Antitumor agents LVI: the protein synthesis inhibition by genkwadaphnin and yuanhuacine of P-388 lymphocytic leukemia cells.

Abstract:

:Two natural products isolated from the plant Daphne genkwa have been shown to possess antileukemic activity in mice. Genkwadaphnin and yuanhuacine were observed to inhibit DNA and protein synthesis in P-388 leukemic cells. A detailed study of the effects of these two diterpene esters on protein synthesis of leukemic cells was undertaken. The major effects of genkwadaphnin and yuanhuacine on protein synthesis were blockage of the elongation process and interference with the peptidyl transferase reaction. The latter reaction was suppressed at concentrations of the diterpene esters which were commensurate with concentrations that inhibited whole cell in vitro protein synthesis in P-388 cells.

journal_name

J Pharm Sci

authors

Liou YF,Hall IH,Lee KH

doi

10.1002/jps.2600711208

subject

Has Abstract

pub_date

1982-12-01 00:00:00

pages

1340-4

issue

12

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)44417-X

journal_volume

71

pub_type

杂志文章
  • Colorimetric determination of nadolol in tablets.

    abstract::Nadolol was extracted from tablet excipients with an acidic potassium chloride solution. The drug was oxidized with periodic acid, and the resulting aldehyde was reacted with 2,4-dinitrophenylhydrazine to form the corresponding hydrazone. Excess reagent was removed with a cupric chloride solution. The hydrazone was ex...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600670743

    authors: Ivashikiv E

    更新日期:1978-07-01 00:00:00

  • Mechanisms of solvent evaporation encapsulation processes: prediction of solvent evaporation rate.

    abstract::The mechanism of organic solvent evaporation during microencapsulation and its role during microsphere hardening has been investigated. Evaporation and encapsulation studies were carried out in a jacketed beaker, filled with aqueous hardening solution, which was maintained at constant temperature and constant stirring...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Wang J,Schwendeman SP

    更新日期:1999-10-01 00:00:00

  • Crystal Structures and Vapor-Induced Crystalline Transformation of 7-Ethyl-10-Hydroxycamptothecin Pseudopolymorphs.

    abstract::Solvent-induced 3 frameworks (the monohydrate, methanol solvate, and dimethyl formamide [DMF] solvate) of an anticancer drug, 7-ethyl-10-hydroxycamptothecin (SN38), were constructed. The crystal structures of the 3 pseudopolymorphs were characterized by single-crystal X-ray diffraction technique for the first time. Cr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1016/j.xphs.2017.03.020

    authors: Fang L,Wang L,Yao C,Song S,Wu Z,Tao X

    更新日期:2017-10-01 00:00:00

  • Correlation of log P with molecular connectivity in hydroxyureas: influence of conformational system on log P.

    abstract::The correlation of log P (in octanol--water) with the nonempirical, topologically dependent, calculated molecular connectivity index (1chiv) delineates substituted hydroxyureas into two families of linearly related groups of compounds. The first group, composed of the 3-substituted ethyl, n-propyl, and n-butyl analogs...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600670419

    authors: Parker GR

    更新日期:1978-04-01 00:00:00

  • Peptide derivation of poorly absorbable drug allows intestinal absorption via peptide transporter.

    abstract::The purpose of the present study was to examine whether the intestinal absorption of low-permeability drugs could be improved by utilization of the intestinal influx transporter PEPT1. We investigated whether peptide derivatives of poorly absorbable nonamino acid-like drugs might be substrates of PEPT1, using rebamipi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.21551

    authors: Kikuchi A,Tomoyasu T,Tanaka M,Kanamitsu K,Sasabe H,Maeda T,Odomi M,Tamai I

    更新日期:2009-05-01 00:00:00

  • On the mechanism and dynamics of uptake and permeation of polyether-copolyester dendrimers across an in vitro blood-brain barrier model.

    abstract::Dendrimers have emerged as a promising drug delivery system due to their well defined size, tailorability, and multifunctional nature. However, their application in brain delivery is relatively a new area of research. The present study was aimed at evaluating the uptake and permeation of polyether-copolyester (PEPE) d...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.21669

    authors: Dhanikula RS,Hammady T,Hildgen P

    更新日期:2009-10-01 00:00:00

  • Comparative bioavailabilities from truncated blood level curves.

