Abstract：
:In other cardiomyopathies, cardiac magnetic resonance imaging (CMR)-derived myocardial delayed enhancement (MDE), a marker of myocardial fibrosis, is a risk factor for sudden cardiac death (SCD). In Duchenne muscular dystrophy (DMD), the prognostic value of MDE for ventricular arrhythmias and death is unknown. This study aimed to evaluate associations between MDE and electrocardiographic (ECG) changes, ventricular remodeling, risk of arrhythmias, and death in DMD. This retrospective study included all subjects with DMD who had undergone a CMR between January 2006 and December 2011 and had available ECG and 24-h Holter records from the same period. Left ventricular (LV) MDE was semiquantitatively graded from 0 to 4. Comparisons of demographic and clinical characteristics between MDE and no-MDE groups were made. Cox regression analysis was performed to assess factors associated with death. This study investigated 32 boys with a median age of 13.8 years (range, 7.2-17.4 years) and found MDE present in 25 (78 %) of the boys. Compared with the no-MDE subjects, the MDE subjects were older (15.7 ± 3.3 vs 12.1 ± 4.8 years) and had a wider QT dispersion (QTd: 74 ± 30 vs 55 ± 33 ms), a higher incidence of ventricular tachycardia (40 vs 0 %), a lower LV ejection fraction (46 ± 12 vs 56 ± 9 %), a larger LV end-diastolic volume (124 ± 58 vs 68 ± 14 ml/m(2)), and a larger end-systolic volume (57 ± 29 vs 28 ± 10 ml/m(2)) (p < 0.05 for all). During the study period, six of the subjects (19 %) died. The factors associated with mortality were increased age, advanced grade of MDE, higher LV end-systolic volume, lower LV ejection fraction, use of beta-blockers, and ventricular tachycardia. Myocardial fibrosis detected by CMR is an independent predictor of adverse cardiac remodeling, ventricular arrhythmias, and death in DMD. Cardiac MRI using MDE can be applied as a screening tool to detect patients at risk for ventricular arrhythmias, more advanced disease, adverse LV remodeling, and death.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Menon SC,Etheridge SP,Liesemer KN,Williams RV,Bardsley T,Heywood MC,Puchalski MDdoi
10.1007/s00246-014-0929-zsubject
Has Abstractpub_date
2014-10-01 00:00:00pages
1279-85issue
7eissn
0172-0643issn
1432-1971journal_volume
35pub_type
杂志文章abstract：:Vitamin D has anti-inflammatory properties, and deficiency is prevalent in children. There is a paucity of data regarding vitamin D status and its correlation with low-grade inflammation and vasculature. We prospectively enrolled 25 children, 9-11 years old (13 male); 21 obese. Eight atherosclerosis-promoting risk fac...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1162-0
更新日期：2015-10-01 00:00:00
abstract：:An aneurysm of the fossa ovalis was identified at autopsy in 17 infants. In each case the aneurysm of the fossa ovalis was considered to have resulted from excessive elevation of pressure in that atrium contralateral to the side into which the aneurysm bulged. The aneurysms were divided into two types: intrinsic (thre...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02282740
更新日期：1985-01-01 00:00:00
abstract：:Atherosclerotic cardiovascular disease (CVD), a leading cause of death globally, has origins in childhood. Major risk factors include family history of premature CVD, dyslipidemia, diabetes mellitus, and hypertension. Lipoprotein (a) [Lp(a)], an inherited lipoprotein, is associated with premature CVD, but its impact o...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-1927-3
更新日期：2018-12-01 00:00:00
abstract：:Transcatheter pulmonary valve implantation in the setting of right ventricle-to-pulmonary artery conduit dysfunction is a relatively new procedure with encouraging early and midterm results. Malpositioning of the valve during implantation is a potentially serious complication. This report describes a case in which val...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0224-9
更新日期：2012-06-01 00:00:00
abstract：:The nuclear cross-sectional area of the muscular fibers from a series of myocardial bridges was analyzed and compared to both the adjacent and underlying myocardial fibers. The series came from 12 hearts of children, ranging in age from 24 h to 2 years, with diverse forms of congenital heart disease, which caused left...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02238364
更新日期：1990-10-01 00:00:00
abstract：:Pediatric primary cardiomyopathy is rare but serious, having high mortality; hypertrophic and dilated types are the most common. Its etiology has been mainly considered idiopathic; however, next generation sequencing techniques have revealed nearly half of idiopathic pediatric cases arose from specific genetic mutatio...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02240-x
更新日期：2020-01-01 00:00:00
abstract：:We report a newborn with a congenital aneurysm of the muscular interventricular septum, a conduction system abnormality involving variable left and right bundle branch block, and an abnormality of the short arm of chromosome 20, This combination of anomalies has not been previously reported. To date, the infant has pr...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0928-6
