New insights into Vogt-Koyanagi-Harada disease.

Abstract:

:Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequately treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment.

journal_name

Arq Bras Oftalmol

authors

Damico FM,Bezerra FT,Silva GC,Gasparin F,Yamamoto JH

doi

10.1590/s0004-27492009000300028

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

413-20

issue

3

eissn

0004-2749

issn

1678-2925

pii

S0004-27492009000300028

journal_volume

72

pub_type

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