Treatment of autochthonous rat brain tumors with fractionated radiotherapy. The effects of graded radiation doses and of combined therapy with BCNU or steroids.

Abstract:

:The avian sarcoma virus-induced glioma model in rats was used to evaluate radiation dose response (survival curves), giving fractionated treatments to the whole head. Groups of 14 to 20 rats received total doses of 2300, 4600, or 5750 rads over 2, 4, or 5 weeks, respectively. Median group survival times were compared to controls and to each other. All doses of radiation significantly prolonged survival with reference to control. The 4600- and 5750-rad doses were significantly more effective than the 2300-rad dose. In another series of experiments, BCNU chemotherapy (10 mg/kg) was combined with 2300 and 4600 rads radiation therapy. Synergism of therapies was demonstrated. Methylprednisolone acetate (2 mg/kg twice weekly over 4 weeks) alone did not affect survival curves, and its combination with 4600 rads radiation therapy negated the prolongation of survival achieved with 4600 rads alone.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Steinbok P,Mahaley MS Jr,U R,Varia MA,Lipper S,Mahaley J,Dalzell JG,Bigner DD

doi

10.3171/jns.1980.53.1.0068

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

68-72

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

53

pub_type

杂志文章
  • Variations of the extreme-lateral craniocervical approach: anatomical study and clinical analysis of 69 patients.

    abstract:OBJECT:The aim of this study was to describe six variations of the extreme-lateral craniocervical approach, their application, and treatment results. METHODS:During a 4-year period 69 patients underwent surgery in which six variations of the extreme-lateral craniocervical approach were performed. The variations includ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.1999.90.2.0206

    authors: Salas E,Sekhar LN,Ziyal IM,Caputy AJ,Wright DC

    更新日期:1999-04-01 00:00:00

  • Risks associated with preoperative anemia and perioperative blood transfusion in open surgery for intracranial aneurysms.

    abstract:OBJECT:Preoperative anemia may be treated with a blood transfusion. Both are associated with adverse outcomes in various surgical procedures, but this has not been clearly elucidated in surgery for cerebral aneurysms. In this study the authors assessed the association of preoperative anemia and perioperative blood tran...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2014.10.JNS14551

    authors: Seicean A,Alan N,Seicean S,Neuhauser D,Selman WR,Bambakidis NC

    更新日期:2015-07-01 00:00:00

  • Extradural lipomatosis simulating an acute herniated nucleus pulposus. Case report.

    abstract::A 48-year-old laborer presented with a 1-year history of low-back pain radiating into the posterior aspects of both thighs. Two weeks before admission, acute exacerbation resulted in signs and symptoms of compressive radiculopathy at L-5. Myelography revealed concentric constriction of the lower thecal sac due to abun...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.57.4.0559

    authors: Archer CR,Smith KR Jr

    更新日期:1982-10-01 00:00:00

  • Body position and cerebrospinal fluid pressure. Part 2: clinical studies on orthostatic pressure and the hydrostatic indifferent point.

    abstract::Lumbar cerebrospinal fluid (CSF) pressure was recorded in 116 adult neurosurgical patients in the lateral and sitting positions. The level of zero CSF pressure while in the sitting position (ZPS) and hydrostatic indifferent point (HIP) for lateral and sitting positions were determined and referred to the craniospinal ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1976.44.6.0698

    authors: Magnaes B

    更新日期:1976-06-01 00:00:00

  • Acquired hemophilia, meningioma, and diphenylhydantoin therapy.

    abstract::A patient is reported in whom a meningioma of the lateral one-third of the sphenoid ridge was completely removed and long-term prophylaxis for seizures with diphenylhydantoin was prescribed. One and a half years later, a powerful inhibitor developed that specifically neutralized Factor VIII, the antihemophilic factor,...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.53.5.0600

    authors: O'Reilly RA,Hamilton RD

    更新日期:1980-11-01 00:00:00

  • Prognosis of severe head injuries.

    abstract::The authors have analyzed retrospectively a series of 288 consecutive patients with severe head injury observed between January, 1977, and May, 1980. Seventy-three patients were excluded as not being compatible with those of the International Data Bank. The remaining 215 patients complied with the definition of coma g...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.57.6.0779

    authors: Levati A,Farina ML,Vecchi G,Rossanda M,Marrubini MB

    更新日期:1982-12-01 00:00:00

  • Optochiasmal arachnoiditis following muslin wrapping of ruptured anterior communicating artery aneurysms.

