Prevalence and clinical relevance of cagA, vacA, and iceA genotypes of Helicobacter pylori isolated from Slovenian children.

Abstract:

BACKGROUND:Although infection with Helicobacter pylori in children mostly induces asymptomatic chronic gastritis, the clinical outcome of H pylori infection is generally unpredictable. To identify the risk subgroup of infected children who can progress toward serious gastrointestinal disease, we assessed the prevalence of H pylori virulence genes cagA, vacA, and iceA in children from southeastern Europe and correlated their presence with the severity of histological changes in the stomach. MATERIALS AND METHODS:A total of 165 children (age range 4-18 years, mean 13 years) with H pylori infection were studied for a 6-year period. Virulence genes were determined by polymerase chain reaction from biopsy samples. RESULTS:The cagA gene was present in 61.2% of patients. The predominant vacA genotype was s1m1 (42%), followed by s1m2 (28%), and s2m2 (24%). IceA genotypes iceA1 and iceA2 were detected in 62% and 31% of the samples, respectively. Multiple genotypes were found in 11.5% of isolates. The H pylori density score, the degree of chronic and acute inflammation, correlated with a cagA-positive status (P < 0.01, P < 0.01, P = 0.01, respectively). Higher bacterial infiltration (P < 0.01) and degree of chronic inflammation (P = 0.03) were detected in vacA s1-positive samples. CONCLUSION:CagA, vacA s1m1, and iceA1 genotypes are the predominant genotypes of H pylori isolated from the southeastern European pediatric population. CagA and vacA s1 are important virulence determinants of H pylori in children, but were not found associated with an increased incidence of precancerous gastric lesions.

authors

Homan M,Luzar B,Kocjan BJ,Orel R,Mocilnik T,Shrestha M,Kveder M,Poljak M

doi

10.1097/MPG.0b013e31818f09f2

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

289-96

issue

3

eissn

0277-2116

issn

1536-4801

journal_volume

49

pub_type

杂志文章
  • High Levels of Decisional Conflict and Decision Regret When Making Decisions About Biologics.

    abstract:OBJECTIVES:The aim of the study was to understand the association between parents' perceptions of the decision process and the decision outcomes in decisions about the use of biologics in pediatric chronic conditions. METHODS:We mailed surveys to parents of children with inflammatory bowel disease or juvenile idiopath...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001425

    authors: Lipstein EA,Lovell DJ,Denson LA,Kim SC,Spencer C,Ittenbach RF,Britto MT

    更新日期:2016-12-01 00:00:00

  • Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial.

    abstract:BACKGROUND:The probiotic Lactobacillus GG is effective in promoting a more rapid recovery of acute, watery diarrhea in children with rotavirus enteritis. Very limited information is available, however, on the potential role of such agents in non-rotaviral diarrheal episodes. Furthermore, no evidence is available concer...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00005176-200001000-00018

    authors: Guandalini S,Pensabene L,Zikri MA,Dias JA,Casali LG,Hoekstra H,Kolacek S,Massar K,Micetic-Turk D,Papadopoulou A,de Sousa JS,Sandhu B,Szajewska H,Weizman Z

    更新日期:2000-01-01 00:00:00

  • Direct medical costs of constipation from childhood to early adulthood: a population-based birth cohort study.

    abstract:BACKGROUND:Although direct medical costs for constipation-related medical visits are thought to be high, to date there have been no studies examining whether longitudinal resource use is persistently elevated in children with constipation. Our aim was to estimate the incremental direct medical costs and types of health...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181e67058

    authors: Choung RS,Shah ND,Chitkara D,Branda ME,Van Tilburg MA,Whitehead WE,Katusic SK,Locke GR 3rd,Talley NJ

    更新日期:2011-01-01 00:00:00

  • Aminotransferase upper reference limits and the prevalence of elevated aminotransferases in the Korean adolescent population.

    abstract:OBJECTIVES:For the pediatric population, upper reference limits (URLs) for aminotransferase levels have not been established. The prevalence of high aminotransferase levels provides important information regarding the burden of liver disease in the current childhood obesity endemic. METHODS:We set the URL of alanine a...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182660669

    authors: Park SH,Park HY,Kang JW,Park J,Shin KJ

    更新日期:2012-12-01 00:00:00

  • Alpha 1-antitrypsin deficiency and the PiMS phenotype: case report and literature review.

    abstract::We describe a premature infant with cholestatic liver disease and protease inhibitor MS phenotype. This infant demonstrated an abnormally low serum alpha 1-antitrypsin concentration. Liver histologic studies revealed diastase-resistant, periodic acid-Schiff-positive globules inside hepatocytes. Immunoperoxidase staini...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-198901000-00021

    authors: Gourley MF,Gourley GR,Gilbert EF,Odell GB

    更新日期:1989-01-01 00:00:00

  • The prevalence of encopresis in a multicultural population.

