Enzymatic activity of "high-mannose" glycosylated forms of intestinal microvillar hydrolases.

abstract：OBJECTIVE:The aim of the study is to identify additional celiac disease associated loci in the major histocompatibility complex (MHC) independent from classical HLA risk alleles (HLA-DR3-DQ2) and to characterize their potential functional impact in celiac disease pathogenesis at the intestinal level. METHODS:We perfor...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Santin I,Jauregi-Miguel A,Velayos T,Castellanos-Rubio A,Garcia-Etxebarria K,Romero-Garmendia I,Fernandez-Jimenez N,Irastorza I,Castaño L,Bilbao JR

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis. METHODS:A cohort of 427 children 4 to 17 years of age newly diagnosed with ulcerative colitis (UC) was prospectively enrolled. Boosted classification trees were used to characterize...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Mack DR,Saul B,Boyle B,Griffiths A,Sauer C,Markowitz J,LeLeiko N,Keljo D,Rosh JR,Baker SS,Steiner S,Heyman MB,Patel AS,Baldassano R,Noe J,Rufo P,Kugathasan S,Walters T,Marquis A,Thomas SM,Denson L,Hyams J,PROT

更新日期：2020-09-01 00:00:00

abstract：:Recurrent bouts of abdominal pain in a 12-year-old patient were diagnosed as due to intermittent obstruction of the choledochus. The condition was corrected by choledochostomy. Incidental liver biopsy showed atypia of intrahepatic histiocytes. However, electron microscopy identified associated foreign bodies suspected...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Finley AJ,Ishak KG

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Patients with autoimmune diseases, such as type 1 diabetes mellitus, atopic dermatitis, autoimmune thyroid diseases, and multiple sclerosis have a different seasonality of month of birth (MOB) from the general population. This study was undertaken to determine the seasonality of MOB in children with celiac d...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Lewy H,Meirson H,Laron Z

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:Hepatitis-associated aplastic anemia (HAAA) is a potentially life-threatening diagnosis without clear treatment guidelines. The goal of the study was to characterize the presentation, evaluation, histopathology, and outcomes of therapy in children with HAAA to guide future research and to develop standardize...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kemme S,Stahl M,Brigham D,Lovell MA,Nakano T,Feldman AG,Mack C

更新日期：2021-02-01 00:00:00

abstract：:In this prospective study, neonates with clinical congenital syphilis were investigated to determine if penicillin therapy caused a deterioration in liver function. The relationship between circulating immune complexes and liver involvement was monitored, and the efficacy of steroid therapy as an adjunct in the treatm...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Venter A,Pettifor JM,Duursma J,Pudifin DJ,Smyth A,Becker PJ

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Infants with intestinal failure (IF) and IF-associated liver disease (IFALD) are at risk for poor somatic growth because of increased metabolic demands, inadequate intake, intestinal malabsorption, chronic liver disease and other comorbidities. There are limited data on the nutritional adequacy of intravenou...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Raphael BP,Mitchell PD,Gura KM,Potemkin AK,Squires RH,Puder M,Duggan CP

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Hepatic lesions have been described in Alagille syndrome (ALGS) in isolated case reports, and most of these have been reported to be hepatocellular carcinoma. OBJECTIVES:The aim of the present study was to determine the frequency, imaging, and histopathologic characteristics of hepatic lesions in children w...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Alhammad A,Kamath BM,Chami R,Ng VL,Chavhan GB

更新日期：2016-02-01 00:00:00

abstract：:The perianal complications of Crohn's disease (CD) seen in children and adolescents include skin tags, anal fissures, fistulae, and abscesses. While these lesions are often chronic and variably responsive to medical therapy, only rarely are they severely destructive. In this report, we characterize the frequency, seve...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Markowitz J,Grancher K,Rosa J,Simpser E,Aiges H,Daum F

更新日期：1995-08-01 00:00:00

abstract：:Data about the use of ranitidine in the early postnatal period are lacking. In this study, 30 term newborn infants < 2 days old with bleeding erosions in their upper gastrointestinal tracts were treated with ranitidine by continuous i.v. infusion (0.2 mg/kg/h) for 48 h and thereafter by mouth (5 mg/kg b.i.d.) for 1 mo...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Fontana M,Tornaghi R,Petrillo M,Lora E,Bianchi Porro G,Principi N

