Risk of intracranial hemorrhage in glioma patients receiving anticoagulant therapy for venous thromboembolism.

Abstract:

:To determine the risk of intracranial hemorrhage in patients with malignant gliomas who are treated with anticoagulant drugs for late postoperative venous thromboembolism, the authors retrospectively reviewed the computerized data base of all patients with primary brain tumors seen at the University of California, San Francisco, over a 9-year period. Of 915 patients 18 years of age or older who had a pathological diagnosis of malignant glioma and an initial Karnofsky performance scale score of 60% or higher, 36 (4%) developed venous thromboembolism 6 to 246 weeks postoperatively and 22 were treated with anticoagulant drugs. Anticoagulant therapy usually consisted of intravenous heparin for 7 to 10 days, followed for at least 3 to 6 months by either subcutaneous heparin (5000 to 8000 U twice daily) or oral warfarin. All patients were closely monitored to ensure control of hypertension, compliance with therapy, maintenance of prothrombin time within the therapeutic range, and early recognition of adverse side effects. No patient had an intracranial hemorrhage. Thus, anticoagulant agents can be safely administered after intracranial operations for malignant gliomas without increased risk of morbidity or mortality if the patients are carefully monitored according to established guidelines.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Choucair AK,Silver P,Levin VA

doi

10.3171/jns.1987.66.3.0357

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

357-8

issue

3

eissn

0022-3085

issn

1933-0693

journal_volume

66

pub_type

杂志文章
  • Single-fraction radiosurgery of benign cavernous sinus meningiomas.

    abstract:OBJECT:Stereotactic radiosurgery (SRS) is an important treatment option for patients with cavernous sinus meningiomas (CSM). To analyze factors associated with local tumor control and complications after single-fraction SRS, the authors reviewed cases involving patients treated with Gamma Knife SRS between 1990 and 200...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.5.JNS13206

    authors: Pollock BE,Stafford SL,Link MJ,Garces YI,Foote RL

    更新日期:2013-09-01 00:00:00

  • Early reversal of acidosis and metabolic recovery following ischemia.

    abstract::Tissue acidosis is believed to be a key element in ischemic injury of neural tissue. The goal of this study was to determine whether persisting postischemic acidosis or the extent of acidosis would affect metabolic recovery following an ischemic event. Intracellular pH (pHi), adenosine triphosphate, phosphocreatine, a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.4.0567

    authors: Hoffman TL,LaManna JC,Pundik S,Selman WR,Whittingham TS,Ratcheson RA,Lust WD

    更新日期:1994-10-01 00:00:00

  • Distinctive electrophysiological characteristics of functionally discrete brain areas: a tenable approach to functional localization.

    abstract::The direct cortical response (DCR), an electrical potential recorded in the immediate vicinity of a surface cortical stimulus, shows a configuration in the primary sensory areas of animals that is different from the one observed in association cortex. This suggested the possibility that systematic study of the DCR in ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.80.4.0701

    authors: Goldring S,Harding GW,Gregorie EM

    更新日期:1994-04-01 00:00:00

  • Long-term outcomes of transsphenoidal surgery for management of growth hormone-secreting adenomas: single-center results.

    abstract:OBJECTIVE:Transsphenoidal surgery is advocated as the first-line management of growth hormone (GH)-secreting adenomas. Although disease control is defined by strict criteria for biochemical remission, the length of follow-up needed is not well defined in literature. In this report, the authors present their long-term r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.6.JNS191187

    authors: Asha MJ,Takami H,Velasquez C,Oswari S,Almeida JP,Zadeh G,Gentili F

    更新日期:2019-10-11 00:00:00

  • Endovascular treatment of intracranial aneurysms: comparative evaluation in a terminal bifurcation aneurysm model in dogs.

    abstract:OBJECT:The authors investigated whether HydroCoils decreased coil compaction and aneurysm recanalization in a canine model of a large, wide-necked, high-flow bifurcation aneurysm. METHODS:Eleven experimental aneurysms were created. Two aneurysms were untreated (Group 1); three were treated with standard platinum coils...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.101.6.0996

    authors: Yoshino Y,Niimi Y,Song JK,Silane M,Berenstein A

    更新日期:2004-12-01 00:00:00

  • Research productivity in neurosurgery: trends in globalization, scientific focus, and funding.

