Endonasal endoscopic transsphenoidal resection of intrinsic third ventricular craniopharyngioma: surgical results.


:OBJECTIVEIntrinsic third ventricular craniopharyngiomas (IVCs) have been reported by some authors to "pose the greatest surgical challenge" of all craniopharyngiomas (CPAs). A variety of open microsurgical approaches have historically been used for resection of these tumors. Despite increased utilization of the endoscopic endonasal approach (EEA) for resection of CPAs in recent years, many authors continue to recommend against use of the EEA for resection of IVCs. In this paper, the authors present the largest series to date utilizing the EEA to remove IVCs.METHODSThe authors reviewed a prospectively acquired database of the EEA for resection of IVCs over 14 years at Weill Cornell Medical College, NewYork-Presbyterian Hospital. Preoperative MR images were examined independently by two neurosurgeons and a neuroradiologist to identify IVCs. Pre- and postoperative endocrinological, ophthalmological, radiographic, and other morbidities were determined from retrospective chart review and volumetric radiographic analysis.RESULTSBetween January 2006 and August 2017, 10 patients (4 men, 6 women) ranging in age from 26 to 67 years old, underwent resection of an IVC utilizing the EEA. Preoperative endocrinopathy was present in 70% and visual deterioration in 60%. Gross-total resection (GTR) was achieved in 9 (90%) of 10 patients, with achievement of near-total (98%) resection in the remaining patient. Pathology was papillary in 30%. Closure incorporated a "gasket-seal" technique with nasoseptal flap coverage and either lumbar drainage (9 patients) or a ventricular drain (1 patient). Postoperatively, complete anterior and posterior pituitary insufficiency was present in 90% and 70% of patients, respectively. In 4 patients with normal vision prior to surgery, 3 had stable vision following tumor resection. One patient noted a new, incongruous, left inferior homonymous quadrantanopsia postoperatively. In the 6 patients who presented with compromised vision, 2 reported stable vision following surgery. Each of the remaining 4 patients noted significant improvement in vision after tumor resection, with complete restoration of normal vision in 1 patient. Aside from the single case (10%) of visual deterioration referenced above, there were no instances of postoperative neurological decline. Postoperative CSF leakage occurred in 1 morbidly obese patient who required reoperation for revision of closure. After a mean follow-up of 46.8 months (range 4-131 months), tumor recurrence was observed in 2 patients (20%), one of whom was treated with radiation and the other with chemotherapy. Both of these patients had previously undergone GTR of the IVC.CONCLUSIONSThe 10 patients described in this report represent the largest number of patients with IVC treated using EEA for resection to date. EEA for resection of IVC is a safe and efficacious operative strategy that should be considered a surgical option in the treatment of this challenging subset of tumors.


J Neurosurg


Journal of neurosurgery


Forbes JA,Ordóñez-Rubiano EG,Tomasiewicz HC,Banu MA,Younus I,Dobri GA,Phillips CD,Kacker A,Cisse B,Anand VK,Schwartz TH




Has Abstract


2018-11-01 00:00:00










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    abstract::Melanocytomas are rare tumors of the central nervous system that are believed to arise from leptomeningeal melanocytes. A young girl presented with a contrast-enhancing cystic mass in the temporal horn of the left lateral ventricle. Microsurgical resection of a black-colored vascular tumor supplied by the anterior cho...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tandon N,O'Neill TJ,Vollmer DG,Wang M

    更新日期:2008-09-01 00:00:00

  • Transpalatal endoscopic endonasal resection of a giant epignathus skull base teratoma in a newborn. Case report.

    abstract::Teratomas are neoplasms composed of tissues from all three germ layers with varying degrees of differentiation. They are most commonly found in the sacrococcygeal and gonadal regions and rarely occur in the head and neck region. A teratoma is termed "epignathus" when it arises from the skull base or hard palate and is...

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    pub_type: 杂志文章


    authors: Prevedello DM,Kassam AB,Carrau RL,Snyderman CH,Thomas A,Gardner P,Mintz A,Vecchione L,Losee J

    更新日期:2007-09-01 00:00:00

  • Endosphenoidal coil for intraoperative magnetic resonance imaging of the pituitary gland during transsphenoidal surgery.

    abstract::OBJECTIVE Pituitary MR imaging fails to detect over 50% of microadenomas in Cushing's disease and nearly 80% of cases of dural microinvasion. Surface coils can generate exceptionally high-resolution images of the immediately adjacent tissues. To improve imaging of the pituitary gland, a receive-only surface coil that ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Chittiboina P,Talagala SL,Merkle H,Sarlls JE,Montgomery BK,Piazza MG,Scott G,Ray-Chaudhury A,Lonser RR,Oldfield EH,Koretsky AP,Butman JA

