Interferon-associated retinopathy in a patient with metastatic melanoma.


:We present the unusual case of a 35 year-old woman with stage IV melanoma and widespread metastases, who was undergoing treatment with interferon alpha-2b and who presented with interferon-associated retinopathy. The patient, who had been taking interferon treatment for three months, complained of a sudden loss of visual acuity in the left eye. An ocular examination revealed multiple cotton wool spots along the retina and macular involvement. Interferon treatment was suspended. Although rare, retinopathy represents a potentially serious adverse effect of interferon treatment. Although normally patients are asymptomatic, complications derived of its use may arise, which can lead to significant visual impairment. We therefore suggest that before initiating treatment with this drug, patients should be informed of its potential ocular risks, and that regular eye examinations are conducted along with the treatment.


Arq Bras Oftalmol


Borrego-Sanz L,Sáenz-Francés F,Fernández-Tresguerres MF,Jiménez-Santos M,Donate-López J




Has Abstract


2014-10-01 00:00:00














  • Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome.

    abstract:PURPOSE:We aimed to compare the thickness of anterior sclera, corneal layers, and pre-ocular tear film between patients with primary Sjögren's syndrome and healthy individuals. METHODS:Fifty-one patients with primary Sjögren's syndrome and 41 healthy control participants were recruited in this cross-sectional and comp...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Pekel G,Taşçı M,Bahar A,Pekel E,Çetin EN,Martin Ç,Çobankara V

    更新日期:2019-07-01 00:00:00

  • Visual loss resulting from immunosuppressive therapy in patients with syphilitic uveitis.

    abstract::Permanent visual loss can be caused by improper use of immunosuppressive therapy in cases of uveitis without differential diagnosis of syphilitic uveitis. We present four cases of syphilitic uveitis that were incorrectly diagnosed as being secondary to rheumatic diseases and were subsequently treated with immunosuppre...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Afonso VC,Nascimento H,Belfort RM,Sato EI,Muccioli C,Belfort R Jr

    更新日期:2015-05-01 00:00:00

  • Ocular involvement in idiopathic hypertrophic pachymeningitis associated with eosinophilic angiocentric fibrosis: a case report.

    abstract::A 43-year-old male with a history of eosinophilic angiocentric fibrosis presented with headache and double vision since 48 h. Idiopathic hypertrophic pachymeningitis was diagnosed based on nuclear magnetic resonance and comprehensive systemic study findings. Eosinophilic angiocentric fibrosis and idiopathic hypertroph...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 信件


    authors: Suárez AR,Capote AC,Barrientos YF,Soto ML,Moreno SG,Martín FG

    更新日期:2018-06-01 00:00:00

  • [Posterior scleritis: clinical features, systemic association, treatment and evolution of 23 patients].

    abstract:PURPOSE:To document the clinical features, systemic association, treatment and evolution of 23 patients with posterior scleritis evaluated in the Uveitis service of the Federal University of Minas Gerais. METHODS:23 patients were identified with the diagnosis of posterior scleritis. Signals and symptoms, visual acuity...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Machado Dde O,Curi AL,Bessa TF,Campos WR,Oréfice F

    更新日期:2009-05-01 00:00:00

  • Metastatic choroidal melanoma to the contralateral eye: a rare case.

    abstract::Uveal melanoma is the most common adult primary intraocular cancer. Although liver metastasis is common to the natural history of the disease, metastasis to the fellow eye is extremely rare. Here we report the case of a 59-year-old man with choroidal melanoma in his right eye who underwent enucleation at a different c...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 信件


    authors: Belfort RN,Müller MS,Isenberg J,Ferraz P,Szejnfeld D

    更新日期:2018-11-01 00:00:00

  • Bilateral retinal vasculitis in a patient with lichen planus.

    abstract::Lichen planus (LP) is an autoimmune, inflammatory disease of unknown etiology that commonly affects the skin and mucous membranes. Retinal vasculitis is a group of vision-threatening disorders, in which autoimmunity is thought to play a role in pathogenesis. We present the case of a patient who was diagnosed with reti...