    abstract::Optochiasmal arachnoiditis has been reported following treatment of ruptured intracranial aneurysms, particularly arising from the anterior communicating artery. It has been suggested that the accompanying loss of vision is due to a muslin-induced optic neuropathy. This paper considers five cases of this condition; th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.75.3.0393

    authors: McFadzean RM,Hadley DM,McIlwaine GG

    更新日期:1991-09-01 00:00:00

  • Extended orbital exenteration for sinonasal malignancy with orbital apex extension: surgical technique and clinical analysis.

    abstract:OBJECT:The majority of sinonasal malignancies present with advanced disease, and cure rates are generally poor. Surgical extirpation remains the mainstay of treatment. In cases of sinonasal malignancy with orbital apex extension, gross-total tumor resection requires orbital exenteration and bony skull base resection ar...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.9.JNS141256

    authors: Sugawara T,Aoyagi M,Ogishima T,Kawano Y,Tamaki M,Yano T,Tsunoda A,Ohno K,Maehara T,Kishimoto S

    更新日期:2015-07-01 00:00:00

  • Ventriculo-ureteral shunt insertion using percutaneous nephrostomy: a novel minimally invasive option in a patient with chronic hydrocephalus complicated by multiple distal ventriculoperitoneal shunt failures.

    abstract::The management of ventriculoperitoneal (VP) shunt failure is a common problem in neurosurgical practice. On occasion, extraperitoneal sites for CSF diversion are required when shunting to the peritoneal cavity has failed after multiple attempts. The authors report a novel minimally invasive procedure allowing cannulat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.8.JNS16342.test

    authors: Pillai A,Mathew G,Nachimuthu S,Kalavampara SV

    更新日期:2017-03-17 00:00:00

  • A novel syndrome of cerebral cavernous malformation and Greig cephalopolysyndactyly. Laboratory investigation.

    abstract:OBJECT:Greig cephalopolysyndactyly syndrome (GCPS) is one of a spectrum of overlapping clinical syndromes resulting from mutations in the gene GLI3 on chromosome 7p. Cerebral cavernous malformation (CCM) is caused by mutations in three distinct genes, including Malcavernin (CCM2), which also maps to chromosome 7p and i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/PED-07/12/495

    authors: Bilguvar K,Bydon M,Bayrakli F,Ercan-Sencicek AG,Bayri Y,Mason C,DiLuna ML,Seashore M,Bronen R,Lifton RP,State M,Gunel M

    更新日期:2007-12-01 00:00:00

  • Bilateral retro-auricular dermal sinus tracts with intradural extension. Case report.

    abstract::The authors describe a previously unreported malformation involving paired, bilaterally symmetrical dermal sinus tracts in the retro-auricular area, both of which passed through the asterion and posterior fossa dura mater to end intracranially. Cranial dermal sinus tracts are congenital lesions that virtually always o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.1.0163

    authors: Nejat F,Dias MS,Eftekhar B,Roodsari NN,Hamidi S

    更新日期:2003-07-01 00:00:00

  • Embolization of incidental cerebral aneurysms by using the Guglielmi detachable coil system.

    abstract:OBJECT:Guglielmi detachable coil (GDC) technology is a valuable therapeutic alternative to the surgical treatment of ruptured or incidental intracranial aneurysms. The authors describe their technical and clinical experience in the use of the GDC technique in patients who underwent endovascular occlusion for the treatm...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.90.2.0207

    authors: Murayama Y,Viñuela F,Duckwiler GR,Gobin YP,Guglielmi G

    更新日期:1999-02-01 00:00:00

  • Reoperation and readmission after clipping of an unruptured intracranial aneurysm: a National Surgical Quality Improvement Program analysis.

    abstract::OBJECTIVE Although reoperation and readmission have been used as quality metrics, there are limited data evaluating the rate of, reasons for, and predictors of reoperation and readmission after microsurgical clipping of unruptured aneurysms. METHODS Adult patients who underwent craniotomy for clipping of an unruptured...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.10.JNS161810

    authors: Dasenbrock HH,Smith TR,Rudy RF,Gormley WB,Aziz-Sultan MA,Du R

    更新日期:2018-03-01 00:00:00

  • Suprascapular entrapment neuropathy.

