Association of Hematocrit and Red Blood Cell Transfusion with Outcomes in Infants Undergoing Norwood Operation.


:The objective of this study was to investigate the association between red blood cell (RBC) transfusion and hematocrit values with outcomes in infants undergoing Norwood operation. This study included infants ≤2 months of age who underwent Norwood operation with either a modified Blalock-Taussig shunt or a right ventricle-pulmonary artery shunt. Demographics, preoperative, operative, daily laboratory data, and postoperative variables were collected. The primary outcome measures evaluated included mortality, ICU length of stay, length of mechanical ventilation, and days to chest closure. The secondary outcome measures evaluated included lactate levels, estimated glomerular filtration rate, and inotrope score in the first 14 days after heart operation. Cox proportional hazard models were fitted to study the probability of study outcomes as a function of hematocrit values and RBC transfusions after operation. Eighty-nine patients qualified for inclusion. With a median hematocrit of 46 (IQR 44, 49), and a median RBC transfusion of 92 ml/kg (IQR 31, 384) in the first 14 days after operation, 81 (91 %) patients received RBC transfusions. A multivariable analysis adjusted for risk factors, including the age, weight, prematurity, cardiopulmonary bypass and cross-clamp time, and postoperative need for nitric oxide and dialysis, demonstrated no association between hematocrit and RBC transfusion with majority of study outcomes. This single-center study found that higher hematocrit values and increasing RBC transfusions are not associated with improved outcomes in infants undergoing Norwood operation.


Pediatr Cardiol


Pediatric cardiology


Gupta P,King C,Benjamin L,Goodhart T,Robertson MJ,Gossett JM,Pesek GA,DasGupta R




Has Abstract


2015-08-01 00:00:00












  • Increasing Burden of Lyme Carditis in United States Children's Hospitals.

    abstract::We sought to characterize the shifting epidemiology and resource utilization of Lyme disease and associated carditis in US children's hospitals. We hypothesized that the Lyme carditis burden has increased and that hospitalizations for Lyme carditis are costlier than those for Lyme disease without carditis. The PHIS da...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Beach CM,Hart SA,Nowalk A,Feingold B,Kurland K,Arora G

    更新日期:2020-02-01 00:00:00

  • Successful management of isolated ventricular inversion in an adult.

    abstract::We report a case of isolated ventricular inversion in a 42-year-old woman. This rare congenital cardiac anomaly was corrected by an intraatrial baffle procedure. She also underwent left-sided double-chamber endocardial pacemaker implantation for postoperative tachycardia bradycardia syndrome. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kannan BR,Kamath KP,Rao SG,Kumar RK

    更新日期:2004-09-01 00:00:00

  • Magnetic resonance imaging of unroofed coronary sinus: three cases.

    abstract::Unroofed coronary sinus is a rare cardiac anomaly in which communication occurs between the coronary sinus and the left atrium due to the partial or complete absence of the roof of the coronary sinus. It is usually associated with other cardiovascular anomalies, especially persistent left superior vena cava. It is oft...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Hahm JK,Park YW,Lee JK,Choi JY,Sul JH,Lee SK,Cho BK,Choe KO

    更新日期:2000-07-01 00:00:00

  • Secondary residual shunt after atrial septal defect closure with an amplatzer occluder: surgical removal and evaluation of device biocompatibility after 7 years.

    abstract::Interventional occluder implantation has become the preferred mode of treatment in children with clinically significant atrial septal defect (ASD). The continuous increase in the number of patients treated calls for long-term data on device integrity and biocompatibility. We report a child who underwent successful int...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Zhu W,Neubauer H

    更新日期:2010-10-01 00:00:00

  • Pulse-oximetry screening to detect critical congenital heart disease in the neonatal intensive care unit.

    abstract::The current pulse-oximetry screening (POS) protocol for detection of critical congenital heart defects (CCHDs) is recommended only for newborns in well-infant and intermediate care nurseries, and there is no evidence-based protocol for infants discharged from the neonatal intensive care unit (NICU). The objectives of ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Iyengar H,Kumar P,Kumar P

    更新日期:2014-03-01 00:00:00

  • Prevalence of Coronary Artery Disease Risk Factors and Metabolic Syndrome in Children with Heart Disease.