    abstract:OBJECT:While research is important for the survival, growth, and expansion of neurosurgery, little work has been done to quantify the status and trends of neurosurgical publications. The purpose of this bibliometric study was to quantitatively analyze trends in neurosurgical publications, including changes in worldwide...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.8.JNS11857

    authors: Hauptman JS,Chow DS,Martin NA,Itagaki MW

    更新日期:2011-12-01 00:00:00

  • Apparent diffusion coefficients for evaluation of the response of brain tumors treated by Gamma Knife surgery.

    abstract:OBJECT:Cellular density is a major factor for change in the apparent diffusion coefficient (ADC). The authors hypothesized that loss of tumor cells after Gamma Knife surgery (GKS) may alter the ADC value and used diffusion weighted MR imaging (DW imaging) to evaluate cellular changes in brain tumors to detect their tre...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Huang CF,Chiou SY,Wu MF,Tu HT,Liu WS,Chuang JC

    更新日期:2010-12-01 00:00:00

  • The effects of deep barbiturate coma on multimodality evoked potentials.

    abstract::The authors report their investigation of the effects of high-dose barbiturates on the multimodality evoked response in 9 cats. After baseline evoked responses were obtained, boluses of pentobarbital were infused intravenously at regular intervals, amounting to cumulative total doses of 9, 18, 27, 45, 63, 123, and 183...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.57.2.0178

    authors: Sutton LN,Frewen T,Marsh R,Jaggi J,Bruce DA

    更新日期:1982-08-01 00:00:00

  • A physical simulator for endoscopic endonasal drilling techniques: technical note.

    abstract::In this paper, the authors present a physical model developed to teach surgeons the requisite drilling techniques when using an endoscopic endonasal approach (EEA) to the skull base. EEA is increasingly used for treating pathologies of the ventral and ventrolateral cranial base. Endonasal drilling is a unique skill in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.3.JNS1552

    authors: Tai BL,Wang AC,Joseph JR,Wang PI,Sullivan SE,McKean EL,Shih AJ,Rooney DM

    更新日期:2016-03-01 00:00:00

  • Malignant triton tumor of the acoustic nerve. Case report.

    abstract::The authors present the clinical, radiological, pathological features, and autopsy findings of a patient with malignant triton tumor of the acoustic nerve, which probably arose from a pre-existing acoustic schwannoma. The term "malignant triton tumor" is applied to malignant schwannomas with rhabdomyoblastic different...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.76.5.0874

    authors: Han DH,Kim DG,Chi JG,Park SH,Jung HW,Kim YG

    更新日期:1992-05-01 00:00:00

  • Transantral transsphenoidal approach to the pituitary. Technical note.

    abstract::The authors describe the technique of a transantral transsphenoidal approach to the sella turcica. The advantages and potential complications are discussed. This procedure may also be applicable when dealing with tumors of the skull base and orbits. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.59.6.1102

    authors: Hoyt TE,Turnbull FM,Kusske JA

    更新日期:1983-12-01 00:00:00

  • A new technique for exposure of the cervical spine laminae. Technical note.

    abstract::The author describes a new technique for exposure of the cervical spine laminae in which the attachments of the semispinalis cervicis and multifidus muscles to the spinous processes are left untouched. It provides a conservative exposure through which a diverse range of posterior cervical surgeries can be performed. I...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2002.96.1.0122

    authors: Shiraishi T

    更新日期:2002-01-01 00:00:00

  • Treatment of blunt injury to the carotid artery by using endovascular stents: an early experience.

    abstract::Identification of blunt carotid injury prior to the development of ischemic symptoms requires aggressive screening of patients at risk. The treatment of these lesions has centered around long-term anticoagulation therapy. However, studies have revealed that many of these lesions persist despite medical treatment, as d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1997.87.6.0825

    authors: Duke BJ,Ryu RK,Coldwell DM,Brega KE

    更新日期:1997-12-01 00:00:00

  • A critical appraisal of drainage in syringomyelia.

    abstract::The use of drains in the treatment of syringomyelia has a simple and immediate appeal and has been practiced widely since the report of Abbe and Coley over 100 years ago. Good short-term results have been claimed in the past, but long-term outcome is largely unknown. An experience in Birmingham, England is reviewed in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.1.0001

    authors: Sgouros S,Williams B

    更新日期:1995-01-01 00:00:00

  • Destructive procedures for control of cancer pain: the case for cordotomy.

