Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction.

Abstract:

:OBJECTIVE: Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat models of cerebral infarction. Although clinical studies are ongoing, most studies have focused on the acute or subacute phase of stroke. In the present study, MSCs derived from bone marrow of rats were intravenously infused 8 weeks after the induction of a middle cerebral artery occlusion (MCAO) to investigate whether delayed systemic injection of MSCs improves functional outcome in the chronic phase of stroke in rats. METHODS: Eight weeks after induction of the MCAO, the rats were randomized and intravenously infused with either MSCs or vehicle. Ischemic volume and behavioral performance were examined. Blood-brain barrier (BBB) integrity was assessed by quantifying the leakage of Evans blue into the brain parenchyma after intravenous infusion. Immunohistochemical analysis was also performed to evaluate the stability of the BBB. RESULTS: Motor recovery was better in the MSC-treated group than in the vehicle-treated group, with rapid improvement (evident at 1 week post-infusion). In MSC-treated rats, reduced BBB leakage and increased microvasculature/repair and neovascularization were observed. CONCLUSIONS: These results indicate that the systemic infusion of MSCs results in functional improvement, which is associated with structural changes in the chronic phase of cerebral infarction, including in the stabilization of the BBB.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Namioka T,Namioka A,Sasaki M,Kataoka-Sasaki Y,Oka S,Nakazaki M,Onodera R,Suzuki J,Sasaki Y,Nagahama H,Kocsis JD,Honmou O

doi

10.3171/2018.5.JNS18140

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1-8

eissn

0022-3085

issn

1933-0693

pii

2018.5.JNS18140

pub_type

杂志文章
  • Transcranial electrical stimulation through screw electrodes for intraoperative monitoring of motor evoked potentials. Technical note.

    abstract::The feasibility of high-frequency transcranial electrical stimulation (TES) through screw electrodes placed in the skull was investigated for use in intraoperative monitoring of the motor pathways in patients who are in a state of general anesthesia during cerebral and spinal operations. Motor evoked potentials (MEPs)...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2004.100.1.0155

    authors: Watanabe K,Watanabe T,Takahashi A,Saito N,Hirato M,Sasaki T

    更新日期:2004-01-01 00:00:00

  • Mercury water and cauterizing stones: Nicolas André and tic douloureux.

    abstract::In his 1756 text, Observations pratiques sur les maladies de l'urèthre et sur plusiers faits convulsifs, Nicolas André coined the term "tic douloureux." He believed that this pain originated from compression of facial sensory peripheral nerves. Using scientific observation and experimentation to confirm this hypothesi...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/jns.1999.90.5.0977

    authors: Brown JA,Coursaget C,Preul MC,Sangvai D

    更新日期:1999-05-01 00:00:00

  • Clinical experience with extra-intracranial arterial anastomosis in 65 cases.

    abstract::Clinical results of an extra-intracranial arterial bypass (EIAB) procedure for cerebral ischemia are assessed in 65 patients. The 5-year-study suggests that the EIAB procedure has a protective effect against further clinically significant cerebrovascular accidents in properly selected patients. Correlation with angiog...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1976.44.3.0313

    authors: Gratzl O,Schmiedek P,Spetzler R,Steinhoff H,Marguth F

    更新日期:1976-03-01 00:00:00

  • Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study.

    abstract:OBJECT:Diffuse axonal injury (DAI) is a major complication of traumatic brain injury (TBI) that leads to functional and psychological deficits. Although DAI is frequently underdiagnosed by conventional imaging modalities, it can be demonstrated using diffusion tensor imaging. The aim of this study was to assess the pre...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.2.0298

    authors: Inglese M,Makani S,Johnson G,Cohen BA,Silver JA,Gonen O,Grossman RI

    更新日期:2005-08-01 00:00:00

  • Inhibition of proliferative growth in glioma cells by calmodulin antagonists.

    abstract::The effects of several calmodulin antagonists, such as N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide hydrochloride (W-7) and its dechlorinated structural analogue (W-5), on the growth and proliferation of cultured and transplanted glioma (GA-1, chemically induced from rat glioblasts) were evaluated. Under cultur...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.65.1.0074

    authors: Suzuki N,Kanno T,Nagata Y,Kato T

    更新日期:1986-07-01 00:00:00

  • Treatment of fusiform aneurysms of the peripheral cerebral arteries. Report of two cases.

