Clinical presentation and pathophysiology of gastroparesis.

Abstract:

:Gastroparesis is a heterogeneous disorder defined by delay in gastric emptying. Symptoms of gastroparesis are nonspecific, including nausea, vomiting, early satiety, bloating, and/or abdominal pain. Normal gastric motor function and sensory function depend on a complex coordination between the enteric and central nervous system. This article discusses the pathophysiology of delayed gastric emptying and the symptoms of gastroparesis, including antropyloroduodenal dysmotility, impaired gastric accommodation, visceral hypersensitivity, and autonomic dysfunction. The underlying pathophysiology of gastroparesis is complex and multifactorial. The article discusses how a combination of these factors leads to symptoms of gastroparesis.

authors

Nguyen LA,Snape WJ Jr

doi

10.1016/j.gtc.2014.11.003

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

21-30

issue

1

eissn

0889-8553

issn

1558-1942

pii

S0889-8553(14)00134-4

journal_volume

44

pub_type

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