Abstract:
:We present the unusual case of a 35 year-old woman with stage IV melanoma and widespread metastases, who was undergoing treatment with interferon alpha-2b and who presented with interferon-associated retinopathy. The patient, who had been taking interferon treatment for three months, complained of a sudden loss of visual acuity in the left eye. An ocular examination revealed multiple cotton wool spots along the retina and macular involvement. Interferon treatment was suspended. Although rare, retinopathy represents a potentially serious adverse effect of interferon treatment. Although normally patients are asymptomatic, complications derived of its use may arise, which can lead to significant visual impairment. We therefore suggest that before initiating treatment with this drug, patients should be informed of its potential ocular risks, and that regular eye examinations are conducted along with the treatment.
journal_name
Arq Bras Oftalmoljournal_title
Arquivos brasileiros de oftalmologiaauthors
Borrego-Sanz L,Sáenz-Francés F,Fernández-Tresguerres MF,Jiménez-Santos M,Donate-López Jdoi
10.5935/0004-2749.20140080subject
Has Abstractpub_date
2014-10-01 00:00:00pages
321-323issue
5eissn
0004-2749issn
1678-2925pii
S0004-27492014000500321journal_volume
77pub_type
杂志文章abstract::Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
doi:10.1590/s0004-27492009000300028
更新日期:2009-05-01 00:00:00
abstract::We describe here a case of a 21-year-old woman who presented with low visual acuity, pain, and hyperemia in the left eye for 45 days. Her eye had extensive corneal infiltrate, with melting and a central perforation that was glued with cyanoacrylate, but with Seidel (+). She underwent tectonic corneal transplantation, ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 信件
doi:10.5935/0004-2749.20190031
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To evaluate the biopsychosocial profile of patients with anophthalmia, with emphasis on the psychological and functional impact of eye loss and the social reintegration of this population. METHODS:Prospective analyses of 84 patients (50 males and 34 females), rehabilitated or in the rehabilitation process with...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492008000600017
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:To investigate the distribution of axial length, anterior chamber depth, lens thickness, vitreous chamber depth, and central corneal thickness in children at different age groups. METHODS:We studied 364 eyes in 182 children with ages between 1 and 12 years. Axial length, anterior chamber depth, lens thickness,...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20140039
更新日期:2014-05-01 00:00:00
abstract::To report a case of gyrate atrophy of the choroid and retina associated with retinal detachment. Hyperornithinemia confirmed the diagnosis of gyrate atrophy. Pars plana vitrectomy with silicone oil infusion was performed with good anatomical results, despite the persistence of low visual acuity. Retinal detachment is ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492012000100012
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To assess the intraocular pressure (IOP) and ocular rigidity (E) at 1, 3, 6 and 24 postoperative months in eyes that underwent LASIK. METHODS:The IOP measured by Goldmann applanation tonometer (GAT) and by the 5.5 and 10 gm. weights of a standardized Schioetz tonometer (ST) and the E measured by differential t...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492009000400003
更新日期:2009-07-01 00:00:00
abstract:PURPOSES:To validate a teleophthalmology mobile system aimed at improving and providing eye urgency screenings in remote and poor area settings in Brazil. The system enables one or more ophthalmologists to remotely examine a patient's condition and submit a decision describing the gravity of the case. If necessary, the...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20140055
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:To evaluate dacrycystographic examination in patients with suspicion of lacrimal apparatus obstruction. METHODS:A retrospective study was performed to evaluate dacryocystographies of 100 adults suspected of nasolacrimal duct obstruction at the "Faculdade de Medicina de Botucatu-UNESP". The data were submitted ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492005000100016
更新日期:2005-01-01 00:00:00
abstract::The authors describe an unusual association between posterior keratoconus and iris atrophy, confirmed by a complete ocular evaluation, scheimpflug imaging and pachymetric curve. A hypothesis for concomitant findings is discussed. ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 信件
doi:10.5935/0004-2749.20190014
更新日期:2019-01-01 00:00:00
abstract::Solitary fibrous tumor (SFT) is a rare mesenchymal spindle-cell neoplasm commonly found in the pleura; it is rare in the orbit and extremely rare in the lacrimal gland. We herein report a case of SFT of the lacrimal gland that mimicked a pleo morphic adenoma. We discuss the clinical, radiological, histopathological, a...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20170046
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Analysis of the relevance of preoperative evaluation to prevent adverse clinical events, pre- and postoperative, on cataract surgery. METHODS:The study includes 1254 patients submitted to cataract surgery at the Instituto da Catarata do Departamento de Oftalmologia da UNIFESP - EPM, in the period of Jan - Dec ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492007000400014
更新日期:2007-07-01 00:00:00
abstract::To report a case of aberrant regeneration followed by acute palsy of the oculomotor nerve caused by intracranial aneurysm. A 59-year-old patient was attended in February 2006 complaining of headache with diplopia and blepharoptosis in the right eye. At the external ocular motility exam. Aduction, supraduction and infr...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492008000300028
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:This study was designed to evaluate the visual and anatomical outcomes after cataract surgery in diabetic patients with different intraoperative therapeutic strategies. METHODS:The research design comprised of a multicentric, retrospective, interventional study conducted at 6 centers in Argentina, Brazil, Cost...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,多中心研究
doi:10.5935/0004-2749.20140089
更新日期:2014-11-01 00:00:00
abstract::Nature has always provided an unlimited source of biologically-active compounds. Since the beginning of mankind, humans have sought resources in fauna and flora to treat eye diseases. However, it was only after the Industrial Revolution that extracts of plants and substances of animal origin could be used safely, as h...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
doi:10.5935/0004-2749.20180086
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To demonstrate optical coherence tomography efficacy to evaluate macular anatomical outcomes, in eyes with silicone oil-filled vitreous cavity after vitrectomy. METHODS:A descriptive observational study of 28 (twenty-eight) patients submitted to pars plana vitrectomy having silicone oil as vitreous substitute....