    abstract::Two patients with fusiform aneurysms and at least one previous subarachnoid hemorrhage were treated by excision of the aneurysms and reconstruction of the arteries. The first case presented with two fusiform aneurysms, the larger of which involved the angular and the smaller one the temporal branch of the left middle ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.49.2.0272

    authors: Dolenc V

    更新日期:1978-08-01 00:00:00

  • Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat.

    abstract:OBJECT:The authors investigated early changes in the cerebral arteries of rats that occur after subarachnoid hemorrhage (SAH). METHODS:Messenger RNA was investigated by performing microarray and quantitative real-time polymerase chain reaction (PCR) analyses, and protein expression was shown by performing immunohistoc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.105.3.438

    authors: Vikman P,Beg S,Khurana TS,Hansen-Schwartz J,Edvinsson L

    更新日期:2006-09-01 00:00:00

  • Endoscopic endonasal resection of Rathke cleft cysts: clinical outcomes and surgical nuances.

    abstract:OBJECT:Rathke cleft cysts (RCCs) are benign lesions that can be diagnosed as an incidental finding associated with headaches, pituitary dysfunction, or vision deterioration. Typically, they occur in a sellar or suprasellar location. The aim of this study was to review the clinical presentation and outcomes associated w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.10.JNS09348

    authors: Madhok R,Prevedello DM,Gardner P,Carrau RL,Snyderman CH,Kassam AB

    更新日期:2010-06-01 00:00:00

  • Endovascular treatment of cerebral aneurysms following incomplete clipping.

    abstract::The authors report their experience using electrolytically detachable coils for the treatment of residual cerebral aneurysms following incomplete surgical clipping. Eight patients were treated for six anterior and two posterior circulation aneurysm remnants. All patients were referred for endovascular treatment by exp...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1997.87.2.0184

    authors: Thielen KR,Nichols DA,Fulgham JR,Piepgras DG

    更新日期:1997-08-01 00:00:00

  • Neurological and neuropsychological outcome after resection of craniopharyngiomas.

    abstract:OBJECTIVE:Craniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.10.JNS181557

    authors: Giese H,Haenig B,Haenig A,Unterberg A,Zweckberger K

    更新日期:2019-04-19 00:00:00

  • Spinal intramedullary cavernoma: clinical presentation and surgical outcome.

    abstract:OBJECT:Improved neuroimaging techniques have led to an increase in the reported cases of intramedullary cavernomas. The purpose of this study was to define the spectrum of presenting signs and symptoms in patients with spinal intramedullary cavernomas and to analyze the role of surgery as a treatment for these lesions....

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2000.93.1.0065

    authors: Deutsch H,Jallo GI,Faktorovich A,Epstein F

    更新日期:2000-07-01 00:00:00

  • Effects of vasopressin and oxytocin on canine cerebral circulation in vivo.

    abstract::In vivo experiments on the vasoactive effects of vasopressin and oxytocin on cerebral circulation were carried out in anesthetized dogs, using an electromagnetic flowmeter to measure vertebral blood flow and angiography to measure the internal diameter of the basilar artery. Direct bolus infusion of 1 pmol to 1 nmol o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.3.0424

    authors: Suzuki Y,Satoh S,Kimura M,Oyama H,Asano T,Shibuya M,Sugita K

    更新日期:1992-09-01 00:00:00

  • Does adjuvant external-beam radiotherapy improve outcomes for nonbenign meningiomas? A Surveillance, Epidemiology, and End Results (SEER)-based analysis.

    abstract:OBJECT:The aim of this study was to examine the effect of postoperative external-beam radiation therapy (EBRT) on disease-specific survival in patients with nonbenign meningiomas. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2007 was queried for cases of resected Grades II (atyp...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.7.JNS111439

    authors: Stessin AM,Schwartz A,Judanin G,Pannullo SC,Boockvar JA,Schwartz TH,Stieg PE,Wernicke AG

    更新日期:2012-10-01 00:00:00

  • Reduction of neural adhesions by biodegradable autocrosslinked hyaluronic acid gel after injury of peripheral nerves: an experimental study.

    abstract:OBJECT:Adhesion formation is a serious problem in peripheral nerve surgery, frequently causing dysfunction and pain. The authors aimed to develop an objective biomechanical method of quantifying nerve adhesions and to use this technique for the evaluation of the efficacy of an autocrosslinked hyaluronic acid (HA) gel a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.101.4.0648

    authors: Smit X,van Neck JW,Afoke A,Hovius SE

    更新日期:2004-10-01 00:00:00

  • Central neurocytoma of the fourth ventricle. Case report.

