The value of the leukocyte esterase test in diagnosing intra-amniotic infection.


:This communication examines the diagnostic value of the leukocyte esterase activity (LEA) test in the detection of intra-amniotic infection. Amniotic fluid from 171 consecutive patients with premature rupture of membranes (n = 149) and preterm labor (n = 22) was obtained through amniocentesis. Gram stain, bacterial and mycoplasma cultures, and LEA tests were performed. The LEA had a sensitivity of 19%, a specificity of 86.7%, a positive predictive value (PPV) of 42.3% and a negative predictive value (NPV) of 67.6% in the prediction of a positive amniotic fluid culture (prevalence of positive cultures = 33.9%). The Gram stain had a sensitivity of 36.2%, specificity of 94.7%, PPV of 77.8%, and NPV of 74.3%. When both tests were combined, a significant increase in sensitivity to 50% was observed. This was associated with a drop in specificity to 81.4%. There was a correlation between the number of white blood cells in the amniotic fluid and the result of the LEA test. A positive LEA assay was associated with an increased likelihood of postpartum endometritis, but not with clinical chorioamnionitis or neonatal infectious morbidity.


Am J Perinatol


Romero R,Emamian M,Wan M,Yarkoni S,McCormack W,Mazor M,Hobbins JC




Has Abstract


1988-01-01 00:00:00












  • Location of accessory connection in infants presenting with supraventricular tachycardia in utero: clinical correlations.

    abstract::The most common mechanism of fetal tachycardia is orthodromic reciprocating tachycardia utilizing an accessory atrioventricular connection, however, data regarding accessory connection location in patients with fetal tachycardia is limited. To investigate the location of accessory connections in fetal tachycardia, pos...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章


    authors: Kannankeril PJ,Gotteiner NL,Deal BJ,Johnsrude CL,Strasburger JF

    更新日期:2003-04-01 00:00:00

  • Transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia.

    abstract::We describe a case of transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia. Although hypoglycemia in birth asphyxiated infants is generally attributed to depletion of glycogen stores, we observed severe hyperinsulinism associated with the hypoglycemia. The hypoglycemia was refractory to high gl...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Clark W,O'Donovan D

    更新日期:2001-06-01 00:00:00

  • Apgar Score at 5 Minutes Is Associated with Mortality in Extremely Preterm Infants Even after Transfer to an All Referral NICU.

    abstract:OBJECTIVE:The Apgar score has been shown to have utility in predicting mortality in the extremely preterm infant in delivery hospital populations, where most mortality occurs within 12 hours of birth. We tested the hypothesis that the 5 minute Apgar score would remain associated with mortality in extremely preterm infa...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Bartman T,Bapat R,Martin EM,Shepherd EG,Nelin LD,Reber KM

    更新日期:2015-11-01 00:00:00

  • Traumatic facial nerve palsy in newborns: is it always iatrogenic?

    abstract::We sought to report an updated incidence, risk factors, and outcome of traumatic facial palsy (TFP) in newborn infants born at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia. We performed a 12-year retrospective study at KAMC. The records of infants with the diagnosis of TFP during the study period were revi...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Al Tawil K,Saleem N,Kadri H,Rifae MT,Tawakol H

    更新日期:2010-10-01 00:00:00

  • Obesity Before, During, and After Pregnancy: A Review and Comparison of Five National Guidelines.

    abstract:OBJECTIVE:This study aims to compare how national guidelines approach the management of obesity in reproductive age women. STUDY DESIGN:We conducted a search for national guidelines in the English language on the topic of obesity surrounding the time of a pregnancy. We identified six primary source documents and sever...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Kominiarek MA,Chauhan SP

    更新日期:2016-04-01 00:00:00

  • Cardiovascular Associations with Abnormal Brain Magnetic Resonance Imaging in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia and Rewarming.

    abstract:OBJECTIVE:This article compares hemodynamic characteristics of neonates with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH) with normal versus abnormal brain magnetic resonance imaging (MRI). METHODS:Serial echocardiography (echo) was performed within 24 hours, after 48 to 72 hours of coo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: More KS,Sakhuja P,Giesinger RE,Ting JY,Keyzers M,Sheth JN,Lapointe A,Jain A,Moore AM,Miller SP,McNamara PJ

    更新日期:2018-08-01 00:00:00

  • Perinatal and neonatal aspects of maternal idiopathic thrombocytopenic purpura.

    abstract::The pregnant woman with idiopathic thrombocytopenic purpura (ITP) and her fetus-neonate present a number of challenging issues for both the perinatologist and neonatologist. A review of these issues within a single format is helpful because of the widely scattered nature of the pertinent information in the medical lit...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Beck R

    更新日期:1984-04-01 00:00:00

  • Gentamicin levels in pregnant women with pyelonephritis.