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492007000200017
更新日期:2007-03-01 00:00:00
abstract::We report the case of a patient who received conjunctival tattooing for cosmetic purposes with associated complications. A 28-year-old male experienced severe ocular pain after undergoing conjunctival tattooing. Slit-lamp examination revealed blue deposits over the conjunctiva in association with intense conjunctival ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type:
doi:10.5935/0004-2749.20170098
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To identify the frequency of ocular diseases among recipients of disability benefits in the metropolitan region of Recife, Brazil. METHODS:A review was performed of 217,221 cases of disability benefits granted between 2010 and 2015 by the executive managerial department of the Brazilian National Institute of S...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20180058
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To report a specific line of research developed at the University of São Paulo/Brazil on fibrin glue used for sealing corneal perforations and the perspectives of use on non-perforated corneal ulcers and photorefractive keratectomy-operated corneas. METHODS:To describe fibrin glue manufacture, development of a...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
doi:10.1590/s0004-27492007000500029
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To document the clinical features, systemic association, treatment and evolution of 23 patients with posterior scleritis evaluated in the Uveitis service of the Federal University of Minas Gerais. METHODS:23 patients were identified with the diagnosis of posterior scleritis. Signals and symptoms, visual acuity...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492009000300008
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To determine a correction factor for refractive errors evaluated without cycloplegy effect. METHODS:A study was made with 623 patients (1,246 eyes) of both sexes, aging between 3 and 40 years old. The dynamic and static refractometries were obtained using the automated refractor Shin-Nippon Accuref-K 9001. 1% ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492009000600009
更新日期:2009-11-01 00:00:00
abstract::Orbital emphysema is the abnormal presence of air in the orbit. Occurrence in the absence of orbital fracture is rare. We report a case of a 40-year-old female presenting unilateral orbital emphysema after vigorous nose blowing. She developed sudden visual loss as a result of elevated intraocular pressure and urgent t...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492009000200024
更新日期:2009-03-01 00:00:00
abstract::Cicatricial ectropion may be a consequence of certain systemic diseases as well as the result of drug use. Our goal here was to research the different causes of this condition as reported in the literature, including more recently suspected etiologies. A detailed PubMed literature search indicated many different etiol...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
doi:10.5935/0004-2749.20190068
更新日期:2019-05-20 00:00:00
abstract::Vogt-Koyanagi-Harada syndrome is chronic systemic autoimmune disease with ocular, nervous, auditory and tegumental manifestations. We report here the case of a child with onset of symptoms at four years and two months of age, with positive HLA DRB1*01. ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492007000200027
更新日期:2007-03-01 00:00:00
abstract:PURPOSES:To investigate the intra-laboratory reproducibility of clinical features and to evaluate corneal optical anisotropies in a rabbit model of limbal stem cell deficiency. METHODS:Limbal injury was induced in the right eye of 23 adult New Zealand White rabbits using a highly aggressive protocol that combined 360 ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20180076
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:We aimed to evaluate the use of automated quantitative static and dynamic pupillometry in screening patients with type 2 diabetes mellitus and different stages of diabetic retinopathy. METHOD:155 patients with type 2 diabetes mellitus (diabetes mellitus group) were included in this study and another 145 age- a...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20210007
更新日期:2021-01-01 00:00:00
abstract::Waardenburg syndrome (WS) type I is a non-progressive auditory-pigmentary disorder comprising congenital sensorineural hearing loss and pigmentary disturbances of the iris, hair, and skin, along with dystopia canthorum (lateral displacement of the inner canthi). Affected individuals may have higher risk of: neural tub...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492011000300013
更新日期:2011-05-01 00:00:00
abstract::Here we report a case of childhood glaucoma refractory to angle and trabeculectomy surgery. The patient was treated with an Ahmed™ drainage implant that was subsequently complicated by rapid-onset panophthalmitis and orbital cellulitis. Intravenous and intravitreal antibiotic therapy was initiated and the drainage tub...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20160037
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. METHODS:A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,随机对照试验
doi:10.1590/s0004-27492012000300006
更新日期:2012-05-01 00:00:00
abstract::Herein, we report two cases of vision loss after successful cataract surgery, associated with drusenoid retinal pigment epithelial detachment without features of choroidal neovascularization on optical coherence tomography along with angiographic examinations suggestive of choroidal neovascularization in which anatomi...
journal_title:Arquivos brasileiros de oftalmologia
pub_type:
doi:10.5935/0004-2749.20170064
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:Pseudoexfoliation syndrome has been linked to impaired function of the heart and blood vessels. We conducted a study to investigate the role of the renin-angiotensin system in the etiopathogenesis of pseudoexfoliation syndrome. METHODS:The subjects were 14 patients with pseudoexfoliation syndrome and 14 health...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20180092
更新日期:2018-11-01 00:00:00