Mycobacterium Phage Butters-Encoded Proteins Contribute to Host Defense against Viral Attack.

abstract：:Dimorphic plant and human mycopathogens require a switch from the usual yeast growth to filamentous growth for host tissue penetration, and the switch is controlled by multiple signaling systems other than the central developmental pathway. Unlike these fungi, dimorphic insect mycopathogens usually grow by hyphal exte...

journal_title：mSystems

authors： Zhang AX,Mouhoumed AZ,Tong SM,Ying SH,Feng MG

更新日期：2019-07-09 00:00:00

abstract：:Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study employed comparative meta...

journal_title：mSystems

authors： Han ML,Zhu Y,Creek DJ,Lin YW,Gutu AD,Hertzog P,Purcell T,Shen HH,Moskowitz SM,Velkov T,Li J

更新日期：2019-01-08 00:00:00

abstract：:For mammals, oxalate enters the body through the diet or is endogenously produced by the liver; it is removed by microbial oxalate metabolism in the gut and/or excretion in feces or urine. Deficiencies in any one of the these pathways can lead to complications, such as calcium oxalate urinary stones. While considerabl...

journal_title：mSystems

authors： Miller AW,Dale C,Dearing MD

更新日期：2017-09-26 00:00:00

abstract：:Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenges to existing appro...

journal_title：mSystems

authors： Langille MGI

更新日期：2018-03-27 00:00:00

abstract：:Nutrient acquisition from the host environment is crucial for the survival of intracellular pathogens, but conceptual and technical challenges limit our knowledge of pathogen diets. To overcome some of these technical roadblocks, we exploited an experimentally accessible model for early infection of human macrophages ...

journal_title：mSystems

authors： Zimmermann M,Kogadeeva M,Gengenbacher M,McEwen G,Mollenkopf HJ,Zamboni N,Kaufmann SHE,Sauer U

更新日期：2017-08-22 00:00:00

abstract：:Advances in sequencing technologies have enabled novel insights into microbial niche differentiation, from analyzing environmental samples to understanding human diseases and informing dietary studies. However, identifying the microbial taxa that differentiate these samples can be challenging. These issues stem from t...

journal_title：mSystems

authors： Morton JT,Sanders J,Quinn RA,McDonald D,Gonzalez A,Vázquez-Baeza Y,Navas-Molina JA,Song SJ,Metcalf JL,Hyde ER,Lladser M,Dorrestein PC,Knight R

更新日期：2017-01-17 00:00:00

abstract：:Many pathogenic bacteria of the family Enterobacteriaceae use type III secretion systems to inject virulence proteins, termed "effectors," into the host cell cytosol. Although host-cellular activities of several effectors have been demonstrated, the function and host-targeted pathways of most of the effectors identifi...

journal_title：mSystems

authors： Sontag RL,Nakayasu ES,Brown RN,Niemann GS,Sydor MA,Sanchez O,Ansong C,Lu SY,Choi H,Valleau D,Weitz KK,Savchenko A,Cambronne ED,Adkins JN

更新日期：2016-07-12 00:00:00

abstract：:Social behavior can alter the microbiome composition via transmission among social partners, but there have been few controlled experimental studies of gut microbiome transmission among social partners in primates. We collected longitudinal fecal samples from eight unrelated male-female pairs of marmoset monkeys prior...

journal_title：mSystems

authors： Zhu L,Clayton JB,Suhr Van Haute MJ,Yang Q,Hassenstab HR,Mustoe AC,Knights D,Benson AK,French JA

更新日期：2020-03-24 00:00:00

abstract：:The gut microbiota has been implicated in immunoglobin A nephropathy (IgAN) because the intestinal immune response is assumed to be one of the disease triggers. Since the microbial composition is heritable, we hypothesize that genetic variants controlling gut microbiota composition may be associated with susceptibilit...

journal_title：mSystems

authors： He JW,Zhou XJ,Li YF,Wang YN,Liu LJ,Shi SF,Xin XH,Li RS,Falchi M,Lv JC,Zhang H

更新日期：2021-01-12 00:00:00

abstract：:Despite insights gained through experimental models, the set of bacterial genes important for human infection is unclear for many of our most threatening pathogens. Klebsiella pneumoniae is a leading cause of health care-associated infections (HAIs) and commonly colonizes hospitalized patients, but the factors that de...

