Dietary Effects on Plasma Glycerophospholipids.

Abstract:

OBJECTIVE:Human milk provides a complex mixture of animal lipids, whereas the fat supply of most modern infant formula is based on vegetable oils. We studied the effects of breast-feeding and of feeding infant formula either without or with dairy goat lipids on the composition of infant plasma glycerophospholipids. METHODS:Healthy-term infants were randomized double blind to feeding with infant formula based on whole goats' milk (GIF, approximately 60% milk fat and 40% vegetable oils) or a control cows' milk infant formula based on vegetable oils (VIF) from 2 weeks after birth. A reference group of fully breast-fed infants was also followed. At the age 4 months, blood samples were collected and plasma glycerophospholipids were analyzed with liquid chromatography coupled to triple quadrupole mass spectrometry. RESULTS:The group of breast-fed infants showed significantly higher contents of glycerophospholipid species containing sn-2 palmitic acid [PC(16:0/16:0) and PC(18:0/16:0)] and significantly higher contents of glycerophospholipid species containing long-chain polyunsaturated fatty acids than infants in both formula groups. The GIF group demonstrated significantly higher glycerophospholipid species containing myristic acid [LPC(14:0), PC(14:0/18:1), PC(16:0/14:0)] and palmitoleic acid [LPC(16:1), PC(16:0/16:1), and PC(16:1/18:1)] than the VIF group. CONCLUSIONS:We conclude that breast-feeding induces marked differences in infant plasma glycerophospholipid profiles compared with formula feeding, whereas the studied different sources of formula fat resulted in limited effects on plasma glycerophospholipids.

authors

Uhl O,Hellmuth C,Demmelmair H,Zhou SJ,Makrides M,Prosser C,Lowry D,Gibson RA,Koletzko B

doi

10.1097/MPG.0000000000000783

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

367-72

issue

3

eissn

0277-2116

issn

1536-4801

journal_volume

61

pub_type

杂志文章,随机对照试验
  • A study of the relationship between bile salts, bile salt-stimulated lipase, and free fatty acids in breast milk: normal infants and those with breast milk jaundice.

    abstract::Breast milk jaundice has been reported to be associated with increased lipase activity and elevated free fatty acid (FFA) concentrations within breast milk. We have previously shown that bile salts are present in small concentrations in breast milk and the aim of this study was to examine the relationship of bile salt...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199008000-00009

    authors: Forsyth JS,Donnet L,Ross PE

    更新日期:1990-08-01 00:00:00

  • Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition.

    abstract::The number of surviving children born prematurely has increased substantially during the last 2 decades. The major goal of enteral nutrient supply to these infants is to achieve growth similar to foetal growth coupled with satisfactory functional development. The accumulation of knowledge since the previous guideline ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,实务指引

    doi:10.1097/MPG.0b013e3181adaee0

    authors: Agostoni C,Buonocore G,Carnielli VP,De Curtis M,Darmaun D,Decsi T,Domellöf M,Embleton ND,Fusch C,Genzel-Boroviczeny O,Goulet O,Kalhan SC,Kolacek S,Koletzko B,Lapillonne A,Mihatsch W,Moreno L,Neu J,Poindexter B,Punti

    更新日期:2010-01-01 00:00:00

  • Renin-angiotensin system activation in congenital hepatic fibrosis in the PCK rat model of autosomal recessive polycystic kidney disease.

    abstract:OBJECTIVES:Congenital hepatic fibrosis (CHF) is an important cause of morbidity and mortality in patients with autosomal recessive polycystic kidney disease (ARPKD). The pathogenesis of CHF remains undefined. Several recent studies suggest that the renin-angiotensin system (RAS) is an important mediator of progressive ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181cc80e4

    authors: Goto M,Hoxha N,Osman R,Wen J,Wells RG,Dell KM

    更新日期:2010-06-01 00:00:00

  • Inflammatory bowel disease in children and adolescents: recommendations for diagnosis--the Porto criteria.

    abstract::Ulcerative colitis and Crohn disease may present before the age of 20 years in 25% to 30% of all patients with inflammatory bowel disease. Reported incidence figures vary considerably depending on the collection of data. Multicenter, multinational collaboration is needed when studying pediatric inflammatory bowel dise...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 指南,杂志文章,实务指引

    doi:10.1097/01.mpg.0000163736.30261.82

    authors: IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition.

