Abstract:
:The objective of this study was to investigate the association between red blood cell (RBC) transfusion and hematocrit values with outcomes in infants undergoing Norwood operation. This study included infants ≤2 months of age who underwent Norwood operation with either a modified Blalock-Taussig shunt or a right ventricle-pulmonary artery shunt. Demographics, preoperative, operative, daily laboratory data, and postoperative variables were collected. The primary outcome measures evaluated included mortality, ICU length of stay, length of mechanical ventilation, and days to chest closure. The secondary outcome measures evaluated included lactate levels, estimated glomerular filtration rate, and inotrope score in the first 14 days after heart operation. Cox proportional hazard models were fitted to study the probability of study outcomes as a function of hematocrit values and RBC transfusions after operation. Eighty-nine patients qualified for inclusion. With a median hematocrit of 46 (IQR 44, 49), and a median RBC transfusion of 92 ml/kg (IQR 31, 384) in the first 14 days after operation, 81 (91 %) patients received RBC transfusions. A multivariable analysis adjusted for risk factors, including the age, weight, prematurity, cardiopulmonary bypass and cross-clamp time, and postoperative need for nitric oxide and dialysis, demonstrated no association between hematocrit and RBC transfusion with majority of study outcomes. This single-center study found that higher hematocrit values and increasing RBC transfusions are not associated with improved outcomes in infants undergoing Norwood operation.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Gupta P,King C,Benjamin L,Goodhart T,Robertson MJ,Gossett JM,Pesek GA,DasGupta Rdoi
10.1007/s00246-015-1147-zsubject
Has Abstractpub_date
2015-08-01 00:00:00pages
1212-8issue
6eissn
0172-0643issn
1432-1971journal_volume
36pub_type
杂志文章abstract::To examine factors associated with low high-density lipoprotein cholesterol (HDL-C) levels among middle school children. HDL-C levels were the primary outcome of interest. A total of 1,104 middle-school children (mean age 11.6 years, 51.2% female) were included in this analysis, of whom 177 (16%) had an HDL-C level ≤4...
journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00246-013-0814-1
更新日期:2014-03-01 00:00:00
abstract::We studied the safety and efficacy of closing patent ductus arteriosus by Nit-Occlud coils via retrograde approach. This is a retrospective study of 46 attempts to close ducts by this method in two hospitals in Egypt and Iran. Ductus arteriosus was crossed by left or right Judkins or endhole catheters. The coil was de...
journal_title:Pediatric cardiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00246-017-1589-6
更新日期:2017-04-01 00:00:00
abstract::Previous studies have indicated the importance of allometric scaling of VO2max for body size. However, no information is available on adjusting maximal cardiac output (Qmax) and stroke volume (SVmax) for body dimensions. The allometric exponent b was determined for the equation Y = aXb (where Y is the physiological ou...
journal_title:Pediatric cardiology
pub_type: 临床试验,杂志文章
doi:10.1007/s002460010102
更新日期:2000-09-01 00:00:00
abstract::The etiology and pathogenesis of Kawasaki disease (KD) is largely unknown. Certain demographic factors and laboratory findings are predictive of the development of coronary artery (CA) aneurysms. The objectives of this study were to determine the epidemiology of KD patients in an urban hospital and determine risk fact...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-005-0916-5
更新日期:2005-11-01 00:00:00
abstract::The American Academy of Pediatrics (AAP) recommends that any child diagnosed with hypertension have an echocardiogram to evaluate for the presence of left-ventricular (LV) hypertrophy (LVH) and advocates that LVH is an indication to initiate or intensify antihypertensive therapy. However, there is no consensus on the ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0829-7
更新日期:2014-04-01 00:00:00
abstract::Dextro-transposition of the great arteries (D-TGA) is one of the most common cyanotic heart lesions. The arterial switch operation (ASO) is the preferred surgical palliation for D-TGA. One of the primary concerns following the ASO is complications arising from the coronary artery transfer. There is a need for myocardi...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-1890-z
更新日期:2018-08-01 00:00:00
abstract::An aneurysm of the fossa ovalis was identified at autopsy in 17 infants. In each case the aneurysm of the fossa ovalis was considered to have resulted from excessive elevation of pressure in that atrium contralateral to the side into which the aneurysm bulged. The aneurysms were divided into two types: intrinsic (thre...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02282740
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:This study applied tissue Doppler imaging and color tissue Doppler imaging to study atrial function changes in patients with hypertrophic cardiomyopathy (HCM). The profile of the segmental atrial velocities and the strain rate were determined and compared with those of normal matched control subjects. METHO...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-007-9112-0
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:The optimal surgical strategy for pulmonary atresia with ventricular septal defect (PA/VSD) in neonates and young infants is controversial. Staged repair may be associated with a higher risk of inter-stage mortality, while primary repair may lead to frequent post-repair re-interventions. METHODS:From 2004 t...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02352-9