    abstract::The author describes the syndrome of suprascapular nerve entrapment neuropathy that occurs as that nerve passes beneath the transverse scapular ligament, and discusses the anatomy, comparative anatomy, and five case histories. The cardinal findings include pain in the shoulder, weakness, and wasting of spinati muscles...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.43.3.0337

    authors: Clein LJ

    更新日期:1975-09-01 00:00:00

  • Transcranial Doppler ultrasonography in raised intracranial pressure and in intracranial circulatory arrest.

    abstract::Transcranial Doppler ultrasonography was used to monitor 71 patients suffering from intracranial hypertension with subsequent brain death. Among these, 29 patients were also assessed for systemic arterial pressure and epidural intracranial pressure, so that a correlation between cerebral perfusion pressure and the Dop...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Hassler W,Steinmetz H,Gawlowski J

    更新日期:1988-05-01 00:00:00

  • High cervical spinal cord compression by an enterogenous cyst. Case report.

    abstract::A case of enterogenous cyst causing compression of the spinal cord at C-1 is presented. The clinical course and radiological and histological findings are discussed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.51.4.0556

    authors: Fabinyi GC,Adams JE

    更新日期:1979-10-01 00:00:00

  • Multiple schwannomas: schwannomatosis or neurofibromatosis type 2?

    abstract:OBJECT:The aim of this study was to clarify the clinical outcome of schwannomatosis, a rare condition characterized by multiple nonvestibular schwannomas in the absence of meningiomas, intraspinal ependymomas, and other clinical signs of neurofibromatosis type 2 (NF2). METHODS:Nine patients with schwannomatosis treate...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.89.1.0036

    authors: Seppälä MT,Sainio MA,Haltia MJ,Kinnunen JJ,Setälä KH,Jääskeläinen JE

    更新日期:1998-07-01 00:00:00

  • The safety and utility of recombinant human bone morphogenetic protein-2 for cranial procedures in a nonhuman primate model.

    abstract:OBJECT:The goal of this study was to evaluate the safety and efficacy of recombinant human bone morphogenetic protein 2 (rhBMP-2) in cranial applications. METHODS:Critical-sized calvarial defects were created bilaterally in four rhesus monkeys, and bilateral rectangular bone flaps were created in six others. Control a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.98.1.0125

    authors: Sheehan JP,Sheehan JM,Seeherman H,Quigg M,Helm GA

    更新日期:2003-01-01 00:00:00

  • Mechanical thrombectomy and intravascular imaging for cerebral venous sinus thrombosis: a preclinical model.

    abstract:OBJECTIVE:Although the majority of patients with cerebral venous sinus thrombosis (CVST) will improve with anticoagulation therapy, a portion of patients will either present in a comatose state or continue to deteriorate clinically despite early anticoagulation. In these cases, along with treating the underlying thromb...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2020.6.JNS201795

    authors: Pasarikovski CR,Ku JC,Keith J,Ramjist J,Dobashi Y,Priola SM,da Costa L,Kumar A,Yang VXD

    更新日期:2020-10-30 00:00:00

  • A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor.

    abstract::In order to assess the clinical and biological effects of glucocorticoids in the therapy of epidural spinal cord compression, the T8-10 epidural space of 50 rats was implanted with Walker 256 tumor. The rats were studied 10 to 20 days later when they became paraparetic. The regional blood-spinal cord transport constan...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1989.70.6.0920

    authors: Delattre JY,Arbit E,Thaler HT,Rosenblum MK,Posner JB

    更新日期:1989-06-01 00:00:00

  • Stereotactic radiosurgery for arteriovenous malformations of the postgeniculate visual pathway.

    abstract:OBJECT:A visual field deficit resulting from the management of an arteriovenous malformation (AVM) significantly impacts a patient's quality of life. The present study was designed to investigate the clinical and radiological outcomes of stereotactic radiosurgery (SRS) performed for AVMs involving the postgeniculate vi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS1453

    authors: Bowden G,Kano H,Caparosa E,Tonetti D,Niranjan A,Monaco EA 3rd,Flickinger J,Arai Y,Lunsford LD

    更新日期:2015-02-01 00:00:00

  • Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker.

