Abstract：
:The cellular and molecular understanding of human gastroparesis has markedly improved due to studies on full-thickness gastric biopsies. A decrease in the number of interstitial cells of Cajal (ICC) and functional changes in ICC constitutes the hallmark cellular feature of gastroparesis. More recently, in animal models, macrophages have also been identified to play a central role in development of delayed gastric emptying. Activation of macrophages leads to loss of ICC. In human gastroparesis, loss of anti-inflammatory macrophages in gastric muscle has been shown. Deeper molecular characterization using transcriptomics and proteomics has identified macrophage-based immune dysregulation in human gastroparesis.
journal_name
Gastroenterol Clin North Amjournal_title
Gastroenterology clinics of North Americaauthors
Chikkamenahalli LL,Pasricha PJ,Farrugia G,Grover Mdoi
10.1016/j.gtc.2020.04.009subject
Has Abstractpub_date
2020-09-01 00:00:00pages
557-570issue
3eissn
0889-8553issn
1558-1942pii
S0889-8553(20)30034-0journal_volume
49pub_type
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