Abstract：
AIM:To document reversible cognitive deterioration associated to high doses of zonisamide, using the Reliable Change Index to control practice effects derived from repetitive neuropsychological assessments. CASE REPORT:A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated within a paediatric epilepsy surgery program. The epileptogenic zone was found to be related with a tuber situated on the left inferior frontal gyrus. The effects of high doses of zonisamide simulate a disturbance of eloquent cortex within the epileptogenic zone and the impact of uncontrolled seizures on cognitive functioning over the language-dominant hemisphere. Drug withdrawal significantly improved total intelligence index, verbal comprehension intellectual index and specific language-sustained cognitive abilities, beyond practice effects. CONCLUSIONS:The differentiation between cognitive effects of drugs and functional deficits resulting from eloquent cortex involvement within the epileptogenic zone can be of crucial importance in the decision-making process for epilepsy surgery. TITLE:Deterioro neuropsicologico reversible asociado a zonisamida en un paciente pediatrico con esclerosis tuberosa. :Objetivo. Documentar el deterioro cognitivo reversible asociado a altas dosis de zonisamida, utilizando indices de cambio fiable para controlar los efectos de practica derivados de evaluaciones neuropsicologicas repetidas. Caso clinico. Niño de 11 años con complejo esclerosis tuberosa y epilepsia refractaria del lobulo frontal izquierdo, evaluado en el contexto de un programa de cirugia de la epilepsia pediatrica. La zona epileptogena se relaciono con un tuber epileptogeno localizado en el giro frontal inferior del hemisferio izquierdo. Los efectos de altas dosis de zonisamida mimetizaron una afectacion de la corteza elocuente en la zona epileptogena y un impacto de las crisis no controladas en el funcionamiento cognitivo asociado al hemisferio dominante para el lenguaje. La retirada del farmaco mejoro significativamente, mas alla de los efectos de practica, el cociente intelectual total, el indice intelectual de comprension verbal y habilidades cognitivas especificas sustentadas en el lenguaje. Conclusiones. La diferenciacion entre los efectos cognitivos de los farmacos y la existencia de un deficit funcional por afectacion de la corteza elocuente en el area epileptogena puede ser crucial para la toma de decisiones en cirugia de la epilepsia.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Fournier-Del Castillo MC,Melero-Llorente J,Blanco-Beregana M,Robles-Bermejo F,Budke M,Garcia-Fernandez M,Garcia-Penas JJ,Perez-Jimenez MÁsubject
Has Abstractpub_date
2015-01-16 00:00:00pages
75-80issue
2eissn
0210-0010issn
1576-6578pii
rn2014475journal_volume
60pub_type
杂志文章abstract：INTRODUCTION:The search for variables that mediate in the shift from mild cognitive impairment (MCI) to dementia is currently a very active field of research. In this area, the term cognitive plasticity or modifiability can be of great interest. Proof of the existence of plasticity in the elderly with MCI and its possi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：INTRODUCTION:Valproic acid (VPA) is an antiepileptic drug widely used in paediatrics. In spite of being a safe and effective anticonvulsant, VPA has been involved in the onset of changes in the metabolism of ammonia and carnitine, although few prospective studies have been made of this. OBJECTIVES:To evaluate the effe...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：INTRODUCTION:There is now growing evidence that essential tremor and Parkinson's disease are related. AIM:To present the main findings from epidemiologic, genetic, clinical, imaging and pathologic studies, contrasting evidences for and against an association between essential tremor and Parkinson's disease. DEVELOPME...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-10-16 00:00:00
abstract：OBJECTIVE:To make a revision of the general point of view on late-onset epilepsy, known as epilepsy that starts in the mature age after 25 years old; around 25% of the patients with epilepsy had their first crisis after that age, with an increase in the incidence in the course of the age. DEVELOPMENT:The main ethiolog...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-04-16 00:00:00
abstract：INTRODUCTION:The presence of quick onset binocular diplopy makes it essential to carry out a comprehensive differential diagnosis. The most frequent causes in adults include vascular, post-traumatic, tumorous and myopathic pathologies. Yet, to perform a differential diagnosis we also have to take into account less comm...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-06-16 00:00:00
abstract：INTRODUCTION:Basilar migraine is a particular form of migraine with an aura in which crises of headache are accompanied by symptoms of dysfunction in the vertebro-basilar territory, including alteration of consciousness in the form of stupor or coma. CLINICAL CASES:We report four patients, three men of 14, 17 and 83 y...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：INTRODUCTION:Recent studies indicate that decreased energy generation by mitochondria is a feature that is common across neurodegenerative diseases. PATIENTS AND METHODS:In order to obtain direct evidence that mitochondrial functioning is altered, we measured the hydrolytic activity of F0F1-ATPase and its capacity to ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-01-16 00:00:00
abstract：INTRODUCTION:The spinocerebellar ataxia type 2 has a prevalence of 43 per 100,000 inhabitants in Holguín province, which is the highest one reported worldwide. It is due to an intergenerational CAG repeat expansion contained in the first exon of disease causing gene, and it is characterized by a high variability in its...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-12-16 00:00:00
abstract：TITLE:Respuesta favorable al uso de inmunoglobulinas intravenosas en la mielinolisis central pontina. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:Perforating artery disease is still the main cause of lacunar infarcts (LI), while the relationship between this type of ischemia and carotid stenosis (CS) is controversial. OBJECTIVE:To assess the association between CS and LI in patients with criteria of localized ischemia in the carotid territory separ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-07-16 00:00:00
abstract：INTRODUCTION:In the early stages of their development, children acquire the skills and knowledge that provide them with the foundations on which they will later add what they learn at school, including skills such as reading, writing and mathematics. The presence of learning difficulties at the infantile stage can affe...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-02-13 00:00:00
abstract：INTRODUCTION:The occupational environment generates a large amount of illness which involves several specialities, including neurology. However, there is little awareness--or little training--in this field as in most medical specialities, since in the basic tool of a doctor's work, the clinical history, importance is s...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:To present the current concepts of the clinical phenomenology and natural history of Gilles de la Tourette syndrome (GTS), differential diagnosis with other involuntary movements, its pathogenesis and current management. DEVELOPMENT:GTS is a disorder characterized by a spectrum of both motor and sonic tics, ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-04-01 00:00:00
abstract：INTRODUCTION:Sneddon syndrome is the association of livedo retricularis and cerebrovascular lesions. It is a vasculopathy of vessels of small and medium calibre which affects young people and is of unknown origin. It is often associated with arterial hypertension and repeated ischemic cerebrovascular accidents which le...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：INTRODUCTION:Cerebrovascular accidents (CVA) are the third most common cause of death and are the main cause of permanent disability in the western world, where they also rank first as regards the loss of years of disability-adapted independent life. Ischaemic CVAs tend to present irreversible sequelae, which reduces t...
