Association of Hematocrit and Red Blood Cell Transfusion with Outcomes in Infants Undergoing Norwood Operation.


:The objective of this study was to investigate the association between red blood cell (RBC) transfusion and hematocrit values with outcomes in infants undergoing Norwood operation. This study included infants ≤2 months of age who underwent Norwood operation with either a modified Blalock-Taussig shunt or a right ventricle-pulmonary artery shunt. Demographics, preoperative, operative, daily laboratory data, and postoperative variables were collected. The primary outcome measures evaluated included mortality, ICU length of stay, length of mechanical ventilation, and days to chest closure. The secondary outcome measures evaluated included lactate levels, estimated glomerular filtration rate, and inotrope score in the first 14 days after heart operation. Cox proportional hazard models were fitted to study the probability of study outcomes as a function of hematocrit values and RBC transfusions after operation. Eighty-nine patients qualified for inclusion. With a median hematocrit of 46 (IQR 44, 49), and a median RBC transfusion of 92 ml/kg (IQR 31, 384) in the first 14 days after operation, 81 (91 %) patients received RBC transfusions. A multivariable analysis adjusted for risk factors, including the age, weight, prematurity, cardiopulmonary bypass and cross-clamp time, and postoperative need for nitric oxide and dialysis, demonstrated no association between hematocrit and RBC transfusion with majority of study outcomes. This single-center study found that higher hematocrit values and increasing RBC transfusions are not associated with improved outcomes in infants undergoing Norwood operation.


Pediatr Cardiol


Pediatric cardiology


Gupta P,King C,Benjamin L,Goodhart T,Robertson MJ,Gossett JM,Pesek GA,DasGupta R




Has Abstract


2015-08-01 00:00:00












  • First case of intracardiac foregut cyst occurring in the left-ventricular outflow tract.

    abstract::An 11 day-old female infant underwent resection of a mass in the subaortic region secondary to critical aortic stenosis. At 3 months of age, recurrent severe left-ventricular outflow obstruction (LVOT) in the setting of heart failure prompted redo surgery, and the resected mass revealed an intracardiac foregut cyst, w...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Huang JH,Rudzinski ER,Minette MS,Langley SM

    更新日期:2013-01-01 00:00:00

  • Crossed pulmonary arteries: a report on 20 cases with an emphasis on the clinical features and the genetic and cardiac abnormalities.

    abstract::Crossed pulmonary arteries (CPAs) are a rare abnormality in which the ostium of the left pulmonary artery originates superior to the right pulmonary artery and to its right. Recognition of this rare pathology is important because it generally is accompanied by other congenital heart defects, extracardiac anomalies, an...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Babaoğlu K,Altun G,Binnetoğlu K,Dönmez M,Kayabey Ö,Anık Y

    更新日期:2013-01-01 00:00:00

  • Exercise stress echocardiography after childhood Ross surgery: functional outcome in 26 patients from a single institution.

    abstract::Adult studies suggest a better functional outcome after aortic valve replacement with a pulmonary autograft compared with mechanical or homograft valves. Little is known about functional results after Ross surgery in growing children. This study reports formal exercise stress echocardiographic data from 26 pediatric R...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Pauliks LB,Brian Clark J,Rogerson A,DiPietro A,Myers JL,Cyran SE

    更新日期:2012-06-01 00:00:00

  • Repair of coarctation of the aorta in children with Turner syndrome.

    abstract::Increased risk of perioperative hemorrhage has been described in patients with Turner syndrome and coarctation of the aorta. We have operated on 11 patients with Turner syndrome and coarctation of the aorta, two of whom developed bleeding. One patient died. End-to-end anastomosis was performed in all patients. Histolo...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Brandt B 3rd,Heintz SE,Rose EF,Ehrenhaft JL,Clark EB

    更新日期:1984-07-01 00:00:00

  • Failure of balloon dilatation in mid-cavity obstruction of the systemic venous atrium after the Mustard operation.

    abstract::Mid-cavity obstruction of the systemic venous atrium developed after the Mustard operation in a child with transposition of the great arteries. Balloon dilatation (BD) was performed twice, to a maximum theoretical transverse diameter of 18 mm. Each time obstruction was initially relieved, but recurred within months. T...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Waldman JD,Waldman J,Jones MC

