Abstract：
:Biopsies obtained from both the perilesional areas and clinically uninvolved skin of patients with pemphigus vulgaris (PV) were studied for antigen-presenting cell and lymphocyte phenotype and/or activation phenotype using monoclonal antibodies in avidin-biotin-peroxidase complex staining. Perilesional PV skin contained CD4+ and CD8+ T lymphocytes as the predominant cell type, but cells with a potential antigen-presenting function displaying CD11b phenotype of monocyte/macrophages and, in particular, CD1 phenotype of Langerhans cells were also present. The number of mononuclear inflammatory cells was greater in perilesional than in clinically uninvolved PV skin, and so were the proportions of CD4+, CD8+, CD25+, Ia+ cells (p less than 0.01), and CD1+ Langerhans cells and transferrin receptor positive cells (p less than 0.05). These findings confirm and extend earlier observations on local involvement of immunocompetent cells in PV.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Mashkilleyson N,Konttinen YT,Visa Ksubject
Has Abstractpub_date
1989-01-01 00:00:00pages
424-8issue
5eissn
0001-5555issn
1651-2057journal_volume
69pub_type
杂志文章abstract：:The expression of blood-group antigens was studied on human epidermal cultures used as allografts in 13 non-immunosuppressed patients treated for leg ulcers. The study was carried out using monoclonal antibodies to A and B antigens by an indirect immunofluorescence technique. Blood-group antigens are weakly expressed ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:BRAF and NRAS genetic analyses are time-consuming and can delay treatment choices in patients with metastatic melanomas presenting with acute deterioration. We compared the rapid, real-time, fully automated molecular diagnosis platform Idylla™ with next-generation sequencing (NGS) and immunohistochemistry for detectio...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2738
更新日期：2018-01-12 00:00:00
abstract：:A 45-year-old woman with solar urticaria is described. She was found to have: (a) increase of skin mast cells; (b) a good therapeutic response to hydroxyzine hydrochloride; (c) frequent peptic ulcers of the stomach; (d) antinuclear IgM antibodies in a titre of 1 : 1 000; (e) cold urticaria and dermographism; (f) anamn...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Peripheral blood T-cell subpopulations were evaluated in 32 patients affected by viral warts and in 32 unaffected individuals belonging to a control group. A significant decrease was found in total lymphocytes as well as OKT3 and OKT4 subsets among affected patients. A significant negative correlation was also found b...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:The forearm skin of 10 Caucasians and 10 American Negroes was inoculated with Candida albicans and the severity of the ensuing dermatitis as well as the population of Candida and other aerobes in the inoculum site have been assessed. Negroid skin proved to be less susceptible to irritation, even though it harboured a ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:To evaluate plasma lipid peroxidation and enzymatic and non-enzymatic antioxidant systems in patients with Behçet's disease, plasma malondialdehyde levels and total antioxidant status, erythrocyte superoxide dismutase and whole blood glutathione peroxidase activities were studied in 15 patients with active disease and...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550310003782
更新日期：2003-01-01 00:00:00
abstract：:The nature of the epidermal cellular infiltrate in pagetoid reticulosis is still subject to intense controversies. Using a panel of recently developed monoclonal antibodies against cell activation and proliferation associated antigens it was possible to demonstrate the activated state of numerous T cells within the le...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Squamous cell carcinomas (SCC) are the most frequent tumours complicating organ transplantation. Whereas most SCC can be successfully treated with conventional surgery, other lesions show an aggressive course with recurrence and metastases. We assessed the value of nuclear morphometry in detecting tumours with an ab i...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555577115117
更新日期：1997-03-01 00:00:00
abstract：:Erythema elevatum diutinum (EED) is a chronic disease with symmetrical persistent erythematous nodules and plaques primarily in an acral distribution. EED is often associated with infections, especially of streptococcals. An immunological reaction has been proposed as pathogenetic mechanism. We describe a patient, who...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Itch and pain are important attention-demanding sensations that allow adaptive responses to potential bodily harm. An attentional bias towards itch and pain stimuli, i.e. preferential attention allocation towards itch- and pain-related information, has been found in healthy, as well as patient groups. However, it rema...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3537
更新日期：2020-07-02 00:00:00
abstract：:The releasability of arachidonic acid-derived inflammatory mediators (eicosanoids) from peripheral blood leukocytes has been tested in patients with atopic eczema and healthy, non-atopic controls. Spontaneous and stimulated release of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and leukotriene C4 (LTC4) has been me...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The hairless mouse has been used as a model to distinguish between local and systemic atrophogenic effects of topical steroids. Hydrocortisone-17-butyrate, betamethasone-17-valerate, budesonide and clobetasol-17-propionate were applied topically daily for 21 days. Skinfold thickness and dermal DNA synthesis of treated...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Normal skin and psoriatic lesions from 35 patients were investigated immunohistochemically with regard to the CD1a+ cell population (Langerhans' cells and indeterminate cells) in the epidermis as well as in the dermal infiltrate. In the normal-appearing skin, we found the regularly typical pattern of CD1a+ dendritic c...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Intraepidermal collections of neutrophils and lymphocytes are unique features of the inflammatory reaction of psoriasis. Migration of leukocytes from dermis to the epidermis suggests a role for chemotactic agent(s). In recent years, increased levels of chemokines such as IL-8 , GRO-a and MCP-1 have been reported in th...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155599750011615
