Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures.

Abstract:

:A randomized double-blind placebo-controlled study was carried out to determine whether phenytoin administered soon after injury lessens the incidence of epilepsy in the 1st week after severe head trauma. In this study, 244 patients were randomized into either a phenytoin or placebo group. The patients in the phenytoin group were administered phenytoin intravenously or intramuscularly within 24 hours of hospital admission. Patients in the placebo group received intravenous or intramuscular diluent. The patients were switched from parenterally administered phenytoin or placebo as soon as oral doses could be tolerated. Over 78% of the phenytoin patients had plasma concentrations of at least 10 micrograms/ml at 1, 3, and 7 days after injury. There was no significant difference in the percentage of patients having early seizures in the treated and placebo groups (p = 0.99). There was no significant difference in the interval from injury to first seizure between the treated and placebo groups (p = 0.41). The early administration of phenytoin did not lessen the occurrence of seizures in the 1st week after head injury. Since the effectiveness of seizure prophylaxis has not been established, the authors suggest that anticonvulsant drugs be administered only after an early seizure has occurred.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Young B,Rapp RP,Norton JA,Haack D,Tibbs PA,Bean JR

doi

10.3171/jns.1983.58.2.0231

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

231-5

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

58

pub_type

临床试验,杂志文章,随机对照试验
  • Results of volume-staged fractionated Gamma Knife radiosurgery for large complex arteriovenous malformations: obliteration rates and clinical outcomes of an evolving treatment paradigm.

    abstract::OBJECTIVE There are few reported series regarding volume-staged Gamma Knife radiosurgery (GKRS) for the treatment of large, complex, cerebral arteriovenous malformations (AVMs). The object of this study was to report the results of using volume-staged Gamma Knife radiosurgery for patients affected by large and complex...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.7.GKS161549

    authors: Franzin A,Panni P,Spatola G,Del Vecchio A,Gallotti AL,Gigliotti CR,Cavalli A,Donofrio CA,Mortini P

    更新日期:2016-12-01 00:00:00

  • Ventricular catheter exchange using a peel-away outer catheter.

    abstract::Ventricular catheter replacement can be challenging, especially in patients with small ventricles. Shunt malfunction due to ventricular catheter obstruction can occur without ventricular enlargement, such as in the setting of slit-ventricle syndrome or benign intracranial hypertension. The authors describe a simple te...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.4.JNS091879

    authors: Omahen DA,Hentschel SJ,Cameron GS

    更新日期:2011-09-01 00:00:00

  • Severe phenytoin-induced bone marrow depression and agranulocytosis treated with human recombinant granulocyte-macrophage colony-stimulating factor. Case report.

    abstract::An unusual instance of severe and potentially lethal depression of the bone marrow is described as a result of the administration of phenytoin for seizure prophylaxis. The patient was treated successfully by prompt cessation of phenytoin and intravenous administration of human recombinant granulocyte-macrophage colony...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1993.79.1.0121

    authors: Rawanduzy A,Sarkis A,Rovit RL

    更新日期:1993-07-01 00:00:00

  • Floating C-shaped orbital osteotomy for orbital rim advancement in craniosynostosis: preliminary report.

    abstract::A method of lateral orbital rim advancement is described for periorbital deformities associated with coronal and metopic synostosis in infants. The technique offers the advantages of a smooth lateral rim contour and improvement in accompanying malar recession. In 13 patients with follow-up periods of up to 2 years fol...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1990.72.1.0022

    authors: Persing JA,Jane JA,Park TS,Edgerton MT,Delashaw JB

    更新日期:1990-01-01 00:00:00

  • Effect of fixed-setting versus programmable valve on incidence of shunt revision after ventricular shunting for idiopathic normal pressure hydrocephalus.

    abstract:OBJECTIVE:Although ventricular shunting is an effective therapy for idiopathic normal pressure hydrocephalus (iNPH), the effect of shunt valve type on the incidence of revision surgery is not well defined. To address this issue, shunt revision rates between patients with iNPH receiving a fixed-setting valve (FSV) versu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.3.JNS183077

    authors: Rinaldo L,Bhargav AG,Nesvick CL,Lanzino G,Elder BD

    更新日期:2019-06-07 00:00:00

  • Vascular corrosion casts mirroring early morphological changes that lead to the formation of saccular cerebral aneurysm: an experimental study in rats.