    更新日期:1983-04-01 00:00:00

  • Truncus arteriosus: diagnostic accuracy, outcomes, and impact of prenatal diagnosis.

    abstract::Limited data exist on the impact of prenatal diagnosis and outcomes of fetal truncus arteriosus (TA). We sought to assess prenatal diagnostic accuracy and prenatal outcomes in fetuses with TA and compare postnatal outcomes in neonates with prenatally and postnatally diagnosed TA. Records were reviewed for patients dia...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Swanson TM,Selamet Tierney ES,Tworetzky W,Pigula F,McElhinney DB

    更新日期:2009-04-01 00:00:00

  • Left ventricular function and myocardial mass after aortic valvotomy in infancy.

    abstract::Eighteen of 25 survivors of aortic valvotomy in infancy were reinvestigated by cross-sectional echocardiography a mean of 7.5 (2.3-13.4) years after surgery. They had been operated at a median age of 38 (5-330) days. At the follow-up examination the gradient across the aortic valve was 41 +/- 19 (15-85) mmHg and the e...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Vogel M,Sebening F,Sauer U,Bühlmeyer K

    更新日期:1992-01-01 00:00:00

  • Prevalence of obesity among patients with congenital and acquired heart disease.

    abstract::Overweight and obesity rates have risen dramatically in the United States, with subsequent detrimental comorbidity risks. The rates for obesity among children with congenital and acquired heart disease have rarely been reported. A retrospective cross-sectional study was conducted to determine the prevalence of overwei...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Shustak RJ,McGuire SB,October TW,Phoon CK,Chun AJ

    更新日期:2012-01-01 00:00:00

  • Does treatment of patent ductus arteriosus with cyclooxygenase inhibitors affect neonatal regional tissue oxygenation?

    abstract::The effect of patent ductus arteriosus (PDA) treatment with cyclooxygenase (COX) inhibitors (indomethacin [INDO] and ibuprofen [IBU]) on regional oxygenation requires further clarification. The authors hypothesized that both INDO and IBU reduce regional tissue oxygenation in preterm neonates with PDA but that the risk...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Bhatt M,Petrova A,Mehta R

    更新日期:2012-12-01 00:00:00

  • Surgical Timing and Outcomes of Unilateral Versus Bilateral Superior Cavopulmonary Anastomosis: An Analysis of Pediatric Heart Network Public Databases.

    abstract::Requiring bilateral superior cavopulmonary anastomosis (bSCPA) instead of unilateral superior cavopulmonary anastomosis (uSCPA) could influence surgical timing and outcomes. We compared surgical timing and outcomes for patients who underwent uSCPA to those who underwent bSCPA through use of the Pediatric Heart Network...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Shuler JM,Statile C,Heydarian H,Lehenbauer DG,Hill GD

    更新日期:2021-01-08 00:00:00

  • Cardiac regeneration in children.

    abstract::Very young mammals have an impressive cardiac regeneration capacity. In contrast, cardiac regeneration is very limited in adult humans. The hearts of young children have a higher regenerative capacity compared with adults, as, for example, seen after surgical correction of an anomalous left coronary artery arising fro...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审


    authors: Rupp S,Schranz D

    更新日期:2015-04-01 00:00:00

  • Ventricular performance after surgery for a congenital heart defect as assessed using advanced echocardiography: from doppler flow to 3D echocardiography and speckle-tracking strain imaging.

    abstract::A varying degree of impairment of ventricular performance is observed over the long-term after surgery for a congenital heart defect (CHD). Impaired ventricular performance has been shown to be of prognostic value for increased risk of cardiovascular events in adult CHD patients. This emphasizes the importance of deli...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审


    authors: Klitsie LM,Roest AA,Blom NA,ten Harkel AD

    更新日期:2014-01-01 00:00:00

  • Study on Maternal SNPs of MTHFR Gene and HCY Level Related to Congenital Heart Diseases.

    abstract::The aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Shi H,Yang S,Lin N,Huang P,Yu R,Chen M,Wang L,Jiang Z,Sun X

    更新日期:2020-11-21 00:00:00

  • Morphometric analysis of myocardial bridges in children with ventricular hypertrophy.

