Dynamics of disinfection of selected preservatives against Escherichia coli.


:Mathematical models were determined relating preservative concentration and D values (decimal reduction times at 25 degrees C; pH 6.9-7.1) against Escherichia coli in aqueous medium. Preservatives investigated were 2-bromo-2-nitro-1,3-propanediol (Bronopol), N-(hydroxymethyl)-N-(1,3-dihydroxymethyl-2, 5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl)urea (Germall II), phenethyl alcohol, and benzyl alcohol. Linear regression was used to determine D values [i.e., the time required for a particular concentration of preservative at a specified pH, temperature, and medium to cause a 90% reduction of viable organisms (E. coli)] from a number of concentrations of each preservative. Linear regression of the log D values versus the log of the concentration (a minimum of 4 concentrations per preservative) were used to derive power curves. Concentration exponents, eta values (the logarithmic values relating changes in rates of kill for specified changes in concentrations) and A values (extrapolated D values at 1% concentration), were determined. Correlation coefficients for these power fits ranged from -0.987 to -0.999. Plots depicting the closeness of fit of the models to the actual data are shown.


J Pharm Sci


Hurwitz SJ,McCarthy TJ




Has Abstract


1985-08-01 00:00:00














  • Determination of safrole, dihydrosafrole, and chloromethyldihydrosafrole in piperonyl butoxide by high-performance liquid chromatography.

    abstract::An HPLC method for the simultaneous determination of safrole (S), dihydrosafrole (DHS), and chloromethyldihydrosafrole (CM-DHS) in piperonyl butoxide, with fluorimetric detection and elution gradient, is described. Samples with internal standard (piperonyl isobutyrate) are adsorbed on silica cartridges, then eluted wi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schreiber-Deturmeny EM,Pauli AM,Pastor JL

    更新日期:1993-08-01 00:00:00

  • Biowaiver monographs for immediate release solid oral dosage forms: efavirenz.

    abstract::Literature data pertaining to the decision to allow a waiver of in vivo bioequivalence testing for the approval of immediate-release (IR) solid oral dosage forms containing efavirenz as the only active pharmaceutical ingredient (API) are reviewed. Because of lack of conclusive data about efavirenz's permeability and i...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Cristofoletti R,Nair A,Abrahamsson B,Groot DW,Kopp S,Langguth P,Polli JE,Shah VP,Dressman JB

    更新日期:2013-02-01 00:00:00

  • On the identification of slip planes in organic crystals based on attachment energy calculation.

    abstract::Knowledge of slip or cleavage planes can facilitate the fundamental understanding of mechanical properties of organic crystals important to pharmaceutical operations, such as tableting and milling. Slip/cleavage planes were frequently assigned based on attachment energy calculation. These crystallographic planes can a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sun CC,Kiang YH

    更新日期:2008-08-01 00:00:00

  • Degradation kinetics of gonadorelin in aqueous solution.

    abstract::The degradation kinetics of gonadorelin were investigated systematically with reversed-phase high-performance liquid chromatography. The stability-indicating properties of this system were checked with photodiode array detection and by comparison with capillary zone electrophoretic analysis. Influences of gonadorelin ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hoitink MA,Beijnen JH,Bult A,van der Houwen OA,Nijholt J,Underberg WJ

    更新日期:1996-10-01 00:00:00

  • Enhancing the Pharmaceutical Behavior of Nateglinide by Cocrystallization: Physicochemical Assessment of Cocrystal Formation and Informed Use of Differential Scanning Calorimetry for Its Quantitative Characterization.

    abstract::The aim of this study was to synthetize cocrystals of nateglinide, an antidiabetic agent of biopharmaceutics classification system Class IIa, as a strategy to improve both the solubility and the dissolution rate of the drug. Benzamide was selected by a screening procedure as a suitable coformer, and binary mixtures wi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bruni G,Maggi L,Mustarelli P,Sakaj M,Friuli V,Ferrara C,Berbenni V,Girella A,Milanese C,Marini A