    abstract:OBJECT:The formation of cerebral aneurysms involves complex processes and little is known about the mechanisms by which they originate, grow, and rupture. The purpose of this study was to identify early ultrastructural morphological changes that lead to the formation of experimental cerebral aneurysms. METHODS:Twenty ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.3.0532

    authors: Jamous MA,Nagahiro S,Kitazato KT,Satoh K,Satomi J

    更新日期:2005-03-01 00:00:00

  • Cardiac myxoma metastasizing to the brain. Case report.

    abstract::A 55-year-old man, who had previously had a left atrial myxoma excised, developed recurrent hematomas of the left occipital lobe. Microscopic examination revealed the presence of metastatic myxoma. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1990.72.2.0295

    authors: Ng HK,Poon WS

    更新日期:1990-02-01 00:00:00

  • Induction of tolerance against ischemia/reperfusion injury in the rat brain by preconditioning with the endotoxin analog diphosphoryl lipid A.

    abstract:OBJECT:Inflammatory responses and oxygen free radicals have increasingly been implicated in the development of ischemic brain injury. In some cases, an attenuation of inflammation or free-radical injury can provide tissue protection. Diphosphoryl lipid A (DPL) is a detoxified derivative of a lipopolysaccharide (endotox...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.92.3.0435

    authors: Toyoda T,Kassell NF,Lee KS

    更新日期:2000-03-01 00:00:00

  • Spinal lesion level in spina bifida: a source of neural and cognitive heterogeneity.

    abstract:OBJECT:The aim of this study was to evaluate whether the level of a spinal lesion is associated with variations in anomalous brain development and neurobehavioral outcomes in children suffering from the meningomyelocele form of spina bifida and hydrocephalus (SBM-H). METHODS:Two hundred sixty-eight children with SBM-H...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/ped.2005.102.3.0268

    authors: Fletcher JM,Copeland K,Frederick JA,Blaser SE,Kramer LA,Northrup H,Hannay HJ,Brandt ME,Francis DJ,Villarreal G,Drake JM,Laurent JP,Townsend I,Inwood S,Boudousquie A,Dennis M

    更新日期:2005-04-01 00:00:00

  • Distinctions between pituicytoma and ordinary pilocytic astrocytoma. Case report.

    abstract::The authors present a rare case of pituicytoma. A dynamic magnetic resonance study performed after Gd injection revealed a markedly, homogeneously enhanced, early-phase pituitary lesion in a 32-year-old woman with a 1-year history of amenorrhea. The tumor bled easily during transsphenoidal resection. The lesion consis...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.98.2.0404

    authors: Katsuta T,Inoue T,Nakagaki H,Takeshita M,Morimoto K,Iwaki T

    更新日期:2003-02-01 00:00:00

  • Suprascapular entrapment neuropathy.

    abstract::The author describes the syndrome of suprascapular nerve entrapment neuropathy that occurs as that nerve passes beneath the transverse scapular ligament, and discusses the anatomy, comparative anatomy, and five case histories. The cardinal findings include pain in the shoulder, weakness, and wasting of spinati muscles...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.43.3.0337

    authors: Clein LJ

    更新日期:1975-09-01 00:00:00

  • Selective peripancreatic sarcoma metastases from primary gliosarcoma. Case report.

    abstract::Two phenomena associated with malignant gliomas are: 1) the ability to metastasize systemically, and 2) the capacity to induce sarcomatous transformation within the supportive mesenchyma. An unusual case is presented of selective metastases of the sarcomatous elements of a mixed gliosarcoma. Immunohistochemical cell s...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.61.3.0599

    authors: Weaver D,Vandenberg S,Park TS,Jane JA

    更新日期:1984-09-01 00:00:00

  • Destructive procedures for control of cancer pain: the case for cordotomy.

    abstract:OBJECT:Historically, destructive procedures for cancer pain were the main line of treatment therapy. However, the use of high-dose opioids has essentially replaced such procedures. Recognition of the limits of medical therapy to treat cancer pain effectively is growing, while conversely, in regions with limited access ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2010.6.JNS10119

    authors: Raslan AM,Cetas JS,McCartney S,Burchiel KJ

    更新日期:2011-01-01 00:00:00

  • The role of extracranial carotid abnormalities in the genesis of cerebral aneurysms.

