Abstract:
:Solubility values of a selected group of nonsteroidal anti-inflammatory drugs have been determined in water and 1-octanol as a function of temperature. Thermodynamic functions of dissolution and partition have been calculated and discussed with respect to various physical parameters of each solute and the two solvents. The calculated solubility values show good agreement with the experimental values. The analysis of the experimental solubility values of these compounds in terms of solid-state contribution and solute-solvent interaction suggests the different importance of these parameters in promoting solubility of solid nonelectrolytes.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Fini A,Laus M,Orienti I,Zecchi Vdoi
10.1002/jps.2600750106subject
Has Abstractpub_date
1986-01-01 00:00:00pages
23-5issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(15)46985-0journal_volume
75pub_type
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