Abstract:
:Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequately treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment.
journal_name
Arq Bras Oftalmoljournal_title
Arquivos brasileiros de oftalmologiaauthors
Damico FM,Bezerra FT,Silva GC,Gasparin F,Yamamoto JHdoi
10.1590/s0004-27492009000300028subject
Has Abstractpub_date
2009-05-01 00:00:00pages
413-20issue
3eissn
0004-2749issn
1678-2925pii
S0004-27492009000300028journal_volume
72pub_type
杂志文章,评审abstract:PURPOSE:To evaluate dacrycystographic examination in patients with suspicion of lacrimal apparatus obstruction. METHODS:A retrospective study was performed to evaluate dacryocystographies of 100 adults suspected of nasolacrimal duct obstruction at the "Faculdade de Medicina de Botucatu-UNESP". The data were submitted ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492005000100016
更新日期:2005-01-01 00:00:00
abstract::Fabry's disease is a rare X-linked lysosomal storage disorder of glycosphingolipid (GL) metabolism, caused by a deficiency of alpha-galactosidase A activity. The progressive accumulation of GL in tissues results in the clinical manifestations of the disease, that are more evident in hemizygous males, and include angio...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492007000400024
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:To evaluate the correlation between the preoperative visual acuity (VA) obtained by the potential acuity meter (PAM) and the postoperative VA in a patient submitted to cataract surgery, as well as its correlation with the dominant morphologic classification of the cataract. METHODS:This is a prospective study ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492008000600007
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:To compare the safety and efficacy of human preserved amniotic membrane (AM) in the trabeculectomy for treatment of primary open-angle glaucoma. METHODS:A prospective, randomized clinical trial compared primary trabeculectomy with amniotic membrane (study group) and without amniotic membrane (control group) in...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,随机对照试验
doi:10.1590/s0004-27492006000300005
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To assess the resources use, costs and effectiveness of non-penetrating deep sclerectomy (NPDS). METHODS:A retrospective cohort of NPDS patients was analyzed. Eyes were stratified according to glaucoma severity into 3 groups: 1 (early), 2 (moderate) and 3 (severe). NPDS associated resources were based on the f...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492011000600003
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To describe the electroretinogram of the South-American opossum (Didelphis aurita) obtained by chromatic stimulus of specific wavelengths. The electroretinogram records voltage variations of retinal cells triggered by light stimulation. The electroretinogram represents the combination of electric activity of ma...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492006000600014
更新日期:2006-11-01 00:00:00
abstract::A case of inadvertent retention of Descemet's membrane after penetrating keratoplasty for Fuchs dystrophy is reported. The challenges to remove it during cataract surgery are commented, as well as a proposal of a new surgical approach. ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492010000600013
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To compare the preferential hyperacuity perimeter (Preview PHP; Carl Zeiss Meditec, Dublin, CA) with the original Amsler grid in the detection of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD). METHODS:Patients were classified into groups, based on the severity of th...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492007000500009
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To correlate provocative test-based intraocular pressure (IOP) variation parameters (fluctuation and peak) with functional status, and to compare these IOP parameters between treated eyes with asymmetric primary open-angle glaucoma (POAG). METHODS:A prospective observational study including consecutively treat...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20190035
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of prostaglandin antagonists on blood-retinal barrier breakdown induced by anterior segment intraocular simulated surgery. METHODS:Rats were randomly assigned to a negative control group, model group, nonsteroidal anti-inflammatory drugs prophylactic treatment group, nonsteroidal anti-...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20180040
更新日期:2018-06-01 00:00:00
abstract::Report on the development of pseudohypopyon immediately after intravitreal injection of triamcinolone acetonide (TAAC). Two phakic patients presenting with a transient pseudohypopyon after having been treated with intravitreal triamcinolone. One had a clinically significant macular edema with cystoid component (CSME w...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492005000200018
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:Ocular akinesia, the use of anticoagulants, and patient collaboration are some of the factors that must be taken into consideration when choosing the appropriate anesthesia for phacoemulsification cataract surgery. The satisfaction of patients with the use of topical anesthesia and conscious sedation for this p...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492013000600005
更新日期:2013-11-01 00:00:00
abstract::The use of intraocular lenses was a great advance in visual recovery after cataract surgery. Although usually with good biocompatibility, some alterations in the intraocular lens material may occur after implantation. Polymethylmethacrylate was the first intraocular lens material to be used on a large scale and assume...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492005000500021
更新日期:2005-09-01 00:00:00
abstract:PURPOSE:To evaluated the retinal nerve fiber layer in chloroquine patients with optical coherence tomography (OCT). METHODS:Nerve fibers layer thickness was measured by a proprietary OCT Stratus through the fast retinal nerve fiber layer protocol in ninety-four eyes of 48 patients exposed to chloroquine for at least o...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492010000100005
更新日期:2010-01-01 00:00:00
abstract::We describe a case of early post-LASIK ectasia detected in the first 6 months after surgery. The patient was treated by means of intrastromal corneal crosslinking under the flap, without de-epithelialization, which resulted in a positive outcome. At the time of writing, 2 years after the procedure, the patient remaine...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20140049
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:To evaluate vascular density in super-ficial and deep capillary plexuses of the retina, measured using optical coherence tomography angiography in patients with branch retinal vein occlusion. Affected eyes were compared with the contralateral eye of the same patient and both were compared with normal eyes. MET...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20200091
更新日期:2020-11-01 00:00:00
abstract::Retinitis and panuveitis in immunocompetent patients is a rare and sight-threatening disease, of difficult diagnosis. A case of a 31-year-old male who presented with unilateral placoid retinitis and panuveitis, unsuccessfully treated as acute retinal necrosis, that in fact was syphilis, with neurosyphilis and excellen...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492010000300016
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:To evaluate ocular straylight before and after photorefractive keratectomy (PRK) for low myopia with and without topical mitomycin (MMC) treatment. METHODS:Patients who underwent PRK for low myopia were enrolled into the study. PRK without MMC was performed in 21 eyes (12 patients), whereas PRK with topical 0....