    abstract::The nuclear cross-sectional area of the muscular fibers from a series of myocardial bridges was analyzed and compared to both the adjacent and underlying myocardial fibers. The series came from 12 hearts of children, ranging in age from 24 h to 2 years, with diverse forms of congenital heart disease, which caused left...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Reig J,Ruiz de Miguel C,Moragas A

    更新日期:1990-10-01 00:00:00

  • Aortic coarctation associated with alveolar capillary dysplasia and misalignment of the pulmonary veins.

    abstract::After surgical repair of an aortic coarctation a term infant presented with severe pulmonary hypertension and cyanosis unresponsive to treatment including extracorporeal membrane oxygenation. The atypical clinical course became apparent once the accompanying diagnosis of congenital alveolar capillary dysplasia with mi...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Gamillscheg A,Zobel G,Spuller E,Reiterer F,Beitzke A

    更新日期:2008-01-01 00:00:00

  • Cardiovascular magnetic resonance imaging for intensive care infants: safe and effective?

    abstract:BACKGROUND:Cardiac magnetic resonance imaging (MRI) is an important diagnostic tool for congenital heart disease (CHD), as reflected by class 1 recommendations for the use of cardiac MRI by various consensus panels. However, little is known about the safety and clinical utility of cardiac MRI for these critically ill i...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Sarikouch S,Schaeffler R,Körperich H,Dongas A,Haas NA,Beerbaum P

    更新日期:2009-02-01 00:00:00

  • Echocardiographic evaluation of systolic and diastolic function in postoperative coarctation patients.

    abstract::Postoperative coarctation (CoA) patients are often found to have signs of persistent myocardial dysfunction. M-mode echocardiography was performed to study left ventricular (LV) size, mass, and systolic function and Doppler ultrasonography to study LV filling and flow velocity in the LV outflow tract and aorta in 28 "...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Sigurdardóttir LY,Helgason H

    更新日期:1997-03-01 00:00:00

  • Pain management after surgery for single-ventricle palliation using the hybrid approach.

    abstract::The hybrid pathway for the management of patients with hypoplastic left heart syndrome was pioneered at our institution and is the preferred approach compared with the traditional Norwood pathway. Patients undergoing this surgery are generally <6 months of age, and pain management in this age group after surgery for c...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Naguib AN,Dewhirst E,Winch PD,Simsic J,Galantowicz M,Tobias JD

    更新日期:2012-10-01 00:00:00

  • The wandering pacemaker: intraperitoneal migration of an epicardially placed pacemaker and femoral nerve stimulation.

    abstract::A premature child with congenital complete heart block had an epicardial single-chamber pacemaker implanted at 2 days of age. At 21 months of age, while sitting or standing, the patient's right anterior thigh muscles contracted at her pulse rate. Surgical exploration revealed a free-floating pacemaker in her peritoneu...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Salim MA,DiSessa TG,Watson DC

    更新日期:1999-03-01 00:00:00

  • Feasibility of pulse oximetry screening for critical congenital heart disease at 2643-foot elevation.

    abstract::To evaluate the feasibility of implementing a pulse oximetry screening protocol at a city of mild elevation with a specific focus on the false-positive screening rate. Pulse oximetry screening was performed according to the proposed guidelines endorsed by the American Academy of Pediatrics at a center in Tucson, AZ, a...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Han LM,Klewer SE,Blank KM,Seckeler MD,Barber BJ

    更新日期:2013-01-01 00:00:00

  • Acute pulmonary vasodilator testing with inhaled treprostinil in children with pulmonary arterial hypertension.

    abstract::Acute pulmonary vasodilator testing (AVT) is essential to determining the initial therapy for children with pulmonary arterial hypertension (PAH). This study aimed to report the initial experience with inhaled treprostinil used for AVT in children with PAH and to evaluate the hemodynamic change after inhaled treprosti...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Takatsuki S,Parker DK,Doran AK,Friesen RH,Ivy DD

    更新日期:2013-04-01 00:00:00

  • Interrupted aortic arch in infancy: a 10-year experience.

    abstract::Fifty infants with interrupted aortic arch (IAA), admitted between 1979 and 1988, were reviewed. They usually presented early in severe cardiac failure or shock. In the initial 5-year period, 17 of the 21 infants underwent diagnostic or confirmatory cardiac catheterization, in contrast with the latter 5 years when onl...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Menahem S,Rahayoe AU,Brawn WJ,Mee RB