    更新日期:2016-12-01 00:00:00

  • Engorged epidural venous plexus and cervical myelopathy due to cerebrospinal fluid overdrainage: a rare complication of ventricular shunts. Case report.

    abstract::The authors report on a 17-year-old boy with cervical myelopathy from dilated epidural veins due to cerebrospinal fluid (CSF) overdrainage. The patient had a long-standing subdural-peritoneal shunt and presented with incapacitating spastic tetraparesis. Magnetic resonance imaging revealed significant cervical spinal c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Wolfe SQ,Bhatia S,Green B,Ragheb J

    更新日期:2007-03-01 00:00:00

  • Research productivity in neurosurgery: trends in globalization, scientific focus, and funding.

    abstract:OBJECT:While research is important for the survival, growth, and expansion of neurosurgery, little work has been done to quantify the status and trends of neurosurgical publications. The purpose of this bibliometric study was to quantitatively analyze trends in neurosurgical publications, including changes in worldwide...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hauptman JS,Chow DS,Martin NA,Itagaki MW

    更新日期:2011-12-01 00:00:00

  • Outcome following aneurysm wrapping: a 10-year follow-up review of clipped and wrapped aneurysms.

    abstract::One hundred and eighty-one patients with single aneurysms involving the anterior circulation were treated either by wrapping (60 cases) or clipping (121 cases), and 96.1% of them were followed for 10 years. The rate of early rebleeding (less than 6 months) from wrapped aneurysms was 8.6% (confidence interval 1.4% to 1...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Todd NV,Tocher JL,Jones PA,Miller JD

    更新日期:1989-06-01 00:00:00

  • Intraarterial abciximab for treatment of thromboembolism during coil embolization of intracranial aneurysms: outcome and fatal hemorrhagic complications.

    abstract:OBJECT:Experience with intraarterial abciximab for the treatment of thromboembolism during endovascular coil embolization is limited. The authors report the outcome of intraarterial abciximab use, with an emphasis on fatal hemorrhagic complications. METHODS:Between March 2003 and May 2006, the authors treated 606 aneu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Park JH,Kim JE,Sheen SH,Jung CK,Kwon BJ,Kwon OK,Oh CW,Han MH,Han DH

    更新日期:2008-03-01 00:00:00

  • Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study.

    abstract::OBJECT Current recommendations stress the need for cognitive parameters to be integrated in the evaluation of outcomes for intracranial meningioma surgery. The aim of this prospective study was to examine neurocognitive function in meningioma patients pre- and postoperatively. METHODS Patients with skull base (anterio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Liouta E,Koutsarnakis C,Liakos F,Stranjalis G

    更新日期:2016-06-01 00:00:00

  • Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery.

    abstract:OBJECT:Temporary arterial occlusion (TAO) during aneurysm surgery carries the risk of ischemic sequelae. Because monitoring of regional cerebral blood flow (rCBF) may limit neurological damage, the authors evaluated a novel thermal diffusion (TD) microprobe for use in the continuous and quantitative assessment of rCBF ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Thomé C,Vajkoczy P,Horn P,Bauhuf C,Hübner U,Schmiedek P

    更新日期:2001-09-01 00:00:00

  • Founder of modern hydrocephalus diagnosis and therapy: Walter Dandy at the Johns Hopkins Hospital.

    abstract::Because of his exceptional and pioneering contributions to the understanding and treatment of neurosurgical conditions, Walter Dandy is considered to be one of the founders of both neurosurgery and neuroradiology. In the field of hydrocephalus, Dandy developed revolutionary research models, imaging modalities, and ope...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Blitz AM,Ahmed AK,Rigamonti D

    更新日期:2018-10-01 00:00:00

  • Long-term outcome in patients harboring intracranial ependymoma.

    abstract:OBJECT:The prognostic significance of tumor grade and resection and the efficacy of prophylactic radiation remain controversial in the management of intracranial ependymoma. The outcomes in patients with intracranial ependymoma treated at the Kyoto University Hospital were reviewed retrospectively, and prognostic signi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kawabata Y,Takahashi JA,Arakawa Y,Hashimoto N

    更新日期:2005-07-01 00:00:00

  • Abscess formation within a parasagittal meningioma. Case report.

    abstract::The authors present the case of a 78-year-old woman who developed right lower-extremity paralysis after a focal seizure. Neuroradiological studies revealed a small parasagittal meningioma, which at the time of resection was found to contain a bacterial intratumoral abscess secondary to Proteus mirabilis. This is only ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Eisenberg MB,Lopez R,Stanek AE

    更新日期:1998-05-01 00:00:00

  • A randomized placebo-controlled double-blind trial of nimodipine after SAH in monkeys. Part 1: Clinical and radiological findings.

