Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction.


:OBJECTIVE: Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat models of cerebral infarction. Although clinical studies are ongoing, most studies have focused on the acute or subacute phase of stroke. In the present study, MSCs derived from bone marrow of rats were intravenously infused 8 weeks after the induction of a middle cerebral artery occlusion (MCAO) to investigate whether delayed systemic injection of MSCs improves functional outcome in the chronic phase of stroke in rats. METHODS: Eight weeks after induction of the MCAO, the rats were randomized and intravenously infused with either MSCs or vehicle. Ischemic volume and behavioral performance were examined. Blood-brain barrier (BBB) integrity was assessed by quantifying the leakage of Evans blue into the brain parenchyma after intravenous infusion. Immunohistochemical analysis was also performed to evaluate the stability of the BBB. RESULTS: Motor recovery was better in the MSC-treated group than in the vehicle-treated group, with rapid improvement (evident at 1 week post-infusion). In MSC-treated rats, reduced BBB leakage and increased microvasculature/repair and neovascularization were observed. CONCLUSIONS: These results indicate that the systemic infusion of MSCs results in functional improvement, which is associated with structural changes in the chronic phase of cerebral infarction, including in the stabilization of the BBB.


J Neurosurg


Journal of neurosurgery


Namioka T,Namioka A,Sasaki M,Kataoka-Sasaki Y,Oka S,Nakazaki M,Onodera R,Suzuki J,Sasaki Y,Nagahama H,Kocsis JD,Honmou O




Has Abstract


2018-10-01 00:00:00










  • Relationship of acute CBF and ICP findings to neuropsychological outcome in severe head injury.

    abstract::Neuropsychological outcome within 1 year after severe head injury was examined in 42 conscious survivors and correlated with acute measurements of cerebral blood flow (CBF) and intracranial pressure (ICP). During acute coma, CBF was elevated in 23 patients, indicating hyperemia, and was reduced in the remaining 19 cas...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Uzzell BP,Obrist WD,Dolinskas CA,Langfitt TW

    更新日期:1986-11-01 00:00:00

  • Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting.

    abstract::OBJECTIVE Mutations in the isocitrate dehydrogenase (IDH) genes are of proven diagnostic and prognostic significance for cerebral gliomas. The objective of this study was to evaluate the clinical feasibility of using a recently described method for determining IDH mutation status by using magnetic resonance spectrosco...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tietze A,Choi C,Mickey B,Maher EA,Parm Ulhøi B,Sangill R,Lassen-Ramshad Y,Lukacova S,Østergaard L,von Oettingen G

    更新日期:2018-02-01 00:00:00

  • Hybrid fluorescein-guided surgery for pituitary adenoma resection: a pilot study.

    abstract:OBJECTIVE:The authors conducted a pilot study on hybrid fluorescein-guided surgery for pituitary adenoma resection and herein describe the feasibility and safety of this technique. METHODS:In this pilot study, the authors included all consecutive patients presenting with pituitary adenomas, functioning and nonfunction...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Romano-Feinholz S,Alcocer-Barradas V,Benítez-Gasca A,Martínez-de la Maza E,Valencia-Ramos C,Gómez-Amador JL

    更新日期:2019-04-05 00:00:00

  • Contemporary trends in extracranial-intracranial bypass utilization: analysis of data from 2008 to 2016.

    abstract:OBJECTIVE:The impact of FDA approval of flow-diversion technology for the treatment of supraclinoid internal carotid artery aneurysms and the publication of the Carotid Occlusion Surgery Study, both of which occurred in 2011, on the utilization of extracranial-intracranial (EC-IC) bypasses is not known. METHODS:The Na...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Alvi MA,Rinaldo L,Kerezoudis P,Rangel-Castilla L,Bydon M,Cloft H,Lanzino G

    更新日期:2019-11-15 00:00:00

  • Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures.

    abstract::A randomized double-blind placebo-controlled study was carried out to determine whether phenytoin administered soon after injury lessens the incidence of epilepsy in the 1st week after severe head trauma. In this study, 244 patients were randomized into either a phenytoin or placebo group. The patients in the phenytoi...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Young B,Rapp RP,Norton JA,Haack D,Tibbs PA,Bean JR

    更新日期:1983-02-01 00:00:00

  • Cavernous hemangioma extending to extracranial, intracranial, and orbital regions. Case report.

