[Improvements in the symptoms of olivopontocerebellar atrophy with gabapentin].

Abstract:

INTRODUCTION:Olivopontocerebellar atrophy (OPCA) is a degenerative disease of the nervous system (NS) which currently has no known cure. The neuronal depopulation it brings about produces a number of neurochemical alterations, including a reduction in levels of gamma-aminobutyric acid (GABA) in tissues and in cerebrospinal fluid (CSF). The drug gabapentin (GBP) has proved to be capable of increasing the concentration of this neurotransmitter in the central nervous system, and of improving the cerebellar ataxia in other diseases with a similar neurochemical substrate. CASE REPORTS:We describe two sporadic cases of OPCA, who were administered GBP. In one of the cases, the ataxia was noticeably reduced after taking one 400 mg dose. In the other case, a considerable improvement was observed in a very intense cerebellar dysarthria, and there was less oscillopsia with better vision, following administration of GBP for a period of over 12 months. CONCLUSIONS:GBP has proved to be capable of slowing down the motor disorders reported by patients in the course of OPCA. We discuss how such effects are due to the increased levels of GABA in the NS triggered by the drug. Finally, we suggest that the administration of GBP could constitute an effective symptomatic treatment for the ataxia and the dysarthria caused by OPCA, and that the improvement in symptoms following single doses of GBP could be valuable in cases of OPCA, as well as other types of ataxia, that are ideal for taking advantage of the stimulus of the GABAergic neurotransmission.

journal_name

Rev Neurol

journal_title

Revista de neurologia

authors

Gazulla J,Benavente MI

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

285-8

issue

5

eissn

0210-0010

issn

1576-6578

pii

rn2004448

journal_volume

40

pub_type

杂志文章
  • [Lamotrigine in refractory epilepsy].

    abstract:INTRODUCTION:Lamotrigine (LTG) is a new antiepileptic drug indicated in all kinds of partial and generalised clonic-tonic seizures, both in monotherapy and polytherapy. Between 20 and 30% of epileptic patients have poor control over their seizures despite adequate treatment. AIMS:We report on our experience regarding ...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: García-Escrivà A,López-Hernández N,Alvarez-Saúco M,Pampliega-Pérez A,Oliver-Navarrete C,Asensio-Asensio M,Moltó-Jordá JM,Palao-Sánchez A

    更新日期:2004-02-16 00:00:00

  • [Congenital insensitivity to pain with anhidrosis associated with congenital myasthenic syndrome].

    abstract:INTRODUCTION:Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV (HSAN IV) is a rare autosomal recessive disorder featuring recurrent fever episodes, inability to sweat, absent response to noxious stimuli, self mutilating behavior and mental retardation. It has...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Raspall-Chaure M,Del Toro-Riera M,Gratacós M,Cuenca-León E,Ferrer I,Indo Y,Roig-Quilis M,Macaya-Ruiz A

    更新日期:2005-08-16 00:00:00

  • Epidemiology and neurological complications of infection by the Zika virus: a new emerging neurotropic virus.

    abstract:INTRODUCTION:The current epidemic outbreak due to Zika virus began in 2015 and since then it has been reported in 31 countries and territories in America. The epidemiological and clinical aspects related to infection by Zika virus are reviewed. DEVELOPMENT:Since 2007, 55 countries in America, Asia, Africa and Oceania ...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Carod-Artal FJ

    更新日期:2016-04-01 00:00:00

  • [Rapid-onset dystonia-parkinsonism: sporadic form].

    abstract:INTRODUCTION:The rapid-onset dystonia-parkinsonism is a movement disorder which associates dystonic symptoms, especially those affecting orofacial muscles, and parkinsonian symptoms. All these symptoms start suddenly and then they stabilize along the process. This disorder usually occurs to young adults and is an autos...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Romero-López J,Moreno-Carretero MJ,Escriche-Jaime D,Corredera-García E

    更新日期:2008-12-16 00:00:00

  • [HIV-1 neuropathogenesis: therapeutic strategies against neuronal loss induced by gp120/Tat glycoprotein in the central nervous system].

    abstract::Neuroinflammation is a key process in the neuropathogenesis of AIDS virus since as a result of the aberrant activation of the chemokine receptors (CXCR4, CX3CR1 and CR5) produces proinflammatory cytokine release by infected cells, increases microglial neurotoxicity and generates lipoperoxides and reactive oxygen speci...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Merino JJ,Montes ML,Blanco A,Bustos MJ,Oreja-Guevara C,Bayon C,Cuadrado A,Lubrini G,Cambron I,Munoz A,Cebolla S,Gutierrez-Fernandez M,Bernardino JI,Arribas JR,Fiala M

    更新日期:2011-01-16 00:00:00

  • [Unilateral isolated paralysis of the soft palate: a case report and a review of the literature].