    abstract:OBJECT:Historically, destructive procedures for cancer pain were the main line of treatment therapy. However, the use of high-dose opioids has essentially replaced such procedures. Recognition of the limits of medical therapy to treat cancer pain effectively is growing, while conversely, in regions with limited access ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2010.6.JNS10119

    authors: Raslan AM,Cetas JS,McCartney S,Burchiel KJ

    更新日期:2011-01-01 00:00:00

  • Intraocular pressure during neurosurgical procedures in context of head position and loss of cerebrospinal fluid.

    abstract:OBJECTIVE:Perioperative visual loss (POVL) is a rare but serious complication in surgical disciplines, especially in spine surgery. The exact pathophysiology of POVL remains unclear, but elevated intraocular pressure (IOP) is known to be part of it. As POVL is rarely described in patients undergoing intracranial or int...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.3.JNS173098

    authors: Czorlich P,Krätzig T,Kluge N,Skevas C,Knospe V,Spitzer MS,Dreimann M,Mende KC,Westphal M,Eicker SO

    更新日期:2018-08-24 00:00:00

  • Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction.

    abstract::OBJECTIVE: Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat models of cerebral infarction. Although clinical studies are ongoing, most studies have focused on the acute or subacute phase of stroke. In the present study, MSCs derived from bone marr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.5.JNS18140

    authors: Namioka T,Namioka A,Sasaki M,Kataoka-Sasaki Y,Oka S,Nakazaki M,Onodera R,Suzuki J,Sasaki Y,Nagahama H,Kocsis JD,Honmou O

    更新日期:2018-10-01 00:00:00

  • Blood-brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure.

    abstract:OBJECTIVE:One of the goals in this study was to set up a semiautomatic method to estimate blood-brain barrier disruption obtained in patients with glioblastoma by using an implantable, unfocused, ultrasound device. Another goal was to correlate the probability of significant ultrasound-induced signal enhancement (SUISE...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.9.JNS182001

    authors: Asquier N,Bouchoux G,Canney M,Martin C,Law-Ye B,Leclercq D,Chapelon JY,Lafon C,Idbaih A,Carpentier A

    更新日期:2019-02-01 00:00:00

  • Insular glioma surgery: an evolution of thought and practice.

    abstract::OBJECTIVEThe goal of this article is to review the history of surgery for low- and high-grade gliomas located within the insula with particular focus on microsurgical technique, anatomical considerations, survival, and postoperative morbidity.METHODSThe authors reviewed the literature for published reports focused on ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2018.10.JNS181519

    authors: Hervey-Jumper SL,Berger MS

    更新日期:2019-01-01 00:00:00

  • Motor areas of the frontal cortex in patients with motor eloquent brain lesions.

    abstract::OBJECTIVE Because of its huge clinical potential, the importance of premotor areas for motor function itself and plastic reshaping due to tumors or ischemic brain lesions has received increased attention. Thus, in this study the authors used navigated transcranial magnetic stimulation (nTMS) to investigate whether tum...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.11.JNS152103

    authors: Bulubas L,Sabih J,Wohlschlaeger A,Sollmann N,Hauck T,Ille S,Ringel F,Meyer B,Krieg SM

    更新日期:2016-12-01 00:00:00

  • Cerebrovascular effects of hypocapnia during adenosine-induced arterial hypotension.

    abstract::Profound arterial hypotension is a commonly used adjunct in surgery for aneurysms and arteriovenous malformations. Hyperventilation with hypocapnia is also used in these patients to increase brain slackness. Both measures reduce cerebral blood flow (CBF). Of concern is whether CBF is reduced below ischemic thresholds ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.6.0937

    authors: Boarini DJ,Kassell NF,Sprowell JA,Olin JJ,Coester HC

    更新日期:1985-12-01 00:00:00

  • CSF rhinorrhea from a transclival meningocele demonstrated with metrizamide CT cisternography. Case report.

    abstract::A 63-year-old woman with a 10-year history of intermittent cerebrospinal fluid (CSF) rhinorrhea was found to have a transclival meningocele. After pluridirectional tomography demonstrated a bone defect in the clivus, the diagnosis was established by means of computerized tomography (CT) by comparing the absorption coe...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.53.4.0553

    authors: Lockwood AH,Quencer RM,Page LK

    更新日期:1980-10-01 00:00:00

  • Diffuse bilateral cerebral astrocytomas with atypical neuroimaging studies.