    更新日期:2019-04-01 00:00:00

  • Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging.

    abstract::Three dimensional terahertz pulsed imaging (TPI) was evaluated as a novel tool for the nondestructive characterization of different solid oral dosage forms. The time-domain reflection signal of coherent pulsed light in the far infrared was used to investigate film-coated tablets, sugar-coated tablets, multilayered con...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zeitler JA,Shen Y,Baker C,Taday PF,Pepper M,Rades T

    更新日期:2007-02-01 00:00:00

  • A linear theory of transdermal transport phenomena.

    abstract::A theory of charge, fluid-mass, and solute (including macromolecular) transport through porous media is applied to describe transport phenomena across the external layer of mammalian skin. Linear relationships are derived between transport fluxes and applied fields. These relationships introduce six effective transder...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Edwards DA,Langer R

    更新日期:1994-09-01 00:00:00

  • In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil.

    abstract::The objective of this study was to investigate the permeation-enhancing effect of thiolated polycarbophil (PCP) on peptide drugs. Mediated by a carbodiimide, increasing amounts of cysteine (Cys) were covalently bound to sodium neutralized PCP (NaPCP). The extent of covalently attached Cys was determined by quantifying...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Clausen AE,Bernkop-Schnürch A

    更新日期:2000-10-01 00:00:00

  • Unified model for the corneal permeability of related and diverse compounds with respect to their physicochemical properties.

    abstract::Corneal permeability data taken from the literature were analyzed for possible quantitative relationships with physicochemical properties. Although a parabolic relationship was obtained with good correlation between lipophilicity, as expressed by the 1-octanol-water partition coefficients, log Poctanol (or the distrib...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Yoshida F,Topliss JG

    更新日期:1996-08-01 00:00:00

  • The Influence of In Vivo Metabolic Modifications on ADMET Properties of Green Tea Catechins-In Silico Analysis.

    abstract::The health effects of green tea are associated with catechins: (-)-epigallocatechin-3-O-gallate (EGCG), (-)-epigallocatechin, (-)-epicatechin-3-O-gallate, and (-)-epicatechin. An understanding of compound absorption, distribution, metabolism, excretion, and toxicity characteristics is essential for explaining its biol...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Matić S,Jadrijević-Mladar Takač M,Barbarić M,Lučić B,Gall Trošelj K,Stepanić V

    更新日期:2018-11-01 00:00:00

  • Dielectric properties of pharmaceutical materials relevant to microwave processing: effects of field frequency, material density, and moisture content.

    abstract::The rising popularity of microwaves for drying, material processing and quality sensing has fuelled the need for knowledge concerning dielectric properties of common pharmaceutical materials. This article represents one of the few reports on the density and moisture content dependence of the dielectric properties of p...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Heng PW,Loh ZH,Liew CV,Lee CC

    更新日期:2010-02-01 00:00:00

  • Control of poorly soluble drug dissolution in conditions simulating the gastrointestinal tract flow. 2. Cocompression of drugs with buffers.

    abstract::The objective of this study was to determine the primary formulation properties that affect the dissolution rate of poorly soluble nondisintegrating drugs. This work focused on compression of orally administered acidic drugs with ionizable buffers. Naproxen was used as the poorly soluble model drug, and calcium salts ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chakrabarti S,Southard MZ

    更新日期:1997-04-01 00:00:00

  • Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate.

    abstract::The intrinsic dissolution rate and solubility of carbamazepine was measured in aqueous solutions of sodium lauryl sulfate (SLS) prepared with two different grades of purity, 95 and 99%, and 95% SLS in 0.15 M NaCl to determine the effect of surface-active impurities and electrolytes. Four significant observations resul...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Crison JR,Weiner ND,Amidon GL

    更新日期:1997-03-01 00:00:00

  • Kinetics and stability of a multicomponent organophosphate antidote formulation in glass and plastic.