    更新日期:1992-10-01 00:00:00

  • Congenital malformations of the tricuspid valve in siblings.

    abstract::The occurrence of familial heart disease in association with tricuspid atresia is rare. The first reported instance of tricuspid atresia and Ebstein's anomaly in siblings is presented. The presence of these two distinct pathologic variants of tricuspid valve malformations in siblings suggests that these malformations ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Grant JW

    更新日期:1996-09-01 00:00:00

  • Can Abbreviated Cardiac Magnetic Resonance Imaging Adequately Support Clinical Decision Making After Repair of Tetralogy of Fallot?

    abstract::Quantification of pulmonary regurgitation (PR), pulmonary flow distribution, and ventricular function is important for clinical surveillance in repaired Tetralogy of Fallot (TOF). Cardiovascular magnetic resonance (CMR) is the established reference, but cost, test duration, and patient discomfort are potential limitat...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: House AV,Muthurangu V,Spanel AJ,Danford DA,Mir B,Schuster A,Hsu H,Kutty S

    更新日期:2019-03-01 00:00:00

  • Closure of symptomatic ventricular septal defects: how early is too early?

    abstract::With improvements in technology and surgical technique, pediatric cardiologists are challenging surgeons to close symptomatic ventricular septal defects (VSDs) in ever smaller patients. Although delaying surgery may facilitate operative repair, early intervention decreases the period of time these patients require the...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kogon B,Butler H,Kirshbom P,Kanter K,McConnell M

    更新日期:2008-01-01 00:00:00

  • Ventricular repolarisation during exercise challenge occurring late after Kawasaki disease.

    abstract::Exercise testing can highlight repolarisation abnormalities in adults with coronary artery disease. Late after Kawasaki disease (KD), increased QT dispersion (QTd) has been reported on resting ECG in children, but there are no reported studies of QTd during exercise. Our objective was to determine the pattern of QTd r...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Gravel H,Dahdah N,Fournier A,Mathieu MÈ,Curnier D

    更新日期:2012-06-01 00:00:00

  • Superoinferior ventricles with criss-cross atrioventricular connections and intact ventricular septum.

    abstract::We report a 6-year-old girl with superoinferior ventricles, criss-cross atrioventricular (AV) relationships with solitus atria, a D-loop, L-transposition of the great arteries, subpulmonary stenosis, but without a ventricular septal defect (VSD). The diagnosis was made by echocardiographic examination and was strength...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Alday LE,Juaneda E

    更新日期:1993-10-01 00:00:00

  • Tissue Doppler echocardiography before and after the surgical reconstruction of an insufficient mitral valve in a patient with Fontan circulation.

    abstract::We report a patient with tricuspid atresia after total cavopulmonary connection who developed significant mitral valve regurgitation. Doppler myocardial echocardiography tracings showed "pseudonormalization" of diastolic velocities. After successful surgical reconstruction of the mitral valve, the diastolic myocardial...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Petzuch K,Eicken A,Marek J,Vogel M,Schreiber C,Hess J

    更新日期:2006-07-01 00:00:00

  • Use of the myocardial performance index to assess right ventricular function in infants with pulmonary hypertension.

    abstract:BACKGROUND:This study aimed to measure and compare right ventricular (RV) function in normal infants and those with pulmonary hypertension (PHT) using the myocardial performance index (RVMPI) and to investigate the relationship between RV function and pulmonary artery pressure. METHODS:A case-control study measured RV...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Patel N,Mills JF,Cheung MM

    更新日期:2009-02-01 00:00:00

  • Relationship of Right Ventricular Size and Function with Respiratory Status in Duchenne Muscular Dystrophy.

    abstract::The relationship between pulmonary function and right ventricle (RV) in Duchenne muscular dystrophy (DMD) has not been evaluated. Using cardiac magnetic resonance (CMR), we describe the relationship of RV size and function with spirometry in a DMD cohort. Fifty-seven boys undergoing CMR and pulmonary function testing ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Mehmood M,Ambach SA,Taylor MD,Jefferies JL,Raman SV,Taylor RJ,Sawani H,Mathew J,Mazur W,Hor KN,Al-Khalidi HR

    更新日期:2016-06-01 00:00:00