Effective suppression of hippocampal seizures in rats by direct hippocampal cooling with a Peltier chip.

Abstract:

OBJECT:The use of focal brain cooling to eliminate epileptic discharges (EDs) has attracted increasing attention in the scientific community. In this study, the inhibitory effect of selective hippocampal cooling on experimental hippocampal seizures was investigated using a newly devised cooling system with a thermoelectric (Peltier) chip. METHODS:A copper needle coated with silicone and attached to the Peltier chip was used for the cooling device. The experiments were performed first in a phantom model with thermography and second in adult male Sprague-Dawley rats in a state of halothane anesthesia. The cooling needle, a thermocouple, and a needle electrode for electroencephalography recording were inserted into the right hippocampus. Kainic acid (KA) was injected into the right hippocampus to provoke the EDs. The animals were divided into hippocampal cooling (10 rats) and noncooling (control, 10 rats) groups. RESULTS:In the phantom study, the cooling effects (9 degrees C) occurred in the spherical areas around the needle tip. In the rats the temperature of the cooled hippocampus decreased below 20 degrees C within a 1.6-mm radius and below 25 degrees C within a 2.4-mm radius from the cooling center. The temperature at the needle tip decreased below 20 degrees C within 1 minute and was maintained at the same level until the end of the cooling process. The amplitude of the EDs was suppressed to 68.1 +/- 4.8% of the precooling value and remained low thereafter. No histological damage due to cooling was observed in the rat hippocampus. CONCLUSIONS:Selective hippocampal cooling effectively suppresses the KA-induced hippocampal EDs. Direct hippocampal cooling with a permanently implantable system is potentially useful as a minimally invasive therapy for temporal lobe epilepsy and therefore could be an alternative to the temporal lobectomy.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Tanaka N,Fujii M,Imoto H,Uchiyama J,Nakano K,Nomura S,Fujisawa H,Kunitsugu I,Saito T,Suzuki M

doi

10.3171/JNS/2008/108/4/0791

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

791-7

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

108

pub_type

杂志文章
  • A stereotactic device for rabbits based on mandibular and cranial landmarks: technical note.

    abstract::The authors have developed a stereotactic device for use in rabbits that uses the plane at the base of the mandible combined with cranial sutures as an anatomical reference. The device was developed for a study designed to evaluate catheters for infection prophylaxis, and this required the implantation of silicone cat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/3/0601

    authors: Kockro RA,Giacomelli R,Scheihing M,Aschoff A,Hampl JA

    更新日期:2008-03-01 00:00:00

  • Mycotic aneurysms of the internal carotid artery. Case report.

    abstract::The authors report a case with two mycotic aneurysms in the cavernous portion of the internal carotid artery, presumably secondary to a transient bacteremia from pneumonia. The strikingly rapid development of the aneurysms was demonstrated by angiography. Painful total ophthalmoplegia and extophthalmos were the main c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1976.44.1.0105

    authors: Shibuya S,Igarashi S,Amo T,Sato H,Fukumitsu T

    更新日期:1976-01-01 00:00:00

  • Acute nonlymphocytic leukemia following treatment of malignant glioma. Report of two cases.

    abstract::Two patients with malignant brain tumors who developed acute nonlymphocytic leukemia after treatment with radiation and chemotherapy are described. Both patients survived more than 2 years after diagnosis of the brain tumor. Survival following the diagnosis of leukemia was short, and both patients died of hemorrhage s...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.6.1287

    authors: Kempin S,Sundaresan N,Shapiro WB,Arlin Z

    更新日期:1984-06-01 00:00:00

  • History of the Journal of Neurosurgery, 1965-1980.

    abstract::The author, who was editor of the Journal of Neurosurgery from 1975 to 1985, recalls the history of the journal during the 15 hears beginning in 1965, when Dr. Louise Eisenhardt resigned as its first editor. In an addendum, he presents some thoughts on the future of neurosurgery and the role the journal should play in...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/jns.1994.80.5.0939

    authors: Schwartz HG

    更新日期:1994-05-01 00:00:00

  • Clinical use of supinator motor branch transfer to the posterior interosseous nerve in C7-T1 brachial plexus palsies.

    abstract:OBJECT:In C7-T1 brachial plexus palsies, finger extension and flexion are absent. At the authors' institution, finger flexion has been successfully reconstructed by transferring the brachialis motor branch to the anterior interosseous nerve. However, there is no reliable method for restoring finger extension. In the pr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.1.JNS091441

    authors: Dong Z,Gu YD,Zhang CG,Zhang L

    更新日期:2010-07-01 00:00:00

  • Local delivery of mitoxantrone for the treatment of malignant brain tumors in rats.