journal_title：Revista de neurologia
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:Devic's optic neuromyelitis is an unusual condition characterized by the association of unilateral or bilateral optic neuritis and myelitis, both of which are relapsing. Prognosis is usually poor, both for the optic nerve and for the spinal medulla which becomes cavitated. This leads to severe handicap and...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:The ischemic stroke represents a very important cause of death in the hospitals. The clinic changes of this disease and the frequent morphological evidence in necropses motived the study of the clinicopathological concordance taking as reference two institutions of the secondary attention. The two medical ce...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-11-16 00:00:00
abstract：INTRODUCTION:Eosinophil infiltration of skeletal muscle is rare, but often no etiological factor can be identified and these are isolated eosinophilic myositis. They may be associated with parasite infections or drugs, or be features of rare systemic disorders of hypereosinophilia, such as the myalgia eosinophilia synd...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-11-16 00:00:00
abstract：INTRODUCTION:A spinal cord injury implies the loss of or alteration to the gait pattern. Stimulating the pattern generating centres in the sublesional spinal cord determines the appearance of flexion and extension automatisms that are useful for gait training in patients with spinal cord injuries. These centres can be ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:Lennox-Gastaut syndrome (LGS) is an epileptic encephalopathy that starts in childhood and has an unknown pathophysiological mechanism. Studies on the progress of LGS reveal a poor prognosis. PATIENTS AND METHODS:A retrospective study of 1629 patients with epilepsy was conducted. Patients included in the s...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:Dysraphias are a varied set of anomalies affecting neuroectodermic tissue caused by the alteration of the neural tube during embryogenesis. Neuroradiological classification is broad and clinical manifestations are numerous: they affect the skin, osteomuscular tissue and the vascular, urological and nervous...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：AIM:To analyse the data and concepts that have been produced in relation to one of the functions that have been suggested for sleep, namely, neuronal recovery. DEVELOPMENT:Sleep is a state of consciousness that is different to that of arousal. Mammals devote an important part of their lives to sleeping; for example, a...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-10-01 00:00:00
abstract：INTRODUCTION:Olivopontocerebellar atrophy (OPCA) is a degenerative disease of the nervous system (NS) which currently has no known cure. The neuronal depopulation it brings about produces a number of neurochemical alterations, including a reduction in levels of gamma-aminobutyric acid (GABA) in tissues and in cerebrosp...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：INTRODUCTION AND METHOD:The issue regarding the relations between behaviour and the brain is no longer the specific goal of neuropsychology, but rather that of the coordinated multidisciplinary activity of all the disciplines that go to make up the neurosciences. The specific contribution of neuropsychology to this mul...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-03-01 00:00:00
abstract：AIMS:To evaluate the presence of epileptiform discharges and the organisation of nocturnal sleep of autistic children without nocturnal polysomnographic epileptic seizures. SUBJECTS AND METHODS:Cross section analysis. SUBJECTS:21 boys and girls with autistic spectrum using DSM IV criteria between the ages of 4 and 12...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-06-16 00:00:00
abstract：INTRODUCTION:According to the 1981 International League Against Epilepsy classification, absence seizures are the paradigm of idiopathic generalised seizures of childhood. Although absences are mainly of an idiopathic origin, there are also symptomatic absences, which account for 10% of all cases of absences. It is tho...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2017-09-16 00:00:00
abstract：INTRODUCTION:The ionic channels are complex glycoprotein structures, which cross the lipidic cellular membrane and allow the passage of electrically charged ions from one side of it to the other, thanks to the electrochemical gradient. A channelopathy is a disorder due to anomalous function of the ionic channels. DEVE...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-01-16 00:00:00
abstract：OBJECTIVES:To obtain better understanding of the neurophysiology of sleep and of depression, together with any relationship there might be between them. DEVELOPMENT:We review the mechanisms of action of the neurotransmitters involved in the sleep-waking cycle, and also the antidepressive drugs, concentrating on those ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-16 00:00:00
abstract：INTRODUCTION:Epileptic seizures and epilepsy are part of daily clinical practice in neurology. Yet, the number of false positive diagnoses is surprisingly high. Almost one out of every five patients treated for epilepsy does not really have this diagnosis, which is a high percentage bearing in mind the social and medic...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：10.33588/rn.6806.2018242
更新日期：2019-03-16 00:00:00
abstract：INTRODUCTION AND AIMS:The exploration of neurocognition in neurology departments has gone a long way from the traditional psychometric tests to the present day use of high technology methods in cognitive neurophysiology, as is the case of event related potentials. Given the increased sensitivity of these procedures, it...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
