Abstract:
INTRODUCTION:Olivopontocerebellar atrophy (OPCA) is a degenerative disease of the nervous system (NS) which currently has no known cure. The neuronal depopulation it brings about produces a number of neurochemical alterations, including a reduction in levels of gamma-aminobutyric acid (GABA) in tissues and in cerebrospinal fluid (CSF). The drug gabapentin (GBP) has proved to be capable of increasing the concentration of this neurotransmitter in the central nervous system, and of improving the cerebellar ataxia in other diseases with a similar neurochemical substrate. CASE REPORTS:We describe two sporadic cases of OPCA, who were administered GBP. In one of the cases, the ataxia was noticeably reduced after taking one 400 mg dose. In the other case, a considerable improvement was observed in a very intense cerebellar dysarthria, and there was less oscillopsia with better vision, following administration of GBP for a period of over 12 months. CONCLUSIONS:GBP has proved to be capable of slowing down the motor disorders reported by patients in the course of OPCA. We discuss how such effects are due to the increased levels of GABA in the NS triggered by the drug. Finally, we suggest that the administration of GBP could constitute an effective symptomatic treatment for the ataxia and the dysarthria caused by OPCA, and that the improvement in symptoms following single doses of GBP could be valuable in cases of OPCA, as well as other types of ataxia, that are ideal for taking advantage of the stimulus of the GABAergic neurotransmission.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Gazulla J,Benavente MIsubject
Has Abstractpub_date
2005-03-01 00:00:00pages
285-8issue
5eissn
0210-0010issn
1576-6578pii
rn2004448journal_volume
40pub_type
杂志文章abstract:INTRODUCTION:Lamotrigine (LTG) is a new antiepileptic drug indicated in all kinds of partial and generalised clonic-tonic seizures, both in monotherapy and polytherapy. Between 20 and 30% of epileptic patients have poor control over their seizures despite adequate treatment. AIMS:We report on our experience regarding ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-02-16 00:00:00
abstract:INTRODUCTION:Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV (HSAN IV) is a rare autosomal recessive disorder featuring recurrent fever episodes, inability to sweat, absent response to noxious stimuli, self mutilating behavior and mental retardation. It has...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-08-16 00:00:00
abstract:INTRODUCTION:The current epidemic outbreak due to Zika virus began in 2015 and since then it has been reported in 31 countries and territories in America. The epidemiological and clinical aspects related to infection by Zika virus are reviewed. DEVELOPMENT:Since 2007, 55 countries in America, Asia, Africa and Oceania ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:The rapid-onset dystonia-parkinsonism is a movement disorder which associates dystonic symptoms, especially those affecting orofacial muscles, and parkinsonian symptoms. All these symptoms start suddenly and then they stabilize along the process. This disorder usually occurs to young adults and is an autos...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-12-16 00:00:00
abstract::Neuroinflammation is a key process in the neuropathogenesis of AIDS virus since as a result of the aberrant activation of the chemokine receptors (CXCR4, CX3CR1 and CR5) produces proinflammatory cytokine release by infected cells, increases microglial neurotoxicity and generates lipoperoxides and reactive oxygen speci...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-16 00:00:00
abstract:INTRODUCTION:Unilateral isolated paralysis of the soft palate is a rare clinical entity. CASE REPORT:We describe the case of a 12 year old girl who presented acute dysphagia, a nasal voice and regurgitation of liquids into the nose. Exploration revealed right velopalatine insufficiency with normal gag reflex and phary...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-02-15 00:00:00
abstract:INTRODUCTION:Epileptic seizures and epilepsy are part of daily clinical practice in neurology. Yet, the number of false positive diagnoses is surprisingly high. Almost one out of every five patients treated for epilepsy does not really have this diagnosis, which is a high percentage bearing in mind the social and medic...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.6806.2018242
更新日期:2019-03-16 00:00:00
abstract:AIM:To assess the budget impact of the treatment for relapsing remitting multiple sclerosis (RRMS), interferons, and glatiramer acetate, from the National Health System perspective in Spain. PATIENTS AND METHODS:A budget impact model was designed to compare the cost of RRMS treatment in different settings, using a fiv...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To review the incidence and causes of the infections and metabolic diseases of the nervous system in patients with systemic neoplasias. DEVELOPMENT:Patients with immunodeficiency, particularly those with hematological neoplasias and persons treated with immunosuppressive drugs have a considerable tendency to...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-16 00:00:00
abstract:INTRODUCTION:Several studies that has focused to the dopaminergic transmission in the basal ganglia in parkinsonian condition, but only a few article has taking into account the imbalance between dopaminergic and cholinergic transmission. OBJECTIVE:To evaluate the muscarinic cholinergic receptors density in SNc and PP...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-01-16 00:00:00
abstract:INTRODUCTION:Acute vascular lesions limited to the midbrain can yield varied disturbances of eye movements. They are more often infarcts than hemorrhages. CLINICAL CASE:We present the case of a 49 year old, non-hypertensive man who presented with sudden onset of bilateral up and down gaze palsy. CT defined a unilatera...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-02-16 00:00:00
abstract:INTRODUCTION:Neuroschistosomiasis is an uncommon and under diagnosed disease in our country because of the no clinical suspicion. The most common neurological manifestations are epileptic seizures as central nervous system involvement or different types of myelopathies: transverse myelitis, myeloradiculopathy, cauda eq...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
abstract:INTRODUCTION:Cockayne syndrome (CS) is a rare autosomal recessive disease which is characterized by physical and mental retardation, progressive neurological disfunction, photosensitivity and other cutaneous features. Usually they present ophthalmologic abnormalities as well as other heterogenous clinical, radiological...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract:INTRODUCTION:OnabotulinumtoxinA (OnabotA) is indicated for headache prophylaxis in patients with chronic migraine. However, there is some controversy about what is the minimum effective dose for treating chronic migraine patients. AIM:To determine the optimal dose of OnabotA for the prophylactic treatment of patients ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-03-10 00:00:00
abstract:INTRODUCTION:Moderate to severe stenosis is the less prevalent among the forms of carotid atherosclerotic disease), but it carries a high risk of ischaemic stroke. AIM:To characterise factors associated with moderate to severe carotid stenosis in a high-risk population. PATIENTS AND METHODS:We performed an analysis o...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-06-16 00:00:00
abstract:AIMS:The aim of this study is to report on the neuropsychological aspects of teenage patients with attention deficit hyperactivity disorder (ADHD), namely disorders affecting attention, memory, the executive functions and language. We also discuss how to perform neuropsychological and functional evaluation of the syste...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-10 00:00:00
abstract::The new communication techniques and, particularly, Internet, are changing our way of collaborating, relating to each other and searching for information, paving the way for telemedicine. Such initiatives are described in the Revista de Neurologia, as well as the methodology followed to prepare the first Electronic Fo...