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:To assess the incidence and location at diagnosis of inflammatory bowel disease in children and adolescents in northern France between 1988 and 1999. METHODS:A 12-year prospective population-based study was conducted by gastroenterologists and pediatric gastroenterologists of northern France (1,312,141 child...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Auvin S,Molinié F,Gower-Rousseau C,Brazier F,Merle V,Grandbastien B,Marti R,Lerebours E,Dupas JL,Colombel JF,Salomez JL,Cortot A,Turck D

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Although a dextran sodium sulfate (DSS)-induced colitis is commonly used as an ulcerative colitis (UC) model in adult rodents, there are no studies using this model in young animals. We examined differences in the severity of DSS-induced colitis as a function of the concentration of DSS administered and soug...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Shimizu T,Suzuki M,Fujimura J,Hisada K,Yoshikazu O,Obinata K,Yamashiro Y

更新日期：2003-10-01 00:00:00

abstract：:Cyclic vomiting syndrome (CVS) is a disorder noted for its unique intensity of vomiting, repeated emergency department visits and hospitalizations, and reduced quality of life. It is often misdiagnosed due to the unappreciated pattern of recurrence and lack of confirmatory testing. Because no accepted approach to mana...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Li BU,Lefevre F,Chelimsky GG,Boles RG,Nelson SP,Lewis DW,Linder SL,Issenman RM,Rudolph CD,North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:Low γ-glutamyl transpeptidase (GGT) level is an important marker for progressive familial intrahepatic cholestasis, yet the cutoff level and clinical application is not well defined. This study aimed to evaluate the role of GGT as a screening marker among diverse etiologies of infantile cholestasis. METHODS...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Lu FT,Wu JF,Hsu HY,Ni YH,Chang MH,Chao CI,Chen HL

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to assess the adequacy of polyunsaturated fatty acid intake by rural Bangladeshi children 24 to 48 months old in relation to their breast-feeding status. MATERIALS AND METHODS:Multistage sampling was used to select a representative sample of children 24 to 48 months of age from 2 rur...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Yakes EA,Arsenault JE,Islam MM,Ahmed T,German JB,Drake C,Hossain MB,Lewis BL,Rahman AS,Jamil KM,Brown KH

更新日期：2011-03-01 00:00:00

abstract：:We compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2-week-old (suckling) and 6-week-old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (mumol/h/g dry weight) were significantly greater in all per...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Meneely R,Ghishan FK

更新日期：1982-01-01 00:00:00

abstract：:Zinc concentrations in plasma, hair, and urine from children and young adults with insulin-requiring or Type I diabetes mellitus were significantly correlated with height, weight, and age, as well as with indices of metabolic control, i.e., fasting serum glucose, percent glycosylated hemoglobin (HbA1), and 24-h urine ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Canfield WK,Hambidge KM,Johnson LK

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to use linear programming (LP) analyses to adapt New Complementary Feeding Guidelines (NCFg) designed for infants aged 6 to 12 months living in poor socioeconomic circumstances in Bogota to ensure dietary adequacy for young children aged 12 to 23 months. DESIGN:A secondary data analy...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Tharrey M,Olaya GA,Fewtrell M,Ferguson E

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Twenty-four-hour pH-metry represents the gold standard for the diagnosis of gastroesophageal reflux. Ambulatory esophageal pH recording provides a better reflection of occurrences under normal domestic living conditions, but it may influence physical activity. The aim of this study was to assess the influenc...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Michaud L,Troadec F,Béghin L,El Rifai N,Guimber D,Turck D,Gottrand F

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:In patients with biliary atresia (BA), liver fibrosis and cirrhosis commonly occur even after Kasai hepatoportoenterostomy. Although liver biopsy is the gold standard to evaluate liver fibrosis, it is invasive and may result in life-threatening complications. The aspartate aminotransferase-to-platelet ratio ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kim SY,Seok JY,Han SJ,Koh H

