Abstract:
:We analysed the cytokine profile of skin T cells by establishing 11 T-cell lines from adult patients with moderate-to-severe atopic eczema using T-cell growth factors interleukin-2 and interleukin-4. We compared T-cell lines from lesional skin of atopic dermatitis patients with those from non-atopic skin of patients with other skin diseases, observing that T-cell lines of patients with atopic dermatitis unstimulated cultures expressed a Th1 profile. After stimulation with anti-CD3 and anti-CD28 monoclonal antibodies, the cytokine expression showed rapid initial upregulation of Th2 followed by a Th1 profile. Furthermore, strong upregulation of interleukin-10 was observed after 24 h stimulation. Our findings suggest that skin T-lymphocytes from atopic dermatitis patients seem to consist of a heterogenous population of Th1 and Th2 or Th0 cells and the results for secreted cytokines indicate that T-cell lines from each inflammatory skin disease showed the corresponding disease-specific original cytokine profile.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Higashi N,Bang K,Gesser B,Lund M,Thestrup-Pedersen Kdoi
10.1080/00015550117325subject
Has Abstractpub_date
2001-01-01 00:00:00pages
3-7issue
1eissn
0001-5555issn
1651-2057journal_volume
81pub_type
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