    abstract:BACKGROUND:Population-based studies on the prevalence of encopresis in children are scarce and generally outdated. Prevalence estimates based on clinical studies are unreliable because parents tend to be reticent to seek medical help for this problem. Professional help is necessary, however, because encopresis can lead...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000149964.77418.27

    authors: van der Wal MF,Benninga MA,Hirasing RA

    更新日期:2005-03-01 00:00:00

  • Diet and chronic constipation in children: the role of fiber.

    abstract:BACKGROUND:Chronic constipation is one of the most common disorders in Western countries and despite numerous clinical, pathophysiologic, and epidemiologic studies its cause is still unclear. Several hypotheses have been proposed and according to experimental studies and clinical observation, fiber intake could play a ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199902000-00015

    authors: Roma E,Adamidis D,Nikolara R,Constantopoulos A,Messaritakis J

    更新日期:1999-02-01 00:00:00

  • Atypia of hepatic histiocytes induced by Renografin-60.

    abstract::Recurrent bouts of abdominal pain in a 12-year-old patient were diagnosed as due to intermittent obstruction of the choledochus. The condition was corrected by choledochostomy. Incidental liver biopsy showed atypia of intrahepatic histiocytes. However, electron microscopy identified associated foreign bodies suspected...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198605000-00025

    authors: Finley AJ,Ishak KG

    更新日期:1986-05-01 00:00:00

  • Early Obesity: Risk Factor for Fatty Liver Disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Fatty liver has become the most frequent indication for live...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002523

    authors: Cuzmar V,Alberti G,Uauy R,Pereira A,García C,De Barbieri F,Corvalán C,Santos JL,Mericq V,Villarroel L,Gana JC

    更新日期:2020-01-01 00:00:00

  • Cow's-milk allergy is a risk factor for the development of FGIDs in children.

    abstract:OBJECTIVES:Functional gastrointestinal disorders (FGIDs) are common in children. Their pathogenesis remains unknown and is most likely multifactorial. We hypothesized that noninfectious causes of inflammation affecting the gastrointestinal (GI) tract early in life, such as cow's-milk allergy (CMA), can predispose to th...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181e85b55

    authors: Saps M,Lu P,Bonilla S

    更新日期:2011-02-01 00:00:00

  • Helicobacter pylori Infection in Pediatric Patients Living in Europe: Results of the EuroPedHP Registry 2013 to 2016.

    abstract:OBJECTIVES:The aim of the study was to assess clinical presentation, endoscopic findings, antibiotic susceptibility and treatment success of Helicobacter pylori (H. pylori) infected pediatric patients. METHODS:Between 2013 and 2016, 23 pediatric hospitals from 17 countries prospectively submitted data on consecutive H...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002816

    authors: Kori M,Le Thi TG,Werkstetter K,Sustmann A,Bontems P,Lopes AI,Oleastro M,Iwanczak B,Kalach N,Misak Z,Cabral J,Homan M,Cilleruelo Pascual ML,Pehlivanoglu E,Casswall T,Urruzuno P,Martinez Gomez MJ,Papadopoulou A,Roma E,

    更新日期:2020-10-01 00:00:00

  • Serodiagnosis of Helicobacter pylori infection in children by an indirect immunofluorescence test.

    abstract::The objective of this study was to evaluate the accuracy of an indirect immunofluorescence (IIF) test for serodiagnosis of Helicobacter pylori infection in children and to determine how the test is affected by the presence of antibodies against Campylobacter jejuni. We studied 65 consecutive children (two with endosco...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199304000-00004

    authors: Rocha GA,Queiroz DM,Mendes EN,de Carvalho AS,de Oliveira AM,de Moura SB

    更新日期:1993-04-01 00:00:00

  • Safe oral rehydration of hypertonic dehydration.

    abstract::Eighteen infants with severe hypernatremic dehydration secondary to acute gastroenteritis were rehydrated during the 1st day with an oral glucose electrolyte solution containing 60 mmol sodium/L at a mean rate of 120 ml/kg/24 h. These 18 children were safely treated with oral therapy alone. No convulsions were observe...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Blum D,Brasseur D,Kahn A,Brachet E

    更新日期:1986-03-01 00:00:00

  • Critical role for P-glycoprotein expression in hematopoietic cells in the FVB.Mdr1a(-/-) model of colitis.

    abstract:OBJECTIVE:P-glycoprotein (P-gp), the functional product of the multidrug resistance gene (MDR), is a transmembrane protein that extrudes substrates from the intracellular environment. P-gp is expressed on the apical surface of epithelial cells and on cells from the hematopoietic lineage. Human MDR polymorphisms have be...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31822860f1

    authors: Staley EM,Dimmitt RA,Schoeb TR,Tanner SM,Lorenz RG

    更新日期:2011-12-01 00:00:00

  • Enzymatic activity of "high-mannose" glycosylated forms of intestinal microvillar hydrolases.