    abstract::This study was performed at University Medical Center, Lubbock, Texas, from July 1989 to June 1990. We obtained serum gentamicin peak and trough levels in 23 pregnant women with pyelonephritis. The patients were given a loading dose of 2 mg/kg gentamicin, followed by 1.5 mg/kg gentamicin adjusted for obesity every 8 h...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Graham JM,Blanco JD,Oshiro BT,Magee KP

    更新日期:1994-01-01 00:00:00

  • Maternal and fetal tuberous sclerosis complicating pregnancy: a case report and overview of the literature.

    abstract::Tuberous sclerosis complex (TSC) is an autosomal-dominant phakomatosis that can result in cardiac and central nervous system lesions and may adversely impact fetal and maternal health. We report a case of a 19-year-old primagravida with TSC whose pregnancy was complicated by preeclampsia, preterm labor, and fetal demi...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: King JA,Stamilio DM

    更新日期:2005-02-01 00:00:00

  • What about the Misgav-Ladach surgical technique in patients with previous cesarean sections?

    abstract:OBJECTIVE:The Misgav-Ladach technique is recommended worldwide to perform cesarean sections but there is no consensus about the appropriate technique to use in patients with previous cesarean sections. This study evaluated the feasibility of the Misgav-Ladach technique in patients with previous cesarean sections. STUD...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章


    authors: Bolze PA,Massoud M,Gaucherand P,Doret M

    更新日期:2013-03-01 00:00:00

  • Sonography of unilateral megalencephaly in the fetus and newborn infant.

    abstract::A 27-year-old primigravida women was referred for ultrasound studies at 32 weeks' gestation because of the suspicion of fetal ventriculomegaly. Sonographic examination of the fetal brain found a marked shift of the midline, with enlarged left hemisphere and ipsilateral occipital horn, and abnormal convolutions. A 3500...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Sandri F,Pilu G,Dallacasa P,Foschi F,Salvioli GP,Bovicelli L

    更新日期:1991-01-01 00:00:00

  • Risks of Preterm Premature Rupture of Membranes and Preterm Birth Post Fetoscopy Based on Location of Trocar Insertion Site.

    abstract:OBJECTIVE:The objective of this study was to assess whether the location of the trocar insertion site for laser treatment of twin-twin transfusion syndrome was associated with preterm-premature rupture of membranes (PPROM) and preterm birth (PTB). STUDY DESIGN:In this study trocar location was documented in the operat...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Chmait RH,Chon AH,Korst LM,Llanes A,Kontopoulos EV,Quintero RA

    更新日期:2018-07-01 00:00:00

  • Pregnancy Outcomes after Preeclampsia: The Effects of Interpregnancy Weight Change.

    abstract:OBJECTIVE: This study aimed to examine the effects of interpregnancy weight change on pregnancy outcomes, including recurrent preeclampsia, preterm birth, small-for-gestational age (SGA), large-for-gestational age (LGA), and cesarean delivery, among women with a history of preeclampsia. We also evaluated whether these ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Tabet M,Banna S,Luong L,Kirby R,Chang JJ

    更新日期:2020-06-10 00:00:00

  • Conservative management of abdominal gunshot wound in a pregnant woman.

    abstract::An abdominal gunshot wound in pregnancy warrants prompt surgical exploration but does not mandate uterine evacuation. Despite an entry and exit bullet wound to the uterus an apparent desire for pregnancy termination, a conservative approach was adopted with primary repair of the uterus, in conjunction with surgical re...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Kirshon B,Young R,Gordon AN

    更新日期:1988-07-01 00:00:00

  • Intravenous immunoglobulins for neonatal alloimmune neutropenia refractory to recombinant human granulocyte colony-stimulating factor.

    abstract::Neonatal alloimmune neutropenia (NAN) results from neutrophil destruction by transplacental maternal neutrophil-specific immunoglobulin G (IgG) antibodies directed against the antigen inherited from the father. Treatment is usually based on recombinant human granulocyte colony-stimulating factor (G-CSF) and prevention...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Desenfants A,Jeziorski E,Plan O,Rodière M,Rimbert M,Muller JY,Taïb J,Cambonie G

    更新日期:2011-06-01 00:00:00

  • The evidence for abandoning the amniotic fluid index in favor of the single deepest pocket.

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    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Magann EF,Chauhan SP,Doherty DA,Magann MI,Morrison JC

    更新日期:2007-10-01 00:00:00

  • Prolactin and plasma prostaglandin metabolite levels in patients undergoing nipple stimulation contraction stress tests.

    abstract::Twenty-five patients undergoing nipple stimulation contraction stress tests were enrolled in this study. Plasma 13,14-dihydro, 15-keto prostaglandin F2 alpha and plasma prolactin concentrations were analyzed before and during the contraction stress tests. Prolactin concentrations were significantly higher (p less than...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Rijhsinghani AG,Dubin NH,Zacur HA,Johnson TR,Niebyl JR

    更新日期:1990-01-01 00:00:00

  • Prediction of recurrent preeclampsia using first-trimester uterine artery Doppler.

