Nipah Virus-Like Particle Egress Is Modulated by Cytoskeletal and Vesicular Trafficking Pathways: a Validated Particle Proteomics Analysis.

abstract：:Polymyxins are used as treatments of last resort for Gram-negative bacterial infections. Their increased use has led to concerns about emerging polymyxin resistance (PR). Phenotypic polymyxin susceptibility testing is resource intensive and difficult to perform accurately. The complex polygenic nature of PR and our in...

journal_title：mSystems

authors： Macesic N,Bear Don't Walk OJ IV,,Pe'er I,Tatonetti NP,Peleg AY,Uhlemann AC

更新日期：2020-05-26 00:00:00

abstract：:The intestinal microbiota and the expanded endocannabinoid (eCB) system, or endocannabinoidome (eCBome), have both been implicated in diet-induced obesity and dysmetabolism. These systems were recently suggested to interact during the development of obesity. We aimed at identifying the potential interactions between g...

journal_title：mSystems

authors： Lacroix S,Pechereau F,Leblanc N,Boubertakh B,Houde A,Martin C,Flamand N,Silvestri C,Raymond F,Di Marzo V,Veilleux A

更新日期：2019-12-17 00:00:00

abstract：:Recent studies of mammalian microbiomes have identified strong phylogenetic effects on bacterial community composition. Bats (Mammalia: Chiroptera) are among the most speciose mammals on the planet and the only mammal capable of true flight. We examined 1,236 16S rRNA amplicon libraries of the gut, oral, and skin micr...

journal_title：mSystems

authors： Lutz HL,Jackson EW,Webala PW,Babyesiza WS,Kerbis Peterhans JC,Demos TC,Patterson BD,Gilbert JA

更新日期：2019-11-12 00:00:00

abstract：:Increasing rates of antibiotic-resistant bacterial infection are one of the most pressing contemporary global health concerns. The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) have been identified as the...

journal_title：mSystems

authors： Brooks LE,Ul-Hasan S,Chan BK,Sistrom MJ

更新日期：2018-04-17 00:00:00

abstract：:The identification of ancestral traits is essential to understanding the evolution of any group. In the case of parasitic groups, this helps us understand the adaptation to this lifestyle and a particular host. Most diplomonads are parasites, but there are free-living members of the group nested among the host-associa...

journal_title：mSystems

authors： Jiménez-González A,Andersson JO

更新日期：2020-12-22 00:00:00

abstract：:Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study employed comparative meta...

journal_title：mSystems

authors： Han ML,Zhu Y,Creek DJ,Lin YW,Gutu AD,Hertzog P,Purcell T,Shen HH,Moskowitz SM,Velkov T,Li J

更新日期：2019-01-08 00:00:00

abstract：:Here, the role of the dairy-processing chain as a reservoir of antimicrobial resistance (AR) determinants and a source of novel biocontrol quorum-sensing inhibitors is assessed through a functional metagenomics approach. A metagenomic library comprising ∼22,000 recombinant clones was built from DNA isolated from raw m...

journal_title：mSystems

authors： Alexa Oniciuc EA,Walsh CJ,Coughlan LM,Awad A,Simon CA,Ruiz L,Crispie F,Cotter PD,Alvarez-Ordóñez A

更新日期：2020-02-18 00:00:00

abstract：:The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host's genome, the microbiome is amenable to change over the course of an organism's lifetime, providing an opportunity to therapeutically modulate the microbiome's im...

journal_title：mSystems

authors： Uhr GT,Dohnalová L,Thaiss CA

更新日期：2019-02-19 00:00:00

abstract：:Health-associated oral Streptococcus species are promising probiotic candidates to protect against dental caries. Ammonia production through the arginine deiminase system (ADS), which can increase the pH of oral biofilms, and direct antagonism of caries-associated bacterial species are desirable properties for oral pr...

journal_title：mSystems

authors： Velsko IM,Chakraborty B,Nascimento MM,Burne RA,Richards VP

更新日期：2018-12-18 00:00:00

abstract：:The gut microbiota has been implicated in immunoglobin A nephropathy (IgAN) because the intestinal immune response is assumed to be one of the disease triggers. Since the microbial composition is heritable, we hypothesize that genetic variants controlling gut microbiota composition may be associated with susceptibilit...

journal_title：mSystems

authors： He JW,Zhou XJ,Li YF,Wang YN,Liu LJ,Shi SF,Xin XH,Li RS,Falchi M,Lv JC,Zhang H