更新日期：2007-01-01 00:00:00
abstract：:This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via n...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-010-9877-4
更新日期：2011-03-01 00:00:00
abstract：:Congenital aneurysms of the thoracic venous system are rare. In particular, innominate venous aneurysms are extremely rare. We describe a 16-year-old girl whose chest x-ray suggested a mediastinal tumor. Three-dimensional contrast-enhancement magnetic resonance venography showed a giant sacciform aneurysm of the left ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0499-y
更新日期：2004-07-01 00:00:00
abstract：:Apelin is an endogenous inotrope that decreased in heart failure (HF). We aimed to evaluate the prognostic value of its level in children with HF due to congenital heart disease (CHD). Sixty children with HF due to CHD were included as a patient group. Sixty healthy children matched for age, sex, and weight served as ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-1879-7
更新日期：2018-08-01 00:00:00
abstract：:This study examined the age-related criteria of signal-averaged electrocardiographic (SA-ECG) parameters in children. SA-ECGs were obtained in 82 healthy volunteers in six groups depending on age (group 1: 1 day to < 1 month; group 2: 1 month to < 1 year; group 3: 1 to < 6 years; group 4: 6 to < 12 years; group 5: 12 ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00796320
更新日期：1994-05-01 00:00:00
abstract：:Near-infrared spectroscopy (NIRS) can monitor changes in cerebral regional oxygen saturation (rSO2) and tissue hemoglobin content (HbT). The relation between cerebral NIRS readings and vital parameters has not been analyzed before at a fine temporal scale. This study analyzed this relation during cardiopulmonary bypas...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0754-9
更新日期：2014-01-01 00:00:00
abstract：:The timing of pulmonary valve replacement (PVR) in asymptomatic patients with repaired tetralogy of Fallot (TOF) is typically based on cardiac magnetic resonance imaging-derived ventricular volume measurements. Current criteria do not account for sex-based differences in chamber size. The purpose of this study was to ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02181-5
更新日期：2019-10-01 00:00:00
abstract：:Systemic candidiasis developed in a seven-week-old premature baby after 6 weeks treatment with antibiotics for suspected septicemia. At that time the echocardiogram showed a dense layer of echoes posteriorly to the anterior tricuspid leaflet during atrial systole. The diagnosis of Candida endocarditis with vegetations...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02281007
更新日期：1983-01-01 00:00:00
abstract：:Previous studies have indicated the importance of allometric scaling of VO2max for body size. However, no information is available on adjusting maximal cardiac output (Qmax) and stroke volume (SVmax) for body dimensions. The allometric exponent b was determined for the equation Y = aXb (where Y is the physiological ou...
journal_title：Pediatric cardiology
pub_type： 临床试验,杂志文章
doi：10.1007/s002460010102
更新日期：2000-09-01 00:00:00
abstract：:A 16-year-old boy with anomalous origin of the left coronary artery from the pulmonary artery, Bland-White-Garland syndrome, underwent a mammary artery bypass grafting to the left coronary artery (LCA) together with closure of the stenosed origin of the left coronary artery. A residual LCA to pulmonary artery fistula ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469910028
更新日期：2000-03-01 00:00:00
abstract：:In 810 schoolchildren (aged 5-14 years) the prevalence of a grade 1-3/6 vibratory innocent heart murmur (VIHM) is 41%. Restricted to a grade 2 or 3 VIHM, the prevalence is 14%, decreasing from 21% in the age-class 5-6 years to 8% for children 13-14 years of age. The prevalence of a grade 3 VIHM is 1%. Together with a ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00798120
更新日期：1994-11-01 00:00:00
abstract：:Calculating pulmonary vascular resistance is important in many fields of medicine. Although the influence of hematocrit on calculated resistance has been known for many years, it is rare to find the appropriate corrections in published articles. This review discusses the relationship between viscosity and resistance a...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-011-9954-3
更新日期：2011-06-01 00:00:00
abstract：:The observation that endocardial fibroelastosis (EFE) can result from an immune response to maternal autoantibody deposition in the fetal myocardium raises the possibility that the fetal immune system may contribute to the pathogenesis of idiopathic EFE and dilated cardiomyopathy (DCM). This study sought to characteri...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-9980-1
更新日期：2011-12-01 00:00:00
abstract：:A two-year-old child who had had palliative surgery as a neonate for an absent right atrioventricular connection and double-inlet ventricle was shown to be developmentally retarded. Trisomy for the short arm of chromosome 8 was demonstrated, resulting from a familial 8:13 translocation, with a high risk of recurrence....