    abstract::The authors describe the clinical behavior of eight patients with cerebral astrocytomas, in whom computerized tomography (CT) or magnetic resonance (MR) imaging of the brain was characterized by diffuse bilateral cerebral hemisphere tissue density abnormalities and minimal focal mass effect. Five patients were newly d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.6.0817

    authors: Rogers LR,Weinstein MA,Estes ML,Cairncross JG,Strachan T

    更新日期:1994-12-01 00:00:00

  • A microsurgical study of the anatomy and course of the ophthalmic artery and its possibly dangerous anastomoses.

    abstract:OBJECT:The authors studied the microsurgical anatomy of the ophthalmic artery (OphA), paying particular attention to its possibly dangerous anastomoses with the middle meningeal artery (MMA). METHODS:The microsurgical anatomy of the OphA and its anastomoses with the MMA were studied in 14 vessels from seven adult cada...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2007.106.1.142

    authors: Perrini P,Cardia A,Fraser K,Lanzino G

    更新日期:2007-01-01 00:00:00

  • Combining endovascular and neurosurgical treatments of high-risk dural arteriovenous fistulas in the lateral sinus and the confluence of the sinuses.

    abstract:OBJECT:The authors describe the use of a systemic approach to treat dural arteriovenous fistulas (DAVFs) in the lateral sinus and the confluence of sinuses in 17 patients who presented with signs and symptoms related to intracranial hemorrhage, infarction, and diffuse brain swelling. METHODS:Angiographic examination r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.90.2.0289

    authors: Goto K,Sidipratomo P,Ogata N,Inoue T,Matsuno H

    更新日期:1999-02-01 00:00:00

  • Phase II study of nimustine, carboplatin, vincristine, and interferon-beta with radiotherapy for glioblastoma multiforme: experience of the Kyoto Neuro-Oncology Group.

    abstract:OBJECT:This Phase II study was performed to determine the safety, tolerability, and efficacy of combining nimustine (ACNU)-carboplatin-vincristine-Interferon-beta (IFNbeta) chemotherapy. METHODS:Ninety-seven patients with Karnofsky Performance Scale scores of 50 or greater were enrolled in the study. Nimustine (60 mg/...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.105.3.385

    authors: Aoki T,Takahashi JA,Ueba T,Oya N,Hiraoka M,Matsui K,Fukui T,Nakashima Y,Ishikawa M,Hashimoto N

    更新日期:2006-09-01 00:00:00

  • Anatomic variations of venous sinuses in the region of the torcular Herophili.

    abstract::In this study of 110 cranial cavities from adult cadavers, the superior sagittal sinus was found to divide into two channels. In most cases, the division was associated with a dural partition. Essentially, the variations as observed in this study could be grouped into three types: Type 1 includes those specimens in wh...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.1.0090

    authors: Bisaria KK

    更新日期:1985-01-01 00:00:00

  • Suprascapular nerve entrapment: experience with 28 cases.

    abstract::Suprascapular nerve entrapment (SNE) in the suprascapular notch is a rare entity that must be considered in the differential diagnosis of radicular pain, as well as that of shoulder discomfort. Over a period of 10 years (1985-1995), the authors treated 28 cases of SNE in 27 patients by surgical decompression of the ne...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.6.1020

    authors: Antoniadis G,Richter HP,Rath S,Braun V,Moese G

    更新日期:1996-12-01 00:00:00

  • Evidence for a conditioning effect of inhalational anesthetics on angiographic vasospasm after aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is characterized by large-artery vasospasm, distal autoregulatory dysfunction, cortical spreading depression, and microvessel thrombi. Large-artery vasospasm has been identified as an independent predictor of poor outcome in numero...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.3.JNS183512

    authors: Athiraman U,Aum D,Vellimana AK,Osbun JW,Dhar R,Tempelhoff R,Zipfel GJ

    更新日期:2019-06-14 00:00:00

  • Transcriptional expression of survivin and its splice variants in brain tumors in humans.

    abstract:OBJECT:Survivin, one of the apoptosis inhibitor proteins, has been detected in most cancers in humans. In addition, two splice variants (survivin-2B and survivin-deltaEx3) have been identified. The authors investigated the transcription levels of survivin messenger (m)RNA and its splice variants in nine tumor cell line...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.4.0738

    authors: Yamada Y,Kuroiwa T,Nakagawa T,Kajimoto Y,Dohi T,Azuma H,Tsuji M,Kami K,Miyatake S

    更新日期:2003-10-01 00:00:00