journal_title：mSystems

authors： Martin RM,Cao J,Wu W,Zhao L,Manthei DM,Pirani A,Snitkin E,Malani PN,Rao K,Bachman MA

更新日期：2018-06-26 00:00:00

abstract：:Dietary intake is difficult to measure reliably in humans because approaches typically rely on self-reporting, which can be incomplete and biased. In field studies of animals, DNA sequencing-based approaches such as metabarcoding have been developed to characterize diets, but such approaches have not previously been w...

journal_title：mSystems

authors： Reese AT,Kartzinel TR,Petrone BL,Turnbaugh PJ,Pringle RM,David LA

更新日期：2019-10-08 00:00:00

abstract：:The reactive intermediate deaminase RidA (EC 3.5.99.10) is conserved across all domains of life and deaminates reactive enamine species. When Salmonella entericaridA mutants are grown in minimal medium, 2-aminoacrylate (2AA) accumulates, damages several pyridoxal 5'-phosphate (PLP)-dependent enzymes, and elicits an ob...

journal_title：mSystems

authors： Borchert AJ,Gouveia GJ,Edison AS,Downs DM

更新日期：2020-03-10 00:00:00

abstract：:Marine oil spills can impact both coastal and offshore marine environments, but little information is available on how the microbial response to oil and dispersants might differ between these biomes. Here, we describe the compositional and functional response of microbial communities to different concentrations of oil...

journal_title：mSystems

authors： Doyle SM,Lin G,Morales-McDevitt M,Wade TL,Quigg A,Sylvan JB

更新日期：2020-08-25 00:00:00

abstract：:The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be fully elucidated. This knowle...

journal_title：mSystems

authors： Brinkac LM,Rahman N,Chua LL,Thomas S

更新日期：2020-10-27 00:00:00

abstract：:When organisms encounter an unfavorable environment, they transition to a physiologically distinct, quiescent state wherein abundant transcripts from the previous active growth state continue to persist, albeit their active transcription is downregulated. In order to generate proteins for the new quiescent physiologic...

journal_title：mSystems

authors： López García de Lomana A,Kusebauch U,Raman AV,Pan M,Turkarslan S,Lorenzetti APR,Moritz RL,Baliga NS

更新日期：2020-07-28 00:00:00

abstract：:Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such minin...

journal_title：mSystems

authors： Medema MH

更新日期：2018-03-06 00:00:00

abstract：:It is important to expedite our understanding of antibiotic resistance to address the increasing numbers of fatalities and environmental pollution due to the emergence of antibiotic resistance and multidrug-resistant strains. Here, we combined the CRISPR-enabled trackable genome engineering (CREATE) technology and tra...

journal_title：mSystems

authors： Chen C,Choudhury A,Zhang S,Garst AD,Song X,Liu X,Chen T,Gill RT,Wang Z

更新日期：2020-04-21 00:00:00

abstract：:The 2,3-seco pathway, the pathway for anaerobic cholesterol degradation, has been established in the denitrifying betaproteobacterium Sterolibacterium denitrificans. However, knowledge of how microorganisms respond to cholesterol at the community level is elusive. Here, we applied mesocosm incubation and 16S rRNA sequ...

journal_title：mSystems

authors： Wei ST,Wu YW,Lee TH,Huang YS,Yang CY,Chen YL,Chiang YR

更新日期：2018-10-30 00:00:00

abstract：:Quantitative understanding and prediction of microbial community dynamics are an outstanding challenge. We test the hypothesis that metabolic mechanisms provide a foundation for accurate prediction of dynamics in microbial systems. In our research, metabolic models have been able to accurately predict species interact...

journal_title：mSystems

authors： Chacón JM,Harcombe WR

更新日期：2019-06-11 00:00:00

abstract：:Acinetobacter baumannii has been reported as a multidrug-resistant bacterium due to biofilms and antimicrobial resistance mechanisms. Hence, novel therapeutic strategies are necessary to overcome A. baumannii infections. This study revealed that citral at 200 μg/ml attenuated A. baumannii biofilms by up to 90% without...

journal_title：mSystems

authors： Selvaraj A,Valliammai A,Muthuramalingam P,Sethupathy S,Subramenium GA,Ramesh M,Pandian SK

更新日期：2020-11-17 00:00:00

abstract：:Health-associated oral Streptococcus species are promising probiotic candidates to protect against dental caries. Ammonia production through the arginine deiminase system (ADS), which can increase the pH of oral biofilms, and direct antagonism of caries-associated bacterial species are desirable properties for oral pr...