    abstract::The authors report on a 17-year-old boy who suffered from slowly progressive and long-standing symptoms of ataxia, neck pain, and headache. Computerized tomography (CT) and magnetic resonance (MR) imaging revealed a tumor arising from the floor of the fourth ventricle that resulted in a moderate hydrocephalus. A parti...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.91.3.0506

    authors: Warmuth-Metz M,Klein R,Sörensen N,Solymosi L

    更新日期:1999-09-01 00:00:00

  • Impaired capillary perfusion and brain edema following experimental subarachnoid hemorrhage: a morphometric study.

    abstract::To evaluate microcirculatory disturbance and cerebral edema associated with subarachnoid hemorrhage (SAH), both stereological morphometry on the intraparenchymal capillary network and microgravimetry were performed on a rabbit SAH model. Autologous arterial blood (5 ml) was injected into the cisterna magna, and the an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1990.73.3.0410

    authors: Johshita H,Kassell NF,Sasaki T,Ogawa H

    更新日期:1990-09-01 00:00:00

  • Outcome after laminectomy for lumbar spinal stenosis. Part I: Clinical correlations.

    abstract::All patients who underwent decompressive lumbar laminectomy in the Washtenaw County, Michigan metropolitan area during a 7-year period were studied for the purpose of defining long-term outcome, clinical correlations, and the need for subsequent fusion. Outcome was determined by questionnaire and physical examination ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.5.0699

    authors: Tuite GF,Stern JD,Doran SE,Papadopoulos SM,McGillicuddy JE,Oyedijo DI,Grube SV,Lundquist C,Gilmer HS,Schork MA

    更新日期:1994-11-01 00:00:00

  • Gamma knife treatment of subfoveal, classic neovascularization in age-related macular degeneration: a pilot study.

    abstract:OBJECT:Age-related macular degeneration (AMD) is the leading cause of severe vision loss in people older than age 65 years in the western world. The visual acuity loss usually results from the ingrowth of new vessels from the choroid capillaries, so called choroidal neovascularization (CNV). The aim of this pilot study...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.93.supplement

    authors: Haas A,Papaefthymiou G,Langmann G,Schröttner O,Feigl B,Leber KA,Hanselmayer R,Pendl G

    更新日期:2000-12-01 00:00:00

  • Spontaneous cerebellar hematoma associated with chronic cerebellar stimulation. Case report.

    abstract::A 24-year-old man developed a spontaneous cerebellar hematoma 5 years after the implantation of cerebellar electrodes. No vascular malformations were found either intraoperatively or radiographically. The histopathological findings of the cerebellar tissue obtained at biopsy from the region surrounding the electrodes ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.65.6.0860

    authors: Zuccarello M,Sawaya R,Lukin R,deCourten-Myers G

    更新日期:1986-12-01 00:00:00

  • Treatment of ruptured lenticulostriate artery aneurysms.

    abstract:OBJECT:Lenticulostriate artery (LSA) aneurysms are rarely reported in the literature, making management decisions challenging. Conservative, endovascular, and surgical treatments have been described primarily through case reports and reports of individual authors' experiences. The purpose of this study is to report neu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/109/7/0028

    authors: Gandhi CD,Gilad R,Patel AB,Haridas A,Bederson JB

    更新日期:2008-07-01 00:00:00

  • Calcified cervical intervertebral discs in children. Report of three cases.

    abstract::Calcified cervical intervertebral discs in children are manifestations of an uncommon, distinct disease of unknown cause. Acute symptoms are usually followed by a benign course of spontaneous recovery, frequently culminating in resorption of the calcium. Rarely herniation of the disc may cause neurological complicatio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.46.2.0233

    authors: Smith RA,Vohman MD,Dimon JH 3rd,Averett JE Jr,Milsap JH Jr

    更新日期:1977-02-01 00:00:00

  • Intracranial hemorrhage associated with cerebral hyperperfusion syndrome following carotid endarterectomy and carotid artery stenting: retrospective review of 4494 patients.

    abstract:OBJECT:Intracranial hemorrhage associated with cerebral hyperperfusion syndrome (CHS) following carotid endarterectomy (CEA) or carotid artery stenting (CAS) is a rare but potentially devastating complication. In the present study the authors evaluated 4494 patients with carotid artery stenosis who had undergone CEA or...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS-07/12/1130

    authors: Ogasawara K,Sakai N,Kuroiwa T,Hosoda K,Iihara K,Toyoda K,Sakai C,Nagata I,Ogawa A,Japanese Society for Treatment at Neck in Cerebrovascular Disease Study Group.