    更新日期:2005-07-01 00:00:00

  • Nutritional copper deficiency in severely handicapped patients on a low copper enteral diet for a prolonged period: estimation of the required dose of dietary copper.

    abstract::Six cases of nutritional copper deficiency were identified in a nursery institute for severely handicapped patients. All had been on prolonged enteral feeding of a copper-deficient diet and all had abnormalities related to the copper deficiency. Two of them had leukopenia, with or without macrocytic and normochromic a...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198807000-00018

    authors: Higuchi S,Higashi A,Nakamura T,Matsuda I

    更新日期:1988-07-01 00:00:00

  • Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients.

    abstract:OBJECTIVE:Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking. PATIENTS AND METHODS:Genotyping for the -25385C/T polymorphism of the PXR gene in 187 white children with IBD and...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31818de1a8

    authors: Lacher M,Kappler R,Schroepf S,Berkholz S,Ballauff A,Bufler P,Baurecht H,von Schweinitz D,Koletzko S

    更新日期:2009-07-01 00:00:00

  • Ferric Carboxymaltose Across all Ages in Paediatric Gastroenterology Shows Efficacy Without Increased Safety Concerns.

    abstract:OBJECTIVES:To assess the efficacy, safety and side-effect profile of ferric carboxymaltose (FCM) for correcting IDA in children and adolescents in paediatric gastroenterology, hepatology and nutrition. METHOD:This was a retrospective study of all gastroenterology patients <18years who had FCM (October 2015 to October ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000003003

    authors: Sasankan N,Duncan H,Curtis L,McGuckin C,Shannon C,Barclay A,Fraser S,Nair M,Russell RK,Hansen R

    更新日期:2020-11-20 00:00:00

  • Corona Virus Disease 2019 and Paediatric Inflammatory Bowel Diseases: Global Experience and Provisional Guidance (March 2020) from the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology, and Nutrition.

    abstract:INTRODUCTION:With the current coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised about the risk to children with inflammatory bowel diseases (IBD). We aimed to collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in the era of COVID-19. METHODS:An electroni...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002729

    authors: Turner D,Huang Y,Martín-de-Carpi J,Aloi M,Focht G,Kang B,Zhou Y,Sanchez C,Kappelman MD,Uhlig HH,Pujol-Muncunill G,Ledder O,Lionetti P,Dias JA,Ruemmele FM,Russell RK,Paediatric IBD Porto group of ESPGHAN.

    更新日期:2020-06-01 00:00:00

  • Sub-10-minute High-quality Diagnostic Colonoscopy With Terminal Ileum Intubation in Children Is Feasible and Safe.

    abstract:OBJECTIVES:To critically appraise ileocolonoscopy (IC) practice in a large tertiary center, where IC is exclusively performed by experienced pediatric colonoscopists, particularly focusing on indications for the procedure; bowel preparation efficacy; IC completion rates and timings; diagnostic yield; and complications....

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002326

    authors: Thomson M,Eltumi M,Singh C,Eyles M,Shah N,Vadamalayan B,Chong S,Thapar N,D'Ambrosio A,Isoldi S

    更新日期:2019-07-01 00:00:00

  • Reduced bile output with chronic enteral and parenteral infusion of amino acids, glucose, and fat emulsion in rabbits.

    abstract::To assess the effect of chronic administration of amino acids, glucose, and fat on hepatic excretory function, bile flow and bile salt secretion were directly measured in adult rabbits alimented either intravenously or intragastrically. Five groups of animals were studied after 9-11 days on different nutritional regim...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198510000-00023

    authors: Zahavi I,Shaffer EA,Kelly J,Gall DG

    更新日期:1985-10-01 00:00:00

  • Prolonged neonatal jaundice: a manifestation of heterozygote state for Crigler--Najjar syndrome?

    abstract::A prolonged but transient neonatal jaundice due to unconjugated hyperbilirubinemia was observed in two unrelated babies who were siblings of patients with Crigler--Najjar disease (Arias type I). The bilirubin-UDP-glucuronyl transferase activity measured in the liver of both patients, at the age of 6 and 7 months, resp...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Odièvre M,Luzeau R,Alagille D

    更新日期:1982-01-01 00:00:00

  • The influence of gestational age, size for dates, and prenatal steroids on cord transferrin levels in newborn infants.

    abstract::Serum transferrin levels assess protein status in older children and adults. To generate standards for its use in newborn infants, we measured umbilical cord serum transferrin levels in 161 appropriate (AGA), 25 large (LGA) and 16 small (SGA) for gestational age infants between 25 and 43 weeks' gestation. We also asse...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198703000-00020

    authors: Chockalingam U,Murphy E,Ophoven JC,Georgieff MK

    更新日期:1987-03-01 00:00:00

  • Eosinophilic gastroenteropathy in childhood.

    abstract::Eosinophilic gastroenteropathy (EG) is an uncommon, idiopathic disease in children that is characterized by eosinophilic inflammation of the intestine. Over a 7-year period 17 infants and children with EG were evaluated; the retrospective review of their clinical data constitutes the basis of this report. A scale deve...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198805000-00011

    authors: Whitington PF,Whitington GL

    更新日期:1988-05-01 00:00:00

  • Prevalence of celiac disease in Brazilian children and adolescents with type 1 diabetes mellitus.