journal_title：mSystems

authors： Velsko IM,Chakraborty B,Nascimento MM,Burne RA,Richards VP

更新日期：2018-12-18 00:00:00

abstract：:Microbiology, like many areas of life science research, is increasingly data-intensive. As such, bioinformatics and data science skills have become essential to leverage microbiome sequencing data for discovery. Short intensive courses have sprung up as formal computational training opportunities at individual institu...

journal_title：mSystems

authors： Taroni JN

更新日期：2019-08-20 00:00:00

abstract：:Streptococcus mutans is a Gram-positive bacterium that thrives under acidic conditions and is a primary cause of tooth decay (dental caries). To better understand the metabolism of S. mutans on a systematic level, we manually constructed a genome-scale metabolic model of the S. mutans type strain UA159. The model, cal...

journal_title：mSystems

authors： Jijakli K,Jensen PA

更新日期：2019-10-29 00:00:00

abstract：:Simplified microbial communities, or "benchtop microbiomes," enable us to manage the profound complexity of microbial ecosystems. Widespread activities aiming to design and control communities result in novel resources for testing ecological theories and also for realizing new biotechnologies. There is much to be gain...

journal_title：mSystems

authors： Bernstein HC

更新日期：2019-05-28 00:00:00

abstract：:Wastewater surveillance represents a complementary approach to clinical surveillance to measure the presence and prevalence of emerging infectious diseases like the novel coronavirus SARS-CoV-2. This innovative data source can improve the precision of epidemiological modeling to understand the penetrance of SARS-CoV-2...

journal_title：mSystems

authors： Wu F,Zhang J,Xiao A,Gu X,Lee WL,Armas F,Kauffman K,Hanage W,Matus M,Ghaeli N,Endo N,Duvallet C,Poyet M,Moniz K,Washburne AD,Erickson TB,Chai PR,Thompson J,Alm EJ

更新日期：2020-07-21 00:00:00

abstract：:Estimations of microbial community diversity based on metagenomic data sets are affected, often to an unknown degree, by biases derived from insufficient coverage and reference database-dependent estimations of diversity. For instance, the completeness of reference databases cannot be generally estimated since it depe...

journal_title：mSystems

authors： Rodriguez-R LM,Gunturu S,Tiedje JM,Cole JR,Konstantinidis KT

更新日期：2018-04-10 00:00:00

abstract：:Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S Pullorum infection ...

journal_title：mSystems

authors： Ding J,Zhou H,Luo L,Xiao L,Yang K,Yang L,Zheng Y,Xu K,He C,Han C,Luo H,Qin C,Akinyemi FT,Gu C,Zhou Z,Huang Q,Meng H

更新日期：2021-01-05 00:00:00

abstract：:In pregnant and lactating sows, metabolism and immunity undergo drastic changes, which can lead to constipation, abortion, and intrauterine growth restriction (IUGR) and reduce production performance. Dietary fiber can regulate animal gut microbiota, alleviate inflammatory responses, and improve performance. Here, 48 ...

journal_title：mSystems

authors： Liu B,Zhu X,Cui Y,Wang W,Liu H,Li Z,Guo Z,Ma S,Li D,Wang C,Shi Y

更新日期：2021-01-26 00:00:00

abstract：:Salmonella infection is one of the main causes of food-borne diarrheal diseases worldwide. Although most Salmonella infections can be cleared without treatment, some cause serious illnesses that require antibiotic treatment. In view of the growing emergence of antibiotic-resistant Salmonella strains, novel treatments ...

journal_title：mSystems

authors： Hu YOO,Hugerth LW,Bengtsson C,Alisjahbana A,Seifert M,Kamal A,Sjöling Å,Midtvedt T,Norin E,Du J,Engstrand L

更新日期：2018-10-02 00:00:00

abstract：:Biocathodes provide a stable electron source to drive reduction reactions in electrotrophic microbial electrochemical systems. Electroautotrophic biocathode communities may be more robust than monocultures in environmentally relevant settings, but some members are not easily cultivated outside the electrode environmen...

journal_title：mSystems

authors： Eddie BJ,Wang Z,Hervey WJ 4th,Leary DH,Malanoski AP,Tender LM,Lin B,Strycharz-Glaven SM

更新日期：2017-03-28 00:00:00