Abstract:
PURPOSE:We aimed to evaluate the use of automated quantitative static and dynamic pupillometry in screening patients with type 2 diabetes mellitus and different stages of diabetic retinopathy. METHOD:155 patients with type 2 diabetes mellitus (diabetes mellitus group) were included in this study and another 145 age- and sex-matched healthy individuals to serve as the control group. The diabetes mellitus group was divided into three subgroups: diabetes mellitus without diabetic retinopathy (No-diabetic retinopathy), nonproliferative diabetic retinopathy, and proliferative diabetic retinopathy. Static and dynamic pupillometry were performed using a rotating Scheimpflug camera with a topography-based system. RESULTS:In terms of pupil diameter in both static and dynamic pupillometry (p<0.05), statistically significant differences were observed between the diabetes mellitus and control groups and also between the subgroups No-diabetic retinopathy, nonproliferative diabetic retinopathy, and proliferative diabetic retinopathy subgroups. But it was noted that No-diabetic retinopathy and nonproliferative diabetic retinopathy groups have showed similarities in the findings derived from static pupillometry under mesopic and photopic conditions. The two groups also appeared similar at all points during the dynamic pupillometry (p>0.05). However, it could be concluded that the proliferative diabetic retinopathy group was significantly different from the rest of the subgroups, No-diabetic retinopathy and nonproliferative diabetic retinopathy groups, in terms of all the static pupillometry measurements (p<0.05). The average speed of dilation was also significantly different between the diabetes mellitus and control groups and among the diabetes mellitus subgroups (p<0.001). While weak to moderate significant correlations were found between all pupil diameters in static and dynamic pupillometry with the duration of diabetes mellitus (p<0.05 for all), the HbA1c values showed no statistically significant correlations with any of the investigated static and dynamic pupil diameters (p>0.05 for all). CONCLUSION:This study revealed that the measurements derived from automated pupillometry are altered in patients with type 2 diabetes mellitus. The presence of nonproliferative diabetic retinopathy does not have a negative effect on pupillometry findings, but with proliferative diabetic retinopathy, significant alterations were observed. These results suggest that using automated quantitative pupillometry may be useful in verifying the severity of diabetic retinopathy.
journal_name
Arq Bras Oftalmoljournal_title
Arquivos brasileiros de oftalmologiaauthors
Cankurtaran V,Ilhan C,Tekin K,Citirik M,Dirican E,Gurkan Edoi
10.5935/0004-2749.20210007subject
Has Abstractpub_date
2021-01-01 00:00:00pages
37-44issue
1eissn
0004-2749issn
1678-2925pii
S0004-27492021000100037journal_volume
84pub_type
杂志文章abstract:PURPOSE:To evaluate the feasibility of the combined use of bevacizumab (Avastin®) and combined with infliximab (Remicade®) in the treatment of naive choroidal neovascularization due to age-related macular degeneration eyes. METHODS:Intravitreal injections of bevacizumab combined with infliximab in 6 neovascular age-re...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492013000300010
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abstract:PURPOSE:To compare the preferential hyperacuity perimeter (Preview PHP; Carl Zeiss Meditec, Dublin, CA) with the original Amsler grid in the detection of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD). METHODS:Patients were classified into groups, based on the severity of th...
journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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abstract:PURPOSE:To investigate whether the time interval between type 2 diabetes mellitus (DM) diagnosis and the first fundoscopic examination is related with the presence and the severity of diabetic retinopathy (DR) observed. METHODS:A survey of 105 type 2 DM patients referred to ophthalmologic evaluation in the "Hospital d...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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abstract::Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the ...
journal_title:Arquivos brasileiros de oftalmologia
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abstract:PURPOSE:To evaluate the ophthalmic artery hemodynamics in patients with chronic heart failure. METHODS:Doppler parameters of ophthalmic artery of 18 patients with chronic heart failure in different stages of the disease were compared with 21 healthy volunteers (control group). These parameters were also correlated wit...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492011000500003
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492005000500011
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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doi:10.1590/s0004-27492005000100006
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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abstract::Eye banks use sterile procedures to manipulate the eye, antiseptic measures for ocular surface decontamination, and rigorous criteria for donor selection to minimize the possibility of disease transmission due to corneal grafting. Donor selection focuses on analysis of medical records and specific post-mortem serologi...
journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492013000200009
更新日期:2013-03-01 00:00:00
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,随机对照试验
doi:10.1590/s0004-27492010000600003
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abstract:PURPOSE:To report the response of choroidal neovascularization to intravitreal ranibizumab or bevacizumab treatment in the setting of age-related macular degeneration with extensive pre-existing geographic atrophy of the retinal pigment epithelium. METHODS:This is a retrospective case series of 11 eyes in ten consecut...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章
doi:10.1590/s0004-27492012000400011
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abstract::Age-related macular degeneration (ARMD) remains a leading cause of blindness in the western world. Several clinical forms of the disease are recognized, whereas choroidal neovascularization (CNV) represents an important manifestation suitable for treatment. The treatment of CNV has been a major focus of research in th...
journal_title:Arquivos brasileiros de oftalmologia
pub_type: 杂志文章,评审
doi:10.1590/s0004-27492006000500027
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