    abstract:OBJECTIVE:A previously unrecognized high prevalence of celiac disease (CD) has been found by screening among European and North American patients with type 1 diabetes mellitus (DM 1). The prevalence of CD among Brazilian children with DM1 is not known. This study was conducted to determine the prevalence of CD in Brazi...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000181400.57884.c3

    authors: Baptista ML,Koda YK,Mitsunori R,Nisihara,Ioshii SO

    更新日期:2005-11-01 00:00:00

  • LPS-binding protein enables intestinal epithelial restitution despite LPS exposure.

    abstract:OBJECTIVES:Intestinal epithelial restitution is the first part in the process of mucosal repair after injury in the intestine. Integrity of the intestinal mucosal barrier is important as a first line of defense against bacteria and endotoxin. Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31823a895a

    authors: Richter JM,Schanbacher BL,Huang H,Xue J,Bauer JA,Giannone PJ

    更新日期:2012-05-01 00:00:00

  • Can We Estimate Quality of Life in Pediatric Inflammatory Bowel Disease Patients? An Asian Multicenter Study.

    abstract:OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic lifelong condition and is related to poor quality of life (QoL). The aim of this study was to evaluate the QoL of Asian pediatric patients with IBD and to determine the clinical factors that can influence QoL. METHODS:Children and adolescents aged 9 to 18 years ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPG.0000000000002119

    authors: Kim S,Park S,Kang Y,Kim JE,Kang B,Choe BH,Lee YJ,Park JH,Yang HR,Lee SH,Kim KM,Ryoo E,Tchah H,Shim JO,Koh H

    更新日期:2019-01-01 00:00:00

  • Immunohistochemical findings in the intestine of IgA-deficient persons: number of intraepithelial T lymphocytes is increased.

    abstract::We studied jejunal biopsy specimens of 13 IgA-deficient persons (IgAdp) and 12 controls. Four Ig-Adp had celiac disease, in the others the jejunal mucosa appeared normal. Monoclonal antibodies and the peroxidase technique were used to identify T lymphocytes, T-lymphocyte subsets, HLA-DR antigens, and IgE-containing ce...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198807000-00010

    authors: Klemola T

    更新日期:1988-07-01 00:00:00

  • Allergenicity of whey protein: its modification by tryptic in vitro hydrolysis of the protein.

    abstract::Enzymatic in vitro hydrolysis was evaluated as a possible treatment to abolish the allergenicity of whey proteins in view of their use in infant formulas. Guinea pigs without prior immunological contact (including fetal life) with cow's milk were fed various preparations of cow's milk proteins. Oral exposure to milk o...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Pahud JJ,Monti JC,Jost R

    更新日期:1985-06-01 00:00:00

  • Evaluation of the use of botulinum toxin in children with achalasia.

    abstract:BACKGROUND:Achalasia is rare in children. Recently, injection of botulinum toxin into the lower esophageal sphincter has been studied as an alternative to esophageal pneumatic dilatation or surgical myotomy as treatment for achalasia. In the current study, the effects of botulinum toxin were investigated in the largest...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200005000-00009

    authors: Hurwitz M,Bahar RJ,Ament ME,Tolia V,Molleston J,Reinstein LJ,Walton JM,Erhart N,Wasserman D,Justinich C,Vargas J

    更新日期:2000-05-01 00:00:00

  • Safety of lansoprazole in the treatment of gastroesophageal reflux disease in children.

    abstract:OBJECTIVES:To evaluate the safety of lansoprazole in children between 1 and 11 years of age. METHODS:In a phase I/II, open-label, multicenter (11 sites) study, children with symptomatic gastroesophageal reflux disease (GERD), erosive esophagitis (> or = grade 2), and/or esophageal pH < 4 for > 4.2% of the 24-hour peri...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00005176-200211004-00002

    authors: Tolia V,Fitzgerald J,Hassall E,Huang B,Pilmer B,Kane R 3rd

    更新日期:2002-01-01 00:00:00

  • Viscosity of Commercial Food-based Formulas and Home-prepared Blenderized Feeds.

    abstract:OBJECTIVE:The aim of the study was to quantify the differences in viscosity of over a range of commercial food-based formulas and home-prepared blenderized feeds used for enteral feeding in the clinical management of gastroesophageal reflux and gastroesophageal reflux-related aspiration in children with oropharyngeal d...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002657

    authors: Hron B,Rosen R

    更新日期:2020-06-01 00:00:00

  • Correction of Iron Deficiency Anemia With Intravenous Iron Sucrose in Children With Inflammatory Bowel Disease.

