Neurosurgical management of acromegaly. Results in 82 patients treated between 1972 and 1977.

Abstract:

:A consecutive series of 82 acromegalic patients who underwent transsphenoidal surgery during a 5-year period is presented. Preoperative and postoperative values for human growth hormone (HGH) were available in 80 cases. Microadenomas were present in 18 patients with a mean preoperative HGH value of 25.2 ng/ml, diffuse adenomas in 39 patients with mean of 53.8 ng/ml, and invasive adenomas in 25 with mean of 68.0 ng/ml. There was no operative mortality. The results reflected the classification of the tumors, with apparent cures accomplished in 87.5% of previously untreated patients with microadenoma, all of whom had anterior pituitary function preserved. The percentages of apparent cures in cases of diffuse adenoma (68%) and invasive adenoma (54%) were much less satisfactory. Transsphenoidal microsurgery is capable of achieving good results, particularly in patients with microadenoma.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Laws ER Jr,Piepgras DG,Randall RV,Abboud CF

doi

10.3171/jns.1979.50.4.0454

subject

Has Abstract

pub_date

1979-04-01 00:00:00

pages

454-61

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

50

pub_type

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