    journal_title:Arquivos brasileiros de oftalmologia



    authors: Dikci S,Genç O,Yılmaz T,Fırat PG

    更新日期:2016-11-01 00:00:00

  • Comparison of PMMA, foldable silicone and foldable acrylic hydrophobic intraocular lenses in combined phacoemulsification and trabeculectomy.

    abstract:PURPOSE:To compare the postoperative results of phacotrabeculectomy with implantation of PMMA, foldable silicone or foldable hydrofobic acrylic intraocular lens (IOL). SETTING:Glaucoma unit, The Royal Liverpool University Hospital, Liverpool, United Kingdom. METHODS:We studied a total of 124 eyes of three consecutive...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Serpa Junior E,Wishart PK

    更新日期:2005-01-01 00:00:00

  • [Correction factor for individuals with accommodative capacity based on automated refractor].

    abstract:PURPOSE:To determine a correction factor for refractive errors evaluated without cycloplegy effect. METHODS:A study was made with 623 patients (1,246 eyes) of both sexes, aging between 3 and 40 years old. The dynamic and static refractometries were obtained using the automated refractor Shin-Nippon Accuref-K 9001. 1% ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Takahagi RU,Lavagnoli A,Fernandes TM,Schelinni SA,Padovani CR

    更新日期:2009-11-01 00:00:00

  • [Transconjunctival vitrectomy: preliminary data using the TSV-25 Millennium System].

    abstract:PURPOSE:To report the preliminary surgical results of pars plana vitrectomy with a transconjunctival technique using the TSV-25 Millennium system. METHODS:Twenty consecutive patients (20 eyes) that underwent transconjunctival vitrectomy with the TSV-25 Millennium system, between July 2003 and January 2004, were prospe...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Rezende Filho F,Alcântara S,Régis LG

    更新日期:2005-11-01 00:00:00

  • Composition of intraocular foreign bodies: experimental study of ultrasonographic presentation.

    abstract:PURPOSE:To investigate the reliability of ultrasound in determining the size and identify the sonographic features and artifacts generated by intraocular foreign bodies of different materials. METHODS:Experimental study using 36 enucleated porcine eyes. Fragments of nine different compositions (wood, glass, plastic, c...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Costa MA,Garcia PN,Barroso LF,Ferreira MA,Okuda ÉA,Allemann N

    更新日期:2013-01-01 00:00:00

  • [Canaliculitis: case report and management].

    abstract::Canaliculitis is a rare infection of the lacrimal canaliculus with Actinomyces israelii as its most common etiologic agent. The objective of this paper is to report a rare pathology, as well as its clinical and surgical management. Female patient, 44 years old, presenting clinical manifestations compatible with canali...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Carneiro RC,Macedo EM,Oliveira PP

    更新日期:2008-01-01 00:00:00

  • The Amazon Ocular Oncology Center: The first three years.

    abstract:PURPOSE:To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil. METHODS:Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin. RESULTS:Two hundred and twenty-one patients were included on thi...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Cohen S,Pretyman CS,Sant'Ana R,Singh N,Morales M,Belfort RN

    更新日期:2019-03-01 00:00:00

  • Syphilitic retinitis and panuveitis simulating acute retinal necrosis: case report.

    abstract::Retinitis and panuveitis in immunocompetent patients is a rare and sight-threatening disease, of difficult diagnosis. A case of a 31-year-old male who presented with unilateral placoid retinitis and panuveitis, unsuccessfully treated as acute retinal necrosis, that in fact was syphilis, with neurosyphilis and excellen...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Zambon F,Silva FL,Cavalcante AF,Nakashima Y,Helal J Jr

    更新日期:2010-05-01 00:00:00

  • [Occupational trauma due to superficial corneal foreign body].

    abstract:PURPOSE:To evaluate the epidemiology of superficial corneal foreign body. METHODS:Patients who were seen at the Emergency Service of the Federal University of São Paulo, from April/05 to June/05, were screened and those with superficial corneal foreign body were interviewed. Data regarding gender, age, occupation, emp...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Gerente VM,Melo GB,Regatieri CV,Alvarenga LS,Martins EN

    更新日期:2008-03-01 00:00:00

  • Assessing patient satisfaction with cataract surgery under topical anesthesia supplemented by intracameral lidocaine combined with sedation.