    abstract::The "high-mannose" glycosylated forms of aminopeptidase N (EC 3.4.11.2), maltase-glucoamylase (EC 3.2.1.20), and sucrase-isomaltase (EC 3.2.1.48, EC 3.2.1.10) have been purified. The high-mannose glycosylated form of sucrase-isomaltase was found to have a lower specific activity than the complex glycosylated form, whe...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198512000-00021

    authors: Sjöström H,Norén O,Danielsen EM

    更新日期:1985-12-01 00:00:00

  • Antiendomysial antibody detection in biopsy culture allows avoidance of gluten challenge in celiac children.

    abstract:OBJECTIVE:Antiendomysial antibody (EMA) production has been induced in vitro by the small bowel mucosa of celiac disease (CD) patients in clinical remission cultured in the presence of gliadin peptides. The aim of the present study was to use this in vitro system to determine whether it could be used to predict the cli...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200502000-00015

    authors: Bonamico M,Sabbatella L,Di Tola M,Vetrano S,Ferri M,Nenna R,Mariani P,Picarelli A

    更新日期:2005-02-01 00:00:00

  • Monitoring of anti-transglutaminase autoantibodies in pediatric celiac disease using a sensitive radiobinding assay.

    abstract:OBJECTIVES:The diagnosis of celiac disease (CD) is based on the histological identification of gluten-sensitive enteropathy and detection of anti-tissue transglutaminase antibodies (tTGA) and/or endomysial antibodies. Serial measurements of tTGA are now recommended as a follow-up strategy to monitor compliance with a g...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e318232c459

    authors: Candon S,Mauvais FX,Garnier-Lengliné H,Chatenoud L,Schmitz J

    更新日期:2012-03-01 00:00:00

  • Healing of erosive esophagitis and improvement of symptoms of gastroesophageal reflux disease after esomeprazole treatment in children 12 to 36 months old.

    abstract:OBJECTIVES:The aim of the study was to evaluate erosive esophagitis healing and symptom improvement with once-daily esomeprazole in children ages 12 to 36 months with endoscopically or histologically proven gastroesophageal reflux disease (GERD). PATIENTS AND METHODS:Data from children ages 12 to 36 months were includ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MPG.0b013e3181ddcf11

    authors: Tolia V,Gilger MA,Barker PN,Illueca M

    更新日期:2010-11-01 00:00:00

  • Use of Fully Covered Self-expanding Metal Biliary Stents in Pediatrics: A Case Series.

    abstract:OBJECTIVES:Endoscopic retrograde cholangiopancreatography is used to manage biliary pathology in pediatric patients. Plastic biliary stents have been used in this population for obstructive lesions and bile leaks; however, they are sometimes not effective due to migration, occlusion, or ineffective sealing. Fully cover...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001723

    authors: Mark JA,Mack CL,Marwan AI,Kramer RE

    更新日期:2018-03-01 00:00:00

  • Effects of zinc exposure on zinc transporter expression in human intestinal cells of varying maturity.

    abstract:OBJECTIVES:Zinc (Zn) homeostasis in adults is achieved principally through a balance between intestinal absorption and excretion involving adaptive mechanisms programmed by levels of dietary Zn. Zn absorption in infants is not as tightly regulated as that in adults, which may induce potential toxicity in infants due to...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181d98e85

    authors: Jou MY,Philipps AF,Kelleher SL,Lönnerdal B

    更新日期:2010-06-01 00:00:00

  • In situ expression of cagA and risk of gastroduodenal disease in Helicobacter pylori-infected children.

    abstract:BACKGROUND AND AIM:Gastroduodenal disease is more common among adults and children with cagA+ Helicobacter pylori infection, but disease severity varies among those infected with cagA+ strains. We examined whether cagA in situ expression can predict disease manifestations among H pylori-infected children. PATIENTS AND...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181bab326

    authors: Rick JR,Goldman M,Semino-Mora C,Liu H,Olsen C,Rueda-Pedraza E,Sullivan C,Dubois A

    更新日期:2010-02-01 00:00:00

  • Gallbladder Ejection Fraction Is Unrelated to Gallbladder Pathology in Children and Adolescents.

    abstract:OBJECTIVES:Biliary dyskinesia is a common diagnosis that frequently results in cholecystectomy. In adults, most clinicians use a cut off value for the gallbladder ejection fraction (GBEF) of <35% to define the disease. This disorder is not well characterized in children. Our aim was to determine the relation between GB...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001065

    authors: Jones PM,Rosenman MB,Pfefferkorn MD,Rescorla FJ,Bennett WE Jr

    更新日期:2016-07-01 00:00:00

  • Reporting outcome measures in trials of infant colic.