    abstract::The authors have developed a method to induce chronic cerebral vasospasm after subarachnoid hemorrhage (SAH) in monkeys. With microsurgical techniques, 33 monkeys had a frontotemporal craniectomy and unilateral opening of the subarachnoid cisterns. Cerebrospinal fluid was drained and a fresh hematoma, obtained from an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Espinosa F,Weir B,Overton T,Castor W,Grace M,Boisvert D

    更新日期:1984-06-01 00:00:00

  • The course of chronic subdural hematomas after burr-hole craniostomy and closed-system drainage.

    abstract::A consecutive series of 32 adult patients with chronic subdural hematoma was studied in respect to postoperative cerebral reexpansion (reduction in diameter of the subdural space) after burr-hole craniostomy and closed-system drainage. Patients with high subdural pressure showed the most rapid brain expansion and clin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Markwalder TM,Steinsiepe KF,Rohner M,Reichenbach W,Markwalder H

    更新日期:1981-09-01 00:00:00

  • Transient cerebellar mutism caused by bilateral damage to the dentate nuclei after the second posterior fossa surgery. Case report.

    abstract::The authors report on the case of a 6-year-old boy who underwent resection of a midline cerebellar tumor. The boy was able to speak fluently after the operation. Magnetic resonance (MR) imaging showed that the right dentate nucleus had been partially removed along with the tumor, but that the left dentate nucleus rema...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kusano Y,Tanaka Y,Takasuna H,Wada N,Tada T,Kakizawa Y,Hongo K

    更新日期:2006-02-01 00:00:00

  • A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder.

    abstract:OBJECT:Deep brain stimulation (DBS) of the ventral [anterior internal] capsule/ventral striatum (VC/VS) is under investigation as an alternative to anterior capsulotomy for severe obsessive-compulsive disorder (OCD). In neuroimaging studies of patients with OCD, dysfunction in the orbitofrontal and anterior cingulate c...

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    authors: Rauch SL,Dougherty DD,Malone D,Rezai A,Friehs G,Fischman AJ,Alpert NM,Haber SN,Stypulkowski PH,Rise MT,Rasmussen SA,Greenberg BD

    更新日期:2006-04-01 00:00:00

  • Treatment of spontaneous carotid-cavernous fistula in Ehlers-Danlos syndrome by transvenous occlusion with Guglielmi detachable coils. Case report and review of the literature.

    abstract::The authors report on a young woman with Ehlers-Danlos syndrome (EDS) Type IV in whom a spontaneous direct carotid-cavernous fistula (CCF) was treated by transvenous occlusion with regular and fiber-coated Guglielmi detachable coils. To the authors' knowledge, this is the first time this approach has been used in a pa...

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    authors: Kanner AA,Maimon S,Rappaport ZH

    更新日期:2000-10-01 00:00:00

  • Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997.

    abstract:OBJECT:The purpose of this study was to examine patterns of diagnosis and relative survival rates in individuals in whom a primary malignant brain tumor was diagnosed between 1973 and 1997; follow-up review of these patients continued through the end of 1999. METHODS:The study population was composed of 21,493 patient...

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    pub_type: 杂志文章


    authors: Barnholtz-Sloan JS,Sloan AE,Schwartz AG

    更新日期:2003-09-01 00:00:00

  • Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome.

    abstract:OBJECT:Oxidative stress may play a role in spontaneous intracerebral hemorrhage (ICH), but data on oxidative burden in cerebral hemorrhage are limited, and it is not clear whether oxidative markers add predictive power regarding ICH outcome beyond that of traditional factors. The authors therefore examined redox status...

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    pub_type: 杂志文章


    authors: Chen YC,Chen CM,Liu JL,Chen ST,Cheng ML,Chiu DT

    更新日期:2011-12-01 00:00:00

  • Treatment of blunt injury to the carotid artery by using endovascular stents: an early experience.

    abstract::Identification of blunt carotid injury prior to the development of ischemic symptoms requires aggressive screening of patients at risk. The treatment of these lesions has centered around long-term anticoagulation therapy. However, studies have revealed that many of these lesions persist despite medical treatment, as d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Duke BJ,Ryu RK,Coldwell DM,Brega KE

    更新日期:1997-12-01 00:00:00

  • Diagnosis and treatment of vertebral aneurysms.

    abstract::The intracranial vertebral artery and its branches are a common site of aneurysms in the posterior fossa. Ninety-four aneurysms in 86 patients were analyzed for their clinical manifestation, diagnosis, and treatment. There were three distinct varieties of aneurysm in this group: 56 (60%) saccular aneurysms, 26 (28%) d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yamaura A

    更新日期:1988-09-01 00:00:00

  • Intracerebral microdialysis in severe brain trauma: the importance of catheter location.