    abstract:INTRODUCTION:Unilateral isolated paralysis of the soft palate is a rare clinical entity. CASE REPORT:We describe the case of a 12 year old girl who presented acute dysphagia, a nasal voice and regurgitation of liquids into the nose. Exploration revealed right velopalatine insufficiency with normal gag reflex and phary...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Villarejo-Galende A,Camacho-Salas A,Penas-Prado M,García-Ramos R,Mendoza MC,Simón de las Heras R,Mateos-Beato F

    更新日期:2003-02-15 00:00:00

  • [Diagnostic challenges in epilepsy].

    abstract:INTRODUCTION:Epileptic seizures and epilepsy are part of daily clinical practice in neurology. Yet, the number of false positive diagnoses is surprisingly high. Almost one out of every five patients treated for epilepsy does not really have this diagnosis, which is a high percentage bearing in mind the social and medic...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:10.33588/rn.6806.2018242

    authors: Hampel KG,Garces-Sanchez M,Gomez-Ibanez A,Palanca-Camara M,Villanueva V

    更新日期:2019-03-16 00:00:00

  • [Budget impact analysis of the first-line treatment of relapsing remitting multiple sclerosis in Spain].

    abstract:AIM:To assess the budget impact of the treatment for relapsing remitting multiple sclerosis (RRMS), interferons, and glatiramer acetate, from the National Health System perspective in Spain. PATIENTS AND METHODS:A budget impact model was designed to compare the cost of RRMS treatment in different settings, using a fiv...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Sánchez-De la Rosa R,Sabater E,Casado MA

    更新日期:2011-08-01 00:00:00

  • [Infectious and metabolic nervous system complications of systemic cancer].

    abstract:OBJECTIVE:To review the incidence and causes of the infections and metabolic diseases of the nervous system in patients with systemic neoplasias. DEVELOPMENT:Patients with immunodeficiency, particularly those with hematological neoplasias and persons treated with immunosuppressive drugs have a considerable tendency to...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Ortiz N

    更新日期:2000-12-16 00:00:00

  • [Lesions in the pars compacta substantiae nigra and the subthalamic nucleus modify the density of muscarinic receptors in different nuclei of the basal ganglia].

    abstract:INTRODUCTION:Several studies that has focused to the dopaminergic transmission in the basal ganglia in parkinsonian condition, but only a few article has taking into account the imbalance between dopaminergic and cholinergic transmission. OBJECTIVE:To evaluate the muscarinic cholinergic receptors density in SNc and PP...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Blanco-Lezcano L,Rocha-Arrieta LL,Martínez-Martí L,Alvarez-González L,Pavón-Fuentes N,Macías-González R,Serrano-Sánchez T,Rosillo-Martí JC,Coro-Grave de Peralta Y,Bauza-Calderín Y,Briones M

    更新日期:2004-01-16 00:00:00

  • [Upward and downward gaze palsy with a unilateral mesencephalic hemorrhage].

    abstract:INTRODUCTION:Acute vascular lesions limited to the midbrain can yield varied disturbances of eye movements. They are more often infarcts than hemorrhages. CLINICAL CASE:We present the case of a 49 year old, non-hypertensive man who presented with sudden onset of bilateral up and down gaze palsy. CT defined a unilatera...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Rodríguez-Gómez J,Colás J,Aragón A,Albo MI,Casado F

    更新日期:2000-02-16 00:00:00

  • [Neuroschistosomiasis: a challenging diagnosis].

    abstract:INTRODUCTION:Neuroschistosomiasis is an uncommon and under diagnosed disease in our country because of the no clinical suspicion. The most common neurological manifestations are epileptic seizures as central nervous system involvement or different types of myelopathies: transverse myelitis, myeloradiculopathy, cauda eq...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Tarabini-Castellani P,González-Chinchón G,Aldamiz-Echebarría M,Portu-Zapirain J,Apraiz-Garmendia L,Alvarez de Arcaya A

    更新日期:2007-02-01 00:00:00

  • [Clinical and neuropathological study of two brothers with Cockayne syndrome].

    abstract:INTRODUCTION:Cockayne syndrome (CS) is a rare autosomal recessive disease which is characterized by physical and mental retardation, progressive neurological disfunction, photosensitivity and other cutaneous features. Usually they present ophthalmologic abnormalities as well as other heterogenous clinical, radiological...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Olaciregui O,Yoldi ME,Gurtubay IG,García-Bragado F,Carrera B,Gila L,Morales G

    更新日期:2001-10-01 00:00:00

  • [What is the optimal dose for the prophylactic treatment of chronic migraine patients?].