更新日期:2020-06-01 00:00:00
abstract::This report describes a case involving the rare combination of persistent truncus arteriosus type A2, double aortic arch, and mitral stenosis. At the age of 26 days, the patient underwent division of the right-sided aortic arch with tracheal compression and bilateral pulmonary banding. Fontan completion was successful...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0572-5
更新日期:2013-01-01 00:00:00
abstract::The slip ring and nutate/rotate configuration of the new, fourth-generation, computed tomography (CT) (TCT-900S, Toshiba Medical Company) makes it possible to scan consecutively 25 slices every 75 s. This scanner also rapidly provides hemodynamic and multiplanar reconstruction images. Studies were performed on 13 chil...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02309917
更新日期:1989-04-01 00:00:00
abstract::Three patients (ages 3, 5, and 8 years) with various forms of functionally univentricular heart lesions received a total cavopulmonary connection with an extracardiac conduit as a final reconstructive procedure. Failure of the Fontan circulation occurred immediately after surgery because of spontaneous closure of surg...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0693-6
更新日期:2005-01-01 00:00:00
abstract::Computed tomographic angiography (CTA) and cardiac catheterization are useful adjuncts to echocardiography for delineating cardiovascular anatomy in pediatric patients. These studies require ionizing radiation, and it is paramount to understand the amount of radiation pediatric patients receive when these tests are pe...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0486-2
更新日期:2013-03-01 00:00:00
abstract::Aortic atresia and interrupted aortic arch is a rare cardiac combination. Review of the literature revealed nine cases. We present two patients with this combination and the additional finding of quadricuspid pulmonary valves, one of which was severely stenotic. In the latter patient, an aortopulmonary window was pres...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0754-x
更新日期:2005-07-01 00:00:00
abstract::Systemic candidiasis developed in a seven-week-old premature baby after 6 weeks treatment with antibiotics for suspected septicemia. At that time the echocardiogram showed a dense layer of echoes posteriorly to the anterior tricuspid leaflet during atrial systole. The diagnosis of Candida endocarditis with vegetations...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02281007
更新日期:1983-01-01 00:00:00
abstract::Double outlet right ventricle (DORV) was produced experimentally in the chick embryo by preventing the incorporation of the posteromedial conus into the left ventricle. This was accomplished by placing a ligature around the caudal end of the conus at a stage in which it is exclusively continuous with the right ventric...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02240456
更新日期:1982-01-01 00:00:00
abstract::Previous studies showed the reliability of cardiac magnetic resonance imaging (cMRI) in the quantification of aortic valve stenosis in adults. The aim of this retrospective study was to assess the ability of cMRI in the quantification of congenital aortic valve stenosis (CAS) in children. Nineteen patients (mean age 1...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0851-9
更新日期:2014-06-01 00:00:00
abstract::Protein-losing enteropathy (PLE) and plastic bronchitis (PB) are major causes of long-term mortality after Fontan operation. The objective of this study was to determine early clinical risk factors before the onset of PLE and PB. In a cohort study, 106 Fontan patients between 2005 and 2013 were examined. A median of 5...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-017-1632-7
更新日期:2017-08-01 00:00:00
abstract::This study identified tracheobronchial cartilage calcification in children with congenital heart disease. Calcification of the tracheobronchial airways has been found previously in adults receiving warfarin and in children receiving warfarin after mitral valve replacement. A 9-year-old girl who had received a Fontan r...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-014-0880-z
更新日期:2014-08-01 00:00:00
abstract::The hybrid pathway for the management of patients with hypoplastic left heart syndrome was pioneered at our institution and is the preferred approach compared with the traditional Norwood pathway. Patients undergoing this surgery are generally <6 months of age, and pain management in this age group after surgery for c...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0233-8
更新日期:2012-10-01 00:00:00
abstract::Children with congenital heart defects often demonstrate a reduced capacity for exercise, even after surgical intervention. Forty subjects, with various heart defects, completed a 5-year study to evaluate the impact of a postoperative training program on their physical exercise capacity. All of the patients were signi...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02238841
更新日期:1990-07-01 00:00:00
abstract::The aim of this study was to evaluate by Doppler echocardiography whether administration of transdermal nitroglycerin (NTG) to children with congestive heart failure could modify mitral flow velocity profile with redistribution of left ventricular filling to late diastole, suggesting preload reduction of the left vent...
