Blood flow and autoregulation in rat pituitary gland.

Abstract:

:The authors describe an experimental model that allows dynamic studies of blood flow in the pituitary gland. Twenty-eight male Wistar rats were anesthetized and the pituitary gland was exposed using a parapharyngeal approach. Teflon-coated platinum wire electrodes were placed in the adenohypophysis near the midline and laterally as well as in the parietal cortex and the white matter. Blood flows were measured by the hydrogen clearance method. Baseline values were as follows: 89.9 +/- 22 ml/100 gm/min in the medial adenohypophysis, 55.9 +/- 8 ml/100 gm/min in the lateral adenohypophysis, 59.2 +/- 14 ml/100 gm/min in the parietal cortex, and 28.1 +/- 8.9 ml/100 gm/min in the white matter. Effective autoregulation was demonstrated by altering the blood pressure with metaraminol infusion or blood withdrawal. The range of autoregulation was wider in the adenohypophysis than in the cerebral cortex.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Kemeny AA,Jakubowski JA,Jefferson AA,Pasztor E

doi

10.3171/jns.1985.63.1.0116

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

116-9

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

63

pub_type

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