    abstract:INTRODUCTION:OnabotulinumtoxinA (OnabotA) is indicated for headache prophylaxis in patients with chronic migraine. However, there is some controversy about what is the minimum effective dose for treating chronic migraine patients. AIM:To determine the optimal dose of OnabotA for the prophylactic treatment of patients ...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Irimia P,Esteve-Belloch P,Murie-Fernandez M,Martinez-Vila E

    更新日期:2014-03-10 00:00:00

  • [Characterisation of factors associated with carotid stenosis in a population at high risk].

    abstract:INTRODUCTION:Moderate to severe stenosis is the less prevalent among the forms of carotid atherosclerotic disease), but it carries a high risk of ischaemic stroke. AIM:To characterise factors associated with moderate to severe carotid stenosis in a high-risk population. PATIENTS AND METHODS:We performed an analysis o...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Chiquete E,Torres-Octavo B,Cano-Nigenda V,Valle-Rojas D,Dominguez-Moreno R,Tolosa-Tort P,Florez-Cardona JA,Flores-Silva F,Reyes-Melo I,Higuera-Calleja J,Garcia-Ramos G,Cantu-Brito C

    更新日期:2014-06-16 00:00:00

  • [Neuropsychological disorders in teenagers with attention deficit hyperactivity disorder].

    abstract:AIMS:The aim of this study is to report on the neuropsychological aspects of teenage patients with attention deficit hyperactivity disorder (ADHD), namely disorders affecting attention, memory, the executive functions and language. We also discuss how to perform neuropsychological and functional evaluation of the syste...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Mulas F,Etchepareborda MC,Abad-Mas L,Díaz-Lucero A,Hernández S,de la Osa A,Pascuale MJ,Ruiz-Andrés R

    更新日期:2006-10-10 00:00:00

  • [The Internet application to neurology: electronic forums of Revista de Neurología. How The Internet, Medicine and Neurology Forum has been developed].

    abstract::The new communication techniques and, particularly, Internet, are changing our way of collaborating, relating to each other and searching for information, paving the way for telemedicine. Such initiatives are described in the Revista de Neurologia, as well as the methodology followed to prepare the first Electronic Fo...

    journal_title:Revista de neurologia

    pub_type: 社论

    doi:

    authors: Botia E

    更新日期:1998-04-01 00:00:00

  • [Glutamate and Alzheimer's disease].

    abstract:AIM:To analyze the importance of the neurotransmitter glutamate in the pathogenesis of Alzheimer's disease (AD). DEVELOPMENT:Elements of the physiological glutamatergic neurotransmission are reviewed, such as the neuronal types that utilize it, glutamatergic receptors and their characteristics, and glutamate transport...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Gazulla J,Cavero-Nagore M

    更新日期:2006-04-01 00:00:00

  • [The treatment of multiple sclerosis with beta-interferon 1a].

    abstract:INTRODUCTION AND OBJECTIVE:Preliminary studies (phase III) have shown that treatment with beta-interferon 1a (avonex) is effective in diverse aspects of relapsing/remitting multiple sclerosis (RRMS). The present study discusses results of an opened prolonged (phase IV) trial at the Baylor/Methodist International Multip...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Rivera VM

    更新日期:2000-09-01 00:00:00

  • [Microdeletion 12p12 involving SOX5 gene: a new syndrome with developmental delay].

    abstract:INTRODUCTION:The SOX5 gene encodes a transcription factor involved in the regulation of chondrogenesis and the development of the nervous system. CASE REPORT:We report a 10 years-old girl with developmental delay, behavior problems and dysmorphic features of this new syndrome with developmental delay. She had a 12p12 ...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Arroyo-Carrera I,de Zaldívar-Tristancho MS,Martín-Fernández R,Hernández-Martín R,López-Lafuente A,Rodríguez-Revenga L

    更新日期:2015-05-16 00:00:00

  • [Primary cranial vault lymphoma].

    abstract:INTRODUCTION:Primary bone lymphomas account for 3-7% of all malignant bone tumours and less than 2% of lymphomas in adults. Having the cranial vault as their primary location is very infrequent. CASE REPORT:A 59-year-old female who presented a painful tumour on the cranial vault which, following radical surgical remov...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Castro-Bouzas D,Prieto-González Á,Serramito-García R,Santín-Amo JM,Reyes-Santías RM,Allut AG,Gelabert-González M

    更新日期:2011-12-16 00:00:00

  • Review of the novelties presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I).

    abstract::The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting, held in Madrid in October 2013, resulting in this review, to be published...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Fernandez O,Alvarez-Cermeno JC,Arnal-Garcia C,Arroyo-Gonzalez R,Brieva L,Calles-Hernandez MC,Casanova-Estruch B,Comabella M,Garcia-Merino JA,Izquierdo G,Meca-Lallana JE,Mendibe-Bilbao MM,Munoz-Garcia D,Olascoaga J,Oliva-Nacar