    abstract:OBJECTIVES:Infant colic (IC), with an estimated prevalence of 5% to 25%, has a high impact on health care costs. Furthermore, reported negative sequelae are disturbed parent-infant interaction, increased susceptibility to abdominal pain, and even child abuse. Its etiology remains unknown, leading to a wide variety in i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0000000000000412

    authors: Steutel NF,Benninga MA,Langendam MW,de Kruijff I,Tabbers MM

    更新日期:2014-09-01 00:00:00

  • Outpatient percutaneous liver biopsy in children.

    abstract::We reviewed data from 184 percutaneous liver biopsies performed as an outpatient procedure in 104 patients (5 weeks to 22 years of age) over a 4-year period. Hepatic allograft rejection was the indication for 130 of the biopsy procedures, while 54 were performed for a variety of indications in patients who had not und...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199311000-00006

    authors: Gonzalez-Vallina R,Alonso EM,Rand E,Black DD,Whitington PF

    更新日期:1993-11-01 00:00:00

  • Prospective evaluation of upper gastrointestinal mucosal lesions in children with ulcerative colitis and Crohn's disease.

    abstract::Eighty-eight consecutive children with inflammatory bowel disease were studied, and upper gastrointestinal endoscopy was performed in 80 of them as one of the initial investigations before commencing medical or nutritional treatment. Forty-one children were found to have Crohn's disease and 47, ulcerative colitis. Upp...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199408000-00007

    authors: Ruuska T,Vaajalahti P,Arajärvi P,Mäki M

    更新日期:1994-08-01 00:00:00

  • Probiotics for the Prevention of Nosocomial Diarrhea in Children.

    abstract::This document provides recommendations developed by the ESPGHAN Working Group on Probiotics and Prebiotics on the role of probiotics in the prevention of nosocomial diarrhea in children based on a systematic review of previously completed systematic reviews and of subsequently published randomized controlled trials. T...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,实务指引

    doi:10.1097/MPG.0000000000001637

    authors: Hojsak I,Szajewska H,Canani RB,Guarino A,Indrio F,Kolacek S,Orel R,Shamir R,Vandenplas Y,van Goudoever JB,Weizman Z,ESPGHAN Working Group for Probiotics\/Prebiotics.

    更新日期:2018-01-01 00:00:00

  • Prevalence of metabolic bone disease in children with celiac disease is independent of symptoms at diagnosis.

    abstract:OBJECTIVES:: Given dietary gluten exposure, growing children with celiac disease may experience malabsorption of nutrients, negatively affecting bone health. The purpose of this study was to determine the prevalence of low bone mass in children with celiac disease, according to the presence of symptoms at diagnosis. M...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31819ca18e

    authors: Turner J,Pellerin G,Mager D

    更新日期:2009-11-01 00:00:00

  • Growth in Infants and Children With Intestinal Failure-associated Liver Disease Treated With Intravenous Fish Oil.

    abstract:BACKGROUND:Infants with intestinal failure (IF) and IF-associated liver disease (IFALD) are at risk for poor somatic growth because of increased metabolic demands, inadequate intake, intestinal malabsorption, chronic liver disease and other comorbidities. There are limited data on the nutritional adequacy of intravenou...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002551

    authors: Raphael BP,Mitchell PD,Gura KM,Potemkin AK,Squires RH,Puder M,Duggan CP

    更新日期:2020-02-01 00:00:00

  • Association between mannose-binding lectin gene polymorphisms and necrotizing enterocolitis in preterm infants.

    abstract:OBJECTIVES:The aim of the present study was to evaluate whether polymorphisms of the mannose-binding lectin (MBL-2) gene and MBL serum levels on admission to neonatal intensive care unit are associated with necrotizing enterocolitis (NEC) in preterm infants and to verify MBL expression in NEC bowels. METHODS:In this r...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31824e5f7a

    authors: Prencipe G,Azzari C,Moriondo M,Devito R,Inglese R,Pezzullo M,Piersigilli F,Trucchi A,De Benedetti F,Auriti C

    更新日期:2012-08-01 00:00:00

  • Factors Determining δ-Bilirubin Levels in Infants With Biliary Atresia.

    abstract:OBJECTIVES:δ-Bilirubin (Bδ) forms when bilirubin conjugates covalently bind to albumin by way of nonenzymatic transesterification in patients with cholestasis. Infants with cholestasis with biliary atresia form Bδ. The aim of the present study was to investigate the factors determining serum Bδ concentrations in infant...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/MPG.0000000000000690

    authors: Ye W,Rosenthal P,Magee JC,Whitington PF,Childhood Liver Disease Research and Education Network.

    更新日期:2015-05-01 00:00:00