    abstract:OBJECT:Telomerase activity is responsible for cell immortality. To examine the role of telomerase in the carcinogenesis of human glioblastomas multiforme (GBMs), the authors studied telomerase activity, telomerase component expression, and telomere lengths in 42 GBM samples. METHODS:In all samples, EGFR and MDM2 ampli...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.93.4.0618

    authors: Harada K,Kurisu K,Tahara H,Tahara E,Ide T,Tahara E

    更新日期:2000-10-01 00:00:00

  • Value of gas myelography in early management of acute cervical spinal cord injuries.

    abstract::Gas myelography was carried out in 22 patients with acute cervical spinal cord injuries in whom oily contrast media seemed contraindicated. The authors believe this technique makes a valuable contribution to the basic decision regarding the surgical versus medical treatment of a specific patient with a cervical cord i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.42.3.0330

    authors: Rossier AB,Berney J,Rosenbaum AE,Hachen J

    更新日期:1975-03-01 00:00:00

  • Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions.

    abstract:OBJECT:Neurogenesis continues throughout the life of mammals in the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus (DG) of the hippocampus. The authors tested the potential of the neuropeptide substance P (SP) acting via the neurokinin-1 receptor (NK1R) in promoting the proliferation of adult...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS-07/09/0593

    authors: Park SW,Yan YP,Satriotomo I,Vemuganti R,Dempsey RJ

    更新日期:2007-09-01 00:00:00

  • Microsurgical anatomy of the central core of the brain.

    abstract::OBJECTIVE The purpose of this study was to describe in detail the cortical and subcortical anatomy of the central core of the brain, defining its limits, with particular attention to the topography and relationships of the thalamus, basal ganglia, and related white matter pathways and vessels. METHODS The authors stud...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.5.JNS162897

    authors: Ribas EC,Yağmurlu K,de Oliveira E,Ribas GC,Rhoton A

    更新日期:2018-09-01 00:00:00

  • Symptoms of pituitary apoplexy rapidly reversed with bromocriptine. Case report.

    abstract::Macroprolactinomas rarely present with apoplexy. The authors describe a patient with a macroprolactinoma who presented with apoplexy and rapid progression of a third nerve palsy. The patient was managed expectantly with bromocriptine, and within 48 hours, the patient's third nerve palsy had completely resolved. The au...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.6.1153

    authors: Brisman MH,Katz G,Post KD

    更新日期:1996-12-01 00:00:00

  • Role of gamma knife surgery for intracranial atypical (WHO grade II) meningiomas.

    abstract:OBJECT:Atypical meningioma often recurs even after resection. As a salvage modality, radiotherapy or stereotactic radiosurgery (SRS) is attempted for this aggressive tumor. This retrospective study was performed to evaluate the efficacy of SRS that involved Gamma Knife surgery (GKS) for atypical meningioma. METHODS:Th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.8.JNS13343

    authors: Hanakita S,Koga T,Igaki H,Murakami N,Oya S,Shin M,Saito N

    更新日期:2013-12-01 00:00:00

  • Megadose corticosteroid therapy following experimental traumatic spinal injury.

    abstract::Corticosteroids are frequently used in the treatment of spinal trauma, although neither experimental nor clinical evidence to support their use is persuasive. Recently there have been claims that extremely high doses ("megadoses") of corticosteroids (equivalent to 15 to 30 mg/kg of methylprednisolone) improve neurolog...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.4.0712

    authors: Faden AI,Jacobs TP,Patrick DH,Smith MT

    更新日期:1984-04-01 00:00:00

  • Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis.

    abstract::The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimen...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.4.JNS153052

    authors: Rennert RC,Hoshide RR,Signorelli JW,Amaro D,Sack JA,Brennan CW,Chen CC

    更新日期:2017-05-01 00:00:00

  • Clinical evaluation of intravenous nitroglycerin for neurosurgery.

    abstract::Moment-to-moment control of blood pressure is important in the management of the neurosurgical patient. The ideal agent to control blood pressure or induce hypotension should be non-toxic, maintain cerebrovascular autoregulation, and not alter cardiac output or change intracranial pressure. Intravenous nitroglycerin h...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.5.0704

    authors: Chestnut JS,Albin MS,Gonzalez-Abola E,Newfield P,Maroon JC

    更新日期:1978-05-01 00:00:00