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    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Demers S,Bujold E,Arenas E,Castro A,Nicolaides KH

    更新日期:2014-02-01 00:00:00

  • An analysis of second-stage labor beyond 3 hours in nulliparous women.

    abstract:OBJECTIVE:To analyze outcomes after second-stage labor beyond 3 hours and determine if prolonged second stages were intentional. STUDY DESIGN:Retrospective cohort analysis of maternal and neonatal outcomes in nulliparous women based on second-stage duration. Medical records were reviewed for management decisions in wo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Bleich AT,Alexander JM,McIntire DD,Leveno KJ

    更新日期:2012-10-01 00:00:00

  • Neurodevelopmental Impairment at Two Years in Premature Infants with Prolonged Patency of Ductus Arteriosus after a Conservative Approach.

    abstract:OBJECTIVE: The study aims to assess the impact on neurodevelopmental outcomes of a prolonged hemodynamically significant patent ductus arteriosus (PDA) after a conservative treatment. STUDY DESIGN: This involves the study of two cohorts of preterm infants 23 to 29 weeks gestation, before (n = 29) and after (n = 54) a ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Aldecoa-Bilbao V,García-Catalán MJ,Gaixa M,Clotet Caba J,Teodoro S,Figaró Voltà C

    更新日期:2019-10-10 00:00:00

  • Improvement of conventional transcutaneous bilirubinometry results in term newborn infants.

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    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Felc Z

    更新日期:2005-05-01 00:00:00

  • Early Postnatal IGF-1 and IGFBP-1 Blood Levels in Extremely Preterm Infants: Relationships with Indicators of Placental Insufficiency and with Systemic Inflammation.

    abstract:OBJECTIVE:To evaluate to what extent indicators of placenta insufficiency are associated with low concentrations of insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein-1 (IGFBP-1) in neonatal blood, and to what extent the concentrations of these growth factors are associated with concentrations of proteins w...

    journal_title:American journal of perinatology

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    authors: Leviton A,Allred EN,Fichorova RN,VanderVeen DK,O'Shea TM,Kuban K,Dammann O,ELGAN Study Investigators.

    更新日期:2019-12-01 00:00:00

  • The Association between Shirodkar Cerclage and Preterm Premature Rupture of Membranes in Singleton Pregnancies.

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    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Muniz Rodriguez A,Pastor A,Fox NS

    更新日期:2020-05-23 00:00:00

  • Does Hydroxychloroquine Protect against Preeclampsia and Preterm Delivery in Systemic Lupus Erythematosus Pregnancies?

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    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Do SC,Rizk NM,Druzin ML,Simard JF

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  • Delayed interval delivery: infection is not an absolute contraindication.

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    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Watson WJ,McNelis T

    更新日期:1998-06-01 00:00:00

  • Sonographic measurement of the fetal iliac bone: growth and relation to femur length in assessment of gestational age.

    abstract::Diagnostic ultrasonography has given us the opportunity to diagnose several congenital malformations in utero. Skeletal dysplasias is a heterogeneous group of disorders of the skeleton. Although disorders of bone growth are often diagnosed in utero, it is usually a general diagnosis because the exact syndrome cannot b...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Jaffe R,Santolaya J,Warsof SL

    更新日期:1993-03-01 00:00:00

  • Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network.

    abstract:BACKGROUND:Obesity is associated with increased risk of stillbirth, although the mechanisms are unknown. Obesity is also associated with inflammation. Serum ferritin, C-reactive protein, white blood cell count, and histologic chorioamnionitis are all markers of inflammation. OBJECTIVE:This article determines if inflam...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Harrison MS,Thorsten VR,Dudley DJ,Parker CB,Koch MA,Hogue CJR,Stoll BJ,Silver RM,Varner MW,Pinar MH,Coustan DR,Saade GR,Bukowski RK,Conway DL,Willinger M,Reddy UM,Goldenberg RL

    更新日期:2018-09-01 00:00:00

  • Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization.

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    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Tıraş M,Can E,Hamilçıkan Ş

    更新日期:2021-01-04 00:00:00

  • A Novel Partogram for Stages 1 and 2 of Labor Based on Fetal Head Station Measured by Ultrasound: A Prospective Multicenter Cohort Study.

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    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Haberman S,Atallah F,Nizard J,Buhule O,Albert P,Gonen R,Ville Y,Paltieli Y

    更新日期:2020-03-02 00:00:00

  • Antenatal Infections and Respiratory Outcome in Preterm Infants.

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    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Bancalari E

    更新日期:2020-09-01 00:00:00