    abstract::The period of time after administration over which blood level measurements are required to obtain a reliable bioavailability comparison of two or more formulations of the same drug was considered by the analysis of bioavailability data taken from the literature. The drugs examined, selected to represent a range of ab...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600640921

    authors: Lovering EG,McGilveray IJ,McMillan I,Tostowaryk W

    更新日期:1975-09-01 00:00:00

  • The fate of free radicals in a cellulose based hydrogel: detection by electron paramagnetic resonance spectroscopy.

    abstract::Cellulose derivatives are commonly used as gelling agents in topical and ophthalmic drug formulations. During the course of manufacturing, cellulose derivatives are believed to generate free radicals. These free radicals may degrade the gelling agent, leading to lower viscosity. Free radicals also may react with the a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.21632

    authors: Basumallick L,Ji JA,Naber N,Wang YJ

    更新日期:2009-07-01 00:00:00

  • An investigation into the digestion of chitosan (noncrosslinked and crosslinked) by human colonic bacteria.

    abstract::Chitosan salts are being investigated as materials for bacterially triggered colonic drug delivery, via the oral route, based on the assumption that they will be degraded by the enzymes produced by the human colonic bacteria. The actual susceptibility of chitosan to these enzymes is, however, unclear. The digestion of...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.21271

    authors: McConnell EL,Murdan S,Basit AW

    更新日期:2008-09-01 00:00:00

  • Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion.

    abstract::The distribution of zidovudine (AZT) between plasma, brain extracellular fluid (ECF), and cerebrospinal fluid (CSF) was investigated in a crossover design study (n = 5) in unanesthetized rabbits. Drug was administered by intravenous (iv) and intracerebroventricular (icv) infusions at the same infusion rate (1.5 mg/h.k...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600840717

    authors: Wang Y,Sawchuk RJ

    更新日期:1995-07-01 00:00:00

  • Optimizing a Novel Au-Grafted Lipid Nanoparticle Through Chelation Chemistry for High Photothermal Biologic Activity.

    abstract::Gold nanoparticles through nucleation of Au clusters have been extensively studied. However, due to low potency, prolonged tissue retention, and irreversible accumulation, the safety considerations have limited their therapeutic and diagnostic applications. Novel gold nanostructures with retained physical properties a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1016/j.xphs.2020.02.010

    authors: Gao Y,Mu Q,Zhu L,Li Z,Ho RJY

    更新日期:2020-05-01 00:00:00

  • Structural functions of the sweet pharmacophore.

    abstract::The relative sweetness, onset times, and durations of response of D-glucose, D-xylose, D-quinovose, D-galactose, L-arabinose, and D-fucose were determined at four temperatures. The results can be interpreted by simple concepts of intramolecular hydrogen bonding which indicate that the so-called gamma-function of the t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600700313

    authors: Birch GG,Dziedzic SZ,Shallenberger RS,Lindley MG

    更新日期:1981-03-01 00:00:00

  • Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis.

    abstract::Application of ultrasound enhances transdermal transport of drugs (sonophoresis). The enhancement may result from enhanced diffusion due to ultrasound-induced skin alteration and/or from forced convection. To understand the relative roles played by these two mechanisms in low-frequency sonophoresis (LFS, 20 kHz), a th...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/1520-6017(200105)90:5<545::aid-jps1012>3.0

    authors: Tang H,Mitragotri S,Blankschtein D,Langer R

    更新日期:2001-05-01 00:00:00

  • Biophysical Characterization and Thermal Stability of Pneumococcal Histidine Triad Protein D in the Presence of Zinc and Manganese.

    abstract::The pneumococcal histidine triad protein D (PhtD) is believed to play a central role in pneumococcal metal ion homeostasis and has been proposed as a promising vaccine candidate against pneumococcal disease. To investigate for potential stabilizers, a panel of physiologically relevant metals was screened using the the...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1016/j.xphs.2017.06.003

    authors: Ausar SF,Jayasundara K,Akawi L,Roque C,Sheung A,Hu J,Kirkitadze M,Rahman N