更新日期：2021-01-12 00:00:00

abstract：:When organisms encounter an unfavorable environment, they transition to a physiologically distinct, quiescent state wherein abundant transcripts from the previous active growth state continue to persist, albeit their active transcription is downregulated. In order to generate proteins for the new quiescent physiologic...

journal_title：mSystems

authors： López García de Lomana A,Kusebauch U,Raman AV,Pan M,Turkarslan S,Lorenzetti APR,Moritz RL,Baliga NS

更新日期：2020-07-28 00:00:00

abstract：:Apoptosis is generally considered the first line of defense against viral infection. However, the role of apoptosis in the interactions between plant viruses and their insect vectors has rarely been investigated. By studying plant DNA viruses of the genus Begomovirus within the family Geminiviridae, which are transmit...

journal_title：mSystems

authors： Wang XR,Wang C,Ban FX,Ghanim M,Pan LL,Qian LX,Liu YQ,Wang XW,Liu SS

更新日期：2020-09-22 00:00:00

abstract：:Bacterial motility is thought to play an important role in virulence. We have previously shown that proficient bacterial swimming and swarming in vitro is correlated with the persistent intramammary infection phenotype observed in cattle. However, little is known about the gene regulation differences important for dif...

journal_title：mSystems

authors： Lippolis JD,Brunelle BW,Reinhardt TA,Sacco RE,Thacker TC,Looft TP,Casey TA

更新日期：2016-08-09 00:00:00

abstract：:Environmental strains of the soil bacterium Bacillus subtilis have valuable applications in agriculture, industry, and biotechnology; however, environmental strains are genetically less accessible. This reduced accessibility is in sharp contrast to laboratory strains, which are well known for their natural competence,...

journal_title：mSystems

authors： She Q,Hunter E,Qin Y,Nicolau S,Zalis EA,Wang H,Chen Y,Chai Y

更新日期：2020-09-01 00:00:00

abstract：:Tripartite symbioses between bacteriophages, the epithelial cell layers of the human gut, and bacterial symbionts may play an important and unrecognized role in the function of the gut microbiome. Traditionally, phages residing within the gut were considered to interact only with their bacterial hosts and thereby to f...

journal_title：mSystems

authors： Barr JJ

更新日期：2019-05-07 00:00:00

abstract：:Using automated genome analysis tools, it is often unclear to what degree genetic variability in homologous biosynthetic pathways relates to structural variation. This hampers strain prioritization and compound identification and can lead to overinterpretation of chemical diversity. Here, we assessed the metabolic pot...

journal_title：mSystems

authors： Männle D,McKinnie SMK,Mantri SS,Steinke K,Lu Z,Moore BS,Ziemert N,Kaysser L

更新日期：2020-06-02 00:00:00

abstract：:Dimorphic plant and human mycopathogens require a switch from the usual yeast growth to filamentous growth for host tissue penetration, and the switch is controlled by multiple signaling systems other than the central developmental pathway. Unlike these fungi, dimorphic insect mycopathogens usually grow by hyphal exte...

journal_title：mSystems

authors： Zhang AX,Mouhoumed AZ,Tong SM,Ying SH,Feng MG

更新日期：2019-07-09 00:00:00

abstract：:Advances in sequencing technologies have enabled novel insights into microbial niche differentiation, from analyzing environmental samples to understanding human diseases and informing dietary studies. However, identifying the microbial taxa that differentiate these samples can be challenging. These issues stem from t...

journal_title：mSystems

authors： Morton JT,Sanders J,Quinn RA,McDonald D,Gonzalez A,Vázquez-Baeza Y,Navas-Molina JA,Song SJ,Metcalf JL,Hyde ER,Lladser M,Dorrestein PC,Knight R

更新日期：2017-01-17 00:00:00

abstract：:The 2,3-seco pathway, the pathway for anaerobic cholesterol degradation, has been established in the denitrifying betaproteobacterium Sterolibacterium denitrificans. However, knowledge of how microorganisms respond to cholesterol at the community level is elusive. Here, we applied mesocosm incubation and 16S rRNA sequ...

journal_title：mSystems

authors： Wei ST,Wu YW,Lee TH,Huang YS,Yang CY,Chen YL,Chiang YR

更新日期：2018-10-30 00:00:00

abstract：:Despite increasing acknowledgment that microorganisms underpin the healthy functioning of basically all multicellular life, few cross-disciplinary teams address the diversity and function of microbiota across organisms and ecosystems. Our newly formed consortium of junior faculty spanning fields such as ecology and ge...

