Abstract:
:Nature has always provided an unlimited source of biologically-active compounds. Since the beginning of mankind, humans have sought resources in fauna and flora to treat eye diseases. However, it was only after the Industrial Revolution that extracts of plants and substances of animal origin could be used safely, as has been determined by controlled interventional studies. Two major challenges faced by ocular pharmacology are the following: developing drugs that are able to reduce blindness due to glaucoma; and controlling the pain associated with eye surgery. The search for a drug that effectively lowers intraocular pressure and controls the progression of glaucoma has led to the development of various ocular hypotensive agents, such as physostigmine from the Physostigma venenosum plant. The anesthetic properties of cocaine, extracted from Erythroxylon coca, finally enabled surgical procedures in the eye. Several new natural compounds have been investigated in an attempt to identify substances with the potential to provide additional benefits to eye tissue and vision. Emerging evidence of anti-inflammatory, wound-healing, antimicrobial, antioxidant, antitumor, and antiangiogenic properties attributed to plant extracts and animal tissues has encouraged more investment in research in this area. Despite technological advances in synthesizing drugs, the pharmaceutical industry still seeks new active compounds from natural sources as well as from revisiting already-established naturally derived compounds. Although a large number of naturally-occurring compounds is known, this review article focuses on the bioactive substances with scientifically-proven benefits for ocular tissues.
journal_name
Arq Bras Oftalmoljournal_title
Arquivos brasileiros de oftalmologiaauthors
Pinheiro GKLO,Araújo Filho I,Araújo Neto I,Rêgo ACM,Azevedo EP,Pinheiro FI,Lima Filho AASdoi
10.5935/0004-2749.20180086subject
Has Abstractpub_date
2018-09-01 00:00:00pages
443-454issue
5eissn
0004-2749issn
1678-2925pii
S0004-27492018000500443journal_volume
81pub_type
杂志文章,评审abstract::We report three rare cases of ethmoid osteoma extending to the medial quadrant of the orbit that had singular particularities, such as occurring in women, at an unusual age group, and complaint of epiphora. The radiographic images were typical of this condition. Patients were submitted to surgery with complete resolut...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
doi:10.1590/s0004-27492007000600027
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abstract:PURPOSE:To estimate the occurrence of adverse effects associated with the use of botulinum toxin by performing a systematic review and meta-analysis. METHODS:A systematic literature search of MEDLINE and Cochrane Library was conducted until September 2007. The occurrence of the adverse effects was estimated of the rel...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,meta分析,评审
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abstract:PURPOSE:To report a specific line of research developed at the University of São Paulo/Brazil on fibrin glue used for sealing corneal perforations and the perspectives of use on non-perforated corneal ulcers and photorefractive keratectomy-operated corneas. METHODS:To describe fibrin glue manufacture, development of a...
journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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abstract:PURPOSE:To evaluate corneal endothelium alterations after applying mitomycin C to the sclera using transmission and scanning electron microscopy, correlating alterations with time, concentration, and evaluation methods. METHODS:The corneal endothelium of both eyes of 32 albino rabbits was evaluated and distributed int...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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abstract:PURPOSE:To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil. METHODS:Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin. RESULTS:Two hundred and twenty-one patients were included on thi...
journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,随机对照试验
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492008000100023
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journal_title:Arquivos brasileiros de oftalmologia
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abstract:PURPOSE:To evaluate the fitting and use of a soft contact lens in keratoconic patients. METHODS:Retrospective study on 80 eyes of 66 patients, fitted with a special soft contact lens for keratoconus, at the Contact Lens Section of UNIFESP and private clinics. Keratoconus was classified according to degrees of disease ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492006000400018
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