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02306750
更新日期：1984-01-01 00:00:00
abstract：:The Norwood procedure with a modified Blalock-Taussig shunt (MBTS) is the first of the three-stage surgical palliation for infants with hypoplastic left heart syndrome. We report a patient with schistocytic hemolytic anemia that developed following a right MBTS with a Gore-Tex graft. Hemolysis associated with a MBTS h...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-006-1410-4
更新日期：2007-05-01 00:00:00
abstract：:The epidemiologic data for pediatric hypertrophic cardiomyopathy (HCM) needs to be periodically updated as diagnostic techniques and management strategies improve. Herein, the incidence, prevalence, and mortality rates of pediatric HCM in a population-based treatment system are described. Patients aged ≤ 17 years and ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02472-2
更新日期：2020-10-03 00:00:00
abstract：:Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a heritable cardiomyopathy characterized by fibro-fatty replacement of right ventricular myocardium. Diagnostic criteria, established in 1994 and modified in 2010, are based on predominately adult manifestations of ARVC/D. The goal of this paper is ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1327-x
更新日期：2016-04-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) is a powerful tool which enables the visualization of anatomy and the assessment of many physiological aspects of organ function. MRI and magnetic resonance angiography and magnetic resonance spectroscopy will play critical roles in cardiac applications during the next millennium. Thus...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469910003
更新日期：2000-01-01 00:00:00
abstract：:We present two term neonates in which intravenous indomethacin usage was associated with successful closure of a persistently patent arterial duct. Both children had congenital heart disease with high pulmonary blood flow following surgical placement of contralateral systemic-pulmonary artery shunts. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0886-z
更新日期：2005-09-01 00:00:00
abstract：:Rhabdomyoma is the most common primary cardiac tumor in infants and children and is often associated with tuberous sclerosis. Surgical resection may be indicated and, if so, is usually curative. We describe a rhabdomyoma in an infant who presented with severe myocardial ischemia necessitating orthotopic heart transpla...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00794197
更新日期：1995-07-01 00:00:00
abstract：:Long-term ECG is widely used in diagnosis and assessment of many cardiac symptoms which may be caused by dangerous arrhythmias that sometimes can be difficult to document. The PocketECG system is a new technological solution for a long-term, noninvasive, continuous and real-time ECG monitoring that provides automatic ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1534-0
更新日期：2017-03-01 00:00:00
abstract：:Routine use of intraoperative transesophageal echocardiography (TEE) is a safe monitoring and diagnostic method during pediatric congenital cardiac surgery. However, the question of whether intraoperative TEE is accurate and cost effective for patients with tetralogy of Fallot (TOF) has not been raised. This study aim...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0423-4
更新日期：2013-02-01 00:00:00
abstract：:Left atrial tumor, diagnosed as myxoma at first investigation, was later demonstrated to be a malignant fibrosarcoma with myxoid change. Myxoma should be diagnosed and managed carefully because of its wide range of histopathologic features. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010218
更新日期：2001-05-01 00:00:00
abstract：:This study is presented to identify and characterize the spectrum of the cardiovascular anomalies in children presenting with Williams-Beuren syndrome and cardiovascular anomalies at The Hospital for Sick Children, Toronto from 1966 to 1988. Forty-nine children were diagnosed and followed. The female to male ratio was...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02310569
更新日期：1991-10-01 00:00:00