更新日期：2010-08-01 00:00:00

abstract：:Five children between the ages of 10 and 17 years with chronic inflammatory bowel disease with involvement of colon had intolerance to sulfasalazine, and desensitization trials had failed in them. In addition, they were steroid dependent. Therefore treatment was tried with an oral 5-aminosalicylic acid (5-ASA) prepara...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Tolia V,Massoud N,Klotz U

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVE:We conducted a systematic review to determine and compare the diagnostic accuracy of contrast enema (CE), anorectal manometry (ARM) and rectal suction biopsy (RSB) in infants suspected of Hirschsprung disease. DESIGN:This is a systematic review. DATA SOURCES:Articles were identified through electronic searc...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： de Lorijn F,Kremer LC,Reitsma JB,Benninga MA

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:This randomized, placebo controlled trial was designed to assess the safety and efficacy of 10-mg zinc supplementation for the treatment of acute diarrhea in infants. METHODS:A total of 1110 infants aged 28 days to 5 months with acute diarrhea were enrolled and randomized to receive either zinc (n = 554) or ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Fischer Walker CL,Bhutta ZA,Bhandari N,Teka T,Shahid F,Taneja S,Black RE,Zinc Study Group.

更新日期：2006-09-01 00:00:00

abstract：:A prospective study was undertaken on 49 infants with prolonged neonatal cholestasis to determine whether the specificity, sensitivity, and accuracy of 99mTc-disofenin scintigraphy can be improved by performing simultaneous radioactivity measurements on duodenal and gastric aspirates along with routine imaging. Specif...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Tolia V,Kuhns L,Dubois RS

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to validate a brief Bowel Habit Questionnaire (BHQ) with prospectively obtained data from a 14-day diary and to determine whether the BHQ predicts the development of medically significant constipation (MSC) during the following year. MATERIALS AND METHODS:The BHQ was distributed to ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Wald ER,Jagodzinski TD,Moyer SC,Wald A,Eickhoff JC,Edmonson MB

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Many patients with chronic hepatitis C do not respond to antiviral treatment. In adult patients the re-treatment of these patients has been extensively investigated. Because the response to re-treatment in children is not well defined we evaluated the efficacy and safety of interferon (IFN)-alpha plus ribavi...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Gerner P,Hilbich J,Wenzl TG,Behrens R,Walther F,Kliemann G,Enninger A,Wirth S

更新日期：2010-08-01 00:00:00

abstract：:The effects of changes in diet on antral gastrin-like immunoreactivities and antral and corporal somatostatin-like immunoreactivities were studied in three groups of young male rats. Group 1 rats were weaned physiologically, group 2 rats received only breast milk, and group 3 rats were fed milk until 20 days of age an...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Okahata H,Nishi Y,Muraki K,Kumamoto T,Sumioka M,Sumii K,Hide M,Tanaka K,Miyachi Y,Usui T

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:Celiac disease (CD) represents a spectrum, which includes cases with minor histological abnormalities (potential CD). The aim of this work is to evaluate the contribution of immunohistochemical analysis of duodenal biopsies to the diagnosis of gluten-related minor enteropathy. METHODS:Duodenal biopsies from...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Tosco A,Maglio M,Paparo F,Greco L,Troncone R,Auricchio R

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:Environmental enteropathy (EE) is likely associated with growth retardation in children, but the association between EE and length velocity z score (LVZ) has not been investigated. The objective of the study was to assess associations between fecal markers for intestinal inflammation and LVZ and whether thes...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Morseth MS,Henjum S,Schwinger C,Strand TA,Shrestha SK,Shrestha B,Chandyo RK,Ulak M,Torheim LE

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Early postnatal glucocorticoid exposure accelerates the maturation of the bowel mucosa but results in bowel wall thinning in the newborn mouse ileum and increases the risk of focal ileal perforation in extremely premature infants. We have previously demonstrated a redistribution of insulin-like growth factor...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Gordon PV,Moats-Staats BM,Stiles AD,Price WA

更新日期：2002-10-01 00:00:00