    abstract::Children with acquired and congenital heart disease (CHD) are increasingly surviving to adulthood. Our aim was to determine the prevalence of coronary artery disease (CAD) risk factors in children at known risk for early CAD or with severe CHD. We recruited children (8-19 years) at risk for early CAD-Kawasaki disease ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Ware AL,Young PC,Weng C,Presson AP,Minich LL,Menon SC

    更新日期:2018-02-01 00:00:00

  • Defibrillator implantation in a child with long QT syndrome.

    abstract::We report the placement of an implantable cardiac defibrillator as preventative treatment in a 2-year-old with long QT syndrome. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Brachlow A,Bell M

    更新日期:2004-07-01 00:00:00

  • Inferior sinus venosus defects: anatomic features and echocardiographic correlates.

    abstract::Inferior sinus venosus defects (SVDs) are rare imperfections located in the inferior portion of the atrial septum, leading to an overriding inferior vena cava (IVC) and an interatrial connection. These defects have increased risk of anomalous pulmonary venous return (PAPVR) and often are confused with secundum atrial ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Plymale J,Kolinski K,Frommelt P,Bartz P,Tweddell J,Earing MG

    更新日期:2013-02-01 00:00:00

  • Elevated Troponin in the First 72 h of Hospitalization for Pediatric Viral Myocarditis is Associated with ECMO: An Analysis of the PHIS+ Database.

    abstract::Serum troponin (Tn) is often elevated in viral myocarditis; however, its prognostic significance is unknown. We tested the hypothesis that abnormal serum Tn is associated with mortality in children hospitalized with myocarditis. We retrospectively studied data from six large children's hospitals participating in the P...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Butto A,Rossano JW,Nandi D,Ravishankar C,Lin KY,O'Connor MJ,Shaddy RE,Shamszad P

    更新日期:2018-08-01 00:00:00

  • Transposition of Great Arteries with Complex Coronary Artery Variants: Time-Related Events Following Arterial Switch Operation.

    abstract::Coronary artery anatomy represents a challenging and, often, determining predictor of outcome in an arterial switch operation (ASO). Impact of specific coronary artery variants, such as single, intramural and inverted, on time-related events following ASO, is, yet, to be determined. We sought to compare early and late...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Al Anani S,Fughhi I,Taqatqa A,Elzein C,Ilbawi MN,Polimenakos AC

    更新日期:2017-03-01 00:00:00

  • Ventricular inversion and tricuspid atresia (VITA complex): long survival without surgical treatment.

    abstract::Five patients with ventricular inversion, corrected transposition of the great arteries, and atresia of the left-sided atrioventricular (tricuspid) valve have been observed. Three patients died in infancy, two had large interatrial communications, one with an early stage of arterial-type hypertensive pulmonary vascula...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Tazelaar HD,Moore GW,Hutchins GM

    更新日期:1986-01-01 00:00:00

  • Extracorporeal membrane oxygenation in children with heart disease and down syndrome: a multicenter analysis.

    abstract::The data on the outcomes of children with heart disease and Down syndrome receiving extracorporeal membrane oxygenation (ECMO) for cardiac or respiratory failure are limited. This study aimed to evaluate morbidity and mortality associated with ECMO in children with Down syndrome and heart disease. Children younger tha...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,多中心研究


    authors: Gupta P,Gossett JM,Rycus PT,Prodhan P

    更新日期:2014-12-01 00:00:00

  • An old autopsy report sheds light on a "new" disease: infantile polyarteritis nodosa and kawasaki disease.

    abstract::Although Kawasaki disease (KD) was first discovered and identified in Japan by Kawasaki in the 1960s, fatal KD cases resulting from coronary artery aneurysms had been identified retrospectively in the West as early as 1871. Kawasaki initially postulated that this disease was a new, as yet unidentified, self-limiting i...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kushner HI,Abramowsky CR

    更新日期:2010-05-01 00:00:00

  • Ultrasound assessment of ductal closure, pulmonary blood flow velocity, and systolic pulmonary arterial pressure in healthy neonates.

    abstract::Ultrasound Doppler was used to establish time of ductal closure, normal values for blood flow velocity in the pulmonary artery (PA), and time interval between pulmonary valve closure (Pc) and tricuspid valve opening (To) in 37 healthy neonates. Ductal closure had occurred in 23% of the children within 12 h after deliv...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Freund M,Wranne B

    更新日期:1986-01-01 00:00:00

  • Cor triatriatum with unroofed coronary sinus and persistent left superior vena cava associated with atrial tachycardia.