    abstract:OBJECT:Mitoxantrone is a drug with potent in vitro activity against malignant brain tumor cell lines; however, its effectiveness as a systemic agent has been hampered by poor central nervous system penetration and dose-limiting myelosuppression. To avoid these problems, we incorporated mitoxantrone into biodegradable p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.5.1173

    authors: DiMeco F,Li KW,Tyler BM,Wolf AS,Brem H,Olivi A

    更新日期:2002-11-01 00:00:00

  • Trigeminal neurinomas: operative approach in eight cases.

    abstract::The authors report eight cases of trigeminal neurinoma managed over the past 13 years with radical resection at a single-stage operation. Three patients were male and five were female, ranging in age from 25 to 56 years (mean 41.5 years). One had von Recklinghausen's disease. The tumors were located mainly within the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1989.71.4.0506

    authors: Yasui T,Hakuba A,Kim SH,Nishimura S

    更新日期:1989-10-01 00:00:00

  • Cell cycle arrest and astrocytic differentiation resulting from PTEN expression in glioma cells.

    abstract:OBJECT:Genetic alterations of the PTEN gene (also known as MMAC1 or TEP1) have frequently been identified in high-grade gliomas, indicating that inactivation of PTEN plays a crucial role in human glioma progression. The aim of this study was to assess the biological significance of PTEN inactivation in the development ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.91.5.0822

    authors: Adachi J,Ohbayashi K,Suzuki T,Sasaki T

    更新日期:1999-11-01 00:00:00

  • Chiasmatic optic glioma treated with chemotherapy. A preliminary report.

    abstract::Chiasmatic optic glioma is a rare tumor with an erratic natural history, usually seen in young children. A prior study from this institution demonstrated that these lesions were frequently lethal, despite initial clinical stabilization following radiation therapy, and that visual, intellectual, and late endocrinologic...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.6.0862

    authors: Rosenstock JG,Packer RJ,Bilaniuk L,Bruce DA,Radcliffe JL,Savino P

    更新日期:1985-12-01 00:00:00

  • Cysts of the atlantoaxial joint: excellent long-term outcome after posterolateral surgical decompression. Report of two cases.

    abstract::Articular cysts of the atlantoaxial joint are infrequently described and probably an underreported cause of upper cervical spinal cord compression. The authors report on two patients with cysts located posteriorly of the dens in whom a C-1 and partial C-2 hemilaminectomy with subtotal resection of the cyst provided ad...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2001.95.1.0111

    authors: Zorzon M,Skrap M,Diodato S,Nasuelli D,Lucci B

    更新日期:2001-07-01 00:00:00

  • Clinical evaluation of flat-panel detector compared with multislice computed tomography in 65 patients with acute intracranial hemorrhage: initial results. Clinical article.

    abstract:OBJECT:The goal in this study was to compare flat-panel detector (FD) CT with multislice (MS) CT in the visualization of intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), intraventricular hemorrhage, and external ventricular drains (EVDs) to evaluate the diagnostic quality and limitations of the new FD CT ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.2.JNS091054

    authors: Struffert T,Eyupoglu IY,Huttner HB,Engelhorn T,Doelken M,Saake M,Ganslandt O,Doerfler A

    更新日期:2010-10-01 00:00:00

  • Clinical characteristics and long-term outcomes in patients with ruptured posterior inferior cerebellar artery aneurysms: a comparative analysis.

    abstract:OBJECT:Subarachnoid hemorrhage (SAH) from ruptured posterior inferior cerebellar artery (PICA) aneurysms is uncommon, and long-term outcome data for patients who have suffered such hemorrhages is lacking. This study investigated in-hospital and long-term clinical data from a prospective cohort of patients with SAH from...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS141079

    authors: Williamson RW,Wilson DA,Abla AA,McDougall CG,Nakaji P,Albuquerque FC,Spetzler RF

    更新日期:2015-08-01 00:00:00

  • Deficits of hand coordination and laterality of carotid endarterectomy.

    abstract:OBJECT:Neurocognitive performance is used to assess multiple cognitive domains, including motor coordination, before and after carotid endarterectomy (CEA). Although gross motor strength is impaired with ischemia of large cortical areas or of the internal capsule, the authors hypothesize that patients undergoing CEA de...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.8.JNS1459

    authors: Heyer EJ,Mallon KA,Mergeche JL,Stern Y,Connolly ES

    更新日期:2015-01-01 00:00:00

  • Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence.