更新日期：1999-01-01 00:00:00
abstract：:We analysed the cytokine profile of skin T cells by establishing 11 T-cell lines from adult patients with moderate-to-severe atopic eczema using T-cell growth factors interleukin-2 and interleukin-4. We compared T-cell lines from lesional skin of atopic dermatitis patients with those from non-atopic skin of patients w...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550117325
更新日期：2001-01-01 00:00:00
abstract：:Pigmented basal cell carcinomas can be difficult to distinguish clinically from melanoma. Dermoscopy has proven to be useful in the differential diagnosis of the two tumour types. SIAscopy (Spectrophotometric intracutaneous analysis) is a fairly new technique of imaging pigmented skin lesions that has been presented p...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0234
更新日期：2007-01-01 00:00:00
abstract：:is missing (Quiz). ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3566
更新日期：2020-08-17 00:00:00
abstract：:Dyschromatosis symmetrica hereditaria (OMIM127400) is a rare autosomal dominant pigmentary genodermatosis caused by mutations in the RNA-specific adenosine deaminase (ADAR) gene. This study investigated 5 families and 3 sporadic patients with dyschromatosis symmetrica hereditaria in the Chinese Han population from Anh...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0168
更新日期：2007-01-01 00:00:00
abstract：:In order to establish whether or not here is an association between cancer and intense growth of seborrheic keratosis, the so-called Leser-Trelat sign, we conducted a case control study in which the number and features of seborrheic keratosis in 82 patients with recent solid tumours, were compared with 82 age- and sex...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Human leukocytes and fibroblasts were cultured in medium containing 3H-8-methoxypsoralen (10(-6) M and 3.3 X 10(-6) M). At different stages during the culturing period the cells were exposed to ultraviolet light (1, 2, and 10 J/cm2). After the culture period the slides for chromosome analysis and smears of the cells w...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:A noninvasive Finn Chamber sampling method and HPLC analysis were used to determine epidermal urocanic acid (UCA) concentrations of psoriasis patients during 4 weeks of heliotherapy on the Spanish Canary Islands and a follow-up period of 8 weeks. During heliotherapy the epidermal cis-UCA concentration increased from a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/000155555571231233
更新日期：1992-01-01 00:00:00
abstract：:A man with AIDS is described in whom a profound weight loss was converted into a weight gain by treatment with megoestrol acetate, a synthetic progesterone. His appetite improved and was accompanied by a feeling of improved well-being. Following abrupt discontinuation of the drug, there was a significant but transient...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555570520521
更新日期：1990-01-01 00:00:00
abstract：:Eruptive pseudoangiomatosis is a distinct exanthem thought to be caused by viruses. The usual rash configu-ration is erythematous papules and macules. An association with echovirus infection has been reported. We present here one adult and one child with this exanthem, supported by clinical, histopathological, and imm...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2541
更新日期：2017-03-10 00:00:00
abstract：:We present a young male patient referred to our hospital with leg ulcers on both legs that were more than 3 years refractory to standard treatment with compression therapy. By thrombophilia screening factor V Leiden mutation, hyperhomocysteinemia and evidence for impaired fibrinolysis were found. Treatment with folic ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155502753600902
更新日期：2002-01-01 00:00:00
abstract：:Peripheral blood lymphocytes from 31 patients with a positive patch test to potassium dichromate (K2Cr2O7) and from 24 healthy controls were stimulated with various concentrations of chromium chloride (CrCl3) and/or chromium basic sulphate (Cr4(SO4)5(OH)2), sodium chromate (Na2CrO4) or K2Cr2O7 on various days of cultu...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Suction blisters were raised on psoriatic lesions and normal appearing skin. The epidermis was separated at the epidermal-dermal junction. Scanning electronmicroscopy of the dermal side of the blister-roofs from normal looking skin and almost healed psoriatic lesions showed stellate cells probably formed by cytoplasmi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The aim of this study was to determine the prevalence and type of cutaneous manifestations which occur in patients with granulomatosis with polyangiitis and to explore the potential association between cutaneous and systemic involvement in these patients. A retrospective case series study was designed, including all g...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3506
更新日期：2020-05-28 00:00:00
abstract：:We report on a 44-year-old patient with erythropoietic protoporphyria who could effectively control his photosensitivity for 22 years with oral carotinoids. The clinical course of his disorder was complicated by liver involvement, initially expressed as marginally raised serum transaminase levels for several years. Te...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555576453456
更新日期：1996-11-01 00:00:00
abstract：:Anorexia nervosa and bulimia nervosa are common yet occult eating disorders which each affect between 1 and 2% of young adult women in the UK (1). Cutaneous signs may provide valuable clues allowing earlier diagnosis. Eating disorders may both imitate (Table I) and complicate other medical illnesses, resulting in unne...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555746869
更新日期：1994-01-01 00:00:00
abstract：:Irritation and staining by dithranol and some 10-meso-substituted acyl analogues was studied with the chamber-testing technique in a series of 50 psoriasis patients. The test concentrations for dithranol, 10-acetyldithranol, 10-propionyldithranol and 10-butyryldithranol were 0.05 and 0.5%, for 10-valeryldithranol 5% a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