    abstract::A 2-year-old girl with cor triatriatum with unroofed coronary sinus and persistent left superior vena cava underwent preoperative radiofrequency catheter ablation for atrial tachycardia attack that developed after admission to our hospital. The procedure was not successful. Cryoablation was successfully performed duri...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Sato T,Suzuki K,Umemura J,Takahashi Y,Tomimoto K

    更新日期:2003-09-01 00:00:00

  • Initial Observations of the Effects of Calcium Chloride Infusions in Pediatric Patients with Low Cardiac Output.

    abstract::Myocardial contractility and relaxation are highly dependent on calcium homeostasis. Immature myocardium, as in pediatric patients, is thought to be more dependent on extracellular calcium for optimal function. For this reason, intravenous calcium chloride infusions may improve myocardial function in the pediatric pat...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Averin K,Villa C,Krawczeski CD,Pratt J,King E,Jefferies JL,Nelson DP,Cooper DS,Ryan TD,Sawyer J,Towbin JA,Lorts A

    更新日期:2016-03-01 00:00:00

  • The Pediatric Heart Failure Workforce: An International, Multicenter Survey.

    abstract::Our objective was to understand the scope of pediatric heart failure (HF) and the current staffing environment of HF programs. An online survey was distributed to members of the Pediatric Heart Transplant Study and the Pediatric Council of the International Society for Heart and Lung Transplantation. All participants ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,多中心研究


    authors: Auerbach SR,Everitt MD,Butts RJ,Rosenthal DN,Law YM

    更新日期:2018-02-01 00:00:00

  • Exercise Capacity in Asymptomatic Adult Patients Treated for Coarctation of the Aorta.

    abstract::A reduced exercise capacity is a common finding in adult congenital heart disease and is associated with cardiovascular morbidity and mortality. However, data on exercise capacity in patients after repair of coarctation of the aorta (CoA) are scarce. Furthermore, a high rate of exercise-induced hypertension has been d...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Dijkema EJ,Sieswerda GT,Breur JMPJ,Haas F,Slieker MG,Takken T

    更新日期:2019-10-01 00:00:00

  • Morbidities in patients with hypoplastic left heart syndrome.

    abstract::We sought to document morbidities and growth for patients with hypoplastic left heart syndrome (HLHS) to inform the initial surgical decision and understand healthcare needs. Data were obtained on 137 patients with HLHS, born between 1989 and 1994, who survived staged surgery ( n = 62) or transplantation ( n = 75) and...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,多中心研究


    authors: Jenkins PC,Flanagan MF,Jenkins KJ,Sargent JD,Canter CE,Chinnock RE,Vincent RN,O'Connor GT

    更新日期:2004-01-01 00:00:00

  • Nesiritide for the treatment of pulmonary hypertension and cor pulmonale in an infant.

    abstract::Nesiritide is a synthetic form of B-type natriuretic peptide. It is approved for the treatment of acute exacerbations of congestive heart failure in hospitalized adult patients. It is currently under investigation for use in other settings and other patient populations. This article describes administration of nesirit...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Reynolds EW,Conely ET,Vranicar M

    更新日期:2007-05-01 00:00:00

  • Echocardiographic predictors of early postsurgical myocardial dysfunction in pediatric patients with aortic valve insufficiency.

    abstract::In chronic aortic insufficiency (AI), left-ventricular (LV) dysfunction must be detected early to allow timely surgery. Strain and strain rate have been used for this purpose in adults, but the value of this method in pediatric AI has not been established. Forty patients with moderate to severe AI were included in thi...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Lowenthal A,Tacy TA,Behzadian F,Punn R

    更新日期:2013-08-01 00:00:00

  • Pattern of recovery for transient complete heart block after open heart surgery for congenital heart disease: duration alone predicts risk of late complete heart block.

    abstract::Transient complete heart block (TCHB) is defined as complete interruption of atrioventricular conduction (AVC) after cardiac surgery followed by return of conduction. This study aimed to assess the risk for the development of late complete heart block (LCHB) after recovery of TCHB and to examine the electrocardiograph...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Aziz PF,Serwer GA,Bradley DJ,LaPage MJ,Hirsch JC,Bove EL,Ohye RG,Dick M 2nd

    更新日期:2013-04-01 00:00:00

  • IL10 Promoter Polymorphisms are Associated with Rheumatic Heart Disease in Saudi Arabian Patients.