    abstract:OBJECT:Intracerebral microdialysis has attracted increasing interest as a monitoring technique during neurological/neurosurgical intensive care. The purpose of this study was to compare cerebral energy metabolism, an indicator of secondary excitotoxic injury and cell membrane degradation close to focal traumatic lesion...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Engström M,Polito A,Reinstrup P,Romner B,Ryding E,Ungerstedt U,Nordström CH

    更新日期:2005-03-01 00:00:00

  • Effects of potassium channel-blocking agents on spontaneous discharges from neuromas in rats.

    abstract::Thirty-five Sprague-Dawley rats with saphenous neuromas underwent acute microfilament recording in the proximal nerve. The effect of the potassium channel-blocking agents, tetraethylammonium bromide (TEA) and 4-aminopyridine, on spontaneous activity in A fibers terminating in the neuroma was observed. The effects of g...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Burchiel KJ,Russell LC

    更新日期:1985-08-01 00:00:00

  • Massive osteolysis of the skull and upper cervical spine. Case report and review of the literature.

    abstract::Massive osteolysis is a type of idiopathic osteolysis in which there is spontaneous onset of bone resorption. Almost any bone in the body can be affected. The authors present the case of a 62-year-old man diagnosed with massive osteolysis of the occipital bone and the upper two cervical vertebrae. Despite extensive pn...

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    pub_type: 杂志文章,评审


    authors: Khosrovi H,Ortiz O,Kaufman HH,Schochet SS Jr,Reddy GN,Simmons D

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  • Gamma knife surgery for cancer pain-pituitary gland-stalk ablation: a multicenter prospective protocol since 2002.

    abstract:OBJECT:The authors have treated intractable pain, particularly cancer pain related to bone metastasis, with various protocols. Cancer pain has been treated by gamma knife radiosurgery (GKS), targeted to the pituitary gland-stalk, as an alternative new pain control method. The purpose of this study was to investigate a ...

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    pub_type: 临床试验,杂志文章,多中心研究


    authors: Hayashi M,Taira T,Chernov M,Fukuoka S,Liscak R,Yu CP,Ho RT,Regis J,Katayama Y,Kawakami Y,Hori T

    更新日期:2002-12-01 00:00:00

  • Alterations in endothelium-dependent responsiveness of the canine basilar artery subarachnoid hemorrhage.

    abstract::To investigate the alteration of endothelium-dependent responses in chronic vasospasm after subarachnoid hemorrhage (SAH), experiments were carried out in the double-hemorrhage canine model. After the presence of vasospasm was confirmed by cerebral angiography on Days 0 and 7, pharmacological studies on the basilar ar...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kim P,Sundt TM Jr,Vanhoutte PM

    更新日期:1988-08-01 00:00:00

  • Myelomeningocele and thick filum terminale with tethered cord appearing as a human tail. Case report.

    abstract::Tail-like caudal appendages may be associated with spinal dysraphism, particularly with spinal lipomas or lipomyelomeningoceles. An unusual case is presented of a patient with a myelomeningocele and a thick filum terminale with tethered spinal cord, which presented with the external appearance of a human tail. A revie...

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    pub_type: 杂志文章


    authors: Chakrabortty S,Oi S,Yoshida Y,Yamada H,Yamaguchi M,Tamaki N,Matsumoto S

    更新日期:1993-06-01 00:00:00

  • Electrospinogram and spinal and cortical evoked potentials in experimental spinal cord trauma.

    abstract::Studies in 28 traumatized cats showed the following acute changes after spinal cord compression in the cord segment below the trauma: 1) increase in size of the spinal cord evoked potential; 2) increase in size of the electrospinogram; and 3) increase in frequency of the electrospinogram. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Morrison G,Lorig RJ,Brodkey J,Nulsen FE

    更新日期:1975-12-01 00:00:00

  • Enhancing nerve regeneration across a silicone tube conduit by using interposed short-segment nerve grafts.

    abstract::Isolated nerve segments may inherently contain all of the necessary factors required to support regeneration within a silicone tube conduit placed across a nerve gap. Thirty-six adult Lewis rats each weighing approximately 250 g were randomized into three groups. A sciatic nerve gap (13-15 mm in length) was bridged by...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Francel PC,Francel TJ,Mackinnon SE,Hertl C

    更新日期:1997-12-01 00:00:00

  • Traumatic intratumoral hemorrhage as the presenting symptom of a spinal neurinoma. Case report.

    abstract::Intratumoral hemorrhage as the presenting symptom of spinal tumors is rare. The authors describe a patient who presented with rapidly progressing paraplegia 24 hours after sustaining a minor traumatic injury of the thoracic spine. Radiological evaluation demonstrated a low-thoracic intradural tumor that was resected a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Cohen ZR,Knoller N,Hadani M,Davidson B,Nass D,Ram Z

    更新日期:2000-10-01 00:00:00