    abstract::Extraaxial cavernous hemangiomas are rare intracranial lesions that can be located in different cranial compartments. Extension across different tissue planes such as the subcutaneous tissue, skull, orbital cavity, intracranial dura mater, and extracranial trigeminal divisions within the same patient has not been prev...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Puca A,Colosimo C,Tirpakova B,Lauriola L,Di Rocco F

    更新日期:2004-12-01 00:00:00

  • Epidemiology of venous thromboembolism in 9489 patients with malignant glioma.

    abstract:OBJECT:The authors sought to define the incidence of symptomatic venous thromboembolism (VTE) in patients harboring malignant gliomas. METHODS:The authors conducted a retrospective analysis of data obtained in all cases of malignant glioma diagnosed in California during a 6-year period; the occurrence of a VTE was ide...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Semrad TJ,O'Donnell R,Wun T,Chew H,Harvey D,Zhou H,White RH

    更新日期:2007-04-01 00:00:00

  • Thrombus organization and healing in an experimental aneurysm model. Part II. The effect of various types of bioactive bioabsorbable polymeric coils.

    abstract:OBJECT:Bioabsorbable polymeric material coils are being used in the endovascular treatment of aneurysms to achieve better thrombus organization than is possible using bare platinum coils. We used immunohistochemical and molecular biological analysis techniques in experimental aneurysms implanted with three different bi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yuki I,Lee D,Murayama Y,Chiang A,Vinters HV,Nismmura I,Wang CJ,Ishii A,Wu BM,Viñuela F

    更新日期:2007-07-01 00:00:00

  • Spontaneous regression of a cerebral arteriovenous malformation in a child with hereditary hemorrhagic telangiectasia. Case report.

    abstract::Patients with hereditary hemorrhagic telangiectasia (HHT) are at risk for the development of cerebral arteriovenous malformations (AVMs). The authors report a case of a spontaneously regressing cerebral AVM in a patient with HHT. The lesion was diagnosed on the basis of findings on screening magnetic resonance imaging...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Leung KM,Agid R,terBrugge K

    更新日期:2006-11-01 00:00:00

  • Surgical experience following intervertebral discolysis with collagenase.

    abstract::Of 410 patients with refractory herniated lumbar disc disease treated with intradiscal collagenase, 82 (20%) did not respond to enzyme treatment and subsequently underwent surgery. Failure to improve in 6 to 8 weeks was the predominant cause for surgical intervention (53 patients). Increased pain (18 patients), progre...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fisher RG,Bromley JW,Becker GL,Brown M,Mooney V

    更新日期:1986-04-01 00:00:00

  • Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model.

    abstract:OBJECTIVE:Direct brain compression and secondary injury due to increased intracranial pressure are believed to be the pathognomic causes of a grave outcome in acute subdural hemorrhage (aSDH). However, ischemic damage from aSDH has received limited attention. The authors hypothesized that cerebral microcirculation is a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Wang HC,Tsai JC,Lee JE,Huang SJ,Po-Hao Huang A,Lin WC,Hsieh ST,Wang KC

    更新日期:2018-10-01 00:00:00

  • The neurophysiology and effect of deep brain stimulation in a patient with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism.

    abstract::Parkinsonism caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure was first identified in intravenous drug users. This neurotoxicant has since been used extensively in nonhuman primates to induce an experimental model of Parkinson disease (PD). In this study, the authors examined the intraoperative p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Christine CW,Langston JW,Turner RS,Starr PA

    更新日期:2009-02-01 00:00:00

  • The impact of raised intracranial pressure on cerebral venous hemodynamics: a prospective venous transcranial Doppler ultrasonography study.

    abstract:OBJECT:The effect of increased intracranial pressure (ICP) on cerebral venous blood flow has been the subject of very few clinical and experimental studies. The authors assessed the usefulness of venous transcranial Doppler (TCD) ultrasonography as a noninvasive monitoring tool for predicting raised ICP. METHODS:Seria...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Schoser BG,Riemenschneider N,Hansen HC

    更新日期:1999-11-01 00:00:00

  • Parasellar epidermoid tumor presenting as painful ophthalmoplegia.

    abstract::In 1964, a 51-year-old man experienced a right abducens nerve palsy, which resolved spontaneously. In 1978, he developed painful ophthalmoplegia on the right with paresis of the right oculomotor and trigeminal nerves. Neuroradiographic evaluation was reported unremarkable, and the painful ophthalmoplegia was attribute...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kline LB,Galbraith JG