    abstract:OBJECT:Nonfunctioning pituitary adenomas (NFPAs) are benign tumors of the pituitary gland that typically cause visual and/or hormonal dysfunction. Surgery is the treatment of choice, but patients remain at risk for tumor recurrence for several years afterwards. The authors evaluate the early results of surgery and the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/3/0525

    authors: Losa M,Mortini P,Barzaghi R,Ribotto P,Terreni MR,Marzoli SB,Pieralli S,Giovanelli M

    更新日期:2008-03-01 00:00:00

  • Tentorial detachment technique in the combined petrosal approach for petroclival meningiomas.

    abstract:OBJECT:The combined petrosal approach is a suitable technique for the resection of medium-to-large petroclival meningiomas (PCMs). Multiple technical modifications have been reported to increase the surgical corridor, including the method of dural and tentorial opening. The authors describe their method of dural openin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.11.JNS11985

    authors: Kusumi M,Fukushima T,Mehta AI,Aliabadi H,Nonaka Y,Friedman AH,Fujii K

    更新日期:2012-03-01 00:00:00

  • Treatment by specialist surgical neurooncologists improves survival times for patients with malignant glioma.

    abstract:OBJECT:Surgeries for CNS tumors are frequently performed by general neurosurgeons and by those who specialize in surgical neurooncology. Subspecialization in neurosurgical practice has become common and may improve patient morbidity and mortality rates. However, the potential benefits for patients of having their surge...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS132057

    authors: Khan UA,Bhavsar A,Asif H,Karabatsou K,Leggate JR,Sofat A,Kamaly-Asl ID

    更新日期:2015-02-01 00:00:00

  • Effect of dexamethasone on cerebral edema from cranial impact in the cat.

    abstract::A Remington humane stunner was used to deliver blows to the skulls of anesthetized cats. Alternate animals were post-treated with either dexamethasone (4 mg/kg/day) or a comparable volume of saline. Each animal was tested for cerebral edema 48 hours after impact by measurement of the change in density of white matter ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.2.0220

    authors: Tornheim PA,McLaurin RL

    更新日期:1978-02-01 00:00:00

  • A critical appraisal of drainage in syringomyelia.

    abstract::The use of drains in the treatment of syringomyelia has a simple and immediate appeal and has been practiced widely since the report of Abbe and Coley over 100 years ago. Good short-term results have been claimed in the past, but long-term outcome is largely unknown. An experience in Birmingham, England is reviewed in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.1.0001

    authors: Sgouros S,Williams B

    更新日期:1995-01-01 00:00:00

  • The human area postrema: clear-cut silhouette and variations shown in vivo.

    abstract::OBJECT The human area postrema (AP) is a circumventricular organ that has only been described in cadaveric specimens and animals. Because of its position in the calamus scriptorius and the absence of surface markers on the floor of the fourth ventricle, the AP cannot be clearly localized during surgical procedures. ME...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.11.JNS14482

    authors: Longatti P,Porzionato A,Basaldella L,Fiorindi A,De Caro P,Feletti A

    更新日期:2015-05-01 00:00:00

  • Craniopharyngioma of the cerebellopontine angle. Case report.

    abstract::The authors report a case of craniopharyngioma presenting in the right cerebellopontine angle. The tumor was removed totally. The purpose of this report is to record this very unusual localization of a craniopharyngioma. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.4.0842

    authors: Altinörs N,Senveli E,Erdoğan A,Arda N,Pak I

    更新日期:1984-04-01 00:00:00

  • Limitations of the transcallosal transchoroidal approach to the third ventricle.

    abstract:OBJECT:The aim of this study was to determine the anatomical limitations of the transcallosal transchoroidal approach to the third ventricle. METHODS:Twenty-six formalin-fixed specimens were studied. Sagittal dissections were used to determine the anatomical relationships of the foramen of Monro, the angle of approach...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.7.JNS08124

    authors: Ulm AJ,Russo A,Albanese E,Tanriover N,Martins C,Mericle RM,Pincus D,Rhoton AL

    更新日期:2009-09-01 00:00:00

  • Endovascular treatment of intracranial aneurysms: comparative evaluation in a terminal bifurcation aneurysm model in dogs.