    abstract::The incidence of extracranial internal carotid artery (ICA) abnormalities, namely kinks, coils, and stenoses, was evaluated in a consecutive unselected series of 76 cases of single supratentorial saccular aneurysms submitted to bilateral carotid angiography. These patients were compared with a control group of 120 pat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.55.5.0693

    authors: Spallone A,Cantore G

    更新日期:1981-11-01 00:00:00

  • Intracranial pressure monitoring in pediatric and adult patients with hydrocephalus and tentative shunt failure: a single-center experience over 10 years in 146 patients.

    abstract::OBJECT In patients with hydrocephalus and shunts, lasting symptoms such as headache and dizziness may be indicative of shunt failure, which may necessitate shunt revision. In cases of doubt, the authors monitor intracranial pressure (ICP) to determine the presence of over- or underdrainage of CSF to tailor management....

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.12.JNS141029

    authors: Sæhle T,Eide PK

    更新日期:2015-05-01 00:00:00

  • Surgical management of camptocormia in Parkinson's disease: systematic review and meta-analysis.

    abstract:OBJECTIVE:Camptocormia is a potentially debilitating condition in the progression of Parkinson's disease (PD). It is described as an abnormal forward flexion while standing that resolves when lying supine. Although the condition is relatively common, the underlying pathophysiology and optimal treatment strategy are unc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,meta分析

    doi:10.3171/2018.4.JNS173032

    authors: Chan AK,Chan AY,Lau D,Durcanova B,Miller CA,Larson PS,Starr PA,Mummaneni PV

    更新日期:2018-09-14 00:00:00

  • Experimental intraoperative localization of retained intracerebral bone fragments using transdural ultrasound.

    abstract::Precise intraoperative localization of retained bone fragments and foreign bodies avoids extensive brain disseciton, cerebral edema, damage to vital structures, incomplete debridement, and prolonged surgical procedures. Such localization after head trauma is often hampered by cerebral distortion, previous incomplete d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.46.1.0065

    authors: Wood JH,Parver M,Doppman JL,Ommaya AK

    更新日期:1977-01-01 00:00:00

  • Intracranial extension of inflammatory pseudotumor of the orbit. Case report.

    abstract::Orbital pseudotumors are inflammatory lesions of the orbit of unknown etiology, which initially mimic an orbital neoplasm. Involvement of the other orbit is uncommon, and extension into the paranasal sinus rare. Intracranial extension of pseudotumor of the orbit is previously unreported. This is a case report of a pat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.3.0625

    authors: Kaye AH,Hahn JF,Craciun A,Hanson M,Berlin AJ,Tubbs RR

    更新日期:1984-03-01 00:00:00

  • The facial nerve in medial acoustic neuromas.

    abstract:OBJECT:Functional results after surgery for acoustic neuromas that have little or no growth within the internal auditory canal are controversial, because these medial tumors can grow to a considerable size within the cerebellopontine angle (CPA) before symptoms occur. METHODS:A prospective study was designed to evalua...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.5.1083

    authors: Strauss C

    更新日期:2002-11-01 00:00:00

  • Chronic subdural hematoma: evaluation of the clinical significance of postoperative drainage volume.

    abstract:OBJECT:A wide variation in postoperative drainage volumes is observed during treatment of chronic subdural hematoma (CSDH) with twist-drill or burr-hole craniostomy and closed-system drainage. In this study the authors investigate the causes of the variation, the clinical significance thereof, and its influence on trea...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.93.5.0796

    authors: Kwon TH,Park YK,Lim DJ,Cho TH,Chung YG,Chung HS,Suh JK

    更新日期:2000-11-01 00:00:00

  • Heterotopic new bone formation in the cervical spine following head injury. Case report.

    abstract::Heterotopic new bone formation, associated with head injuries, usually affects the shoulder, elbow, and hip joints. The authors present a case with an unusual involvement of the cervical spine, confirmed by bone scanning and computerized tomography. Although the etiology of heterotopic new bone formation is not well u...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.3.0513

    authors: Groswasser Z,Reider-Groswasser I

    更新日期:1986-03-01 00:00:00

  • Insular glioma resection: assessment of patient morbidity, survival, and tumor progression.

    abstract:OBJECT:Insular gliomas remain surgically challenging cases due to complex anatomy, including surrounding vasculature and the relationship to functional structures. To define the morbidity profile associated with aggressive insular glioma removal as well as its impact on long-term outcome, the authors retrospectively ev...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.6.JNS0952

    authors: Sanai N,Polley MY,Berger MS

    更新日期:2010-01-01 00:00:00

  • Postoperative deficits and functional recovery following removal of tumors involving the dominant hemisphere supplementary motor area.