    更新日期:1981-01-01 00:00:00

  • Mononuclear leukocyte ADP-ribosylation as an indicator of immune function in malignant-glioma patients treated with betamethasone for cerebral edema.

    abstract::Glioma patients receiving corticosteroids (16 mg/day betamethasone) were examined for evidence of immune cell dysfunction by using quantitative estimates of adenosine diphosphate (ADP)-ribosylation in peripheral mononuclear leukocytes as the physiological indicator. The duration of daily treatment with corticosteroids...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pero RW,Salford LG,Strömblad LG,Andersson C

    更新日期:1992-10-01 00:00:00

  • Role of tumor necrosis factor-alpha and matrix metalloproteinase-9 in blood-brain barrier disruption after peripheral thermal injury in rats.

    abstract:OBJECT:A relationship has been found between peripheral thermal injury and cerebral complications leading to injury and death. In the present study, the authors examined whether tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-9 (MMP-9) play a causative role in blood-brain barrier (BBB) disruption a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Reyes R,Guo M,Swann K,Shetgeri SU,Sprague SM,Jimenez DF,Barone CM,Ding Y

    更新日期:2009-06-01 00:00:00

  • Intracranial desmoplastic small round cell tumor presenting as a suprasellar mass.

    abstract::Desmoplastic small round cell tumors (DSRCTs) are rare, aggressive neoplasms that typically arise from abdominal and pelvic peritoneum in young adults. Other primary sites are uncommon, and an intracranial origin is exceptionally rare. Here the authors report the first case of a DSRCT presenting as a primary suprasell...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Thondam SK,du Plessis D,Cuthbertson DJ,Das KS,Javadpour M,MacFarlane IA,Leggate J,Haylock B,Daousi C

    更新日期:2015-04-01 00:00:00

  • Increased prevalence of autoimmune disease in patients with unilateral compared with bilateral moyamoya disease.

    abstract::OBJECT This study explored whether there were differences between the autoimmune disease prevalence rates in unilateral and bilateral moyamoya disease (MMD). METHODS The authors performed a retrospective review of data obtained from the medical records of their hospital, analyzing and comparing the clinical characteri...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Chen JB,Liu Y,Zhou LX,Sun H,He M,You C

    更新日期:2016-05-01 00:00:00

  • Familial communicating hydrocephalus, posterior cerebellar agenesis, mega cisterna magna, and port-wine nevi. Report on five members of one family.

    abstract::This report deals with a family in which the maternal grandmother, the mother, and all three male children have port-wine nevi and mega cisterna magna. Two of the three male children have, in addition, congenital communicating hydrocephalus associated with agenesis of the posterior cerebellar vermis. This case of fami...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Nova HR

    更新日期:1979-12-01 00:00:00

  • Long-term outcome after removal of spinal schwannoma: a clinicopathological study of 187 cases.

    abstract::Are spinal schwannomas as benign as we think? To what extent do patients recover? Are patients prone to develop late complications such as cystic myelopathy or symptomatic spinal deformity? Is their life expectancy compromised? In an effort to answer these questions, the authors analyzed the long-term outcome for 187 ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Seppälä MT,Haltia MJ,Sankila RJ,Jääskeläinen JE,Heiskanen O

    更新日期:1995-10-01 00:00:00

  • Thalamic syndrome caused by unruptured cerebral aneurysm. Case report.

    abstract::A case is reported of a 63-year-old woman with thalamic syndrome as the presenting feature of an unruptured cerebral aneurysm. Unruptured aneurysm is a rare cause of thalamic syndrome; the possible mechanisms of production of the sensory disturbance are discussed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Stoodley MA,Warren JD,Oatey PE

    更新日期:1995-02-01 00:00:00

  • Outcome following hindbrain decompression of symptomatic Chiari malformations in children previously treated with myelomeningocele closure and shunts.

    abstract::Between 1975 and 1989, 25 children treated with myelomeningocele closure and shunting for hydrocephalus at the Children's Hospital of Pittsburgh developed progressive lower brain-stem dysfunction from their Chiari malformation. Retrospective univariate and multivariate analyses of these cases were undertaken to assess...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pollack IF,Pang D,Albright AL,Krieger D

    更新日期:1992-12-01 00:00:00

  • Silver colloid staining technique for analysis of glioma malignancy.

