Hepatoblastoma in a child of extremely low birth weight.

Abstract:

:Hepatoblastoma is a rare childhood embryonal malignancy. Recent reports suggested a linkage between premature birth and later development of hepatoblastoma. In August 2000, we encountered a 24-month-old boy with extremely low birth weight who developed hepatoblastoma with an unfavorable histology. His birth weight was only 584 g. Radiological evaluation of the liver revealed a hypoattenuated tumor occupying the left lobe. His initial serum alpha-fetoprotein level was 4032 ng/mL. The patient underwent successful left hepatectomy. The histological examination showed that the tumor, weighing 210 g, was a hepatoblastoma of epithelial type in two different patterns. One was composed purely of fetal type of tumor cells, whereas another was made up of embryonal type of cells in a macrotrabecular pattern. Four courses of adjuvant chemotherapy were given after surgery and were well tolerated. The patient remained in clinical remission 18 months after diagnosis.

journal_name

Am J Perinatol

authors

Jaing TH,Hung IJ,Lin JN,Lien RI,Hsueh C,Lu CS

doi

10.1055/s-2002-25309

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

149-53

issue

3

eissn

0735-1631

issn

1098-8785

journal_volume

19

pub_type

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