journal_title:Pediatric cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002460010144
更新日期:2001-01-01 00:00:00
abstract::We report a case of isolated ventricular inversion in a 42-year-old woman. This rare congenital cardiac anomaly was corrected by an intraatrial baffle procedure. She also underwent left-sided double-chamber endocardial pacemaker implantation for postoperative tachycardia bradycardia syndrome. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0583-3
更新日期:2004-09-01 00:00:00
abstract::A 10-month-old boy was referred for tachypnea and heart murmur. An echocardiogram showed unexplained left heart dilation without evidence of an intracardiac shunt. A 64-slice computed tomographic contrast-enhanced angiography showed a large tortuous anomalous artery arising from the descending thoracic aorta and suppl...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-008-9287-z
更新日期:2009-01-01 00:00:00
abstract::Hyperplastic left heart syndrome (HLHS) patients are palliated by creating a Fontan-type circulation passing from different surgical stages. The aim of this work is to describe the evolution of ventricular energetics parameters in HLHS patients during the different stages of palliation including the hybrid, the Norwoo...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-017-1704-8
更新日期:2017-12-01 00:00:00
abstract::There is often a diagnostic dilemma in pediatric patients presenting with depressed ventricular function, as myocarditis and dilated cardiomyopathy (DCM) of other etiologies can appear very similar. Accurate identification is critical to guide treatment and to provide families with the most accurate expectation of lon...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-1867-y
更新日期:2018-08-01 00:00:00
abstract::The mechanism of heart failure in patients with enterovirus 71 rhombencephalitis (brain stem encephalitis) remains unknown. Our previous reports hypothesized that a catecholamine storm induced by rhombencephalitis may account for the heart failure. The aim of this study was to develop a novel feline model of norepinep...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-005-0915-6
更新日期:2006-09-01 00:00:00
abstract::Heart failure (HF) has high morbidity and mortality in children. This study aimed to investigate the value of cardiac myosin binding protein-C (cMyBP-C) as a diagnostic and prognostic biomarker in children with heart failure. This study was a prospective case-control study that involved 50 children with acute HF and 2...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-016-1532-2
更新日期:2017-02-01 00:00:00
abstract::Beta-blocker therapy is one of the principal therapies for congenital long-QT syndrome (LQTS). However, breakthrough cardiac events occur while being treated with beta-blockers. We sought to determine the frequency of and clinical correlates underlying beta-blocker therapy failures in genotyped, symptomatic LQTS proba...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0567-3
更新日期:2004-09-01 00:00:00
abstract::We sought to document morbidities and growth for patients with hypoplastic left heart syndrome (HLHS) to inform the initial surgical decision and understand healthcare needs. Data were obtained on 137 patients with HLHS, born between 1989 and 1994, who survived staged surgery ( n = 62) or transplantation ( n = 75) and...
journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00246-003-0471-x
更新日期:2004-01-01 00:00:00