Hemodynamic effects of digoxin during acute cardiac failure: a comparison in patients with and without acute myocardial infarction.

Abstract:

:The hemodynamic effects of digitalis were examined in ten patients with acute cardiac failure. Administration of 10 micrograms/kg of digoxin iv resulted in significant increases in cardiac index, stroke volume index, and left ventricular stroke work index within one hour in five patients with acute myocardial infarction (AMI) and five patients with atherosclerotic heart disease without AMI. These increases were maintained 2 h after digoxin therapy. Indirect assessment of global myocardial oxygen supply (coronary perfusion pressure) and demand (heart rate X systolic arterial pressure X wedge pressure product) did not reveal adverse changes. Digoxin therapy results in rapid improvement in cardiac function during acute cardiac failure in patients with and without AMI.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Rackow EC,Packman MI,Weil MH

doi

10.1097/00003246-198711000-00002

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

1001-5

issue

11

eissn

0090-3493

issn

1530-0293

journal_volume

15

pub_type

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