    abstract::Rheumatic heart disease (RHD) is an inflammatory disease that develops following streptococcal infections. IL10 helps to balance immune responses to pathogens. IL10 polymorphisms have been associated with RHD, although results remain inconclusive. Our aim was to investigate the association between IL10 polymorphisms a...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Abdallah AM,Alnuzha A,Al-Mazroea AH,Eldardear AE,AlSamman AY,Almohammadi Y,Al-Harbi KM

    更新日期:2016-01-01 00:00:00

  • Prognostic Value of Serum Apelin Level in Children with Heart Failure Secondary to Congenital Heart Disease.

    abstract::Apelin is an endogenous inotrope that decreased in heart failure (HF). We aimed to evaluate the prognostic value of its level in children with HF due to congenital heart disease (CHD). Sixty children with HF due to CHD were included as a patient group. Sixty healthy children matched for age, sex, and weight served as ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: El Amrousy D,El-Mahdy H

    更新日期:2018-08-01 00:00:00

  • Percutaneous closure of ventricular septal defect associated with tunnel-shaped aneurysm using the Amplatzer duct occluder.

    abstract::Different devices have been used for percutaneous closure of ventricular septal defects (VSDs). Over the past 6 months, we have used the Amplatzer duct occluder for VSDs associated with tunnel-shaped aneurysm in three patients here at our institution. Due to the anatomic resemblance between such VSDs and the duct occl...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Dilawar M,Numan M,El-Sisi A,Gendi SM,Ahmad Z

    更新日期:2008-03-01 00:00:00

  • Nomenclature and databases - the past, the present, and the future : a primer for the congenital heart surgeon.

    abstract::This review discusses the historical aspects, current state of the art, and potential future advances in the areas of nomenclature and databases for congenital heart disease. Five areas will be reviewed: (1) common language = nomenclature, (2) mechanism of data collection (database or registry) with an established uni...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审


    authors: Jacobs JP,Mavroudis C,Jacobs ML,Maruszewski B,Tchervenkov CI,Lacour-Gayet FG,Clarke DR,Gaynor JW,Spray TL,Kurosawa H,Stellin G,Ebels T,Bacha EA,Walters HL 3rd,Elliott MJ

    更新日期:2007-03-01 00:00:00

  • Trends in Infant Mortality After TAPVR Repair over 18 Years in Texas and Impact of Hospital Surgical Volume.

    abstract::For some congenital heart lesions, higher institutional surgical volume has been associated with better survival than in lower volume centers. The relationship between institutional surgical volume and mortality in infants after total anomalous pulmonary vein return (TAPVR) repair has not been well explored. The Texas...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Lahiri S,Wang Y,Caldarone CA,Morris SA

    更新日期:2020-01-01 00:00:00

  • Concordance of measures of left-ventricular hypertrophy in pediatric hypertension.

    abstract::The American Academy of Pediatrics (AAP) recommends that any child diagnosed with hypertension have an echocardiogram to evaluate for the presence of left-ventricular (LV) hypertrophy (LVH) and advocates that LVH is an indication to initiate or intensify antihypertensive therapy. However, there is no consensus on the ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Mirchandani D,Bhatia J,Leisman D,Kwon EN,Cooper R,Chorny N,Frank R,Infante L,Sethna C

    更新日期:2014-04-01 00:00:00

  • Partial absence of the left parietal pericardium with herniation of the left atrial appendage: diagnosis by cross-sectional echocardiography and contrast-enhanced computed tomography.

    abstract::This report describes the use of cross-sectional imaging--echocardiography and contrast-enhanced computed tomography--to confirm the presence of a foramen-type defect of the left pericardium with herniation of the left atrial appendage. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Burrows PE,Smallhorn JS,Trusler GA,Daneman A,Moes CA,Rowe RD

    更新日期:1987-01-01 00:00:00

  • Left-ventricular noncompaction in a pediatric population: predictors of survival.

    abstract::Left-ventricular noncompaction (LVNC) is an echocardiographic finding of increasing frequency in pediatrics; however, predictors of outcomes have been difficult to identify. We conducted a retrospective review of pediatric patients at the Morgan Stanley Children's Hospital of New York from January of 1993 to September...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Zuckerman WA,Richmond ME,Singh RK,Carroll SJ,Starc TJ,Addonizio LJ

    更新日期:2011-04-01 00:00:00