    更新日期:2017-10-01 00:00:00

  • Expanded solubility parameter approach. II: p-Hydroxybenzoic acid and methyl p-hydroxybenzoate in individual solvents.

    abstract::The recently introduced four-parameter extended Hansen approach was used to study the solubility of p-hydroxybenzoic acid and methyl p-hydroxybenzoate in 32 and 35 individual solvents, respectively. The results are compared with those for benzoic acid in 40 solvents. Seventeen of the thirty-two or 53% of the calculate...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600730211

    authors: Martin A,Wu PL,Beerbower A

    更新日期:1984-02-01 00:00:00

  • Colloidal and thermal characteristics of concentrated dispersions of polymethacrylate-based latices for aqueous enteric coating.

    abstract::We have used rheological and thermal methods to study the colloidal characteristics of a widely used technical latex. The dispersions of poly(methacrylic acid-ethyl acrylate) (Eudragit L100-55) were found to be stabilized by a combination of electrostatic and steric mechanisms termed as electrosteric stabilization. Th...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1021/js9803555

    authors: Paulsson M,Singh SK

    更新日期:1999-04-01 00:00:00

  • Protein effects on surfactant adsorption suggest the dominant mode of surfactant-mediated stabilization of protein.

    abstract::Surfactants stabilize proteins through two major mechanisms: (1) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (2) their association with protein into "complexes" that prevent proteins from interacting with surfaces as well as each other. However, selection of surf...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.23908

    authors: Kim HL,McAuley A,McGuire J

    更新日期:2014-05-01 00:00:00

  • Thermochemical investigations of associated solutions: calculation of solute--solvent equilibrium constants from solubility measurements.

    abstract::A simple solution model that has lead to successful predictive equations for the partial molar excess properties of a solute in simple binary solvent mixtures containing only nonspecific interactions is extended to include association between the solute and one of the solvent components. An expression is derived and t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600720822

    authors: Acree WE Jr,McHan DR,Rytting JH

    更新日期:1983-08-01 00:00:00

  • Physics of amorphous solids.

    abstract::The physical state of a dosage form, crystalline versus amorphous, is critical in determining its solid-state physical and chemical properties. This minireview describes the physics associated with the preparation and storage of amorphous solids including a review of the common theories of the glass transition and rel...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审

    doi:10.1002/jps.10489

    authors: Hilden LR,Morris KR

    更新日期:2004-01-01 00:00:00

  • Physicochemical, crystallographic, thermal, and spectroscopic behavior of crystalline and X-ray amorphous ciclesonide.

    abstract::Single crystal structure experiments revealed that the orthorhombic needles of Ciclesonide crystallized in P2(1)2(1)2(1) space group with four independent molecules in the unit cell. Amorphous Ciclesonide was prepared by lyophilization and characterized in comparison with crystalline material by differential scanning ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.21223

    authors: Feth MP,Volz J,Hess U,Sturm E,Hummel RP

    更新日期:2008-09-01 00:00:00

  • Surfactant Effects on Lipid-Based Vesicles Properties.

    abstract::Understanding the effect of surfactant properties is critical when designing vesicular delivery systems. This review evaluates previous studies to explain the influence of surfactant properties on the behavior of lipid vesicular systems, specifically their size, charge, stability, entrapment efficiency, pharmacokineti...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.xphs.2018.01.005

    authors: Bnyan R,Khan I,Ehtezazi T,Saleem I,Gordon S,O'Neill F,Roberts M

    更新日期:2018-05-01 00:00:00

  • Instantaneous input hypothesis in pharmacokinetic studies.

    abstract::Observed venous plasma concentrations of furosemide, propranolol, griseofulvin, and theophylline at 0.33 and 0.66 min after intravenous bolus injections to unanesthetized dogs were compared with those extrapolated using the instantaneous input hypothesis. At 0.33 min, extrapolated/observed plasma level ratios as high ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600700918

    authors: Chiou WL,Lam G,Chen ML,Lee MG

    更新日期:1981-09-01 00:00:00

  • Variable pH kinetics: an easy determination of pH-rate profile.