    abstract::The supplementary motor area (SMA) is a region located within each cerebral hemisphere at the posterior mesial border of the frontal lobe adjacent to the falx. The functional significance of this area has been somewhat unclear, and information regarding its influence on motor output has largely been based on evoked re...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.75.1.0062

    authors: Rostomily RC,Berger MS,Ojemann GA,Lettich E

    更新日期:1991-07-01 00:00:00

  • Microneurosurgery for aneurysms of the basilar artery.

    abstract::The authors report microsurgical treatment in 32 cases of basilar artery aneurysms, operated on with good results in 28 cases, fair results in one, and poor results in one; there were two deaths. Twenty-nine patients (91%) were able to return to social activities. Characteristics of the surgical techniques include 1) ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.51.5.0615

    authors: Sugita K,Kobayashi S,Shintani A,Mutsuga N

    更新日期:1979-11-01 00:00:00

  • Operating room waste: disposable supply utilization in neurosurgical procedures.

    abstract::OBJECTIVE Disposable supplies constitute a large portion of operating room (OR) costs and are often left over at the end of a surgical case. Despite financial and environmental implications of such waste, there has been little evaluation of OR supply utilization. The goal of this study was to quantify the utilization ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.2.JNS152442

    authors: Zygourakis CC,Yoon S,Valencia V,Boscardin C,Moriates C,Gonzales R,Lawton MT

    更新日期:2017-02-01 00:00:00

  • Catecholamine-secreting paragangliomas of the base of the skull. Report of two cases.

    abstract::Two cases of catecholamine-secreting paragangliomas of the base of the skull are described. The patients presented with uncontrollable hypertension and, after investigation, tumors were discovered in the regions of the glomus jugulare and pterygopalatine ganglion, respectively. After cardiovascular stabilization and t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.66.4.0604

    authors: Matishak MZ,Symon L,Cheeseman A,Pamphlett R

    更新日期:1987-04-01 00:00:00

  • Frequency of thromboembolic events associated with endovascular aneurysm treatment: retrospective case series.

    abstract:OBJECT:There is little evidence addressing whether procedures requiring adjunctive devices lead to an increased frequency of thromboembolic complications. The authors report their experience with 155 aneurysms treated with and without adjunctive devices. METHODS:The authors retrospectively reviewed their last 155 aneu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/6/1095

    authors: Brooks NP,Turk AS,Niemann DB,Aagaard-Kienitz B,Pulfer K,Cook T

    更新日期:2008-06-01 00:00:00

  • Expanding lacunae causing triventricular hydrocephalus. Report of two cases.

    abstract::Two patients are reported in whom the presence of triventricular hydrocephalus and aqueductal obstruction or stenosis due to multiple expanding lacunae in the mesencephalothalamic region possibly corresponds to abnormally dilated perivascular spaces. Placement of a ventriculoperitoneal cerebrospinal fluid (CSF) shunt ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.91.4.0669

    authors: Mascalchi M,Salvi F,Godano U,Nistri M,Taiuti R,Tosetti M,Villari N,Calbucci F

    更新日期:1999-10-01 00:00:00

  • Neurosurgical management of acromegaly. Results in 82 patients treated between 1972 and 1977.

    abstract::A consecutive series of 82 acromegalic patients who underwent transsphenoidal surgery during a 5-year period is presented. Preoperative and postoperative values for human growth hormone (HGH) were available in 80 cases. Microadenomas were present in 18 patients with a mean preoperative HGH value of 25.2 ng/ml, diffuse...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.50.4.0454

    authors: Laws ER Jr,Piepgras DG,Randall RV,Abboud CF

    更新日期:1979-04-01 00:00:00

  • Structural heterogeneity within the axis: the main cause in the etiology of dens fractures. A histomorphometric analysis of 37 normal and osteoporotic autopsy cases.

    abstract::Fractures of the odontoid process are potentially serious injuries; Type II and III fractures, as described by Anderson and D'Alonzo, are seen in the emergency room especially in young adolescents and individuals over 60 years of age. The etiology of these fractures is still controversial. Malunion and nonunion in bot...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.83.2.0330

    authors: Amling M,Pösl M,Wening VJ,Ritzel H,Hahn M,Delling G

    更新日期:1995-08-01 00:00:00