    abstract::An aqueous solution of trimedoxime bromide, atropine, and benactyzine hydrochloride was formulated to have maximum stability as an antidote in organophosphorus poisoning. The stability of the mixture in glass and plastic cartridges was determined. Glass cartridges were more desirable than plastic; there was less vapor...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zvirblis P,Ellin RI

    更新日期:1982-03-01 00:00:00

  • Chromogenic reactions of tertiary amines with polycarboxylic acids and acetic anhydride: carbon suboxide as the reactive species in the malonic acid reagent.

    abstract::Analytical methods based on the title reactions are reviewed, and the malonic acid-acetic anhydride system was selected for detailed study. It is postulated that carbon suboxide, O = C = C = C = O, formed by the action of acetic anhydride on malonic acid, is the effective reactive species in this system. Carbon suboxi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Connors KA,Ifan A

    更新日期:1987-10-01 00:00:00

  • Development of quality-by-design analytical methods.

    abstract::Quality-by-design (QbD) is a systematic approach to drug development, which begins with predefined objectives, and uses science and risk management approaches to gain product and process understanding and ultimately process control. The concept of QbD can be extended to analytical methods. QbD mandates the definition ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Vogt FG,Kord AS

    更新日期:2011-03-01 00:00:00

  • Polynitro aromatic compounds in analytical chemistry II: Reaction of menadione with 2,4-dinitrophenylhydrazine.

    abstract::The intense blue color formed in the official assay of menadione injection by treatment of the sample with 2,4-dinitrophenylhydrazine and ammonia is shown by data from visible light spectra and mass spectra and by comparison of the pKa value with that of the corresponding reaction product of acetone to be due to proto...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Burns LB,Stedman RJ,Tuckerman MM

    更新日期:1978-02-01 00:00:00

  • Determination of ketoprofen by direct injection of deproteinized body fluids into a high-pressure liquid chromatographic system.

    abstract::A rapid, sensitive, and specific determination of ketoprofen in human and animal deproteinized body fluids by reversed-phase high-pressure liquid chromatography is presented. The acid is detectable in amounts as low as 0.1 microgram/ml. Limits of error are in the range of +/- 5.1% of the sample mean. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ballerini R,Cambi A,Del Soldato P,Melani F,Meli A

    更新日期:1979-03-01 00:00:00

  • Technical decision-making with higher order structure data: specific binding of a nonionic detergent perturbs higher order structure of a therapeutic monoclonal antibody.

    abstract::Robust higher order structure (HOS) characterization capability and strategy are critical throughout biopharmaceutical development from initial candidate selection and formulation screening to process optimization and manufacturing. This case study describes the utility of several orthogonal HOS methods as investigati...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Budyak IL,Doyle BL,Weiss WF 4th

    更新日期:2015-04-01 00:00:00

  • The complex inter-relationships between protein flexibility and stability.

    abstract::The ability to successfully formulate and manufacture therapeutic protein dosage forms requires a thorough understanding of their physico-chemical properties. Proteins are inherently dynamic molecules of marginal stability. These properties present unique challenges to the pharmaceutical scientist attempting to develo...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Kamerzell TJ,Middaugh CR

    更新日期:2008-09-01 00:00:00

  • Application of binary polymer system in drug release rate modulation. 2. Influence of formulation variables and hydrodynamic conditions on release kinetics.

    abstract::The significance of factors such as drug solubility, polymer molecular weight, drug loading dose, compression force, and hydrodynamic conditions on drug release from a swellable hydrophilic delivery system was investigated. Hydroxypropyl methylcellulose (HPMC) and pectin were major polymeric constituents of the delive...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kim H,Fassihi R

    更新日期:1997-03-01 00:00:00

  • Hot Melt Extrusion and Spray Drying of Co-amorphous Indomethacin-Arginine With Polymers.

    abstract::Co-amorphous drug-amino acid systems have gained growing interest as an alternative to common amorphous formulations which contain polymers as stabilizers. Several preparation methods have recently been investigated, including vibrational ball milling on a laboratory scale or spray drying in a larger scale. In this st...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lenz E,Löbmann K,Rades T,Knop K,Kleinebudde P