    更新日期:2007-12-01 00:00:00

  • Intracranial cavernous angioma: presentation and management.

    abstract::Thirteen cases of cerebral cavernous angiomas are reported, and their radiological and pathological features are reviewed. The clinical presentation was variable: 53.8% of patients had seizures, 30.8% intracerebral hemorrhage, and 15.4% focal neurological signs, including one unusual case that presented as a cerebello...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.5.0720

    authors: Tagle P,Huete I,Méndez J,del Villar S

    更新日期:1986-05-01 00:00:00

  • Effects of potassium channel-blocking agents on spontaneous discharges from neuromas in rats.

    abstract::Thirty-five Sprague-Dawley rats with saphenous neuromas underwent acute microfilament recording in the proximal nerve. The effect of the potassium channel-blocking agents, tetraethylammonium bromide (TEA) and 4-aminopyridine, on spontaneous activity in A fibers terminating in the neuroma was observed. The effects of g...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.2.0246

    authors: Burchiel KJ,Russell LC

    更新日期:1985-08-01 00:00:00

  • Outcomes and prognostic stratification of patients with recurrent glioblastoma treated with salvage stereotactic radiosurgery.

    abstract:OBJECTIVE:Glioblastoma (GBM) is the most malignant form of astrocytoma. The average survival is 6-10 months in patients with recurrent GBM (rGBM). In this study, the authors evaluated the role of stereotactic radiosurgery (SRS) in patients with rGBMs. METHODS:The authors performed a retrospective review of their brain...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.4.JNS172909

    authors: Sharma M,Schroeder JL,Elson P,Meola A,Barnett GH,Vogelbaum MA,Suh JH,Chao ST,Mohammadi AM,Stevens GHJ,Murphy ES,Angelov L

    更新日期:2018-10-19 00:00:00

  • Preoperative functional magnetic resonance imaging assessment of higher-order cognitive function in patients undergoing surgery for brain tumors.

    abstract:OBJECT:Resection of brain tumors has been shown to increase patient survival. The extent of the possible resection, however, depends on whether the tumor has invaded brain regions important for motor, sensory, or cognitive processes and whether the brain tissue surrounding the tumor maintains its functional role. The g...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/2/0258

    authors: Amiez C,Kostopoulos P,Champod AS,Collins DL,Doyon J,Del Maestro R,Petrides M

    更新日期:2008-02-01 00:00:00

  • Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury.

    abstract:OBJECT:Recent observations indicate that traumatic brain injury (TBI) may be associated with mitochondrial dysfunction. This, along with growing use of brain tissue PO2 monitors, has led to considerable interest in the potential use of ventilation with 100% oxygen to treat patients who have suffered a TBI. To date, the...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2007.106.4.526

    authors: Diringer MN,Aiyagari V,Zazulia AR,Videen TO,Powers WJ

    更新日期:2007-04-01 00:00:00

  • The importance of pial blood supply to the development of peritumoral brain edema in meningiomas.

    abstract::In a retrospective analysis, the authors studied the pial and dural blood supplies in 74 intracranial meningiomas and quantified their associated peritumoral brain edema (PTBE). The extent and localization of pial blush in relation to the total tumor volume were determined angiographically. The amount of edema and tum...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1997.87.3.0368

    authors: Bitzer M,Wöckel L,Luft AR,Wakhloo AK,Petersen D,Opitz H,Sievert T,Ernemann U,Voigt K

    更新日期:1997-09-01 00:00:00

  • Intraoperative magnetic resonance imaging and early prognosis for vision after transsphenoidal surgery for sellar lesions.

    abstract:OBJECT:Sellar lesions with suprasellar extension may cause loss of visual acuity and visual field damage due to compression of the optic chiasm. Using intraoperative MR (iMR) imaging to detect symptomatic lesion remnants adjacent to the optic chiasm (that may be resected in the same procedure) may positively affect the...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.4.JNS101568

    authors: Berkmann S,Fandino J,Zosso S,Killer HE,Remonda L,Landolt H

    更新日期:2011-09-01 00:00:00

  • Development of experimental meningeal gliomatosis models in rats.

    abstract::Experimental models of meningeal gliomatosis (MG) have been produced by intracisternal inoculation of rat C6 and 9L glioma cells into Wistar and Fischer 344 rats, respectively. Tumor growth was steady and rapid in both MG models when more than 10(6) tumor cells were implanted. The median survival time of the rats inoc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.65.4.0503

    authors: Yoshida T,Shimizu K,Ushio Y,Hayakawa T,Arita N,Mogami H

    更新日期:1986-10-01 00:00:00