    更新日期:2014-09-16 00:00:00

  • [Anatomical and neurochemical bases accounting for the frequent association between headaches and sleep: the hypnic headache paradigm].

    abstract:INTRODUCTION:The relationship between headache and sleep is complex and runs in two directions. Headache may be the consequence of a (primary or secondary) sleep disorder or its cause (in chronic tension-type headache and/or chronic migraine with or without painkiller abuse). It can also be related to sleep in an intri...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Caminero-Rodriguez AB,Pareja JA

    更新日期:2008-09-16 00:00:00

  • [The role of the age on the quality of life of patients older than 65 years of age with vertebrobasilar ischemia treated with nicardipine].

    abstract:OBJECTIVES:To establish the role of the age on quality of life of a group of normotensive patients, older than 65 years with vertebrobasilar ischemia, treated with nicardipine. To evaluate the influence of the Nicardipine side effects on the quality of life of these patients within general practice prescription limits....

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Galiano L

    更新日期:1995-07-01 00:00:00

  • [Clinical utility of the 64-card version of the Wisconsin Card Sorting Test in patients with traumatic brain injury].

    abstract:AIMS:To analyze the validity of the single deck 64-card Wisconsin Card Sorting Test (WCST-64) compared to the standard version (WCST-128), and to study the sensibility of both versions to identify changes over time in patients with traumatic brain injury (TBI). PATIENTS AND METHODS:The WCST was administered twice acro...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: del Valle-del Valle G,Puerta-Cuestas MV,Renau-Hernández O,Noguera-Escalera P,García-Blázquez MC,Ferri-Salvador N,Chirivella-Garrido J,Ferri-Campos J,Noé-Sebastián E

    更新日期:2008-02-01 00:00:00

  • [A neuropsychological study of Huntington's disease in families in Antioquia, Colombia].

    abstract:INTRODUCTION:Various neuropsychological studies have been conducted to determine the cognitive functioning of patients with Huntington s disease and their results have shown that the pattern of cognitive decline is thought to be typical of a frontal subcortical dementia. OBJECTIVES:To determine if significant differen...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Arango-Lasprilla JC,Iglesias-Dorado J,Moreno S,Lopera F

    更新日期:2003-07-01 00:00:00

  • [Increased level of Gerstmann's syndrome secondary to thalamic hematoma].

    abstract::A patient developed enlarged Gerstmann syndrome after left thalamic haematoma. Single photon emission computerised tomography (SPECT) showed left parietal-temporal cortical hypocapture. These findings would lead us to believe that the clinical picture of our patient was due to a thalamic-cortical diaschitic phenomenon...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Casado JL,Jarrín S,Madrid A,Gil-Peralta A

    更新日期:1995-09-01 00:00:00

  • [Demyelinating disease and vaccination of the human papillomavirus].

    abstract:INTRODUCTION:Primary prevention by prophylactic vaccination against the major cause of cervical cancer, the carcinogenic human papillomavirus (HPV) types 16 and 18, is now available worldwide. Postlicensure adverse neurological effects have been described. The studies realized after the license are descriptive and limi...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Álvarez-Soria MJ,Hernández-González A,Carrasco-García de León S,del Real-Francia MÁ,Gallardo-Alcañiz MJ,López-Gómez JL

    更新日期:2011-04-16 00:00:00

  • [A descriptive study of the neuropsychological and psychopathological profile in patients with type 1 myotonic dystrophy].

    abstract:INTRODUCTION:Type 1 myotonic dystrophy (MD-1) or Steinert disease is a multisystemic progressive disorder. Studies have shown cognitive deficits, depressive symptoms and a high incidence of anxiety personality traits that compromise both the functionality and the quality of life of these patients. AIM:To describe the ...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Seijas-Gomez R,Basterra-Jimenez I,Luna-Lario P,Tirapu-Ustarroz J,Cabada-Giadas T,Iridoy-Zulet M,Jerico-Pascual I,Gargallo-Vaamonde Á,Lopez-Goni JJ

    更新日期:2015-12-16 00:00:00

  • [The most frequent causative agents of Guillain-Barre syndrome in a Mexican general hospital].

    abstract:INTRODUCTION:After Zika virus outbreak and the increase in the incidence of Guillain-Barre syndrome (GBS), the causal relationship has been studied, however a full etiological correlation has not been found. PATIENTS AND METHODS:From January 1 to December 31, 2017, patients with GBS were included. In addition to the b...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Del Carpio-Orantes L,Pola-Ramirez MR,Garcia-Mendez S,Mata-Miranda MP,Perfecto-Arroyo MA,Solis-Sanchez I,Trujillo-Ortega BM,Gonzalez-Flores EE

    更新日期:2018-09-16 00:00:00