journal_title:Revista de neurologia
pub_type: 社论
doi:
更新日期:1998-04-01 00:00:00
abstract:AIM:To analyze the importance of the neurotransmitter glutamate in the pathogenesis of Alzheimer's disease (AD). DEVELOPMENT:Elements of the physiological glutamatergic neurotransmission are reviewed, such as the neuronal types that utilize it, glutamatergic receptors and their characteristics, and glutamate transport...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-04-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:Preliminary studies (phase III) have shown that treatment with beta-interferon 1a (avonex) is effective in diverse aspects of relapsing/remitting multiple sclerosis (RRMS). The present study discusses results of an opened prolonged (phase IV) trial at the Baylor/Methodist International Multip...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:INTRODUCTION:The SOX5 gene encodes a transcription factor involved in the regulation of chondrogenesis and the development of the nervous system. CASE REPORT:We report a 10 years-old girl with developmental delay, behavior problems and dysmorphic features of this new syndrome with developmental delay. She had a 12p12 ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2015-05-16 00:00:00
abstract:INTRODUCTION:Primary bone lymphomas account for 3-7% of all malignant bone tumours and less than 2% of lymphomas in adults. Having the cranial vault as their primary location is very infrequent. CASE REPORT:A 59-year-old female who presented a painful tumour on the cranial vault which, following radical surgical remov...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2011-12-16 00:00:00
abstract::The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting, held in Madrid in October 2013, resulting in this review, to be published...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-09-16 00:00:00
abstract:INTRODUCTION:The relationship between headache and sleep is complex and runs in two directions. Headache may be the consequence of a (primary or secondary) sleep disorder or its cause (in chronic tension-type headache and/or chronic migraine with or without painkiller abuse). It can also be related to sleep in an intri...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2008-09-16 00:00:00
abstract:OBJECTIVES:To establish the role of the age on quality of life of a group of normotensive patients, older than 65 years with vertebrobasilar ischemia, treated with nicardipine. To evaluate the influence of the Nicardipine side effects on the quality of life of these patients within general practice prescription limits....
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract:AIMS:To analyze the validity of the single deck 64-card Wisconsin Card Sorting Test (WCST-64) compared to the standard version (WCST-128), and to study the sensibility of both versions to identify changes over time in patients with traumatic brain injury (TBI). PATIENTS AND METHODS:The WCST was administered twice acro...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract:INTRODUCTION:Various neuropsychological studies have been conducted to determine the cognitive functioning of patients with Huntington s disease and their results have shown that the pattern of cognitive decline is thought to be typical of a frontal subcortical dementia. OBJECTIVES:To determine if significant differen...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::A patient developed enlarged Gerstmann syndrome after left thalamic haematoma. Single photon emission computerised tomography (SPECT) showed left parietal-temporal cortical hypocapture. These findings would lead us to believe that the clinical picture of our patient was due to a thalamic-cortical diaschitic phenomenon...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract:INTRODUCTION:Primary prevention by prophylactic vaccination against the major cause of cervical cancer, the carcinogenic human papillomavirus (HPV) types 16 and 18, is now available worldwide. Postlicensure adverse neurological effects have been described. The studies realized after the license are descriptive and limi...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2011-04-16 00:00:00
abstract:INTRODUCTION:Type 1 myotonic dystrophy (MD-1) or Steinert disease is a multisystemic progressive disorder. Studies have shown cognitive deficits, depressive symptoms and a high incidence of anxiety personality traits that compromise both the functionality and the quality of life of these patients. AIM:To describe the ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2015-12-16 00:00:00
abstract:INTRODUCTION:After Zika virus outbreak and the increase in the incidence of Guillain-Barre syndrome (GBS), the causal relationship has been studied, however a full etiological correlation has not been found. PATIENTS AND METHODS:From January 1 to December 31, 2017, patients with GBS were included. In addition to the b...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2018-09-16 00:00:00