Development of experimental meningeal gliomatosis models in rats.

Abstract:

:Experimental models of meningeal gliomatosis (MG) have been produced by intracisternal inoculation of rat C6 and 9L glioma cells into Wistar and Fischer 344 rats, respectively. Tumor growth was steady and rapid in both MG models when more than 10(6) tumor cells were implanted. The median survival time of the rats inoculated with tumor cells was inversely related to the number of the cells inoculated. The clinicopathological features observed in both MG models were similar to those seen in diffuse leptomeningeal involvement of gliomas in humans. The models may be useful for investigating the pathophysiology of MG and for the determination of the efficacy of chemotherapeutic agents in brain-tumor chemotherapy.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Yoshida T,Shimizu K,Ushio Y,Hayakawa T,Arita N,Mogami H

doi

10.3171/jns.1986.65.4.0503

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

503-7

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

65

pub_type

杂志文章
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