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 临床试验,杂志文章
doi:10.5935/0004-2749.20160027
更新日期:2016-04-01 00:00:00
abstract::We present the unusual case of a 35 year-old woman with stage IV melanoma and widespread metastases, who was undergoing treatment with interferon alpha-2b and who presented with interferon-associated retinopathy. The patient, who had been taking interferon treatment for three months, complained of a sudden loss of vis...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20140080
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Evaluation of the nerve fiber thicknesses of the macula, choroid, and retina using the apnea-hypopnea index in individuals with obstructive sleep apnea syndrome (OSAS) without systemic components. METHODS:Prospective, controlled study. The central macular, choroidal, and retinal nerve fiber layer (RNFL) thickn...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.5935/0004-2749.20160070
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To report the response of choroidal neovascularization to intravitreal ranibizumab or bevacizumab treatment in the setting of age-related macular degeneration with extensive pre-existing geographic atrophy of the retinal pigment epithelium. METHODS:This is a retrospective case series of 11 eyes in ten consecut...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492012000400011
更新日期:2012-07-01 00:00:00
abstract::To report a case of gyrate atrophy of the choroid and retina associated with retinal detachment. Hyperornithinemia confirmed the diagnosis of gyrate atrophy. Pars plana vitrectomy with silicone oil infusion was performed with good anatomical results, despite the persistence of low visual acuity. Retinal detachment is ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492012000100012
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To measure, using the retinal thickness analyzer, the mean foveal thickness and the mean perifoveal thickness values on patients suffering from mild non-proliferative diabetic retinopathy without clinically detectable macular edema (classified by the ETDRS study), and compare them with healthy individuals. MET...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492009000400013
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:The treatment of glaucoma is made initially with the use of eyedrops, with the purpose to decrease intraocular pressure and to minimize the damages to the optic nerve. The lack of compliance with drug therapy can be influenced by factors related to patients, doctors and medicines. PURPOSES:To estimate the...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492008000200014
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To describe an outbreak of Pseudomonas aeruginosa endophthalmitis post cataract surgery. Clinical findings, treatment and outcome are discussed. METHODS:Clinical charts review of forty-five patients treated for endophthalmitis in a two-day period. The patients underwent primary vitrectomy, anterior chamber irr...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492012000500010
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To assess the microsurgery dexterity outcomes of two sequential training evaluations using virtual reality technology. METHODS:This was a multicenter cross-sectional study of all candidates who were accepted as first-year residents at one of six ophthalmology teaching institutions. Residents were subjected to ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,多中心研究
doi:10.5935/0004-2749.20200050
更新日期:2020-08-01 00:00:00
abstract::Regardless of significant progress in the field of corneal transplantation to treat corneal opacification, some cases of corneal blindness still present a poor prognosis for conventional penetrating keratoplasty. In patients with repeated graft failure and/or with severe ocular surface disease, the Boston type I kerat...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
doi:10.1590/s0004-27492012000300016
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:Compare the retinal structure of the macula and fovea among premature infants with retinopathy of prematurity (ROP) stages II and III post treatment, premature infants with ROP stages II and III with spontaneous regression and premature infants without ROP, through optical coherence tomography (OCT) and binocul...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492013000200009
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:To evaluate fixation by a bioadhesive of the external ocular muscles to the porous polyethylene spheres. METHODS:An experimental study was performed using eight white rabbits that underwent right eye enucleation with placement of 12 mm spheres of porous polyethylene. The rectus muscles (superior and inferior) ...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492007000200007
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:To assess the long-term refractive outcomes of photorefractive keratectomy in myopia and myopic astigmatism. METHODS:A retrospective study of 120 photorefractive keratectomy operated eyes with at least four-year follow-up (maximum of 96 months, mean follow-up 55 months). We divided patients into group 1 (G1) s...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492007000600017
更新日期:2007-11-01 00:00:00