    更新日期:2017-01-01 00:00:00

  • Acetylcarnitine and cholinergic receptors.

    abstract::Acetylcarnitine, a naturally occurring compound found in high concentration in heart and skeletal muscle of vertebrates, bears structural resemblance to acetylcholine, and studies have shown that it has slight cholinergic properties. Acetylcarnitine was subjected to conformational analysis by extended Hückel theory (E...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Reed KW,Murray WJ,Roche EB

    更新日期:1980-09-01 00:00:00

  • Water evaporation rates from a model of stratum corneum lipids.

    abstract::Water evaporation rates were measured from thin samples of a model layered structure of stratum corneum lipids with 32% water. A model with only free fatty acids present gave the lowest evaporation rates, while a model with only oleic acid gave values approximately 50% higher. Using the total lipid spectrum of stratum...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Friberg SE,Kayali I

    更新日期:1989-08-01 00:00:00

  • Quantification of the effect of excipients on bioavailability by means of response surfaces III: In vivo--in vitro correlations.

    abstract::This study compares one of the previously studied formulations with commercial amoxicillin capsules. The results indicate that the percentage of the dose absorbed is similar in both formulations; nevertheless, the amoxicillin capsules present a higher absorption rate. The in vivo--in vitro correlations in terms of res...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Llabrés M,Vila JL,Martínez-Pacheco R

    更新日期:1982-08-01 00:00:00

  • Determination of (+)- and (-)-nilvadipine in human plasma using chiral stationary-phase liquid chromatography and gas chromatography-mass spectrometry, and a preliminary pharmacokinetic study in humans.

    abstract::A stereoselective and sensitive method for the determination of nilvadipine, a new dihydropyridine calcium antagonist, in human plasma was developed. An internal standard, the deuterated analogue of racemic nilvadipine, was added to the plasma and extracted with an n-hexane:ethyl acetate (92.5:7.5) mixture under alkal...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tokuma Y,Fujiwara T,Noguchi H

    更新日期:1987-04-01 00:00:00

  • Structural and thermal characterization of zolpidem hemitartrate hemihydrate (Form E) and its decomposition products by laboratory X-ray powder diffraction.

    abstract::The crystal structure of zolpidem hemitartrate hemihydrate (I, Form E) has been solved from high-resolution laboratory powder diffraction data. It crystallizes in the orthorhombic P2(1)2(1)2(1) space group with a = 22.4664(6) A, b = 26.0420(7) A, and c = 7.4391(1) A. Protonation of zolpidem molecules could not be unam...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Halasz I,Dinnebier RE

    更新日期:2010-02-01 00:00:00

  • A Mechanistic Model for Predicting the Physical Stability of Amorphous Solid Dispersions.

    abstract::In this paper, we establish a mechanistic model for the prediction of amorphous solid dispersion (ASD) stability. The novel approach incorporates fundamental physical parameters, principally supersaturation, diffusivity, and interfacial energy, to model crystallization in ASDs accounting for both kinetic and thermodyn...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ojo AT,Lee PI

    更新日期:2020-08-18 00:00:00

  • Micellar aggregation of poloxamer 213 and its interaction with cholesterol derivatives.

    abstract::The micellar properties of Poloxamer 213 (1), a Pluronic copolymer shown to affect lipid absorption and serum cholesterol level in experimental animals, are investigated by surface tension measurements, photon correlation spectroscopy (PCS), Reichardt's dye solubilization technique, differential scanning calorimetry (...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cheng HY,Holl WW

    更新日期:1990-10-01 00:00:00

  • Effect of inorganic additives on solutions of nonionic surfactants III: CMC's and surface properties.

    abstract::Continuing work on the interaction of inorganic additives with nonionic surfactants in aqueous solution dealt with their effect on the CMC and surface tension. The surfactants were octoxynol and polyoxyethylated oleyl alcohol, containing an average of 9.5 and 10 ethylene oxide units, respectively. Their CMC values wer...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schott H,Han SK

    更新日期:1976-07-01 00:00:00