    abstract:OBJECT:The authors investigated whether HydroCoils decreased coil compaction and aneurysm recanalization in a canine model of a large, wide-necked, high-flow bifurcation aneurysm. METHODS:Eleven experimental aneurysms were created. Two aneurysms were untreated (Group 1); three were treated with standard platinum coils...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.101.6.0996

    authors: Yoshino Y,Niimi Y,Song JK,Silane M,Berenstein A

    更新日期:2004-12-01 00:00:00

  • Platelet-activating factor and edema surrounding meningiomas.

    abstract:OBJECT:The purpose of this study was to evaluate the involvement of platelet-activating factor (PAF) in the formation of edema surrounding meningiomas. METHODS:Volumes of tumor and peritumoral edema were calculated based on three-dimensional reconstructed magnetic resonance images in 31 patients with intracranial meni...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.88.2.0304

    authors: Hirashima Y,Hayashi N,Fukuda O,Ito H,Endo S,Takaku A

    更新日期:1998-02-01 00:00:00

  • Posterior plates in the management of cervical instability: long-term results in 44 patients.

    abstract::Although posterior plates are increasingly used to manage cervical spinal instability, long-term follow-up evaluation of patients with a critical analysis of efficacy and complications has not been reported. The authors have retrospectively analyzed the outcome in 44 consecutive patients (37 males and seven females, a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.3.0341

    authors: Fehlings MG,Cooper PR,Errico TJ

    更新日期:1994-09-01 00:00:00

  • A novel syndrome of cerebral cavernous malformation and Greig cephalopolysyndactyly. Laboratory investigation.

    abstract:OBJECT:Greig cephalopolysyndactyly syndrome (GCPS) is one of a spectrum of overlapping clinical syndromes resulting from mutations in the gene GLI3 on chromosome 7p. Cerebral cavernous malformation (CCM) is caused by mutations in three distinct genes, including Malcavernin (CCM2), which also maps to chromosome 7p and i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/PED-07/12/495

    authors: Bilguvar K,Bydon M,Bayrakli F,Ercan-Sencicek AG,Bayri Y,Mason C,DiLuna ML,Seashore M,Bronen R,Lifton RP,State M,Gunel M

    更新日期:2007-12-01 00:00:00

  • The use of clip-suture in thoracic sympathectomy. Technical note.

    abstract::A technique is described for using a clip-suture to expedite handling of the divided sympathetic chain in a deep, small upper-thoracic exposure. No late failures were experienced in 23 patients with hyperhydrosis surgically treated using this technique. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.3.0482

    authors: Beatty RA

    更新日期:1994-09-01 00:00:00

  • New approach to cervical flexion deformity in ankylosing spondylitis. Case report.

    abstract::The treatment of cervical fixed flexion deformity in ankylosing spondylitis presents a challenging problem that is traditionally managed by a corrective cervicothoracic osteotomy. The authors report a new approach to this problem that involves performing a two-level osteotomy at the level of maximum spinal curvature, ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2000.93.2.0283

    authors: Duff SE,Grundy PL,Gill SS

    更新日期:2000-10-01 00:00:00

  • George J. Heuer: forgotten pioneer neurosurgeon at the Johns Hopkins Hospital.

    abstract::George J. Heuer was a pioneer in neurosurgery at The Johns Hopkins Hospital in the early 20th century; he trained under Harvey Cushing and acted as a mentor to Walter Dandy. In his early career, Heuer focused on research and clinical work in the field of neurosurgery and temporarily led the neurosurgery section at Joh...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/jns.2002.96.6.1139

    authors: Borden WB,Tamargo RJ

    更新日期:2002-06-01 00:00:00

  • Reversible occlusion of donor vessel caused by mouth opening after superficial temporal artery-middle cerebral artery anastomosis in adult moyamoya patients.

    abstract:OBJECT:The authors experienced an intriguing phenomenon in 2 adult patients with moyamoya disease. Mouth opening caused reversible occlusion of the donor superficial temporal artery (STA), and the patients exhibited transient cerebral ischemic symptoms. The aim of this study was to assess the incidence of such occlusio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS141805

    authors: Katsuta T,Abe H,Miki K,Inoue T

    更新日期:2015-09-01 00:00:00

  • Post-craniotomy wound infection caused by Pseudallescheria boydii. Case report.

    abstract::The authors describe the first reported case of post-craniotomy wound infection due to Pseudallescheria boydii. The patient was a 24-year-old man who sustained a direct blunt injury to the calvaria, resulting in a large subdural hematoma that was surgically evacuated. Subsequently, the surgical wound became infected w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.1.0153

    authors: Lazarus HS,Myers JP,Brocker RJ

    更新日期:1986-01-01 00:00:00