New pharmacologic therapies for gastroenteropancreatic neuroendocrine tumors.

Abstract:

:Successful treatment of unresectable and metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) requires the thoughtful choice of systemic therapy as a component of a multidisciplinary therapeutic approach. The role of somatostatin analogues is established in symptom relief, but the efficacy of interferon and radiopeptide targeted therapy is not clear. The utility of a variety of tyrosine kinase and antiangiogenic agents is variable and under investigation, whereas the role of cytotoxic chemotherapy in poorly differentiated GEP-NETs is accepted. Overall, the ideal treatment of more indolent tumors is less certain. Reassessments of the GEP-NET pathology classification has provided improved logic for the role of a variety of agents, whereas the precise positioning of many new agents that target molecular pathways of angiogenesis and proliferation is under examination. This article describes the current options for systemic therapy for GEP-NETs within the framework of the current World Health Organization classification system.

authors

Lawrence B,Gustafsson BI,Kidd M,Modlin I

doi

10.1016/j.gtc.2010.08.013

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

615-28

issue

3

eissn

0889-8553

issn

1558-1942

pii

S0889-8553(10)00055-5

journal_volume

39

pub_type

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