstract：:Trauma patients (TPs) are highly susceptible to infections, which often lead to sepsis. Among the numerous causative agents, Pseudomonas aeruginosa is especially important, as P. aeruginosa sepsis is often fatal. Understanding the mechanism of its pathogenesis in bloodstream infections is imperative; however, this mec...

journal_title：mSystems

authors： Elmassry MM,Mudaliar NS,Kottapalli KR,Dissanaike S,Griswold JA,San Francisco MJ,Colmer-Hamood JA,Hamood AN

更新日期：2019-05-07 00:00:00

abstract：:Improvements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides (GOS) in broiler feed enhanced the growth rate and feed conversion of chickens relative to those obtained with a calorie-matched control diet. Comparison of the cecal microbiota id...

journal_title：mSystems

authors： Richards PJ,Flaujac Lafontaine GM,Connerton PL,Liang L,Asiani K,Fish NM,Connerton IF

更新日期：2020-01-14 00:00:00

abstract：:The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be fully elucidated. This knowle...

journal_title：mSystems

authors： Brinkac LM,Rahman N,Chua LL,Thomas S

更新日期：2020-10-27 00:00:00

abstract：:Biocathodes provide a stable electron source to drive reduction reactions in electrotrophic microbial electrochemical systems. Electroautotrophic biocathode communities may be more robust than monocultures in environmentally relevant settings, but some members are not easily cultivated outside the electrode environmen...

journal_title：mSystems

authors： Eddie BJ,Wang Z,Hervey WJ 4th,Leary DH,Malanoski AP,Tender LM,Lin B,Strycharz-Glaven SM

更新日期：2017-03-28 00:00:00

abstract：:Interactions between plant pathogens and root-associated microbes play an important role in determining disease outcomes. While several studies have suggested that steering these interactions may improve plant health, such approaches have remained challenging in practice. Because of low iron availability in most soils...

journal_title：mSystems

authors： Gu S,Yang T,Shao Z,Wang T,Cao K,Jousset A,Friman VP,Mallon C,Mei X,Wei Z,Xu Y,Shen Q,Pommier T

更新日期：2020-06-30 00:00:00

abstract：:Nutrient acquisition from the host environment is crucial for the survival of intracellular pathogens, but conceptual and technical challenges limit our knowledge of pathogen diets. To overcome some of these technical roadblocks, we exploited an experimentally accessible model for early infection of human macrophages ...

journal_title：mSystems

authors： Zimmermann M,Kogadeeva M,Gengenbacher M,McEwen G,Mollenkopf HJ,Zamboni N,Kaufmann SHE,Sauer U

更新日期：2017-08-22 00:00:00

abstract：:The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host's genome, the microbiome is amenable to change over the course of an organism's lifetime, providing an opportunity to therapeutically modulate the microbiome's im...

journal_title：mSystems

authors： Uhr GT,Dohnalová L,Thaiss CA

更新日期：2019-02-19 00:00:00

abstract：:Arctic regions, which are changing rapidly as they warm 2 to 3 times faster than the global average, still retain microbial habitats that serve as natural laboratories for understanding mechanisms of microbial adaptation to extreme conditions. Seawater-derived brines within both sea ice (sea-ice brine) and ancient lay...

journal_title：mSystems

authors： Zhong ZP,Rapp JZ,Wainaina JM,Solonenko NE,Maughan H,Carpenter SD,Cooper ZS,Jang HB,Bolduc B,Deming JW,Sullivan MB

更新日期：2020-06-16 00:00:00

abstract：:Dietary intake is difficult to measure reliably in humans because approaches typically rely on self-reporting, which can be incomplete and biased. In field studies of animals, DNA sequencing-based approaches such as metabarcoding have been developed to characterize diets, but such approaches have not previously been w...

journal_title：mSystems

authors： Reese AT,Kartzinel TR,Petrone BL,Turnbaugh PJ,Pringle RM,David LA

更新日期：2019-10-08 00:00:00

abstract：:Ambient temperature (Ta ) is an important factor in shaping phenotypic plasticity. Plasticity is generally beneficial for animals in adapting to their environments. Gut microbiota are crucial in regulating host physiological and behavioral processes. However, whether the gut microbiota play a role in regulating host p...

journal_title：mSystems

authors： Khakisahneh S,Zhang XY,Nouri Z,Wang DH

更新日期：2020-10-20 00:00:00

abstract：:Fecal microbiota transplantation (FMT) is a proposedly useful strategy for the treatment of gastrointestinal (GI) disorders through remediation of the patient gut microbiota. However, its therapeutic success has been variable, necessitating research to uncover mechanisms that improve patient response. Antibiotic pretr...

journal_title：mSystems

authors： Oliphant K,Cochrane K,Schroeter K,Daigneault MC,Yen S,Verdu EF,Allen-Vercoe E

更新日期：2020-01-28 00:00:00

abstract：:Social behavior can alter the microbiome composition via transmission among social partners, but there have been few controlled experimental studies of gut microbiome transmission among social partners in primates. We collected longitudinal fecal samples from eight unrelated male-female pairs of marmoset monkeys prior...

journal_title：mSystems

authors： Zhu L,Clayton JB,Suhr Van Haute MJ,Yang Q,Hassenstab HR,Mustoe AC,Knights D,Benson AK,French JA

更新日期：2020-03-24 00:00:00

abstract：:Single mutations frequently alter several aspects of cell behavior but rarely reveal whether a particular statistically significant change is biologically significant. To determine which behavioral changes are most important for multicellular self-organization, we devised a new methodology using Myxococcus xanthus as ...

journal_title：mSystems

authors： Zhang Z,Cotter CR,Lyu Z,Shimkets LJ,Igoshin OA

更新日期：2020-07-14 00:00:00

abstract：:Biological sulfur cycling in polar, low-temperature ecosystems is an understudied phenomenon in part due to difficulty of access and the dynamic nature of glacial environments. One such environment where sulfur cycling is known to play an important role in microbial metabolisms is located at Borup Fiord Pass (BFP) in ...

journal_title：mSystems

authors： Trivedi CB,Stamps BW,Lau GE,Grasby SE,Templeton AS,Spear JR

更新日期：2020-08-04 00:00:00

abstract：:Streptococcus mutans is a Gram-positive bacterium that thrives under acidic conditions and is a primary cause of tooth decay (dental caries). To better understand the metabolism of S. mutans on a systematic level, we manually constructed a genome-scale metabolic model of the S. mutans type strain UA159. The model, cal...

journal_title：mSystems

authors： Jijakli K,Jensen PA

更新日期：2019-10-29 00:00:00