    abstract::A silver colloid staining technique for identifying nucleolar organizer region-associated proteins (Ag-NOR's) was applied to 51 human gliomas. These comprised 20 glioblastomas multiforme, 15 anaplastic astrocytomas, and 16 astrocytomas, in which the mean numbers of Ag-NOR's per cell (+/- standard error of the mean) we...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kajiwara K,Nishizaki T,Orita T,Nakayama H,Aoki H,Ito H

    更新日期:1990-07-01 00:00:00

  • Feeding artery pedicle aneurysms: association with parenchymal hemorrhage and arteriovenous malformation in the brain.

    abstract::The association between arteriovenous malformations (AVM's) and aneurysms is well documented in the literature. However, a specific type of aneurysm, termed a "pedicle" aneurysm, has received little attention despite its role as a primary source of hemorrhage. The authors report four recent cases of patients with cere...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Perata HJ,Tomsick TA,Tew JM Jr

    更新日期:1994-04-01 00:00:00

  • Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent.

    abstract:OBJECT:Bone morphogenetic proteins (BMPs) have been shown to have significant osteoinductive activity in numerous in vitro and in vivo assay systems, and BMP-2 and BMP-7 are currently being evaluated in human clinical studies. In the spinal region, BMPs have been shown to promote spinal arthrodesis at a higher rate tha...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Helm GA,Alden TD,Beres EJ,Hudson SB,Das S,Engh JA,Pittman DD,Kerns KM,Kallmes DF

    更新日期:2000-04-01 00:00:00

  • Neuronal heterotopia with capillary penetration of neurons and cortical dysplasia in a patient with complex partial seizures. Case report.

    abstract::Unusual pathological findings were encountered in a temporal lobectomy specimen from a 9-year-old boy with intractable complex partial seizures. Magnetic resonance imaging revealed an enlarged left temporal lobe, with diffuse high signal intensity over the cortex and poor gray-white differentiation on T2-weighted imag...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Jay V,Becker LE,Otsubo H,Hwang P,Hoffman HJ,Armstrong DC

    更新日期:1993-04-01 00:00:00

  • Reliability assessment of the Biffl Scale for blunt traumatic cerebrovascular injury as detected on computer tomography angiography.

    abstract::OBJECTIVE Blunt traumatic cerebrovascular injury (TCVI) represents structural injury to a vessel due to high-energy trauma. The Biffl Scale is a widely accepted grading scheme for these injuries that was developed using digital subtraction angiography. In recent years, screening CT angiography (CTA) has been used to i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Foreman PM,Griessenauer CJ,Kicielinski KP,Schmalz PGR,Rocque BG,Fusco MR,Sullivan JC 3rd,Deveikis JP,Harrigan MR

    更新日期:2017-07-01 00:00:00

  • Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery.

    abstract:OBJECTIVE:Decision-making for intracranial tumor surgery requires balancing the oncological benefit against the risk for resection-related impairment. Risk estimates are commonly based on subjective experience and generalized numbers from the literature, but even experienced surgeons overestimate functional outcome aft...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Staartjes VE,Broggi M,Zattra CM,Vasella F,Velz J,Schiavolin S,Serra C,Bartek J Jr.,Fletcher-Sandersjöö A,Förander P,Kalasauskas D,Renovanz M,Ringel F,Brawanski KR,Kerschbaumer J,Freyschlag CF,Jakola AS,Sjåvik K,Solhei

    更新日期:2020-06-12 00:00:00

  • Speech changes induced by deep brain stimulation of the subthalamic nucleus in Parkinson disease: involvement of the dentatorubrothalamic tract.

    abstract::OBJECTIVE Patients with Parkinson disease (PD) who undergo subthalamic nucleus (STN) deep brain stimulation (DBS) often develop a deterioration in speech performance, but there is no clear consensus on the specific effects seen or the mechanism involved and little description of the impact of DBS on conversational spe...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fenoy AJ,McHenry MA,Schiess MC

    更新日期:2017-06-01 00:00:00

  • The clinical application of plugging patterns for the Leksell gamma knife.

    abstract:OBJECT:In this report the authors explore the use of standardized plugging templates in formulating stereotactic radiosurgery dose plans for the Leksell gamma knife. METHODS:Unplugged gamma knife dose plans previously used in the treatment of patients with trigeminal neuralgia (TN) and vestibular schwannoma (VS) were ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Vaughan P,Hampshire A,Soanes T,Kemeny A,Radatz M,Rowe J,Walton L

    更新日期:2002-12-01 00:00:00