    abstract:PURPOSE:Ocular akinesia, the use of anticoagulants, and patient collaboration are some of the factors that must be taken into consideration when choosing the appropriate anesthesia for phacoemulsification cataract surgery. The satisfaction of patients with the use of topical anesthesia and conscious sedation for this p...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Fernandes MB,Souza RV,Vasconcelos GC,Ribeiro KG,Andrade BB,Fernandes CR

    更新日期:2013-11-01 00:00:00

  • [Treatment of acute retinal necrosis: systematic review].

    abstract:PURPOSE:The purpose of this study was to identify, according to an systematic review, the best treatment for acute retinal necrosis. METHODS:Following the methodologic guidance of the Cochrane Collaboration and its editorial subgroup "Eye and Vision Group", using search strategy for study identification, articles abou...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,评审


    authors: Zajdenweber ME,Muccioli C

    更新日期:2005-07-01 00:00:00

  • Clinical and epidemiological characteristics of patients with uveitis in an emergency eye care center in Brazil.

    abstract:PURPOSE:To analyze the clinical and epidemiological characteristics of patients with uveitis in an emergency eye care center. METHODS:We conducted a prospective, observational study of patients with active uveitis admitted between May 2012 and July 2012 to an emergency eye care center. RESULTS:The majority of patient...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Camilo EN,Moura GL,Arantes TE

    更新日期:2014-01-01 00:00:00

  • A fibrin-related line of research and theoretical possibilities for the use of fibrin glue as a temporary basal membrane in non-perforated corneal ulcers and in photorefractive keratectomy (PRK)-operated corneas.

    abstract:PURPOSE:To report a specific line of research developed at the University of São Paulo/Brazil on fibrin glue used for sealing corneal perforations and the perspectives of use on non-perforated corneal ulcers and photorefractive keratectomy-operated corneas. METHODS:To describe fibrin glue manufacture, development of a...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,评审


    authors: Bonatti JA,Bechara SJ,Dall'Col MW,Cresta FB,Carricondo PC,Kara-José N

    更新日期:2007-09-01 00:00:00

  • [Effects of reading, exercise and exercise combined with reading on intraocular pressure for patients sustaining primary glaucoma (open angle) or ocular hypertension, both clinically controlled with topic medication].

    abstract:PURPOSE:To check intraocular pressure (IOP) in individuals using prostaglandin, prostamide or beta-blocker analogues, who sustain either primary open angle glaucoma or ocular hypertension after reading, exercise or exercise combined with reading. METHODS:40 individuals (79 eyes), subdivided in to five groups: G1 (with...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,随机对照试验


    authors: Medina AM,Lima NV,Santos RC,Pereira MC,Santos PM

    更新日期:2007-01-01 00:00:00

  • Upper lid crease approach for margin rotation in trachomatous cicatricial entropion without external sutures.

    abstract:PURPOSE:To describe the use of a lid crease incision for upper eyelid margin rotation in cicatricial entropion combining internal traction on the anterior lamella, tarsotomy, and tarsal overlap without external sutures. METHODS:Surgical description: The main steps of the procedure consisted of exposure of the entire t...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Cruz AA,Akaishi PM,Al-Dufaileej M,Galindo-Ferreiro A

    更新日期:2015-11-01 00:00:00

  • [Penetrating keratoplasty indications in "Hospital das Clínicas-UNICAMP"].

    abstract:PURPOSE:To determine the main causes of penetrating keratoplasty indications at "Hospital das Clínicas-UNICAMP" (January, 1999 to December, 2003). METHODS:A non-comparative, retrospective series of case studies. The authors reviewed the files of 857 patients who underwent penetrating keratoplasty at "Hospital das Clín...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Flores VG,Dias HL,de Castro RS

    更新日期:2007-05-01 00:00:00

  • [Ectopia lentis et pupillae: case report].

    abstract::The main purpose of this report is to describe a case of ectopia lentis et pupillae syndrome, highlighting the secondary ocular complications and their differential diagnoses. A 27-year-old man presented with complaint of low visual acuity. No evidence of the syndrome was found at presentation. The results of suppleme...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Bernardes CS,Leite LV,Castro FA