    abstract:OBJECTIVES:Iron deficiency anemia (IDA) is common in children with inflammatory bowel disease (IBD) affecting their cognitive development and school performance. Oral iron supplementation has serious limitations including poor adherence and iron malabsorption related to chronic inflammation. Our objective was to evalua...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001383

    authors: Danko I,Weidkamp M

    更新日期:2016-11-01 00:00:00

  • Vitamin A concentration in the liver decreases with age in patients with cystic fibrosis.

    abstract:BACKGROUND:Vitamin A deficiency is a common manifestation in cystic fibrosis (CF), but high levels of vitamin A in the liver have also been described. High levels of vitamin A in the liver are toxic, while normal levels might be protective against liver damage. In order to investigate whether liver damage in patients w...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199703000-00006

    authors: Lindblad A,Diczfalusy U,Hultcrantz R,Thorell A,Strandvik B

    更新日期:1997-03-01 00:00:00

  • Esophageal impedance monitoring for gastroesophageal reflux.

    abstract::Dual pH-multichannel intraluminal impedance (pH-MII) is a sensitive tool for evaluating overall gastroesophageal reflux disease, and particularly for permitting detection of nonacid reflux events. pH-MII technology is especially useful in the postprandial period or at other times when gastric contents are nonacidic.pH...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e3181ffde67

    authors: Mousa HM,Rosen R,Woodley FW,Orsi M,Armas D,Faure C,Fortunato J,O'connor J,Skaggs B,Nurko S

    更新日期:2011-02-01 00:00:00

  • Use of a novel laparoscopic gastrostomy technique in children with severe epidermolysis bullosa.

    abstract:OBJECTIVE:Supplementing nutrition in children with severe epidermolysis bullosa (EB) is challenging because of skin and mucosal fragility. Percutaneous endoscopic gastrostomy is contraindicated in EB, whereas more invasive open surgical gastrostomy placement can be complicated by chronic leakage. The aim of the study w...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000256

    authors: Patel K,Wells J,Jones R,Browne F,Moss C,Parikh D

    更新日期:2014-05-01 00:00:00

  • Diagnostic value of serum gamma-glutamyl transpeptidase activity in liver diseases in children.

    abstract::The clinical usefulness of serum gamma-glutamyl transpeptidase (gamma GT) assay for the diagnosis of liver disease in children was assessed retrospectively in 398 children investigated from 1981 to 1986, in whom diagnosis was ascertained according to currently accepted criteria including liver histology in each case. ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199101000-00005

    authors: Maggiore G,Bernard O,Hadchouel M,Lemonnier A,Alagille D

    更新日期:1991-01-01 00:00:00

  • Use of Breast Milk and Other Feeding Practices Following Gastrointestinal Surgery in Infants.

    abstract:OBJECTIVES:The aim of the study was to characterize the enteral feeding practices in infants after gastrointestinal surgery. METHODS:We performed a retrospective analysis of infants who underwent intestinal surgery at age <6 months who survived to be fed enterally between January 2012 and June 2017. Demographics, surg...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002128

    authors: Varma S,Bartlett EL,Nam L,Shores DR

    更新日期:2019-02-01 00:00:00

  • Prevalence of metabolic bone disease in children with celiac disease is independent of symptoms at diagnosis.

    abstract:OBJECTIVES:: Given dietary gluten exposure, growing children with celiac disease may experience malabsorption of nutrients, negatively affecting bone health. The purpose of this study was to determine the prevalence of low bone mass in children with celiac disease, according to the presence of symptoms at diagnosis. M...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31819ca18e

    authors: Turner J,Pellerin G,Mager D

    更新日期:2009-11-01 00:00:00

  • Fasting gastric fluid and fecal polyamine concentrations in premature infants.

    abstract:BACKGROUND:The role of milk polyamines in the development of the gastrointestinal tract of human infants is presently unknown. Polyamine concentrations are higher in human milk than in infant formulas. The aim of the present study was to gather data on luminal polyamines by measuring gastric fluid and fecal polyamine c...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199704000-00006

    authors: Forget PP,Degraeuwe PL,Smeets C,Deutz NE

    更新日期:1997-04-01 00:00:00

  • Antenatal diagnosis of choledochal cyst.

    abstract::We report five infants in whom antenatal diagnosis of choledochal cyst was established by ultrasonography, and we review the seven previously reported cases. All but one infant had cystic dilatation of the common bile duct (type 1 cysts), and all infants were diagnosed during the second or third trimester. Eight of 12...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-199402000-00004

    authors: Bancroft JD,Bucuvalas JC,Ryckman FC,Dudgeon DL,Saunders RC,Schwarz KB

    更新日期:1994-02-01 00:00:00