journal_title：mSystems

authors： Hynson NA,Frank KL,Alegado RA,Amend AS,Arif M,Bennett GM,Jani AJ,Medeiros MCI,Mileyko Y,Nelson CE,Nguyen NH,Nigro OD,Prisic S,Shin S,Takagi D,Wilson ST,Yew JY

更新日期：2018-03-13 00:00:00

abstract：:Quantitative understanding and prediction of microbial community dynamics are an outstanding challenge. We test the hypothesis that metabolic mechanisms provide a foundation for accurate prediction of dynamics in microbial systems. In our research, metabolic models have been able to accurately predict species interact...

journal_title：mSystems

authors： Chacón JM,Harcombe WR

更新日期：2019-06-11 00:00:00

abstract：:Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such minin...

journal_title：mSystems

authors： Medema MH

更新日期：2018-03-06 00:00:00

abstract：:Intestinal bacterial dysbiosis has been increasingly linked to ankylosing spondylitis (AS), which is a prototypic and best studied subtype of spondyloarthritis (SpA). Fungi and bacteria coexist in the human gut and interact with each other. Although they have been shown to contribute actively to health or disease, no ...

journal_title：mSystems

authors： Li M,Dai B,Tang Y,Lei L,Li N,Liu C,Ge T,Zhang L,Xu Y,Hu Y,Li P,Zhang Y,Yuan J,Li X

更新日期：2019-03-26 00:00:00

abstract：:Biocathodes provide a stable electron source to drive reduction reactions in electrotrophic microbial electrochemical systems. Electroautotrophic biocathode communities may be more robust than monocultures in environmentally relevant settings, but some members are not easily cultivated outside the electrode environmen...

journal_title：mSystems

authors： Eddie BJ,Wang Z,Hervey WJ 4th,Leary DH,Malanoski AP,Tender LM,Lin B,Strycharz-Glaven SM

更新日期：2017-03-28 00:00:00

abstract：:In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of expression from ribosomal promoters; this can deplete the pool of RNA polyme...

journal_title：mSystems

authors： Zhang Q,Brambilla E,Li R,Shi H,Cosentino Lagomarsino M,Sclavi B

更新日期：2020-09-08 00:00:00

abstract：:Methylobacter species, members of the Methylococcales, have recently emerged as some of the globally widespread, cosmopolitan species that play a key role in the environmental consumption of methane across gradients of dioxygen tensions. In this work, we approached the question of how Methylobacter copes with hypoxia,...

journal_title：mSystems

authors： Yu Z,Pesesky M,Zhang L,Huang J,Winkler M,Chistoserdova L

更新日期：2020-01-21 00:00:00

abstract：:Acinetobacter baumannii has been reported as a multidrug-resistant bacterium due to biofilms and antimicrobial resistance mechanisms. Hence, novel therapeutic strategies are necessary to overcome A. baumannii infections. This study revealed that citral at 200 μg/ml attenuated A. baumannii biofilms by up to 90% without...

journal_title：mSystems

authors： Selvaraj A,Valliammai A,Muthuramalingam P,Sethupathy S,Subramenium GA,Ramesh M,Pandian SK

更新日期：2020-11-17 00:00:00

abstract：:Social behavior can alter the microbiome composition via transmission among social partners, but there have been few controlled experimental studies of gut microbiome transmission among social partners in primates. We collected longitudinal fecal samples from eight unrelated male-female pairs of marmoset monkeys prior...

journal_title：mSystems

authors： Zhu L,Clayton JB,Suhr Van Haute MJ,Yang Q,Hassenstab HR,Mustoe AC,Knights D,Benson AK,French JA

更新日期：2020-03-24 00:00:00

abstract：:Microbial heterotopic metabolism in the ocean is fueled by a supply of essential nutrients acquired via exoenzymes catalyzing depolymerization of high-molecular-weight compounds. Although the rates of activity for a variety of exoenzymes across various marine environments are well established, the factors regulating t...

journal_title：mSystems

authors： Kamalanathan M,Doyle SM,Xu C,Achberger AM,Wade TL,Schwehr K,Santschi PH,Sylvan JB,Quigg A

更新日期：2020-04-14 00:00:00

abstract：:Estimations of microbial community diversity based on metagenomic data sets are affected, often to an unknown degree, by biases derived from insufficient coverage and reference database-dependent estimations of diversity. For instance, the completeness of reference databases cannot be generally estimated since it depe...

journal_title：mSystems

authors： Rodriguez-R LM,Gunturu S,Tiedje JM,Cole JR,Konstantinidis KT

更新日期：2018-04-10 00:00:00