    更新日期:2005-11-01 00:00:00

  • The effects of riboflavin and ultraviolet light on keratocytes cultured in vitro.

    abstract:PURPOSE:To culture quiescent human keratocytes and evaluate the effects of ultraviolet light and riboflavin on human corneal keratocytes in vitro. METHODS:Keratocytes were obtained from remaining corneoscleral ring donor corneas previously used in corneal transplant surgeries and cultured in DMEM/F12 with 2% FBS until...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Covre JL,Cristovam PC,Loureiro RR,Hazarbassanov RM,Campos M,Sato ÉH,Gomes JÁ

    更新日期:2016-05-01 00:00:00

  • Refractive errors in children and adolescents in Bucaramanga (Colombia).

    abstract:PURPOSE:The aim of this study was to establish the frequency of refractive errors in children and adolescents aged between 8 and 17 years old, living in the metropolitan area of Bucaramanga (Colombia). METHODS:This study was a secondary analysis of two descriptive cross-sectional studies that applied sociodemographic ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Galvis V,Tello A,Otero J,Serrano AA,Gómez LM,Castellanos Y

    更新日期:2017-11-01 00:00:00

  • Post-laser in situ keratomileusis interface Arthrographis kalrae keratitis.

    abstract::We describe a case of keratomycosis caused by Arthographis kalrae after excimer laser keratomileusis. A 38-year-old female developed stromal keratitis eight weeks after refractive surgery. She developed severe corneal stromal infiltration and mild anterior segment inflammation, which could not be treated with topical ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 信件


    authors: Fernández-Barrientos Y,Ramos-Suárez A,Fernández-Sánchez F,Tirado-Carmona A

    更新日期:2020-01-01 00:00:00

  • [Influence of cataract surgical correction on working perception].

    abstract:PURPOSE:To analyze the benefits after cataract surgery in professional activities. METHODS:A prospective, randomized study was conducted at the Clinical Hospital of the University of São Paulo. The patients had cataract surgery by phacoemulsification (PHACO) and by extracapsular extraction (EECP). RESULTS:The sample ...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章,随机对照试验


    authors: Kara-Junior N,Santhiago MR,Parede TR,Espindola RF,Mazurek MG,Germano R,Kara-Jose N

    更新日期:2010-11-01 00:00:00

  • [Traumatic optic nerve avulsion by high caliber bullet: case report].

    abstract::Traumatic optic nerve avulsion occurs most commonly after blunt ocular trauma. Optic nerve avulsion by high caliber bullet is exceptional and must be thought of in the management of those patients victims of gunshot wounds to the globe and orbit. The present paper reports the first documented case of this singular con...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Tárcia Rde A

    更新日期:2006-05-01 00:00:00

  • [Trends on anophthalmic socket repair in Brazil].

    abstract:PURPOSE:To determine the most common approach to repair the anophthalmic socket in Brazil, and to compare the data with the trends in other countries. METHODS:Exploratory study using electronic questionnaire sent by Internet to ophthalmologists members of the Brazilian Orbit and Oculoplastic Society (SBCPO). The recei...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Sousa RL,Schellini SA,Zornoff Dde C,Padovani CR

    更新日期:2012-11-01 00:00:00

  • [Ocular toxicity caused by chloroquine: case report].

    abstract::To report a case of ocular toxicity due to chloroquine. The best visual acuity was measured in both eyes with the Snellen chart. Slit-lamp examination of anterior segment, refraction, dilated fundus examination, fluorescein angiography and retinography was done in a 53-year-old patient, female, with rheumatoid arthrit...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Inada ET,Watanabe KP,Tanaka SG,Sakakisbara LA

    更新日期:2005-05-01 00:00:00

  • [Noncompliance with drug therapy for glaucoma].

    abstract:INTRODUCTION:The treatment of glaucoma is made initially with the use of eyedrops, with the purpose to decrease intraocular pressure and to minimize the damages to the optic nerve. The lack of compliance with drug therapy can be influenced by factors related to patients, doctors and medicines. PURPOSES:To estimate the...

    journal_title:Arquivos brasileiros de oftalmologia

    pub_type: 杂志文章


    authors: Castro AN,Mesquita WA

    更新日期:2008-03-01 00:00:00