    abstract::The complete pH-rate profile of the hydrolysis reaction of aspirin, requiring many experiments in the past, was obtained by a single variable-parameter kinetic experiment carried out by varying the hydrogen ion concentration. The experiment was carried out spectrophotometrically, reading automatically absorbance, pH, ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/1520-6017(200103)90:3<270::aid-jps2>3.0.co

    authors: Alibrandi G,Coppolino S,Micali N,Villari A

    更新日期:2001-03-01 00:00:00

  • Drying rates of tablet granulations II: effect of particle size and granular densities.

    abstract::The effects of the granule size and density on the drying rate kinetics of tablet granulations were studied using lactose and sulfathiazole granules prepared with acacia mucilage and providone solution. The drying rate kinetics consisted of three distinct phases of drying when the drying rate was platted against remai...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600640631

    authors: Opankunle WO,Bhutani BR,Bhatia VN

    更新日期:1975-06-01 00:00:00

  • Precursor-dependent indirect pharmacodynamic response model for tolerance and rebound phenomena.

    abstract::A precursor-dependent model of indirect pharmacodynamic response which can describe tolerance and rebound was characterized in terms of the effects of changes in the fundamental properties of the drug on its response profiles. The model extends previous models by considering inhibition or stimulation of production of ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1021/js980171q

    authors: Sharma A,Ebling WF,Jusko WJ

    更新日期:1998-12-01 00:00:00

  • Determination of aqueous solubility and pKa values of estrogens.

    abstract::Reported estrone pKa and solubility data show wide variation. Improved experimental procedures were designed and used to obtain reproducible results. The pKa values for several estrogens and related compounds also were determined to assess the effects of structural differences on ionization. No evidence was obtained f...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600660504

    authors: Hurwitz AR,Liu ST

    更新日期:1977-05-01 00:00:00

  • Independence of antimineralocorticoid and catatoxic effects of various steroids.

    abstract::A series of unrelated steroids were tested for antimineralocorticoid activity by Kagawa's test in male rats and by modified test in female rats. Adrenalectomized male rats given 12 mcg desoxycorticosterone (DOC) and 2.5 ml normal saline received 1 mg of the test steroid, and their urine was analyzed for sodium and po...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.2600590532

    authors: Solymoss B,Krajny M,Varga S

    更新日期:1970-05-01 00:00:00

  • Effect of benzalkonium chloride/EDTA on the ocular bioavailability of ketorolac tromethamine following ocular instillation to normal and de-epithelialized corneas of rabbits.

    abstract::This study was designed to examine the effect of benzalkonium chloride/ethylenediaminetetraacetic acid (BAK/EDTA) on the ocular bioavailability (Focular) of ketorolac tromethamine after ocular instillation to normal and de-epithelialized corneas of rabbits both in vitro and in vivo. The in vitro Focular of the formula...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1021/js9504189

    authors: Madhu C,Rix PJ,Shackleton MJ,Nguyen TG,Tang-Liu DD

    更新日期:1996-04-01 00:00:00

  • Surface Tracking of Curcumin Amorphous Solid Dispersions Formulated by Binary Polymers.

    abstract::Herein, curcumin amorphous solid dispersions (Cur ASDs) were prepared using binary polymers (Eudragit EPO with polyvinylpyrrolidone K30 [EuD-PVP], Eudragit EPO with hydroxypropyl methylcellulose E50 [EuD-HPMC]) as excipient, and surface tracking of Cur ASDs was mainly addressed. Infrared spectroscopy, in situ Raman im...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1016/j.xphs.2019.10.030

    authors: Fan N,Lu T,Li J

    更新日期:2020-02-01 00:00:00

  • On the influence of protein binding on pharmacological activity of drugs.

    abstract::The effect of variable protein binding (taken as independent parameter) on pharmacological activity of drugs is considered in terms of the exposure or the steady state concentration of unbound drug at targeted tissue. Based on the application of the parallel tube or dispersion models it is shown that for the most comm...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.1002/jps.21958

    authors: Berezhkovskiy LM

    更新日期:2010-04-01 00:00:00